Comparison of a new nanoform of the photosensitizer chlorin e6, based on plant phospholipids, with its free form.

abstract：:Thymic stromal lymphopoietin (TSLP) has been identified as a crucial inflammatory cytokine in immune homeostasis. Previous studies have reported conflicting effects of TSLP on sepsis in mice, and the effect of TSLP on sepsis in humans has not been investigated. In this study, we used the ELISA to measure serum levels ...

journal_title：FEBS open bio

authors： Yu Q,Li Y,Wang H,Xiong H

更新日期：2019-12-01 00:00:00

abstract：:Growth hormone receptor (GHR), a member of the class I cytokine receptor family, plays key roles in cancer progression. Recently, GHR has been reported to be associated with breast cancer development, but the molecular mechanism of GHR in this malignancy is not fully understood. To investigate this issue, we stably in...

journal_title：FEBS open bio

authors： Zhu X,Li Y,Xu G,Fu C

更新日期：2020-06-01 00:00:00

abstract：:Despite progress in the treatment of hepatocellular carcinoma (HCC), 5-year survival rates remain low. Thus, a more comprehensive approach to explore the mechanism of HCC is needed to provide new leads for targeted therapy. We performed an integrated analysis to discover the relationship between DNA methylation and ge...

journal_title：FEBS open bio

authors： Sun XJ,Wang MC,Zhang FH,Kong X

更新日期：2018-05-30 00:00:00

abstract：:Identification of viral encoded proteins that interact with RNA-dependent RNA polymerase (RdRp) is an important step towards unraveling the mechanism of replication. Sesbania mosaic virus (SeMV) RdRp was shown to interact strongly with p10 domain of polyprotein 2a and moderately with the protease domain. Mutational an...

journal_title：FEBS open bio

authors： Govind K,Bakshi A,Savithri HS

更新日期：2014-03-29 00:00:00

abstract：:IL-1 family cytokines act as apical initiators of inflammation in many settings and can promote the production of a battery of inflammatory cytokines, chemokines and other inflammatory mediators in diverse cell types. IL-36α, IL-36β and IL-36γ, which belong to the extended IL-1 family, have been implicated as key init...

journal_title：FEBS open bio

authors： Sullivan GP,Davidovich PB,Sura-Trueba S,Belotcerkovskaya E,Henry CM,Clancy DM,Zinoveva A,Mametnabiev T,Garabadzhiu AV,Martin SJ

更新日期：2018-03-25 00:00:00

abstract：:Human STIL (SCL/TAL1 interrupting locus) protein maintains centriole stability and spindle pole localisation. It helps in recruitment of CENPJ (Centromere protein J)/CPAP (centrosomal P4.1-associated protein) and other centrosomal proteins. Mutations in STIL protein are reported in several disorders, especially in der...

journal_title：FEBS open bio

authors： Kumar A,Rajendran V,Sethumadhavan R,Purohit R

更新日期：2012-09-25 00:00:00

abstract：:Due to its exceptionally small genome size and protogynous hermaphroditism, Monopterus albus has been proposed as a model for vertebrate sexual development. The Kiss/GPR54 system is a central regulator of sexual development in most vertebrates, but its role in sex reversal remains hypothetical. In contrast to mammals,...

journal_title：FEBS open bio

authors： Yi TL,Pei MT,Yang DQ

更新日期：2019-10-01 00:00:00

abstract：:The vertebrate egg coat, including mammalian zona pellucida, is an oocyte-specific extracellular matrix comprising two to six zona pellucida (ZP) glycoproteins. The egg coat plays important roles in fertilization, especially in species-specific interactions with sperm to induce the sperm acrosome reaction and to form ...

journal_title：FEBS open bio

authors： Okumura H,Sato T,Sakuma R,Fukushima H,Matsuda T,Ujita M

更新日期：2015-05-27 00:00:00

abstract：:Adult T-cell leukemia/lymphoma (ATL), an aggressive T-cell malignancy that develops after long-term infection with human T-cell leukemia virus (HTLV-1), requires new treatments. Drug repositioning, reuse of a drug previously approved for the treatment of another condition to treat ATL, offers the possibility of reduce...

journal_title：FEBS open bio

authors： Kozako T,Soeda S,Yoshimitsu M,Arima N,Kuroki A,Hirata S,Tanaka H,Imakyure O,Tone N,Honda S,Soeda S

更新日期：2016-04-13 00:00:00

abstract：:The antipsychotic drug olanzapine is widely prescribed to treat schizophrenia and other psychotic disorders. However, it often causes unwanted side effects, including diabetes, due to disruption of insulin-dependant glucose metabolism through a mechanism yet to be elucidated. To determine if olanzapine can affect the ...

journal_title：FEBS open bio

authors： Babkin P,George Thompson AM,Iancu CV,Walters DE,Choe JY

更新日期：2015-04-15 00:00:00

abstract：:Candida albicans is a harmless commensal resident in the human gut, and a prevalent opportunistic pathogen. A key part of its commensalism and pathogenesis is its ability to switch between different morphological forms, including white-to-opaque switching. The Wor1 protein was previously identified as a master regulat...

journal_title：FEBS open bio

authors： Dai B,Xu Y,Gao N,Chen J

更新日期：2020-12-22 00:00:00

abstract：:Previous studies have proposed that the human papillomavirus (HPV) E6 oncoproteins modify the transcriptional activity of eIF4E through mechanisms dependent on p53 degradation. However, the effect of these oncoproteins on pathways regulating the activity of the eIF4E protein remains poorly understood. Hence, we invest...

journal_title：FEBS open bio

authors： Morales-Garcia V,Contreras-Paredes A,Martinez-Abundis E,Gomez-Crisostomo NP,Lizano M,Hernandez-Landero F,de la Cruz-Hernandez E

更新日期：2020-12-01 00:00:00

abstract：:Osteonecrosis of the femoral head (ONFH) is a common clinical disease with a high disability rate. Apoptosis of osteoblasts caused by high-dose short-term or low-dose long-term glucocorticoid (GC) administration is the biological basis of steroid-induced avascular necrosis of the femoral head (SANFH). The pathogenesis...

journal_title：FEBS open bio

authors： Peng P,Nie Z,Sun F,Peng H

更新日期：2020-11-15 00:00:00

abstract：:Lactobionic acid (O-β-galactosyl-(1-4)-gluconic acid) (LBA) is a high-value lactose derivative, produced via oxidation of the reducing terminal of lactose. LBA can be produced by fermentation using certain microorganisms, although subsequent purification is challenging. Therefore, we have attempted to identify an enzy...

journal_title：FEBS open bio

authors： Lin SF,Li CK,Chung YP

更新日期：2019-01-16 00:00:00

abstract：:Abscisic acid (ABA) response elements (ABREs) are a group of cis-acting DNA elements that have been identified from promoter analysis of many ABA-regulated genes in plants. We are interested in understanding the mechanism of binding specificity between ABREs and a class of bZIP transcription factors known as ABRE bind...

journal_title：FEBS open bio

authors： Sarkar AK,Lahiri A

更新日期：2013-01-22 00:00:00

abstract：:Metastasis is the primary contributor to colorectal cancer mortality. High-intensity focused ultrasound (HIFU) is an emerging technology for tumor therapy that exerts its effects through tumor ablation, mechanical disruption, and enhancement of immune responses. However, it remains unclear whether HIFU can influence t...

journal_title：FEBS open bio

authors： Li M,Wan G,Yu H,Xiong W

更新日期：2019-06-01 00:00:00

abstract：:Glioma is one of the most common types of malignant primary central nervous system tumor, and prognosis for this disease is poor. As autophagic drugs have been reported to induce glioma cell death, we investigated the potential prognostic role of autophagy-associated long non-coding RNA (lncRNA) in glioma patients. In...

journal_title：FEBS open bio

authors： Luan F,Chen W,Chen M,Yan J,Chen H,Yu H,Liu T,Mo L

更新日期：2019-03-05 00:00:00

abstract：:Ovarian cancer is the most common cause of gynaecological cancer-associated death; thus, promising biomarkers and new therapeutic targets for ovarian cancer must be explored. Here, we report that eukaryotic translation initiation factor 3 subunit D (EIF3D), a member of the EIF3 family, was overexpressed in ovarian can...

journal_title：FEBS open bio

authors： Lin Y,Zhang R,Zhang P

更新日期：2016-10-31 00:00:00

abstract：:A plant-derived Enterococcus mundtii 15-1A, that has been previously isolated from Brassica rapa L. subsp. nipposinica (L.H. Bailey) Hanelt var. linearifolia by our group, possesses two kinds of l-lactate dehydrogenase (l-LDH): LDH-1 and LDH-2. LDH-1 was activated under low concentration of fluctose-1,6-bisphosphate (...

journal_title：FEBS open bio

authors： Matoba Y,Miyasako M,Matsuo K,Oda K,Noda M,Higashikawa F,Kumagai T,Sugiyama M

更新日期：2014-09-06 00:00:00

abstract：:Glutathione transferases (GSTs) are involved in many processes in plant biochemistry, with their best characterised role being the detoxification of xenobiotics through their conjugation with glutathione. GSTs have also been implicated in noncatalytic roles, including the binding and transport of small heterocyclic li...

journal_title：FEBS open bio

authors： Ahmad L,Rylott EL,Bruce NC,Edwards R,Grogan G

更新日期：2016-12-22 00:00:00

abstract：:The A/B domains of nuclear receptors such as thyroid receptor α (TRα) are considered to be conformationally flexible and can potentially adopt multiple structural conformations. We used intrinsic tryptophan fluorescence quenching and circular dichroism spectroscopy to characterize the unfolding of this A/B domain upon...

journal_title：FEBS open bio

authors： Fernandez EJ,Gahlot V,Rodriguez C,Amburn J

更新日期：2017-05-15 00:00:00

abstract：:In the brain, REST (Repressor Element-1 Silencing Transcription factor) is a key regulator of neuron cell-specific gene expression. Nuclear translocation of neuronal REST has been shown to be neuroprotective in a healthy ageing context. In contrast, inability to upregulate nuclear REST is thought to leave ageing neuro...

journal_title：FEBS open bio

authors： Mampay M,Velasco-Estevez M,Rolle SO,Chaney AM,Boutin H,Dev KK,Moeendarbary E,Sheridan GK

更新日期：2020-11-13 00:00:00

abstract：:Sunitinib (Sun), a tyrosine kinase inhibitor of vascular endothelial growth factor receptor, is the standard first-line treatment against advanced clear cell renal cell carcinoma (RCC), but resistance to therapy is inevitable. Reactive oxygen species production is associated with sensitivity to chemotherapy, but the u...

journal_title：FEBS open bio

authors： Meng L,Chen D,Meng G,Lu L,Han C

更新日期：2021-01-16 00:00:00

abstract：:The bacterial phosphotransferase system is central to sugar uptake and phosphorylation. Enzyme I (EI), the first enzyme of the system, autophosphorylates as a dimer using phosphoenolpyruvate (PEP), but it is not clearly understood how dimerization activates the enzyme activity. Here, we show that EI dimerization is im...

journal_title：FEBS open bio

authors： Lee KO,Yun YJ,Kim I,Suh JY

更新日期：2017-07-17 00:00:00

abstract：:Decorin (DCN) is a major member of the small leucine-rich proteoglycan (SLRP) family that is critically involved in tumorigenesis and the development of metastasis of cancers, including glioma. Overexpression of DCN was indicated to suppress glioma cell growth. However, the role of DCN in the migration of glioma cells...

journal_title：FEBS open bio

authors： Yao T,Zhang CG,Gong MT,Zhang M,Wang L,Ding W

更新日期：2016-05-31 00:00:00

abstract：:Centrins are members of the EF-hand family of calcium-binding proteins, which are highly conserved among eukaryotes. Centrins bind to several cellular targets, through a hydrophobic triad. However, the W(1)xxL(4)xxxL(8) triad in XPC (Xeroderma Pigmentosum Group C protein) is found in the reverse orientation, as in the...

journal_title：FEBS open bio

authors： Grecu D,Blouquit Y,Assairi L

更新日期：2013-12-05 00:00:00

abstract：:Sorafenib, the first-line agent for treatment of advanced hepatocellular carcinoma (HCC), improves median overall survival by approximately 3 months. In the present study, we investigated whether sorafenib combined with cucurbitacin B (CuB), a natural tetracyclic triterpenoid isolated from Cucurbitaceae, exerts enhanc...

journal_title：FEBS open bio

authors： Wang X,Li H,Li D,Bai Y,Zhang Y,Yan X,Li J,Zhao R,Liu J,Liu W,Shi M,Xu C,Yang T,Zhang T

更新日期：2020-11-11 00:00:00

abstract：:Recent evidence has shown that miR-409-3p was down-regulated in several types of cancer, including osteosarcoma. However, the potential role of miR-409-3p in osteosarcoma remains largely unknown. In the present study, we showed that overexpression of miR-409-3p in osteosarcoma cells inhibited cell proliferation in vit...

journal_title：FEBS open bio

authors： Zhang J,Hou W,Jia J,Zhao Y,Zhao B

更新日期：2017-01-27 00:00:00

abstract：:Fibroblast growth factor 11 (FGF11) is a member of the intracellular fibroblast growth factor superfamily. Here, we identified FGF11 as a novel mediator of adipogenesis. During 3T3-L1 adipocyte differentiation, the expression of FGF11 decreased at the mitotic clonal expansion stage and increased at the terminal differ...

journal_title：FEBS open bio

authors： Lee KW,Jeong JY,An YJ,Lee JH,Yim HS

更新日期：2019-03-12 00:00:00

abstract：:In this study, we showed that cyanocobalamin dodecylamine, a ribose 5'-carbamate derivative of cyanocobalamin, was absorbed and accumulated to significant levels by Caenorhabditis elegans and was not further metabolized. The levels of methylmalonic acid and homocysteine, which serve as indicators of cobalamin deficien...

journal_title：FEBS open bio

authors： Bito T,Yabuta Y,Ichiyanagi T,Kawano T,Watanabe F

更新日期：2014-08-01 00:00:00