Abstract:
BACKGROUND:Stem/progenitor cell-mediated pulpal regeneration could represent a promising therapeutic alternative in the field of clinical endodontics. AIM:The present study aimed to systematically assess and meta-analyse dental pulpal tissue regeneration, pulpal vitality and apical healing after the transplantation of stem/progenitor cells versus no transplantation. DATA SOURCES:MEDLINE, Cochrane CENTRAL and EMBASE were searched up to January 2019 for animal experiments and human trials evaluating the pulpal transplantation of stem/progenitor cells. Cross-referencing and hand search were additionally performed. STUDY ELIGIBILITY CRITERIA, PARTICIPANTS AND INTERVENTIONS:Based on randomized controlled clinical trials (RCTs) or controlled clinical trials (CCTs), conducted in animals or humans, the effect of the transplantation of stem/progenitor cells compared to no transplantation on pulpal tissue regeneration, pulpal vitality and apical healing was examined. STUDY APPRAISAL AND SYNTHESIS METHODS:The primary outcome was histologically determined pulpal tissue regeneration, whilst pulpal vitality and apical healing were secondary outcomes. The SYstematic Review Centre for Laboratory animal Experimentation (SYRCLE) guidelines and the revised Cochrane risk of bias tool (RoB 2.0) were used for risk-of-bias assessment. Pooled standardized differences in means (SDM) and 95% confidence intervals (95% CI) were calculated using random-effects meta-analyses. RESULTS:From 2834 identified articles, eight animal experiments (82 animals with 336 experimental pulpal defects) and one human trial (40 humans with 40 pulpal defects) were included. Risk of bias of most animal studies was high, whilst the human trial revealed 'some concerns'. Stem/progenitor cell-transplanted pulps demonstrated significantly increased pulpal tissue regeneration compared with controls (SDM [95%CI]: 6.29 [3.78-8.80]). LIMITATIONS:Data on pulpal vitality and apical healing were sparse and inconsistent. Heterogeneity across studies was substantial, publication bias was present, and mainly indirect, surrogate outcome measures were applied. The overall strength of evidence was very low. CONCLUSIONS AND IMPLICATIONS OF KEY FINDINGS:The transplanation of stem/progenitor cells shows promise for pulp regeneration, whilst clinical routine application is still not in reach. Further investigations, employing a comprehensive set of outcomes including those demonstrating functional pulp regeneration relevant for patient-centred care, are required.
journal_name
Int Endod Jjournal_title
International endodontic journalauthors
Fawzy El-Sayed KM,Ahmed GM,Abouauf EA,Schwendicke Fdoi
10.1111/iej.13177subject
Has Abstractpub_date
2019-11-01 00:00:00pages
1573-1585issue
11eissn
0143-2885issn
1365-2591journal_volume
52pub_type
杂志文章,meta分析abstract::This study was conducted to evaluate the efficacy of the antibacterial activity of Ca(OH)2 and a sustained-release device containing chlorhexidine (SRD) in both sterilization and prevention of secondary infection of the root canal system. Bovine root dentine specimens previously incubated with Streptococcus faecalis w...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.1992.tb00944.x
更新日期:1992-01-01 00:00:00
abstract:AIM:To evaluate the adhesive strength of Resilon to Next root canal sealant (Heraeus-Kulzer), a methacrylate-based root canal sealer, using a modified microshear bond testing design. METHODOLOGY:Flat Resilon surfaces of different roughnesses (smooth surface and surface roughness equivalent to 320-grit and 180-grit) we...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2005.01012.x
更新日期:2005-10-01 00:00:00
abstract::The cutting heads of the first 18 instruments in six sets of clinically used Lightspeed instruments (sizes 20-65) were examined in a scanning electron microscope (SEM). Three sets had been used by full-time faculty and discarded as follows: instrument sizes 20-32.5 after 18 treated root canals; instrument sizes 35-47....
journal_title:International endodontic journal
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract:AIM:To examine the clinical and radiographic appearance of teeth that suffered premature interruption of root development and were treated by an mineral trioxide aggregate (MTA) apical plug technique. SUMMARY:Eleven teeth with immature root apices in 11 patients were treated nonsurgically by the manual application of ...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2007.01240.x
更新日期:2007-06-01 00:00:00
abstract::The aim of this in vitro study was to determine the effect of removal of the smear layer on canal obturation as measured by penetration of bacteria from a coronal direction. One hundred and twenty extracted human teeth with straight, single root canals were decoronated. The canals were prepared using the modified doub...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.1996.tb01376.x
更新日期:1996-07-01 00:00:00
abstract:AIM:To evaluate the presence of bacteria in permanent teeth with intact crowns (without caries, periodontal disease or dental trauma) in patients with sickle cell anaemia (HbSS genotype) by analysing their clinical, imaging and microbiological parameters. METHODOLOGY:This is a case series study nested in a cohort. In ...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.13476
更新日期:2021-01-12 00:00:00
abstract:AIM:To evaluate ex vivo the incidence of defects in root dentine before and after root canal preparation and filling. METHODOLOGY:Eighty extracted mandibular premolars were divided equally in four groups. Group 1 was left unprepared. All other root canals were prepared using Gates Glidden drills and System GT files up...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2008.01502.x
更新日期:2009-03-01 00:00:00
abstract::Thirty single-rooted teeth were prepared to receive cast posts. After cementation of the post the teeth were divided into three groups. Group I did not receive any treatment, whereas the posts in groups II and III were treated with an ultrasonic device, for 2 min and 5 min, respectively. The force required for post re...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.1995.tb00157.x
更新日期:1995-01-01 00:00:00
abstract:AIM:To identify, search for and critically interpret the results from clinical studies on single- versus multiple-visit root canal treatment in the light of an evidence-based paradigm. For that purpose, the quality of the available body of evidence was assessed using the SORT 'grade' - Strength of Recommendation Taxono...
journal_title:International endodontic journal
pub_type: 杂志文章,评审
doi:10.1111/iej.12621
更新日期:2017-03-01 00:00:00
abstract:AIM:To assess and correlate three distinct states of severely painful endodontically derived inflammation with their depiction on periapical radiographs using periapical index (PAI) scores. METHODOLOGY:During a period of 15 months, 368 consecutively enrolled patients with suspected endodontic emergency conditions were...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.13407
更新日期:2021-02-01 00:00:00
abstract:AIM:To report the management of an iatrogenic incident in which an endodontic file was swallowed accidentally and passed into the gastrointestinal tract. SUMMARY:A 51-year-old male swallowed a 21 mm, size 30 endodontic file during root canal treatment without rubber dam. In the absence of clinical complications, the p...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2008.01392.x
更新日期:2008-07-01 00:00:00
abstract::Chelating agents were introduced into endodontics as an aid for the preparation of narrow and calcified root canals in 1957 by Nygaard-Østby. A liquid solution of ethylenediaminetetraacetic acid (EDTA) was thought to chemically soften the root canal dentine and dissolve the smear layer, as well as to increase dentine ...
journal_title:International endodontic journal
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2591.2003.00754.x
更新日期:2003-12-01 00:00:00
abstract::The reliability of two commonly used methods of sealability testing, dye leakage under normal atmospheric pressure and dye leakage in a partial vacuum, was tested using a repeated studies design. Forty extracted teeth were instrumented and obturated using lateral condensation of gutta-percha and Sealapex sealer. One-h...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.1995.tb00291.x
更新日期:1995-05-01 00:00:00
abstract:AIM:To engineer systems using polyisoprene (PI) or polycaprolactone (PCL) and nanometric bioactive glass 45S5 (BG) that could create a hydroxyapatite interface and thus ultimately make the use of an endodontic sealer unnecessary. METHODOLOGY:Different composites using PI or PCL as matrix material were prepared with BG...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2010.01772.x
更新日期:2010-11-01 00:00:00
abstract:AIM:To assess and compare the resistance to cyclic fatigue, torsional stress, bending and buckling of ProGlider (PG; Dentsply Maillefer, Ballaigues, Switzerland) instruments with PathFile (PF; Dentsply Maillefer) pathfinding nickel-titanium rotary instruments. METHODOLOGY:Size 16, .02 taper PG and PF instruments were ...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.12386
更新日期:2015-09-01 00:00:00
abstract:AIM:The aim of this study was to determine the percentage of anatomical canal configurations of the mesiobuccal root of the maxillary first molar in Japanese patients. METHODOLOGY:Three hundred teeth were obtained from general dentists who knew absolutely that they were extracted from Japanese patients. The distobucca...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1046/j.1365-2591.1999.00186.x
更新日期:1999-03-01 00:00:00
abstract:AIM:To obtain concurrent radicular measurements in the mesiobuccal (MB) and mesiolingual (ML) canals of mandibular first molars using scanned data of micro-computed tomography (μCT) with novel software. METHODOLOGY:The scanned data from 37 mandibular first molar mesial roots were reconstructed and analysed with custom...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.12326
更新日期:2015-04-01 00:00:00
abstract:AIM:To assess the inflammatory potential of biofilm matrix constituents of Enterococcus faecalis and Pseudomonas aeruginosa monospecies biofilms on macrophages. METHODOLOGY:In vitro biofilms of E. faecalis and P. aeruginosa were grown (7 days) in aerobic and anaerobic conditions. The biofilm matrix components: exopoly...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.13093
更新日期:2019-07-01 00:00:00
abstract:AIM:To determine the cleaning effectiveness and shaping ability of ProTaper and RaCe nickel-titanium rotary instruments during the preparation of curved root canals in extracted human teeth. METHODOLOGY:A total of 48 root canals of mandibular and maxillary molars with curvatures ranging between 25 degrees and 35 degre...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.0143-2885.2004.00783.x
更新日期:2004-04-01 00:00:00
abstract::A case is described in which root canal treatment with calcium hydroxide was used successfully to repair a fracture site with internal resorption of the tooth. ...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.1996.tb01404.x
更新日期:1996-11-01 00:00:00
abstract::The purpose of this study was to observe the quality of seal of the glass ionomer cement, Ketac-Endo, after treatment of the root canal wall. The root canals of 140 extracted human teeth were prepared biomechanically. The root canals were treated with either EDTA or received an intracanal dressing of calcium hydroxide...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.1995.tb00298.x
更新日期:1995-07-01 00:00:00
abstract:AIM:To evaluate the effect of irrigation with 5% sodium hypochlorite (NaOCl) alone and in conjunction with 17% ethylenediaminetetraacetic acid (EDTA) on tooth surface strain (TSS) and to analyse the influence of irrigation time, root morphology and dentine thickness. METHODOLOGY:Thirty-six single-rooted pre-molars wit...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2009.01655.x
更新日期:2010-03-01 00:00:00
abstract::When operated in air, the sonic endodontic instrument produced a movement at the driver head which resulted in a large elliptical oscillation of the file. This motion had similar properties to ultrasonically operated files in that there was a distinct variability in the magnitude of the vibratory motion between files ...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.1989.tb00910.x
更新日期:1989-05-01 00:00:00
abstract:AIM:To evaluate the bond strength of self-adhesive resin cements (SARCs) to glass fibre posts with or without a silane coupling agent. METHODOLOGY:The SARCs tested were: Maxcem Elite (MXE; Kerr), RelyX Unicem clicker (UNI; 3M ESPE), seT capsule (SET; SDI), and SmartCem 2 (SC2; Dentsply Caulk). The conventional cement ...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2011.01883.x
更新日期:2011-08-01 00:00:00
abstract:AIM:To investigate the prevalences of four Treponema species in primary root canal infections using a nested PCR assay. METHODOLOGY:Samples were obtained from 32 infected root canals. Twenty-two cases showed chronic asymptomatic periradicular lesions and 10 symptomatic cases were diagnosed as acute apical periodontiti...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1046/j.0143-2885.2003.00607.x
更新日期:2003-01-01 00:00:00
abstract:AIM:To evaluate the radiopacity of calcium hydroxide-based root canal sealers (Acroseal, Sealapex and Sealer 26), a glass-ionomer-based sealer (Activ GP Sealer) and a zinc oxide and eugenol-based sealer (Intrafill). METHODOLOGY:Five disc-shaped specimens (10 x 1 mm) were fabricated from each material, according to the...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2007.01309.x
更新日期:2008-01-01 00:00:00
abstract:AIM:The aim of the present study was to identify periapical changes 20-27 years after root-canal treatment. METHODOLOGY:The periapical condition of 265 roots filled by undergraduate students was evaluated in two series of intraoral radiographs taken 10-17 and 20-27 years after treatment. Roots (72) not recorded with a...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1046/j.1365-2591.2002.00568.x
更新日期:2002-09-01 00:00:00
abstract:AIM:To evaluate the effect of capsaicin on substance P (SP) expression during induced inflammation in rat pulp tissue. METHODOLOGY:Radioimmunoanalysis was used to measure SP levels in 36 mandibular molar pulps taken from six Wistar rats. Twelve samples were obtained from healthy pulps and used as negative control grou...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2004.00893.x
更新日期:2005-01-01 00:00:00
abstract:AIM:To conduct three-dimensional micro-CT analysis of bone destruction, periapical sclerotic changes and inflammatory root resorption (IRR) to compare the differences between Enterococcus faecalis (Ef)- and Porphyromonas gingivalis (Pg)-induced chronic apical periodontitis (CAP). METHODOLOGY:Mono-species bacteria-indu...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/iej.13095
更新日期:2019-07-01 00:00:00
abstract::The effect on coronal leakage of the use of either a single gutta-percha cone or cold lateral condensation of gutta-percha, with a glass ionomer sealer cement was studied. In addition, the effect of the removal of the smear layer was also determined. Eighty-eight single-rooted teeth were prepared chemomechanically usi...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.1994.tb00255.x
更新日期:1994-07-01 00:00:00