ELM-the eukaryotic linear motif resource in 2020.

Abstract:

:The eukaryotic linear motif (ELM) resource is a repository of manually curated experimentally validated short linear motifs (SLiMs). Since the initial release almost 20 years ago, ELM has become an indispensable resource for the molecular biology community for investigating functional regions in many proteins. In this update, we have added 21 novel motif classes, made major revisions to 12 motif classes and added >400 new instances mostly focused on DNA damage, the cytoskeleton, SH2-binding phosphotyrosine motifs and motif mimicry by pathogenic bacterial effector proteins. The current release of the ELM database contains 289 motif classes and 3523 individual protein motif instances manually curated from 3467 scientific publications. ELM is available at: http://elm.eu.org.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Kumar M,Gouw M,Michael S,Sámano-Sánchez H,Pancsa R,Glavina J,Diakogianni A,Valverde JA,Bukirova D,Čalyševa J,Palopoli N,Davey NE,Chemes LB,Gibson TJ

doi

10.1093/nar/gkz1030

subject

Has Abstract

pub_date

2020-01-08 00:00:00

pages

D296-D306

issue

D1

eissn

0305-1048

issn

1362-4962

pii

5611669

journal_volume

48

pub_type

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