Abstract:
:The initiation of polymorphic ventricular tachycardia in long QT syndrome type 2 (LQT2) has been associated with a characteristic ECG pattern of short-long RR intervals. We hypothesize that this characteristic pattern increases APD dispersion in LQT2, thereby promoting arrhythmia. We investigated APD dispersion and its dependence on two previous cycle lengths (CLs) in transgenic rabbit models of LQT2, LQT1, and their littermate controls (LMC) using random stimulation protocols. The results show that the short-long RR pattern was associated with a larger APD dispersion in LQT2 but not in LQT1 rabbits. The multivariate analyses of APD as a function of two previous CLs (APDn = C + α1CLn-1 + α2CLn-2) showed that α1 (APD restitution slope) is largest and heterogeneous in LQT2 but uniform in LQT1, enhancing APD dispersion under long CLn-1 in LQT2. The α2 (short-term memory) was negative in LQT2 while positive in LQT1, and the spatial pattern of α1 was inversely correlated to α2 in LQT2, which explains why a short-long combination causes a larger APD dispersion in LQT2 but not in LQT1 rabbits. In conclusion, short-long RR pattern increased APD dispersion only in LQT2 rabbits through heterogeneous APD restitution and the short-term memory, underscoring the genotype-specific triggering of arrhythmias in LQT syndrome.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kim TY,Jeng P,Hwang J,Pfeiffer Z,Patel D,Cooper LL,Kossidas K,Centracchio J,Peng X,Koren G,Qu Z,Choi BRdoi
10.1038/s41598-019-51230-9subject
Has Abstractpub_date
2019-10-16 00:00:00pages
14849issue
1issn
2045-2322pii
10.1038/s41598-019-51230-9journal_volume
9pub_type
杂志文章abstract::Kaposis's sarcoma associated herpesvirus (KSHV) has been reported to infect, among others, monocytes and dendritic cells DCs impairing their function. However, the underlying mechanisms remain not completely elucidated yet. Here we show that DC exposure to active or UV-inactivated KSHV resulted in STAT3 phosphorylatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04241
更新日期:2014-02-28 00:00:00
abstract::The analysis of DNA methylation at CpG dinucleotides has become a major research focus due to its regulatory role in numerous biological processes, but the requisite need for assays which amplify bisulfite-converted DNA represents a major bottleneck due to the unique design constraints imposed on bisulfite-PCR primers...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41328
更新日期:2017-01-24 00:00:00
abstract::There is a need to develop economical, efficient and widely available therapeutic approaches to enhance the rate of skin wound healing. The optimal outcome of wound healing is restoration to the pre-wound quality of health. In this study we investigate the cellular response to biological stimuli using functionalized n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06903
更新日期:2014-11-11 00:00:00
abstract::We consider the electromagnetic response of a topological Weyl semimetal (TWS) with a pair of Weyl nodes in the bulk and corresponding Fermi arcs in the surface Brillouin zone. We compute the frequency-dependent complex conductivities σαβ(ω) and also take into account the modification of Maxwell equations by the topol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12683
更新日期:2015-08-03 00:00:00
abstract::In the present study rice straw (R, control) was mixed with Cowdung (C), Azolla (A) and cellulolytic fungus Aspergillus terreus (F) in different combinations viz. RC, RA, RF, RCF, RCA, RFA and RCFA and subjected to aerobic composting (Acom) and vermicomposting (Vcom - with Eisenia fetida). It was found that addition o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37880-1
更新日期:2019-02-04 00:00:00
abstract::Ten to twenty percent of the hepatocellular carcinoma (HCC) patients fulfilling the Milan criteria (MC) recurred within three years after orthotopic liver transplantation (OLT). We therefore utilize a training cohort to develop an improved prognostic model for predicting the recurrence in these patients. By univariate...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/srep44036
更新日期:2017-03-09 00:00:00
abstract::This paper presents a digital elevation model (DEM) of the dunes found in the Lençóis Maranhenses National Park, an environmental protection area located in the Maranhão state (Brazil). The DEM supports the modeling studies of sand-dune evolution using multi-temporal satellite images and ground truth data, obtained th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43735-0
更新日期:2019-05-15 00:00:00
abstract::Conversion of lignocellulosic biomass to biofuels and biomaterials suffers from high production costs associated with biomass pretreatment and enzymatic hydrolysis. In-planta expression of lignocellulose-digesting enzymes is a promising approach to reduce these cost elements. However, this approach faces a number of c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11026-1
更新日期:2017-09-13 00:00:00
abstract::The chemiresistive thin film gas sensors with fast response, high sensitivity, low power consumption and mass-produced potency, have been expected for practical application. It requires both sensitive materials, especially exquisite nanomaterials, and efficient substrate chip for heating and electrical addressing. How...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01669
更新日期:2013-01-01 00:00:00
abstract::Prostate cancer (PCa) is the most common solid neoplasm diagnosed in developed countries. Nerve-sparing radical prostatectomy (NS-RP) has been widely accepted as the best choice treatment for localised PCa. However, erectile dysfunction (ED) and urinary incontinence are commonly observed after NS-RP. Using meta-analys...
journal_title:Scientific reports
pub_type: 杂志文章,评审
doi:10.1038/srep05801
更新日期:2014-07-23 00:00:00
abstract::Protein phosphorylation is an important type of post-translational modification that is involved in a variety of biological activities. Most phosphorylation events occur on serine, threonine and tyrosine residues in eukaryotes. In recent years, many phosphorylation sites have been identified as a result of advances in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24735
更新日期:2016-04-19 00:00:00
abstract::Polycrystalline CeGe is investigated by means of DC and AC susceptibility, non-linear DC susceptibility, electrical transport and heat capacity measurements in the low temperature regime. This compound shows two peaks at low magnetic field around TI ~ 10.7 and TII ~ 7.3 K due to antiferromagnetic ordering and subseque...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41565-8
更新日期:2019-03-26 00:00:00
abstract::Taking advantage of the magnetoelectric and its inverse effect, this article demonstrates strain-mediated magnetoelectric write and read operations simultaneously in Co60Fe20B20/Pb(Mg1/3Nb2/3)0.7Ti0.3O3 heterostructures based on a pseudo-magnetization µ ≡ mx2 - my2. By applying an external DC-voltage across a (011)-cu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67776-y
更新日期:2020-07-01 00:00:00
abstract::Short-range interaction can give rise to particle pairing with a short-range correlation, which may be destroyed in the presence of an external field. We study the transition between correlated and uncorrelated particle states in the framework of one- dimensional Hubbard model driven by a field. We show that the long ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27189
更新日期:2016-06-02 00:00:00
abstract::Brønsted-Lewis acidic ionic liquids (ILs) were applied to catalyze cellobiose to prepare levulinic acid (LA) in one pot under hydrothermal conditions. Under the optimum conditions, the highest LA yield of 67.51% was obtained when low [HO3S-(CH2)3-mim]Cl-FeCl3 (molar fraction of FeCl3 x = 0.60) was used. This indicated...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38051-y
更新日期:2019-02-12 00:00:00
abstract::Activated coke (AC) has great potential in the field of low-temperature NO removal (DeNOx), especially the branch prepared by blending modification. In this study, the AC-based pyrolusite and/or titanium ore blended catalysts were prepared and applied for DeNOx. The results show blending pyrolusite and titanium ore pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76592-3
更新日期:2020-11-10 00:00:00
abstract::Mitochondria play an essential role in bioenergetics and cellular Ca[Formula: see text] handling. The mitochondrial permeability transition pore (mPTP) is a non-specific channel located in the inner mitochondrial membrane. Long-lasting openings of the pore allow the rapid passage of ions and large molecules, which can...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60177-1
更新日期:2020-03-03 00:00:00
abstract::Leprosy remains persistently endemic in several low- or middle income countries. Transmission is still ongoing as indicated by the unabated rate of leprosy new case detection, illustrating the insufficiency of current prevention methods. Therefore, low-complexity tools suitable for large scale screening efforts to spe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36323-1
更新日期:2018-12-18 00:00:00
abstract::The majority of oligomeric proteins form clusters which have rotational or dihedral symmetry. Despite the many advantages of symmetric packing, protein oligomers are only nearly symmetric, and the origin of this phenomenon is still in need to be fully explored. Here we apply near-symmetry analyses by the Continuous Sy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65097-8
更新日期:2020-05-20 00:00:00
abstract::Gait is an important health indicator and poor gait is strongly associated with disability and risk of falls. Thyroid dysfunction is suggested as a potential determinant of gait deterioration, but this has not been explored in a population-based study. We therefore investigated the association of thyroid function with...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/srep38912
更新日期:2016-12-14 00:00:00
abstract::Aquatic phytoplankton experience large fluctuations in environmental conditions during seasonal succession and across salinity gradients, but the impact of this variation on their diversity is poorly understood. We examined spatio-temporal variation in nano- and microphytoplankton (> 2 µm) community structure using al...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74428-8
更新日期:2020-10-19 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) patients are at higher risk of developing lung cancer and its metastasis, but no suitable biomarker has been reported for differential diagnosis of these patients. Levels of serum biomarkers (VEGF, IL-8, MMP-9 and MMP-2) were analyzed in these patients, which were compared ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36065
更新日期:2016-11-04 00:00:00
abstract::Despite our increasing understanding of zebrafish heart development and regeneration, there is limited information about the distribution of endothelial cells (ECs) in the adult zebrafish heart. Here, we investigate and compare the distribution of cardiac ECs (cECs) in adult mouse and zebrafish ventricles. Surprisingl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02461-1
更新日期:2017-06-02 00:00:00
abstract::The exposure of humans to erionite fibres of appropriate morphology and dimension has been unambiguously linked to the occurrence of Malignant Mesothelioma. For this reason, a detailed morpho-structural investigation through Electron Microscopy techniques has been performed on erionite samples collected at two differe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16757
更新日期:2015-11-16 00:00:00
abstract::Exploiting new, low-cost and efficient electrocatalysts for hydrogen evolution reaction (HER) is important to resolve the energy crisis and environment pollution. In this work, graphene decorated with Ni nanoparticles (NPs) were synthesized via one-pot reduction using graphene oxide (GO, the obtained composite was den...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10589
更新日期:2015-06-12 00:00:00
abstract::The relative effects of internal fixation strategies for intertrochanteric fracture after operation remain uncertain. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to address this important issue. We searched PubMed, EMBASE and CENTRAL for RCTs that compared different intern...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析,评审
doi:10.1038/srep18195
更新日期:2015-12-11 00:00:00
abstract::Sampling the concentration of insulin in human skin using microdialysis is challenging because of low intracutaneous concentrations and low recovery, presumably due to adsorption of insulin to the microdialysis system. In this study, we aimed to (1) measure how the concentration of insulin varies in three different ti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78728-x
更新日期:2020-12-15 00:00:00
abstract::We report a non-iterative localization algorithm that utilizes the scaling of a three-dimensional (3D) image in the axial direction and focuses on evaluating the radial symmetry center of the scaled image to achieve the desired single-particle localization. Using this approach, we analyzed simulated 3D particle images...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02462
更新日期:2013-01-01 00:00:00
abstract::The androgen receptor (AR) regulates male sexual development. We have now investigated AR homodimerization, hormone-dependent monomerization and nuclear translocation in PC-3 and COS-1 cells, by utilizing mutations associated with the androgen insensitivity syndrome: Pro767Ala, Phe765Leu, Met743Val and Trp742Arg. AR w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53139-9
更新日期:2019-11-13 00:00:00
abstract::Environmental impacts from ecotourism and outdoor recreation activities on terrestrial and aquatic ecosystems are well-reported in the literature, but less is known regarding the impacts of outdoor environmental education activities. Student activity during stream classes may cause substrate disruption and localized i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38210-1
更新日期:2019-02-05 00:00:00