Abstract:
:Neural stem cells (NSC) from the adult hippocampus easily lose their activity in vitro. Efficient in vitro expansion of adult hippocampus-derived NSC is important for generation of tools for research and cell therapy. Here, we show that a single copy disruption or pharmacological inhibition of p38α enables successful long-term neurosphere culture of adult mouse hippocampal cells. Expanded neurospheres with high proliferative activity differentiated into the three neuronal lineages under differentiating conditions. Thus, inhibition of p38α can maintain adult hippocampal NSC activity in vitro.
journal_name
FEBS Open Biojournal_title
FEBS open bioauthors
Yoshioka K,Namiki K,Sudo T,Kasuya Ydoi
10.1016/j.fob.2015.05.001subject
Has Abstractpub_date
2015-05-08 00:00:00pages
437-44issn
2211-5463pii
S2211-5463(15)00046-7journal_volume
5pub_type
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