Abstract:
:Hepatocellular carcinoma (HCC) is a common malignancy with poor prognosis and high mortality. To identify key genes associated with HCC and the underlying mechanisms, we performed weighted correlation network analysis (WGCNA) of potential key genes of HCC. We identified 17 key genes closely related to HCC by yellow module combined with PPI analysis. Verification of the role of these genes revealed that SPC25 knockdown results in a significant decrease in proliferation and metastasis of HCC cells and increased protein levels of components of the p53 pathway in vitro. In summary, we identified that SPC25 is a potential tumor-promoting factor in HCC and may act via the p53 pathway.
journal_name
FEBS Open Biojournal_title
FEBS open bioauthors
Chen F,Zhang K,Huang Y,Luo F,Hu K,Cai Qdoi
10.1002/2211-5463.12872subject
Has Abstractpub_date
2020-07-01 00:00:00pages
1261-1275issue
7issn
2211-5463journal_volume
10pub_type
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