Bergapten alleviates osteoarthritis by regulating the ANP32A/ATM signaling pathway.

abstract：:Neural stem cells (NSC) from the adult hippocampus easily lose their activity in vitro. Efficient in vitro expansion of adult hippocampus-derived NSC is important for generation of tools for research and cell therapy. Here, we show that a single copy disruption or pharmacological inhibition of p38α enables successful ...

journal_title：FEBS open bio

authors： Yoshioka K,Namiki K,Sudo T,Kasuya Y

更新日期：2015-05-08 00:00:00

abstract：:Recent evidence has shown that miR-409-3p was down-regulated in several types of cancer, including osteosarcoma. However, the potential role of miR-409-3p in osteosarcoma remains largely unknown. In the present study, we showed that overexpression of miR-409-3p in osteosarcoma cells inhibited cell proliferation in vit...

journal_title：FEBS open bio

authors： Zhang J,Hou W,Jia J,Zhao Y,Zhao B

更新日期：2017-01-27 00:00:00

abstract：:Heterocyst-forming cyanobacteria grow as filaments that can be hundreds of cells long. Proteinaceous septal junctions provide cell-cell binding and communication functions in the filament. In Anabaena sp. strain PCC 7120, the SepJ protein is important for the formation of septal junctions. SepJ consists of integral me...

journal_title：FEBS open bio

authors： Ramos-León F,Mariscal V,Battchikova N,Aro EM,Flores E

更新日期：2017-08-30 00:00:00

abstract：:Colorectal cancer (CRC) is the third main cause of cancer-relevant deaths worldwide, and its incidence has increased in recent decades. Previous studies have indicated that certain long non-coding RNAs (lncRNAs) have regulatory roles in tumor occurrence and progression. Often, lncRNAs are competitive endogenous RNAs (...

journal_title：FEBS open bio

authors： Liu J,Zhu J,Xiao Z,Wang X,Luo J

更新日期：2020-01-27 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection can be accelerated by intracellular and extracellular hydrogen peroxide (H2O2) stimulation, mediated by the activation of the p38 mitogen-activated protein kinase (MAPK) pathway. However, it remains unknown whether host gene expression is involved in H2O2-upregulated HCMV replica...

journal_title：FEBS open bio

authors： Xiao J,Song X,Deng J,Lv L,Ma P,Gao B,Zhou X,Zhang Y,Xu J

更新日期：2016-08-15 00:00:00

abstract：:Ovarian cancer is the most common cause of gynaecological cancer-associated death; thus, promising biomarkers and new therapeutic targets for ovarian cancer must be explored. Here, we report that eukaryotic translation initiation factor 3 subunit D (EIF3D), a member of the EIF3 family, was overexpressed in ovarian can...

journal_title：FEBS open bio

authors： Lin Y,Zhang R,Zhang P

更新日期：2016-10-31 00:00:00

abstract：:Extensive simple sequence repeat (SSR) surveys have been performed for eukaryotic prokaryotic and viral genomes, but information regarding SSRs in viroids is limited. We undertook a survey to examine the presence of SSRs in viroid genomes. Our results show that the distribution of SSRs in viroids may influence seconda...

journal_title：FEBS open bio

authors： Qin L,Zhang Z,Zhao X,Wu X,Chen Y,Tan Z,Li S

更新日期：2014-02-07 00:00:00

abstract：:Glutathione transferases (GSTs) are involved in many processes in plant biochemistry, with their best characterised role being the detoxification of xenobiotics through their conjugation with glutathione. GSTs have also been implicated in noncatalytic roles, including the binding and transport of small heterocyclic li...

journal_title：FEBS open bio

authors： Ahmad L,Rylott EL,Bruce NC,Edwards R,Grogan G

更新日期：2016-12-22 00:00:00

abstract：:Photodynamic therapy is an advanced method of treating cancer and various benign diseases, including infections. It uses light-activated molecules [photosensitizers (PSs)] to generate reactive oxygen species (ROS) when irradiated with light of a specific wavelength. This study examined the photophysical and photosensi...

journal_title：FEBS open bio

authors： Kostryukova LV,Prozorovskiy VN,Medvedeva NV,Ipatova OM

更新日期：2018-01-02 00:00:00

abstract：:Liver cancer stem cells (L-CSCs) are considered to be an important therapeutic target for hepatocellular carcinoma (HCC). This study provides a new in vitro long-term culture model for a specific subpopulation of L-CSCs enriched by cell surface markers. We combined CD13, CD133 and EpCAM to selectively enrich L-CSCs, w...

journal_title：FEBS open bio

authors： Zhang B,Wang HY,Wang DX,Zeng Q,Fan Z,Xi JF,Nan X,He LJ,Zhou JN,Pei XT,Yue W

更新日期：2020-09-01 00:00:00

abstract：:Transformation of fungi by complementation of auxotrophs is generally much more reliable than usage of antibiotic resistance markers. In order to establish such a system for the model zygomycete Absidia glauca, a stable methionine auxotrophic mutant was isolated after X-ray mutagenesis of the minus mating type and cha...

journal_title：FEBS open bio

authors： Karimi S,Wetzel J,Wöstemeyer J,Burmester A

更新日期：2012-07-20 00:00:00

abstract：:The pathogenic bacteria Streptococcus pyogenes can cause an array of diseases in humans, including moderate infections such as pharyngitis (strep throat) as well as life threatening conditions such as necrotizing fasciitis and puerperal fever. The antigen I/II family proteins are cell wall anchored adhesin proteins fo...

journal_title：FEBS open bio

authors： Hall M,Nylander S,Jenkinson HF,Persson K

更新日期：2014-03-12 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a common malignancy with poor prognosis and high mortality. To identify key genes associated with HCC and the underlying mechanisms, we performed weighted correlation network analysis (WGCNA) of potential key genes of HCC. We identified 17 key genes closely related to HCC by yellow mo...

journal_title：FEBS open bio

authors： Chen F,Zhang K,Huang Y,Luo F,Hu K,Cai Q

更新日期：2020-07-01 00:00:00

abstract：:An imbalance of branched-chain amino acids (BCAAs) in the brain may result in neuropathological conditions, such as autism spectrum disorders. The L-type amino acid transporter 1 (LAT1), encoded by the solute carrier transporter 7a5 (Slc7a5) gene, is critical for maintaining normal levels of BCAAs in the brain. Howeve...

journal_title：FEBS open bio

authors： Onishi Y,Hiraiwa M,Kamada H,Iezaki T,Yamada T,Kaneda K,Hinoi E

更新日期：2019-01-07 00:00:00

abstract：:The proton-coupled folate transporter (PCFT, SLC46A1) transports folic acid across the plasma membrane, together with an excess of protons such that the net charge translocation is positive. We developed 3D structural models of PCFT threaded onto the X-ray structures of major facilitator superfamily (MFS) members that...

journal_title：FEBS open bio

authors： Date SS,Chen CY,Chen Y,Jansen M

更新日期：2016-02-22 00:00:00

abstract：:Low-density lipoprotein receptor (LDLR) mediates hepatic clearance of plasma cholesterol; proprotein convertase subtilisin/kexin 9 (PCSK9) opposes this clearance by promoting LDLR degradation. The plant flavonoid quercetin-3-β-d-glucoside (Q3G) has been shown to reduce hypercholesterolemia in experimental animals. Her...

journal_title：FEBS open bio

authors： Mbikay M,Sirois F,Simoes S,Mayne J,Chrétien M

更新日期：2014-09-02 00:00:00

abstract：:Flavonoids represent one of the most important molecules of plant secondary metabolism, playing many different biochemical and physiological roles. Although their essential role in plant life and human health has been elucidated by many studies, their subcellular transport and accumulation in plant tissues remains unc...

journal_title：FEBS open bio

authors： Filippi A,Petrussa E,Peresson C,Bertolini A,Vianello A,Braidot E

更新日期：2015-08-29 00:00:00

abstract：:Immunoglobulin (Ig) A nephropathy (IgAN) is the most common glomerulonephritis, which is characterized by the deposition of IgA antibody in the glomerulus. Systematic dissection of immune composition may contribute to a better understanding of the alternations in the immune system in IgAN. To this end, here we applied...

journal_title：FEBS open bio

authors： Zhang X,Zeng J,Tong Y,Zhang L,Lu X,Zhu S,Li Z

更新日期：2020-12-01 00:00:00

abstract：:Understanding the role of specific amino acid residues in the molecular mechanism of a protein's function is one of the most challenging problems in modern biology. A systematic bioinformatic analysis of protein families and superfamilies can help in the study of structure-function relationships and in the design of i...

journal_title：FEBS open bio

authors： Fesko K,Suplatov D,Švedas V

更新日期：2018-05-21 00:00:00

abstract：:As a small fruit rich in anthocyanins, blueberry (Vaccinium corymbosum × angustifolium) has become a focus of research in recent years for identifying genes related to anthocyanin transport and stress resistance mechanisms based on transcriptome sequencing. However, the lack of validated, stably expressed reference ge...

journal_title：FEBS open bio

authors： Deng Y,Li Y,Sun H

更新日期：2020-08-01 00:00:00

abstract：:The Wilms tumor protein 1 (WT1) transcription factor has been associated in malignant melanoma with cell survival and metastasis, thus emerging as a candidate for targeted therapy. A lysine-arginine rich peptide, WT1-pTj, derived from the ZF domain of WT1 was evaluated as an antitumor agent against A2058 human melanom...

journal_title：FEBS open bio

authors： Massaoka MH,Matsuo AL,Figueiredo CR,Girola N,Faria CF,Azevedo RA,Travassos LR

更新日期：2014-01-21 00:00:00

abstract：:Abscisic acid (ABA) response elements (ABREs) are a group of cis-acting DNA elements that have been identified from promoter analysis of many ABA-regulated genes in plants. We are interested in understanding the mechanism of binding specificity between ABREs and a class of bZIP transcription factors known as ABRE bind...

journal_title：FEBS open bio

authors： Sarkar AK,Lahiri A

更新日期：2013-01-22 00:00:00

abstract：:Baicalin (5,6-dihydroxy-7-o-glucuronide flavone) is an extract from the roots of Chinese herb Huang Qin (Scutellaria baicalensis Georgi) and is reported to have antioxidative, antiproliferative, anti-inflammatory, and anticancer activities. This study aimed to investigate the inhibitory effect of baicalin on human hep...

journal_title：FEBS open bio

authors： Yu Z,Luo X,Wang C,Ye J,Liu S,Xie L,Wang F,Bao J

更新日期：2016-10-24 00:00:00

abstract：:Oxidative stress has been associated with prostate cancer development and progression due to an increase of reactive oxygen species (ROS). However, the mechanisms whereby ROS and the antioxidant system participate in cancer progression remain unclear. In order to clarify the influence of oxidative stress in prostate c...

journal_title：FEBS open bio

authors： Freitas M,Baldeiras I,Proença T,Alves V,Mota-Pinto A,Sarmento-Ribeiro A

更新日期：2012-05-30 00:00:00

abstract：:The A/B domains of nuclear receptors such as thyroid receptor α (TRα) are considered to be conformationally flexible and can potentially adopt multiple structural conformations. We used intrinsic tryptophan fluorescence quenching and circular dichroism spectroscopy to characterize the unfolding of this A/B domain upon...

journal_title：FEBS open bio

authors： Fernandez EJ,Gahlot V,Rodriguez C,Amburn J

更新日期：2017-05-15 00:00:00

abstract：:In the brain, REST (Repressor Element-1 Silencing Transcription factor) is a key regulator of neuron cell-specific gene expression. Nuclear translocation of neuronal REST has been shown to be neuroprotective in a healthy ageing context. In contrast, inability to upregulate nuclear REST is thought to leave ageing neuro...

journal_title：FEBS open bio

authors： Mampay M,Velasco-Estevez M,Rolle SO,Chaney AM,Boutin H,Dev KK,Moeendarbary E,Sheridan GK

更新日期：2020-11-13 00:00:00

abstract：:Mediterranean Carthamus tinctorius (Safflower) is used for treatment of inflammatory conditions and neuropsychiatric disorders. Recently C. tinctorius lignans arctigenin and trachelogenin but not matairesinol were described to interfere with the activity of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO)...

journal_title：FEBS open bio

authors： Temml V,Kuehnl S,Schuster D,Schwaiger S,Stuppner H,Fuchs D

更新日期：2013-09-07 00:00:00

abstract：:The identification of non-invasive biomarkers for the detection of renal cell carcinoma (RCC) in early-stage patients may help improve disease outcome. Certain long non-coding RNAs (lncRNAs) have been reported to be possible biomarkers for the diagnosis and prognosis of cancer. Here, we examined the suitability of the...

journal_title：FEBS open bio

authors： Xie J,Zhong Y,Chen R,Li G,Luo Y,Yang J,Sun Z,Liu Y,Liu P,Wang N,An J,Li C,Song Y

更新日期：2020-09-01 00:00:00

abstract：:Human melanoma is a highly malignant tumor originating from cutaneous melanocytes. The noncoding RNA microRNA (miR)-21-5p has been reported to be expressed at high levels in malignant melanocytic skin tissues, but its potential functional role in melanoma remains poorly understood. Here, we explored the cellular effec...

journal_title：FEBS open bio

authors： Yang Z,Liao B,Xiang X,Ke S

更新日期：2020-05-01 00:00:00

abstract：:The antipsychotic drug olanzapine is widely prescribed to treat schizophrenia and other psychotic disorders. However, it often causes unwanted side effects, including diabetes, due to disruption of insulin-dependant glucose metabolism through a mechanism yet to be elucidated. To determine if olanzapine can affect the ...

journal_title：FEBS open bio

authors： Babkin P,George Thompson AM,Iancu CV,Walters DE,Choe JY

更新日期：2015-04-15 00:00:00