Efficacy and safety of once daily versus twice daily mesalazine for mild-to-moderate ulcerative colitis: A meta-analysis of randomized controlled trials.

Abstract:

BACKGROUND:We aimed to conduct a meta-analysis to evaluate the efficacy and safety between once daily (OD) and twice daily (BD) regime dosing of mesalazine for mild-to-moderate ulcerative colitis (UC). METHODS:PubMed, Embase, the Cochrane library, and Web of Science from 1990 to November 2018 were investigated. We searched randomized controlled trials (RCTs) comparing OD with BD regime dosing of mesalazine for mild-to-moderate UC. The software Review Manager 5.3 was used to pool the risk ratio (RR) with a 95% confidence interval (CI). RESULTS:Eight RCTs containing 3495 patients were identified. Regardless of induction of remission or maintenance of remission of UC, OD regime dosing of mesalazine was as effective as BD regime dosing in clinical and endoscopic remission and clinical remission. Also, no obvious difference was found between OD and BD regime dosing of mesalazine regardless of total adverse events, treatment-related adverse events or serious adverse events. CONCLUSION:OD is as effective and safe as BD regime dosing of mesalazine for active UC.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Zheng X,Zhang Z,Wang B,Li J,Qiu C,Zhang Q,Wang X

doi

10.1097/MD.0000000000015113

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

e15113

issue

14

eissn

0025-7974

issn

1536-5964

pii

00005792-201904050-00072

journal_volume

98

pub_type

杂志文章,meta分析

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