Quercetin-3-glucoside increases low-density lipoprotein receptor (LDLR) expression, attenuates proprotein convertase subtilisin/kexin 9 (PCSK9) secretion, and stimulates LDL uptake by Huh7 human hepatocytes in culture.

abstract：:Soft cheese with white rind lacks essential fatty acids (EFAs), and as a result its long-term consumption may lead to various kinds of cardiovascular and cerebrovascular diseases, such as hyperlipidemia, hypertension, and atherosclerosis. Geotrichum candidum is a dimorphic yeast that plays an important role in the rip...

journal_title：FEBS open bio

authors： Luo X,Shi H,Wu R,Wu J,Pi Y,Zheng Y,Yue X

更新日期：2018-12-06 00:00:00

abstract：:Post-transcriptional regulation of cytokine production is crucial to ensure appropriate immune responses. We previously demonstrated that poly-rC-binding protein-1 (PCBP1) can act as a trans-acting factor to stabilize transcripts encoding sortilin, which mediates cytokine trafficking. Here, we report that PCBP2, which...

journal_title：FEBS open bio

authors： Yabe-Wada T,Philpott CC,Onai N

更新日期：2020-03-01 00:00:00

abstract：:Redox-coupled folding pathways of bovine pancreatic ribonuclease A (RNase A) with four intramolecular disulfide (SS) bonds comprise three phases: (I) SS formation to generate partially oxidized intermediate ensembles with no rigid folded structure; (II) SS rearrangement from the three SS intermediate ensemble (3S) to ...

journal_title：FEBS open bio

authors： Arai K,Kumakura F,Iwaoka M

更新日期：2012-04-16 00:00:00

abstract：:Receptor activator of nuclear factor-κB ligand (RANKL) is required for initiation of osteoclastogenesis, with the signaling pathway including the NF-kB, c-Fos, and nuclear factor of activated T cells, cytoplasmic 1 (NFATc1) transcription factors. Because NFATc1 expression is autoamplified, we investigated the molecula...

journal_title：FEBS open bio

authors： Park KL,Oh DG,Kim YO,Song KS,Ahn DW

更新日期：2018-09-10 00:00:00

abstract：:Prostate cancer (PCa) is the most frequently diagnosed male cancer. An earlier study of a cohort of 333 primary prostate carcinomas showed that 74% of these tumors fell into one of seven subtypes of a molecular taxonomy defined by specific gene fusions (ERG, ETV1/4 and FLI1) or mutations (SPOP, FOXA1 and IDH1). Molecu...

journal_title：FEBS open bio

authors： Tang L,Zhang L,Liu L,Dong L,Dong Y,Zhu W,Wang H

更新日期：2020-12-01 00:00:00

abstract：:Increased glucose consumption is a known hallmark of cancer cells. Increased glycolysis provides ATP, reducing agents and substrates for macromolecular synthesis in intensely dividing cells. Therefore, inhibition of glycolysis is one strategy in anticancer therapy as well as in improved efficacy of conventional antica...

journal_title：FEBS open bio

authors： Korga A,Ostrowska M,Iwan M,Herbet M,Dudka J

更新日期：2019-05-01 00:00:00

abstract：:Centrins are members of the EF-hand family of calcium-binding proteins, which are highly conserved among eukaryotes. Centrins bind to several cellular targets, through a hydrophobic triad. However, the W(1)xxL(4)xxxL(8) triad in XPC (Xeroderma Pigmentosum Group C protein) is found in the reverse orientation, as in the...

journal_title：FEBS open bio

authors： Grecu D,Blouquit Y,Assairi L

更新日期：2013-12-05 00:00:00

abstract：:One practical application of genome-scale metabolic reconstructions is to interrogate multispecies relationships. Here, we report a consensus metabolic model in four yeast species (Saccharomyces cerevisiae, S. paradoxus, S. mikatae, and S. bayanus) by integrating metabolic network simulations with RNA sequencing (RNA-...

journal_title：FEBS open bio

authors： Zhao Y,Wang Y,Zou L,Huang J

更新日期：2016-02-27 00:00:00

abstract：:Fibroblast growth factor 11 (FGF11) is a member of the intracellular fibroblast growth factor superfamily. Here, we identified FGF11 as a novel mediator of adipogenesis. During 3T3-L1 adipocyte differentiation, the expression of FGF11 decreased at the mitotic clonal expansion stage and increased at the terminal differ...

journal_title：FEBS open bio

authors： Lee KW,Jeong JY,An YJ,Lee JH,Yim HS

更新日期：2019-03-12 00:00:00

abstract：:The expense and time required for in vivo reproductive and developmental toxicity studies have driven the development of in vitro alternatives. Here, we used a new in vitro split luciferase-based assay to screen a library of 177 toxicants for inhibitors of apoptosome formation. The apoptosome contains seven Apoptotic ...

journal_title：FEBS open bio

authors： Tashakor A,H-Dehkordi M,O'Connell E,Gomez Ganau S,Gozalbes R,Eriksson LA,Hosseinkhani S,Fearnhead HO

更新日期：2019-07-01 00:00:00

abstract：:Arbutin, a glycoside extracted from the plant Arctostaphylos uva-ursi, has been previously reported to possess antioxidant, anti-inflammatory and anticancer effects. Here, we investigated whether arbutin affects the proliferation of the cells of the osteosarcoma (OS) cell lines MG-63 and SW1353. Arbutin suppressed OS ...

journal_title：FEBS open bio

authors： Wang CQ,Wang XM,Li BL,Zhang YM,Wang L

更新日期：2020-11-03 00:00:00

abstract：:The Wilms tumor protein 1 (WT1) transcription factor has been associated in malignant melanoma with cell survival and metastasis, thus emerging as a candidate for targeted therapy. A lysine-arginine rich peptide, WT1-pTj, derived from the ZF domain of WT1 was evaluated as an antitumor agent against A2058 human melanom...

journal_title：FEBS open bio

authors： Massaoka MH,Matsuo AL,Figueiredo CR,Girola N,Faria CF,Azevedo RA,Travassos LR

更新日期：2014-01-21 00:00:00

abstract：:Oxidative stress in plants causes ferredoxin down-regulation and NADP(+) shortage, over-reduction of the photosynthetic electron transport chain, electron leakage to oxygen and generation of reactive oxygen species (ROS). Expression of cyanobacterial flavodoxin in tobacco chloroplasts compensates for ferredoxin declin...

journal_title：FEBS open bio

authors： Giró M,Ceccoli RD,Poli HO,Carrillo N,Lodeyro AF

更新日期：2011-11-11 00:00:00

abstract：:Flavin adenine dinucleotide (FAD), synthesized from riboflavin, is redox cofactor in energy production and plays an important role in cell survival. More recently, riboflavin deficiency has been linked to developmental disorders, but its role in stem cell differentiation remains unclear. Here, we show that FAD treatme...

journal_title：FEBS open bio

authors： Hirano K,Namihira M

更新日期：2017-10-17 00:00:00

abstract：:In this study, it was shown for the first time that l-amino acid oxidase of Pseudomonas sp. AIU813, renamed as l-amino acid oxidase/monooxygenase (l-AAO/MOG), exhibits l-lysine 2-monooxygenase as well as oxidase activity. l-Lysine oxidase activity of l-AAO/MOG was increased in a p-chloromercuribenzoate (p-CMB) concent...

journal_title：FEBS open bio

authors： Matsui D,Im DH,Sugawara A,Fukuta Y,Fushinobu S,Isobe K,Asano Y

更新日期：2014-02-07 00:00:00

abstract：:Amino acids are known to play a key role in gene expression regulation, and in mammalian cells, amino acid signaling is mainly mediated via two pathways, the mammalian target of rapamycin complex 1 (mTORC1) pathway and the amino acid responsive (AAR) pathway. It is vital for cells to have a system to sense amino acid ...

journal_title：FEBS open bio

authors： Hellsten SV,Lekholm E,Ahmad T,Fredriksson R

更新日期：2017-01-11 00:00:00

abstract：:As a small fruit rich in anthocyanins, blueberry (Vaccinium corymbosum × angustifolium) has become a focus of research in recent years for identifying genes related to anthocyanin transport and stress resistance mechanisms based on transcriptome sequencing. However, the lack of validated, stably expressed reference ge...

journal_title：FEBS open bio

authors： Deng Y,Li Y,Sun H

更新日期：2020-08-01 00:00:00

abstract：:Proteins of the serum amyloid A (SAA) family have been remarkably conserved in evolution. Their biologic function(s) are not fully defined but they are likely to be a part of primordial host defense. We have detected a ∼ 12-kDa protein reacting with antibodies against serum amyloid A (SAA) in human colostrum by wester...

journal_title：FEBS open bio

authors： Sack GH Jr,Zachara N,Rosenblum N,Talbot CC Jr,Kreimer S,Cole R,McDonald TL

更新日期：2018-01-31 00:00:00

abstract：:Tight regulation of the eukaryotic cell cycle is paramount to ensure genomic integrity throughout life. Cell cycle checkpoints are present in each phase of the cell cycle and prevent cell cycle progression when genomic integrity is compromised. The G2 checkpoint is an intricate signaling network that regulates the pro...

journal_title：FEBS open bio

authors： de Gooijer MC,van den Top A,Bockaj I,Beijnen JH,Würdinger T,van Tellingen O

更新日期：2017-03-04 00:00:00

abstract：:The major functions of adipocytes include both lipid storage and the production of secretory factors. However, the type of proteins released from mouse 3T3-L1 cells during adipocyte differentiation remains poorly understood. We examined the dynamics of secreted proteins during adipocyte differentiation using mass spec...

journal_title：FEBS open bio

authors： Ojima K,Oe M,Nakajima I,Muroya S,Nishimura T

更新日期：2016-06-15 00:00:00

abstract：:Angiotensin converting enzyme (ACE) is a zinc-dependent dipeptidyl carboxypeptidase with an essential role in blood pressure homeostasis in mammals. ACE has long been targeted in the treatment of hypertension through ACE inhibitors, however current inhibitors are known to cause severe side effects. Therefore, there is...

journal_title：FEBS open bio

authors： Harrison C,Acharya KR

更新日期：2015-08-11 00:00:00

abstract：:Tropomyosins, a family of actin-associated proteins, bestow actin filaments with distinct biochemical and physical properties which are important for determining cell shape and regulating many cellular processes in eukaryotic cells. Here, we used RNA-seq to investigate the effect of four tropomyosin isoforms on gene e...

journal_title：FEBS open bio

authors： Stefen H,Suchowerska AK,Chen BJ,Brettle M,Kuschelewski J,Gunning PW,Janitz M,Fath T

更新日期：2018-02-19 00:00:00

abstract：:Micro-exons are a set of ultrashort exons with lengths ≤ 51 nucleotides. Our previous study revealed that micro-exons were enriched in AP2 domains and K-box domains, which are crucial components of AP2/ERF (APETALA2/ethylene-responsive element-binding protein) and MADS-box (an acronym of MCM1, AGAMOUS, DEFICIENS and S...

journal_title：FEBS open bio

authors： Song Q,Bari A,Li H,Chen LL

更新日期：2020-12-01 00:00:00

abstract：:Neointimal hyperplasia (NIH) is a complicated inflammatory process contributing to vascular restenosis. The present study aimed to explore whether chemokine-like factor 1 (CKLF1) aggravates NIH via the nuclear factor-kappa B (NF-κB)/vascular cell adhesion molecule-1 (VCAM-1) pathway. We found the expression of CKLF1 a...

journal_title：FEBS open bio

authors： Liu X,Qu C,Zhang Y,Fang J,Teng L,Zhang R,Zhang X,Shen C

更新日期：2020-09-01 00:00:00

abstract：:Megakaryoblastic leukemia 1 (MKL1) is a member of the MKL family of serum response factor (SRF) coactivators. Here we have identified three rat MKL1 transcripts: two are homologues of mouse MKL1 transcripts, full-length MKL1 (FLMKL1) and basic, SAP, and coiled-coil domains (BSAC), the third is a novel transcript, MKL1...

journal_title：FEBS open bio

authors： Ishikawa M,Shiota J,Ishibashi Y,Hakamata T,Shoji S,Fukuchi M,Tsuda M,Shirao T,Sekino Y,Ohtsuka T,Baraban JM,Tabuchi A

更新日期：2013-09-07 00:00:00

abstract：:Lysophosphatidylcholine acyltransferase 3 (LPCAT3) is an important enzyme in phospholipid remodeling, a process that influences the biophysical properties of cell membranes and thus cell function. Multiple lines of evidence suggest that LPCAT3 is involved in several diseases, including atherosclerosis, non-alcoholic s...

journal_title：FEBS open bio

authors： Du X,Hu J,Zhang Q,Liu Q,Xiang X,Dong J,Lou B,He S,Gu X,Cao Y,Li Y,Ding T

更新日期：2019-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a common malignancy with poor prognosis and high mortality. To identify key genes associated with HCC and the underlying mechanisms, we performed weighted correlation network analysis (WGCNA) of potential key genes of HCC. We identified 17 key genes closely related to HCC by yellow mo...

journal_title：FEBS open bio

authors： Chen F,Zhang K,Huang Y,Luo F,Hu K,Cai Q

更新日期：2020-07-01 00:00:00

abstract：:Metastasis is the primary contributor to colorectal cancer mortality. High-intensity focused ultrasound (HIFU) is an emerging technology for tumor therapy that exerts its effects through tumor ablation, mechanical disruption, and enhancement of immune responses. However, it remains unclear whether HIFU can influence t...

journal_title：FEBS open bio

authors： Li M,Wan G,Yu H,Xiong W

更新日期：2019-06-01 00:00:00

abstract：:Renin is the rate-limiting enzyme of the renin-angiotensin system cascade, which drives the pathophysiological progression of heart failure. Species differences in the amino acid sequence of the catalytic domain of renin limit evaluations of the potency and efficacy of human renin inhibitors in animal models, and a hi...

journal_title：FEBS open bio

authors： Hara T,Yamamura T,Murakami-Asahina M,Matsumoto H,Takeyama M,Kanagawa R,Nishimoto T

更新日期：2020-05-01 00:00:00

abstract：:Previous studies have proposed that the human papillomavirus (HPV) E6 oncoproteins modify the transcriptional activity of eIF4E through mechanisms dependent on p53 degradation. However, the effect of these oncoproteins on pathways regulating the activity of the eIF4E protein remains poorly understood. Hence, we invest...

journal_title：FEBS open bio

authors： Morales-Garcia V,Contreras-Paredes A,Martinez-Abundis E,Gomez-Crisostomo NP,Lizano M,Hernandez-Landero F,de la Cruz-Hernandez E

更新日期：2020-12-01 00:00:00