Survey and analysis of simple sequence repeats (SSRs) present in the genomes of plant viroids.

abstract：:The major functions of adipocytes include both lipid storage and the production of secretory factors. However, the type of proteins released from mouse 3T3-L1 cells during adipocyte differentiation remains poorly understood. We examined the dynamics of secreted proteins during adipocyte differentiation using mass spec...

journal_title：FEBS open bio

authors： Ojima K,Oe M,Nakajima I,Muroya S,Nishimura T

更新日期：2016-06-15 00:00:00

abstract：:The tumour microenvironment comprises a diverse range of cells, including fibroblasts, immune cells and endothelial cells, along with extracellular matrix. In particular, fibroblasts are of significant interest as these cells are reprogrammed during tumorigenesis to become cancer-associated fibroblasts (CAFs), which i...

journal_title：FEBS open bio

authors： Aguilera-Rojas M,Sharbati S,Stein T,Einspanier R

更新日期：2020-05-01 00:00:00

abstract：:The base excision repair pathway plays an important role in correcting damage induced by either physiological or external effects. This repair pathway removes incorrect bases from the DNA. The uracil base is among the most frequently occurring erroneous bases in DNA, and is cut out from the phosphodiester backbone via...

journal_title：FEBS open bio

authors： Papp-Kádár V,Balázs Z,Vékey K,Ozohanics O,Vértessy BG

更新日期：2019-02-09 00:00:00

abstract：:Proteins of the serum amyloid A (SAA) family have been remarkably conserved in evolution. Their biologic function(s) are not fully defined but they are likely to be a part of primordial host defense. We have detected a ∼ 12-kDa protein reacting with antibodies against serum amyloid A (SAA) in human colostrum by wester...

journal_title：FEBS open bio

authors： Sack GH Jr,Zachara N,Rosenblum N,Talbot CC Jr,Kreimer S,Cole R,McDonald TL

更新日期：2018-01-31 00:00:00

abstract：:The expression of death receptor 6 (DR6) is abnormal in some cancer types, but the function and underlying molecular mechanisms of DR6 in tumor progression are not yet clear. In the present study, our analysis of ovarian cancer RNA sequencing data from The Cancer Genome Atlas revealed that DR6 is upregulated in human ...

journal_title：FEBS open bio

authors： Shi B,Bao J,Liu Y,Shi J

更新日期：2018-08-07 00:00:00

abstract：:Human type 2 diabetes is associated with β-cell apoptosis, and human islets from diabetic donors are ∼80% deficient in PAK1 protein. Toward addressing linkage of PAK1 to β-cell survival, PAK1-siRNA targeted MIN6 pancreatic β-cells were found to exhibit increased caspase-3 cleavage, cytosolic cytochrome-C and the pro-a...

journal_title：FEBS open bio

authors： Wang Z,Thurmond DC

更新日期：2012-09-08 00:00:00

abstract：:Osteosarcoma is the most common primary solid malignancy of the bone, and its high mortality usually correlates with early metastasis. In this study, we developed a risk score model to help predict metastasis at the time of diagnosis. We downloaded and mined four expression profile datasets associated with osteosarcom...

journal_title：FEBS open bio

authors： Dong S,Huo H,Mao Y,Li X,Dong L

更新日期：2019-02-02 00:00:00

abstract：:The yeast cyclins Cln1 and Cln2 are very similar in both sequence and function, but some differences in their functionality and localization have been recently described. The control of Cln1 and Cln2 cellular levels is crucial for proper cell cycle initiation. In this work, we analyzed the degradation patterns of Cln1...

journal_title：FEBS open bio

authors： Quilis I,Igual JC

更新日期：2016-12-14 00:00:00

abstract：:In this study, we showed that cyanocobalamin dodecylamine, a ribose 5'-carbamate derivative of cyanocobalamin, was absorbed and accumulated to significant levels by Caenorhabditis elegans and was not further metabolized. The levels of methylmalonic acid and homocysteine, which serve as indicators of cobalamin deficien...

journal_title：FEBS open bio

authors： Bito T,Yabuta Y,Ichiyanagi T,Kawano T,Watanabe F

更新日期：2014-08-01 00:00:00

abstract：:Decorin (DCN) is a major member of the small leucine-rich proteoglycan (SLRP) family that is critically involved in tumorigenesis and the development of metastasis of cancers, including glioma. Overexpression of DCN was indicated to suppress glioma cell growth. However, the role of DCN in the migration of glioma cells...

journal_title：FEBS open bio

authors： Yao T,Zhang CG,Gong MT,Zhang M,Wang L,Ding W

更新日期：2016-05-31 00:00:00

abstract：:Tight regulation of the eukaryotic cell cycle is paramount to ensure genomic integrity throughout life. Cell cycle checkpoints are present in each phase of the cell cycle and prevent cell cycle progression when genomic integrity is compromised. The G2 checkpoint is an intricate signaling network that regulates the pro...

journal_title：FEBS open bio

authors： de Gooijer MC,van den Top A,Bockaj I,Beijnen JH,Würdinger T,van Tellingen O

更新日期：2017-03-04 00:00:00

abstract：:The identification of non-invasive biomarkers for the detection of renal cell carcinoma (RCC) in early-stage patients may help improve disease outcome. Certain long non-coding RNAs (lncRNAs) have been reported to be possible biomarkers for the diagnosis and prognosis of cancer. Here, we examined the suitability of the...

journal_title：FEBS open bio

authors： Xie J,Zhong Y,Chen R,Li G,Luo Y,Yang J,Sun Z,Liu Y,Liu P,Wang N,An J,Li C,Song Y

更新日期：2020-09-01 00:00:00

abstract：:Hirschmanniella mucronata is a plant-parasitic nematode that is widespread in rice production areas and causes 10-25% yield losses a year on average. Here, we investigated the mechanism of resistance to this nematode by comparing the transcriptomes of roots from resistant (Jiabali) and susceptible (Bawangbian) varieti...

journal_title：FEBS open bio

authors： Sun X,Zhang L,Tang Z,Shi X,Ma J,Cui R

更新日期：2019-11-01 00:00:00

abstract：:Epigallocatechin gallate (EGCG), a major polyphenol in green tea, possesses antioxidant properties and regulates various cell functions. Here, we examined the function of EGCG in inflammatory bone resorption. In calvarial organ cultures, lipopolysaccharide (LPS)-induced bone resorption was clearly suppressed by EGCG. ...

journal_title：FEBS open bio

authors： Tominari T,Matsumoto C,Watanabe K,Hirata M,Grundler FM,Miyaura C,Inada M

更新日期：2015-06-12 00:00:00

abstract：:The Malayan pangolin (Manis javanica) is a mammal that feeds primarily on ants and termites, which contain the energy-rich carbohydrate chitin. Chitin is digestible by endogenous enzymes of the typical mammalian gastrointestinal tract, especially the acidic mammalian chitinase (AMCase). The objective of this research ...

journal_title：FEBS open bio

authors： Ma JE,Li LM,Jiang HY,Zhang XJ,Li J,Li GY,Chen JP

更新日期：2018-07-04 00:00:00

abstract：:The Wilms tumor protein 1 (WT1) transcription factor has been associated in malignant melanoma with cell survival and metastasis, thus emerging as a candidate for targeted therapy. A lysine-arginine rich peptide, WT1-pTj, derived from the ZF domain of WT1 was evaluated as an antitumor agent against A2058 human melanom...

journal_title：FEBS open bio

authors： Massaoka MH,Matsuo AL,Figueiredo CR,Girola N,Faria CF,Azevedo RA,Travassos LR

更新日期：2014-01-21 00:00:00

abstract：:Nisin is the most prominent and applied bacteriocin that serves as a model for class I lantibiotics. The nisin leader peptide importantly determines interactions between precursor nisin and its modification enzymes NisB and NisC that mature nisin posttranslationally. NisB dehydrates serines and threonines, while NisC ...

journal_title：FEBS open bio

authors： Khusainov R,Moll GN,Kuipers OP

更新日期：2013-05-30 00:00:00

abstract：:Inorganic polyphosphate (polyP) is a linear polymer containing tens to hundreds of orthophosphate residues linked by high-energy phosphoanhydride bonds. PolyP promotes osteocalcification and bone mineralization in both mouse and human osteoblastic cells. In the present study, we examined the molecular mechanism by whi...

journal_title：FEBS open bio

authors： Tsutsumi K,Sasase T

更新日期：2019-09-01 00:00:00

abstract：:Metastasis is the primary contributor to colorectal cancer mortality. High-intensity focused ultrasound (HIFU) is an emerging technology for tumor therapy that exerts its effects through tumor ablation, mechanical disruption, and enhancement of immune responses. However, it remains unclear whether HIFU can influence t...

journal_title：FEBS open bio

authors： Li M,Wan G,Yu H,Xiong W

更新日期：2019-06-01 00:00:00

abstract：:Fluorine is a bone-seeking element ubiquitously present in the environment and widely used in many oral hygiene products. In humans, excessive intake of fluoride may cause dental and skeletal fluorosis. However, endemic fluorosis does not appear to develop in a proportion of individuals exposed to the same levels of f...

journal_title：FEBS open bio

authors： Ran S,Sun N,Liu Y,Zhang W,Li Y,Wei L,Wang J,Liu B

更新日期：2017-06-05 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma coactivator-1β (PGC-1β) is a transcriptional regulator whose increased expression activates energy expenditure-related genes in skeletal muscles. However, how PGC-1β is regulated remains largely unclear. Here, we show that PGC-1β gene expression is negatively correlated...

journal_title：FEBS open bio

authors： Nakai S,Oyabu M,Hatazawa Y,Akashi S,Kitamura T,Miura S,Kamei Y

更新日期：2020-07-01 00:00:00

abstract：:Osteoarthritis (OA) is a chronic degenerative disease that commonly affects the elderly. Current drug therapies for treating OA may cause adverse side effects, and so there remains a need to develop alternative treatments. Bergapten (BG) is a coumarin phytohormone that is widely found in fruits and has antioxidative a...

journal_title：FEBS open bio

authors： He Y,Zisan Z,Lu Z,Zheng L,Zhao J

更新日期：2019-06-01 00:00:00

abstract：:The vertebrate egg coat, including mammalian zona pellucida, is an oocyte-specific extracellular matrix comprising two to six zona pellucida (ZP) glycoproteins. The egg coat plays important roles in fertilization, especially in species-specific interactions with sperm to induce the sperm acrosome reaction and to form ...

journal_title：FEBS open bio

authors： Okumura H,Sato T,Sakuma R,Fukushima H,Matsuda T,Ujita M

更新日期：2015-05-27 00:00:00

abstract：:Iron overload affects the cell cycle of various cell types, but the effect of iron overload on human pluripotent stem cells has not yet been reported. Here, we show that the proliferation capacities of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) were significantly inhibited by ...

journal_title：FEBS open bio

authors： Han Z,Xu Z,Chen L,Ye D,Yu Y,Zhang Y,Cao Y,Djibril B,Guo X,Gao X,Zhang W,Yu M,Liu S,Yan G,Jin M,Huang Q,Wang X,Hua B,Feng C,Yang F,Ma W,Liu Y

更新日期：2020-05-01 00:00:00

abstract：:Small heat shock proteins (sHsps) endow cells with stress tolerance. Of the various sHsps in mammals, HspB1, also known as Hsp27, is the most ubiquitous. To examine the structure and function of HspB1, we expressed, purified, and characterized HspB1 from Chinese hamster (Cricetulus griseus) ovary cells (CgHspB1). CgHs...

journal_title：FEBS open bio

authors： Sha E,Nakamura M,Ankai K,Yamamoto YY,Oka T,Yohda M

更新日期：2019-10-01 00:00:00

abstract：:Neointimal hyperplasia (NIH) is a complicated inflammatory process contributing to vascular restenosis. The present study aimed to explore whether chemokine-like factor 1 (CKLF1) aggravates NIH via the nuclear factor-kappa B (NF-κB)/vascular cell adhesion molecule-1 (VCAM-1) pathway. We found the expression of CKLF1 a...

journal_title：FEBS open bio

authors： Liu X,Qu C,Zhang Y,Fang J,Teng L,Zhang R,Zhang X,Shen C

更新日期：2020-09-01 00:00:00

abstract：:Previous studies have proposed that the human papillomavirus (HPV) E6 oncoproteins modify the transcriptional activity of eIF4E through mechanisms dependent on p53 degradation. However, the effect of these oncoproteins on pathways regulating the activity of the eIF4E protein remains poorly understood. Hence, we invest...

journal_title：FEBS open bio

authors： Morales-Garcia V,Contreras-Paredes A,Martinez-Abundis E,Gomez-Crisostomo NP,Lizano M,Hernandez-Landero F,de la Cruz-Hernandez E

更新日期：2020-12-01 00:00:00

abstract：:Nitrobindins (Nbs), constituting a heme-protein family spanning from bacteria to Homo sapiens, display an all-β-barrel structural organization. Human Nb has been described as a domain of the nuclear protein named THAP4, whose physiological function is still unknown. We report the first evidence of the heme-Fe(III)-bas...

journal_title：FEBS open bio

authors： De Simone G,di Masi A,Polticelli F,Ascenzi P

更新日期：2018-11-09 00:00:00

abstract：:Transformation of fungi by complementation of auxotrophs is generally much more reliable than usage of antibiotic resistance markers. In order to establish such a system for the model zygomycete Absidia glauca, a stable methionine auxotrophic mutant was isolated after X-ray mutagenesis of the minus mating type and cha...

journal_title：FEBS open bio

authors： Karimi S,Wetzel J,Wöstemeyer J,Burmester A

更新日期：2012-07-20 00:00:00

abstract：:Adult T-cell leukemia/lymphoma (ATL), an aggressive T-cell malignancy that develops after long-term infection with human T-cell leukemia virus (HTLV-1), requires new treatments. Drug repositioning, reuse of a drug previously approved for the treatment of another condition to treat ATL, offers the possibility of reduce...

journal_title：FEBS open bio

authors： Kozako T,Soeda S,Yoshimitsu M,Arima N,Kuroki A,Hirata S,Tanaka H,Imakyure O,Tone N,Honda S,Soeda S

更新日期：2016-04-13 00:00:00