Abstract:
:Ultrasound has significantly increased safety and effectiveness in regional anesthesia. However, little is known about its clinical use. We studied clinical approaches currently used by anesthesiologists, conducted a nationwide survey, and analyzed data collected in ordered logistic regression models. All active members of the Swiss Society for Anaesthesiology and Resuscitation (SSAR/SGAR) were asked to participate. Reported practice in nerve localization, safety, and techniques used for peripheral nerve blocks (PNB) were main outcome measures. Experience ranged from 3 to >30 years. The mean number of block techniques mastered was 11.5 ± 5.9. Standard monitoring was regularly used, whereas sterile coats were less frequently used by anesthesiologists who self-estimated a higher level of expertise in PNB (ordered logit coefficient -0.05, 95% CI -0.07 to -0.02, P < 0.001; pseudo r2 = 0.019; probability > Chi2 = 0.02). The more self-estimated expertise anesthesiologists had, the less likely they were to use nerve stimulation in combination with ultrasound (dual guidance) (ordered logit coefficient -0.31; 95% CI -0.85 to -0.03: P = 0.03; pseudo r2 = 0.007; probability > Chi2 = 0.05). The high share of reported standard monitoring meets the recommendations of the Helsinki Patient Safety Declaration. Dual guidance appears to be the preferred approach for safely localizing nerves for PNB in Switzerland.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Luedi MM,Upadek V,Vogt AP,Steinfeldt T,Eichenberger U,Sauter ARdoi
10.1038/s41598-019-45700-3subject
Has Abstractpub_date
2019-06-24 00:00:00pages
9178issue
1issn
2045-2322pii
10.1038/s41598-019-45700-3journal_volume
9pub_type
杂志文章abstract::The prognosis of pancreatic cancer remains dismal despite continuous and considerable efforts. Integrins (ITGs) are highly expressed in various malignant cancers. However, very few studies investigated the role of integrin α3 (ITGα3) in malignant cancers. Here, we determined the functional role of ITGα3 in pancreatic ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39628-x
更新日期:2019-02-26 00:00:00
abstract::The spinal cord is an integration center for descending, ascending, and segmental neural signals. Noninvasive transspinal stimulation may thus constitute an effective method for concomitant modulation of local and distal neural circuits. In this study, we established changes in cortical excitability and input/output f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18872-z
更新日期:2018-01-15 00:00:00
abstract::Measuring toxicity is one of the main steps in drug development. Hence, there is a high demand for computational models to predict the toxicity effects of the potential drugs. In this study, we used a dataset, which consists of four toxicity effects:mutagenic, tumorigenic, irritant and reproductive effects. The propos...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38660
更新日期:2016-12-09 00:00:00
abstract::The phytohormone auxin is a major determinant and regulatory component important for plant development. Auxin transport between cells is mediated by a complex system of transporters such as AUX1/LAX, PIN, and ABCB proteins, and their localization and activity is thought to be influenced by phosphatases and kinases. Fl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41906
更新日期:2017-02-06 00:00:00
abstract::PCGEM1 is a long non-coding RNA (lncRNA) that is often upregulated in prostate cancer. However, little is known how PCGEM1 is regulated. In the present study, we show transcriptional regulation of PCGEM1 in response to androgen deprivation by p54/nrb. While ectopic expression of p54/nrb increases, suppression of p54/n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34529
更新日期:2016-09-29 00:00:00
abstract::In this study we introduce the starch-recognising carbohydrate binding module family 20 (CBM20) from Aspergillus niger for screening biological variations in starch molecular structure using high throughput carbohydrate microarray technology. Defined linear, branched and phosphorylated maltooligosaccharides, pure star...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30551
更新日期:2016-07-29 00:00:00
abstract::Surface plasmonics from metal nanoparticles have been demonstrated as an effective way of improving the performance of low-efficiency light emitters. However, reducing the inherent losses of the metal nanoparticles remains a challenge. Here we study the enhancement properties by Ag nanoparticles for InGaN/GaN quantum-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06392
更新日期:2014-09-22 00:00:00
abstract::Exhibiting a red-shifted absorption/scattering feature compared to conventional plasmonic metals, titanium nitride nanoparticles (TiN NPs) look as very promising candidates for biomedical applications, but these applications are still underexplored despite the presence of extensive data for conventional plasmonic coun...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37519-1
更新日期:2019-02-04 00:00:00
abstract::The association between choline uptake and androgen receptor (AR) expression is suggested by the upregulation of choline kinase-alpha in prostate cancer. Recently, detection of AR aberration in cell-free DNA as well as early 18F-fluorocholine positron emission tomography/computed tomography (FCH-PET/CT) were associate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15928-y
更新日期:2017-11-14 00:00:00
abstract::The synthesis and subsequent genomic integration of DNA that is complementary to the genomes of non-retroviral RNA viruses are rarely observed. However, upon infection of various human cell lines and primary fibroblasts with the vesicular stomatitis virus (VSV), we detected DNA complementary to the VSV RNA. The VSV DN...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05074
更新日期:2014-05-30 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-65027-8
更新日期:2020-05-20 00:00:00
abstract::Are cooperative decisions typically made more quickly or slowly than non-cooperative decisions? While this question has attracted considerable attention in recent years, most research has focused on one-shot interactions. Yet it is repeated interactions that characterize most important real-world social interactions. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29622
更新日期:2016-07-20 00:00:00
abstract::Astragalus membranaceus (HUANG QI, HQ) is a kind of traditional Chinese medicine. Researchers have widely concerned its antitumor effect. At present, there is still a lack of research on the treatment of laryngeal cancer with HQ. In this study, we integrated data from the weighted gene co-expression network of larynge...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68093-0
更新日期:2020-07-07 00:00:00
abstract::Long-branch attraction (LBA) is a major obstacle in phylogenetic reconstruction. The phylogenetic relationships among Juniperus (J), Cupressus (C) and the Hesperocyparis-Callitropsis-Xanthocyparis (HCX) subclades of Cupressoideae are controversial. Our initial analyses of plastid protein-coding gene matrix revealed bo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41005
更新日期:2017-01-25 00:00:00
abstract::Nowadays, various collaborations are creating immense machines to try to track and understand the origin of high-energy cosmic particles (e.g., IceCube, ANTARES, Baikal-GVD, P-ONE). The detection mechanism of these sophisticated experiments relies mainly on an optical signal generated by the passage of charged particl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68954-8
更新日期:2020-07-24 00:00:00
abstract::Swarming bacteria are an example of a complex, active biological system, where high cell density and super-diffusive cell mobility confer survival advantages to the group as a whole. Previous studies on the dynamics of the swarm have been limited to easily observable regions at the advancing edge of the swarm where ce...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34192-2
更新日期:2018-10-25 00:00:00
abstract::The critical role of the regulatory elements at the 5' end of the HIV-1 genome in controlling the life cycle of HIV-1 indicates that this region significantly influences virus fitness and its biological properties. In this study, we performed a detailed characterization of strain-specific variability of sequences from...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70083-1
更新日期:2020-08-06 00:00:00
abstract::Novel amorphous iron hydrides (AIHs) are synthesized for the first time under ambient conditions by employing novel "quiescent reaction", without stirring for mixing solutions, during a conventional aqueous reduction-precipitation process. The kind and morphology of AIHs are dependent on the processing condition, wher...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63124-2
更新日期:2020-04-10 00:00:00
abstract::Spontaneous pattern formation in a variety of spatially extended nonlinear systems always occurs through a modulation instability, sometimes called Turing instability: the homogeneous state of the system becomes unstable with respect to growing modulation modes. Therefore, the manipulation of the modulation instabilit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13268
更新日期:2015-08-19 00:00:00
abstract::First discovered in rural areas of middle-eastern China in 2009, severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne zoonosis affecting hundreds of cases reported in China each year. Using the national surveillance data from 2010 to 2013, we conducted this retrospective epidemiological study a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09679
更新日期:2015-04-23 00:00:00
abstract::To understand the impact of PIK3CA mutations on clinical characteristics and treatment response to epidermal growth factor tyrosine kinase inhibitors (EGFR TKIs) of lung adenocarcinoma, we examined PIK3CA and EGFR mutations in lung adenocarcinoma patients, and analyzed their clinical outcomes. Surgically excised tumor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35249
更新日期:2016-10-13 00:00:00
abstract::Human NAD-dependent isocitrate dehydrogenase (NAD-IDH) catalyzes the oxidative decarboxylation of isocitrate in the citric acid cycle. In the α2βγ heterotetramer of NAD-IDH, the γ subunit plays the regulatory role and the β subunit the structural role. Previous biochemical data have shown that mammalian NAD-IDHs can b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21584-7
更新日期:2018-02-16 00:00:00
abstract::Sheepgrass (Leymus chinensis) is one of the dominant grass species present on typical steppes of the Inner Mongolia Plateau. However, L. chinensis has developed a dwarfing phenotype in response to the stressful habitat in grasslands that are severely degraded due to heavy grazing. The lack of transcriptomic and genomi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35605-y
更新日期:2018-12-17 00:00:00
abstract::Ciliate Mesodinium species are commonly distributed in diverse aquatic systems worldwide. Among Mesodinium species, M. rubrum is closely associated with microbial food webs and red tide formation and is known to acquire chloroplasts from its cryptophyte prey for use in photosynthesis. For these reasons, Mesodinium has...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50659-2
更新日期:2019-10-01 00:00:00
abstract::Alcohol use disorder (AUD) is a chronic and relapsing disease with a substantial genetic influence. Given the recent discovery of the association of PPM1G methylation with alcohol use disorder (AUD) from a genome-wide methylation study, we sought to verify and extend the previous work of AUD-related impulsivity in a K...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62504-y
更新日期:2020-03-26 00:00:00
abstract::Afforestation is an important approach to mitigate global warming. Its complex interactions with the climate system, however, makes it controversial. Afforestation is expected to be effective in the tropics where biogeochemical and biogeophysical effects act in concert; however, its potential in the large semi-arid re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19265-6
更新日期:2018-01-17 00:00:00
abstract::Patients who survive influenza A (H7N9) virus infection are at risk of physical and psychological complications of lung injury and multi-organ dysfunction. However, there were no prospectively individualized assessments of physiological, functional and quality-of-life measures after hospital discharge. The current stu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17497-6
更新日期:2017-12-08 00:00:00
abstract::Habitat filtering models predict ecologically similar plant species to jointly colonize sites due to comparable environmental characteristics leading to an aggregated pattern of species spatial occurrence. Models focused on interspecific competition expect species with similar ecological requirements to be spatially s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00255-z
更新日期:2017-03-21 00:00:00
abstract::Thioflavin T (ThT) is standardly used as a fluorescent marker to detect aggregation of amyloid fibrils by conventional fluorescence microscopy, including polarization resolved imaging that brings information on the orientational order of the fibrils. These techniques are however diffraction limited and cannot provide ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12864-9
更新日期:2017-10-02 00:00:00
abstract::SerpinB3 has been recently described as an early marker of liver carcinogenesis, but the potential mechanistic role of this serpin in tumor development is still poorly understood. Overexpression of Myc often correlates with more aggressive tumour forms, supporting its involvement in carcinogenesis. Yes-associated prot...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17701
更新日期:2015-12-04 00:00:00