当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > Mutagenic Study of Benzimidazole Derivatives with (+S9) and without (-S9) Metabolic Activation.

Mutagenic Study of Benzimidazole Derivatives with (+S9) and without (-S9) Metabolic Activation.

Abstract：

:Benzimidazole derivatives have a diverse range of biological activities, including antiulcer, antihypertensive, antiviral, antifungal, anti-inflammatory, and anticancer. Despite these activities, previous studies have revealed that some of the derivatives can induce mutations. This study aimed to screen for potential mutagenic activities of novel benzimidazole derivatives 1-4 using the Ames test and to study their structure-activity relationship (SAR). An Ames test was carried out on two strains of Salmonella typhimurium (TA98 and TA100) in the absence and presence of metabolic activation. Genetic analysis was performed prior to the Ames test to determine the genotypes of the bacterial tester strains. Both bacterial strains showed dependency on histidine with the presence of rfa mutation, uvrB deletion, and plasmid pKM101. Further, all derivatives tested showed no mutagenic activity in the absence of metabolic activation in both tester strains. However, in the presence of metabolic activation, compound 1 appeared to induce mutation at 2.5 µg/plate when tested against the TA98 strain. These results suggest that the absence of the -OH group at the ortho-position over the phenyl ring might be the cause of increased mutagenic activity in compound 1. Additionally, the presence of mutagenic activity in compound 1 when it was metabolically activated indicates that this compound is a promutagen.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Azahar NH,Ab Dullah SS,Abdullah R,Ahmat N,Md Akim A,Ab Hamid H

doi

10.3390/ijms20184324

subject

Has Abstract

pub_date

2019-09-04 00:00:00

issue

18

issn

1422-0067

pii

ijms20184324

journal_volume

20

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • Zebrafish as a Model for the Study of Microvascular Complications of Diabetes and Their Mechanisms.

    abstract：:Diabetes mellitus (DM) is a crucial metabolic disease that leads to severe disorders. These include macrovascular complications such as myocardial infarction, stroke, and peripheral artery disease and microvascular complications including diabetic nephropathy, neuropathy, and retinopathy. Diabetes mellitus, along with...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18092002

    authors： Heckler K,Kroll J

    更新日期：2017-09-19 00:00:00

  • Phlorotannins from Fucus vesiculosus: Modulation of Inflammatory Response by Blocking NF-κB Signaling Pathway.

    abstract：:Due to their large spectrum of bioactive properties, much attention has recently been drawn to phlorotannins-i.e., phenolic compounds characteristic from brown macroalgae. This study aimed to evaluate the antioxidant and anti-inflammatory properties of F. vesiculosus phlorotannin extracts and purified fractions. Overa...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21186897

    authors： Catarino MD,Silva A,Cruz MT,Mateus N,Silva AMS,Cardoso SM

    更新日期：2020-09-20 00:00:00

  • STVNa Attenuates Isoproterenol-Induced Cardiac Hypertrophy Response through the HDAC4 and Prdx2/ROS/Trx1 Pathways.

    abstract：:Recent data show that cardiac hypertrophy contributes substantially to the overall heart failure burden. Mitochondrial dysfunction is a common feature of cardiac hypertrophy. Recent studies have reported that isosteviol inhibits myocardial ischemia-reperfusion injury in guinea pigs and H9c2 cells. This work investigat...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21020682

    authors： Liu F,Su H,Liu B,Mei Y,Ke Q,Sun X,Tan W

    更新日期：2020-01-20 00:00:00

  • Rational Design of Diketopyrrolopyrrole-Based Small Moleculesas Donating Materials for Organic Solar Cells.

    abstract：:A series of diketopyrrolopyrrole-based small molecules have been designed to explore their optical, electronic, and charge transport properties as organic solar cell(OSCs) materials. The calculation results showed that the designed molecules can lower the band gap and extend the absorption spectrum towards longer wave...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms160920326

    authors： Jin R,Wang K

    更新日期：2015-08-27 00:00:00

  • Somatic Mutation Profiling in Premalignant Lesions of Vulvar Squamous Cell Carcinoma.

    abstract：:Vulvar squamous cell carcinoma (VSCC) originates from the progression of either a high-grade squamous intraepithelial lesion (HSIL) or differentiated-type vulvar intraepithelial neoplasia (dVIN), often in a background of lichen sclerosus (LS). The mechanisms leading to the progression of these premalignant lesions to ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21144880

    authors： Zięba S,Pouwer AW,Kowalik A,Zalewski K,Rusetska N,Bakuła-Zalewska E,Kopczyński J,Pijnenborg JMA,de Hullu JA,Kowalewska M

    更新日期：2020-07-10 00:00:00

  • Let-7 in cardiovascular diseases, heart development and cardiovascular differentiation from stem cells.

    abstract：:The let-7 family is the second microRNA found in C. elegans. Recent researches have found it is highly expressed in the cardiovascular system. Studies have revealed the aberrant expression of let-7 members in cardiovascular diseases, such as heart hypertrophy, cardiac fibrosis, dilated cardiomyopathy (DCM), myocardial...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms141123086

    authors： Bao MH,Feng X,Zhang YW,Lou XY,Cheng Y,Zhou HH

    更新日期：2013-11-21 00:00:00

  • Regulation of miRNA expression by low-level laser therapy (LLLT) and photodynamic therapy (PDT).

    abstract：:Applications of laser therapy, including low-level laser therapy (LLLT), phototherapy and photodynamic therapy (PDT), have been proven to be beneficial and relatively less invasive therapeutic modalities for numerous diseases and disease conditions. Using specific types of laser irradiation, specific cellular activiti...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms140713542

    authors： Kushibiki T,Hirasawa T,Okawa S,Ishihara M

    更新日期：2013-06-27 00:00:00

  • Multidisciplinary Treatment, Including Locoregional Chemotherapy, for Merkel-Polyomavirus-Positive Merkel Cell Carcinomas: Perspectives for Patients Exhibiting Oncogenic Alternative Δ exon 6-7 TrkAIII Splicing of Neurotrophin Receptor Tropomyosin-Related

    abstract：:Merkel cell carcinomas (MCCs) are rare, aggressive, cutaneous neuroendocrine tumours, approximately 80% of which are caused by the genomic integration of Merkel cell polyomavirus (MCPyV). MCPyV-positive MCCs carry poor prognosis in approximately 70% of cases, highlighting the need for greater understanding of the onco...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21218222

    authors： Guadagni S,Farina AR,Cappabianca LA,Sebastiano M,Maccarone R,Zelli V,Clementi M,Chiominto A,Bruera G,Ricevuto E,Fiorentini G,Sarti D,Mackay AR

    更新日期：2020-11-03 00:00:00

  • At the Crossroads of Clinical and Preclinical Research for Muscular Dystrophy-Are We Closer to Effective Treatment for Patients?

    abstract：:Among diseases affecting skeletal muscle, muscular dystrophy is one of the most devastating and complex disorders. The term 'muscular dystrophy' refers to a heterogeneous group of genetic diseases associated with a primary muscle defect that leads to progressive muscle wasting and consequent loss of muscle function. M...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19051490

    authors： Gawlik KI

    更新日期：2018-05-16 00:00:00

  • Lower Exposure to Busulfan Allows for Stable Engraftment of Donor Hematopoietic Stem Cells in Children with Mucopolysaccharidosis Type I: A Case Report of Four Patients.

    abstract：:Busulfan is an alkylating agent routinely used in conditioning regimens prior to allogeneic hematopoietic cell transplantation (HCT) for various nonmalignant disorders, including inborn errors of metabolism. The combination of model-based dosing and therapeutic drug monitoring (TDM) of busulfan pharmacokinetics (PK) t...

    journal_title：International journal of molecular sciences

    pub_type：

    doi：10.3390/ijms21165634

    authors： Shukla P,Dvorak CC,Long-Boyle J,Kharbanda S

    更新日期：2020-08-06 00:00:00

  • MicroRNA29a Reverts the Activated Hepatic Stellate Cells in the Regression of Hepatic Fibrosis through Regulation of ATPase H⁺ Transporting V1 Subunit C1.

    abstract：:Activated hepatic stellate cells (aHSCs) play a key role in liver fibrosis. During the regression of fibrosis, aHSCs are transformed into inactivated cells (iHSCs), which are quiescent lipid-containing cells and express higher levels of lipid-related genes, such as peroxisome proliferators-activated receptors gamma (P...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20040796

    authors： Jing F,Geng Y,Xu XY,Xu HY,Shi JS,Xu ZH

    更新日期：2019-02-13 00:00:00

  • The Role of the Nuclear Factor κB Pathway in the Cellular Response to Low and High Linear Energy Transfer Radiation.

    abstract：:Astronauts are exposed to considerable doses of space radiation during long-term space missions. As complete shielding of the highly energetic particles is impracticable, the cellular response to space-relevant radiation qualities has to be understood in order to develop countermeasures and to reduce radiation risk un...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19082220

    authors： Hellweg CE,Spitta LF,Koch K,Chishti AA,Henschenmacher B,Diegeler S,Konda B,Feles S,Schmitz C,Berger T,Baumstark-Khan C

    更新日期：2018-07-30 00:00:00

  • Eicosapentaenoic acid protects against palmitic acid-induced endothelial dysfunction via activation of the AMPK/eNOS pathway.

    abstract：:Recent studies have shown that free fatty acids are associated with chronic inflammation, which may be involved in vascular injury. The intake of eicosapentaenoic acid (EPA) can decrease cardiovascular disease risks, but the protective mechanisms of EPA on endothelial cells remain unclear. In this study, primary human...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms150610334

    authors： Lee CH,Lee SD,Ou HC,Lai SC,Cheng YJ

    更新日期：2014-06-10 00:00:00

  • Transcriptional and Morpho-Physiological Responses of Marchantia polymorpha upon Phosphate Starvation.

    abstract：:Phosphate (Pi) is a pivotal nutrient that constraints plant development and productivity in natural ecosystems. Land colonization by plants, more than 470 million years ago, evolved adaptive mechanisms to conquer Pi-scarce environments. However, little is known about the molecular basis underlying such adaptations at ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21218354

    authors： Rico-Reséndiz F,Cervantes-Pérez SA,Espinal-Centeno A,Dipp-Álvarez M,Oropeza-Aburto A,Hurtado-Bautista E,Cruz-Hernández A,Bowman JL,Ishizaki K,Arteaga-Vázquez MA,Herrera-Estrella L,Cruz-Ramírez A

    更新日期：2020-11-07 00:00:00

  • Linking Pesticide Exposure with Pediatric Leukemia: Potential Underlying Mechanisms.

    abstract：:Leukemia is the most common cancer in children, representing 30% of all childhood cancers. The disease arises from recurrent genetic insults that block differentiation of hematopoietic stem and/or progenitor cells (HSPCs) and drives uncontrolled proliferation and survival of the differentiation-blocked clone. Pediatri...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms17040461

    authors： Hernández AF,Menéndez P

    更新日期：2016-03-29 00:00:00

  • Dietary Salt Accelerates Orthodontic Tooth Movement by Increased Osteoclast Activity.

    abstract：:Dietary salt uptake and inflammation promote sodium accumulation in tissues, thereby modulating cells like macrophages and fibroblasts. Previous studies showed salt effects on periodontal ligament fibroblasts and on bone metabolism by expression of nuclear factor of activated T-cells-5 (NFAT-5). Here, we investigated ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22020596

    authors： Schröder A,Gubernator J,Leikam A,Nazet U,Cieplik F,Jantsch J,Neubert P,Titze J,Proff P,Kirschneck C

    更新日期：2021-01-09 00:00:00

  • Genetic Landscape of Rett Syndrome Spectrum: Improvements and Challenges.

    abstract：:Rett syndrome (RTT) is an early-onset neurodevelopmental disorder that primarily affects females, resulting in severe cognitive and physical disabilities, and is one of the most prevalent causes of intellectual disability in females. More than fifty years after the first publication on Rett syndrome, and almost two de...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20163925

    authors： Vidal S,Xiol C,Pascual-Alonso A,O'Callaghan M,Pineda M,Armstrong J

    更新日期：2019-08-12 00:00:00

  • The tRNA-dependent biosynthesis of modified cyclic dipeptides.

    abstract：:In recent years it has become apparent that aminoacyl-tRNAs are not only crucial components involved in protein biosynthesis, but are also used as substrates and amino acid donors in a variety of other important cellular processes, ranging from bacterial cell wall biosynthesis and lipid modification to protein turnove...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms150814610

    authors： Giessen TW,Marahiel MA

    更新日期：2014-08-21 00:00:00

  • Influence of Hypoxic and Hyperoxic Preconditioning on Endothelial Function in a Model of Myocardial Ischemia-Reperfusion Injury with Cardiopulmonary Bypass (Experimental Study).

    abstract：:The aim of the experiment was to evaluate the effect of preconditioning based on changes in inspiratory oxygen fraction on endothelial function in the model of ischemia-reperfusion injury of the myocardium in the condition of cardiopulmonary bypass. The prospective randomized study included 32 rabbits divided into fou...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21155336

    authors： Mandel IA,Podoksenov YK,Suhodolo IV,An DA,Mikheev SL,Podoksenov AY,Svirko YS,Gusakova AM,Shipulin VM,Yavorovskiy AG

    更新日期：2020-07-27 00:00:00

  • Structural Differences between the Lignin-Carbohydrate Complexes (LCCs) from 2- and 24-Month-Old Bamboo (Neosinocalamus affinis).

    abstract：:The lignin-carbohydrate complex (LCC) was isolated from milled wood lignin of 2- and 24-month-old crude bamboo (Neosinocalamus affinis) culms using acetic acid (AcOH) and then characterized. The results have shown that the LCC preparation from 2-month-old bamboo (L₂) exhibited a slightly lower molecular weight than th...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19010001

    authors： Yue PP,Hu YJ,Fu GQ,Sun CX,Li MF,Peng F,Sun RC

    更新日期：2017-12-21 00:00:00

  • A single-chamber microbial fuel cell without an air cathode.

    abstract：:Microbial fuel cells (MFCs) represent a novel technology for wastewater treatment with electricity production. Electricity generation with simultaneous nitrate reduction in a single-chamber MFC without air cathode was studied, using glucose (1 mM) as the carbon source and nitrate (1 mM) as the final electron acceptor ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms13033933

    authors： Nimje VR,Chen CC,Chen HR,Chen CY,Tseng MJ,Cheng KC,Shih RC,Chang YF

    更新日期：2012-01-01 00:00:00

  • Synthesis of Fmoc-Triazine Amino Acids and Its Application in the Synthesis of Short Antibacterial Peptidomimetics.

    abstract：:To combat the escalating rise of antibacterial resistance, the development of antimicrobial peptides (AMPs) with a unique mode of action is considered an attractive strategy. However, proteolytic degradation of AMPs remains the greatest challenge in their transformation into therapeutics. Herein, we synthesized Fmoc-t...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21103602

    authors： Gunasekaran P,Kim EY,Lee J,Ryu EK,Shin SY,Bang JK

    更新日期：2020-05-20 00:00:00

  • Influence of Dental Prosthesis and Restorative Materials Interface on Oral Biofilms.

    abstract：:Oral biofilms attach onto both teeth surfaces and dental material surfaces in oral cavities. In the meantime, oral biofilms are not only the pathogenesis of dental caries and periodontitis, but also secondary caries and peri-implantitis, which would lead to the failure of clinical treatments. The material surfaces exp...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19103157

    authors： Hao Y,Huang X,Zhou X,Li M,Ren B,Peng X,Cheng L

    更新日期：2018-10-14 00:00:00

  • Structure prediction, molecular dynamics simulation and docking studies of D-specific dehalogenase from Rhizobium sp. RC1.

    abstract：:Currently, there is no three-dimensional structure of D-specific dehalogenase (DehD) in the protein database. We modeled DehD using ab initio technique, performed molecular dynamics (MD) simulation and docking of D-2-chloropropionate (D-2CP), D-2-bromopropionate (D-2BP), monochloroacetate (MCA), monobromoacetate (MBA)...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms131215724

    authors： Sudi IY,Wong EL,Joyce-Tan KH,Shamsir MS,Jamaluddin H,Huyop F

    更新日期：2012-11-26 00:00:00

  • Major Challenges and Potential Microenvironment-Targeted Therapies in Glioblastoma.

    abstract：:Glioblastoma (GBM) is considered one of the most malignant, genetically heterogeneous, and therapy-resistant solid tumor. Therapeutic options are limited in GBM and involve surgical resection followed by chemotherapy and/or radiotherapy. Adjuvant therapies, including antiangiogenic treatments (AATs) targeting the VEGF...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18122732

    authors： Arbab AS,Rashid MH,Angara K,Borin TF,Lin PC,Jain M,Achyut BR

    更新日期：2017-12-16 00:00:00

  • Citrate-Induced p85α⁻PTEN Complex Formation Causes G2/M Phase Arrest in Human Pharyngeal Squamous Carcinoma Cell Lines.

    abstract：:Citrate is a key intermediate of the tricarboxylic acid cycle and acts as an allosteric signal to regulate the production of cellular ATP. An elevated cytosolic citrate concentration inhibits growth in several types of human cancer cells; however, the underlying mechanism by which citrate induces the growth arrest of ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20092105

    authors： Hung KC,Wang SG,Lin ML,Chen SS

    更新日期：2019-04-29 00:00:00

  • DNA Repair Deficient Chinese Hamster Ovary Cells Exhibiting Differential Sensitivity to Charged Particle Radiation under Aerobic and Hypoxic Conditions.

    abstract：:It has been well established that hypoxia significantly increases both cellular and tumor resistance to ionizing radiation. Hypoxia associated radiation resistance has been known for some time but there has been limited success in sensitizing cells to radiation under hypoxic conditions. These studies show that, when i...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19082228

    authors： Cartwright IM,Su C,Haskins JS,Salinas VA,Sunada S,Yu H,Uesaka M,Hirakawa H,Chen DJ,Fujimori A,Kato TA

    更新日期：2018-07-30 00:00:00

  • The Cytoskeletal Protein Cyclase-Associated Protein 1 (CAP1) in Breast Cancer: Context-Dependent Roles in Both the Invasiveness and Proliferation of Cancer Cells and Underlying Cell Signals.

    abstract：:As a conserved actin-regulating protein, CAP (adenylyl Cyclase-Associated Protein) functions to facilitate the rearrangement of the actin cytoskeleton. The ubiquitously expressed isoform CAP1 drives mammalian cell migration, and accordingly, most studies on the involvement of CAP1 in human cancers have largely been ba...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20112653

    authors： Hasan R,Zhou GL

    更新日期：2019-05-30 00:00:00

  • Mapping of CaM, S100A1 and PIP2-Binding Epitopes in the Intracellular N- and C-Termini of TRPM4.

    abstract：:Molecular determinants of the binding of various endogenous modulators to transient receptor potential (TRP) channels are crucial for the understanding of necessary cellular pathways, as well as new paths for rational drug designs. The aim of this study was to characterise interactions between the TRP cation channel s...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21124323

    authors： Bousova K,Barvik I,Herman P,Hofbauerová K,Monincova L,Majer P,Zouharova M,Vetyskova V,Postulkova K,Vondrasek J

    更新日期：2020-06-17 00:00:00

  • Functional Recovery of a GCDH Variant Associated to Severe Deflavinylation-Molecular Insights into Potential Beneficial Effects of Riboflavin Supplementation in Glutaric Aciduria-Type I Patients.

    abstract：:Riboflavin is the biological precursor of two important flavin cofactors-flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN)-that are critical prosthetic groups in several redox enzymes. While dietary supplementation with riboflavin is a recognized support therapy in several inborn errors of metabolism, ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21197063

    authors： Ribeiro JV,Gomes CM,Henriques BJ

    更新日期：2020-09-25 00:00:00