Abstract:
BACKGROUND:We aimed to conduct a meta-analysis to evaluate the efficacy and safety between once daily (OD) and twice daily (BD) regime dosing of mesalazine for mild-to-moderate ulcerative colitis (UC). METHODS:PubMed, Embase, the Cochrane library, and Web of Science from 1990 to November 2018 were investigated. We searched randomized controlled trials (RCTs) comparing OD with BD regime dosing of mesalazine for mild-to-moderate UC. The software Review Manager 5.3 was used to pool the risk ratio (RR) with a 95% confidence interval (CI). RESULTS:Eight RCTs containing 3495 patients were identified. Regardless of induction of remission or maintenance of remission of UC, OD regime dosing of mesalazine was as effective as BD regime dosing in clinical and endoscopic remission and clinical remission. Also, no obvious difference was found between OD and BD regime dosing of mesalazine regardless of total adverse events, treatment-related adverse events or serious adverse events. CONCLUSION:OD is as effective and safe as BD regime dosing of mesalazine for active UC.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Zheng X,Zhang Z,Wang B,Li J,Qiu C,Zhang Q,Wang Xdoi
10.1097/MD.0000000000015113subject
Has Abstractpub_date
2019-04-01 00:00:00pages
e15113issue
14eissn
0025-7974issn
1536-5964pii
00005792-201904050-00072journal_volume
98pub_type
杂志文章,meta分析相关文献
MEDICINE文献大全abstract:RATIONALE:Extubation strategy for mechanically ventilated patients with Coronavirus Disease 19 is different from that for patients with other viral pneumonia. We reported 2 cases of Coronavirus Disease 19 receiving tracheal intubation twice during the hospitalization. PATIENT CONCERNS:Two elderly patients with onset o...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020843
更新日期:2020-07-02 00:00:00
abstract::The aim of this study was to compare preoperative dual-time point F-fluorodeoxyglucose (FDG) uptake pattern with intraoperative 5-aminolevulinic acid (5-ALA) fluorescence in high-grade gliomas. In addition, we assessed for possible associations with a pathologic parameter (Ki-67 index).Thirty-one patients with high-gr...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014397
更新日期:2019-02-01 00:00:00
abstract::The public sector scale-up of antiretroviral therapy (ART) in South Africa commenced in 2004. We aimed to describe the hospital-level disease burden and factors contributing to morbidity and mortality among hospitalized HIV-positive patients in the era of widespread ART availability. Between June 2012 and October 2013...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002269
更新日期:2015-12-01 00:00:00
abstract::Multilevel cervical reconstruction and fusion after cervical tuberculosis has always been a challenge. The current implantation materials for cervical fusion, including titanium mesh, cage, and plate are limited by its inferior biological mechanical characteristics and the properties of the metallic material. This has...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009382
更新日期:2018-01-01 00:00:00
abstract:RATIONALE:Late complement deficiency increases susceptibility to meningococcal disease and recurrent infections. In Korea, 5 case reports have described meningococcal disease with complement deficiency. However, C6 deficiency has not been described previously. PATIENT CONCERNS:A 21-year-old police trainee presented wi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020362
更新日期:2020-05-22 00:00:00
abstract:RATIONALE:All the enteric ganglion cells are fully mature by 2 to 5 years of age in human. No one had reported the presentation of immature enteric ganglion cells in elder ones. Colorectal carcinoma is also rare in the adolescent population. The coincidence of these 2 rare events in a 13-year-old boy has never been rep...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000007036
更新日期:2017-06-01 00:00:00
abstract::Rs1495741 has been identified to infer N-acetyltransferase 2 (NAT2) acetylator phenotype, and to decrease the risk of bladder cancer. However, a number of studies conducted in various regions showed controversial results. To quantify the association between rs1495741 and the risk of bladder cancer and to estimate the ...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000004417
更新日期:2016-08-01 00:00:00
abstract::Previous studies on the association between serotonin transporter linked polymorphic region (5-HTTLPR) polymorphism and premature ejaculation (PE) have led to inconsistent results. The purpose of the present meta-analysis was to examine whether 5-HTTLPR polymorphism is associated with PE susceptibility.All eligible st...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000022169
更新日期:2020-10-09 00:00:00
abstract::Scrub typhus is caused by Orientia tsutsugamushi. Any delay in diagnosis can result in delayed treatment and severe complications, including secondary hemophagocytic lymphohistiocytosis, which is rare but potentially fatal.In this paper, the authors present 3 cases of secondary hemophagocytic lymphohistiocytosis assoc...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000002928
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Kangfuxin (KFX), a well-known Chinese patent medicine which extracted from Periplaneta americana, is widely used as an adjuvant in the treatment of peptic ulcers (PUs) with proton pump inhibitors (PPIs) such as rabeprazole, in China. However, no clear consensus has been reached on the efficacy for PU treatme...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000023103
更新日期:2020-11-25 00:00:00
abstract::Exosomes are nanometer-sized vesicles with intercellular communication functions, and their encapsulated proteins may participate in the pathological process of neurodegenerative disorders. The aim of this study was to identify the protein changes of serum exosomes in Parkinson disease (PD) patients with different dis...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017478
更新日期:2019-10-01 00:00:00
abstract::Lipoprotein-associated phospholipase A2 (Lp-PLA2) probably plays an important role in the development of acute coronary syndrome (ACS). However, alterations of Lp-PLA2 levels during ACS and its association with cardiovascular outcome are unclear. Our aim was to investigate the change in Lp-PLA2 and its association wit...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011517
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:At present, many scholars have studied the periodontal health status of patients undergoing orthodontic treatment with fixed appliances and invisalign. However, those results are inconsistent. Therefore, we conducted this meta-analysis, and then provide reference for clinical treatment. METHODS:Most databas...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000010248
更新日期:2018-03-01 00:00:00
abstract::The aim of this study was to elucidate the relationship between spinal cord injury (SCI) and the risk of peripheral arterial disease (PAD) in a cohort study with a large representative sample.The National Health Insurance Database was used to select patients who were diagnosed from 2000 to 2010. Patients with a histor...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001655
更新日期:2015-10-01 00:00:00
abstract:RATIONALE:Acute kidney injury is common and correctable in patients with a hyperosmolar hyperglycemic state (HHS). Nevertheless, hyperglycemic crisis may also contribute to the development of rhabdomyolysis, which can worsen renal function and lead to high mortality in such patients. PATIENT CONCERNS:Herein, we report...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013647
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Cervical spondylotic radiculopathy (CSR) is a clinical syndrome of radial neck and shoulder pain. Both Massage and Acupotomy have been widely used in the treatment of CSR, in China and achieved satisfied efficacy. Therefore, the aim of this study is to systematically evaluate the clinical efficacy of acupoto...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021587
更新日期:2020-08-07 00:00:00
abstract:RATIONALE:The establishment of lung isolation is often particularly challenging for the anesthesiologist in patients with difficult airway. Usually, orotracheal intubation with double lumen tube is the commonly used technique for achieving 1 lung anesthesia. Whereas, in patients with limited mouth opening and restricte...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021521
更新日期:2020-08-07 00:00:00
abstract:INTRODUCTION:Henoch-Schönlein purpura nephritis (HSPN) involves the renal impairment of Henoch-Schönlein purpura and can easily relapse into life-threatening late nephropathy in severe cases. Although there is a lack of validated evidence for its effectiveness, Chinese herbal medicine (CHM) is one of the most commonly ...
journal_title:Medicine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/MD.0000000000011064
更新日期:2018-06-01 00:00:00
abstract::The aim of the study was to investigate current situation of postoperative pain management in medical institutions in Shandong Province.A questionnaire was developed on the basis of guidelines of acute pain and pain quality assessment scale. The questionnaire was used to obtain information regarding the nature and sca...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002690
更新日期:2016-02-01 00:00:00
abstract::Calcific aortic valve disease (CAVD) is highly prevalent in our aging world and has no effective pharmaceutical treatment. Intense efforts have been made but the underlying molecular mechanisms of CAVD are still unclear.This study was designed to identify the critical genes and pathways in CAVD by bioinformatics analy...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021286
更新日期:2020-07-17 00:00:00
abstract:RATIONALE:Rosacea is an irritating disease that affects patients' health and life quality. The current treatments for rosacea have limited efficacy and are generally not satisfying most patients. This report presents a patient diagnosed with rosacea who was treated with acupuncture to a satisfactory effect. Laser Doppl...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011931
更新日期:2018-08-01 00:00:00
abstract:RATIONALE:Recurrent laryngeal nerve block is an uncommon complication that can occur after an interscalene brachial plexus block (ISB), which may lead to vocal cord palsy or paresis. However, if the recurrent laryngeal nerve is blocked in patients with a preexisting contralateral vocal cord palsy following neck surgery...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006598
更新日期:2017-04-01 00:00:00
abstract::The objective of this study was to develop a venous computed tomography (CT)-based radiomics model to predict the lymph node metastasis (LNM) in patients with non-small cell lung cancer (NSCLC). A total of 411 consecutive patients with NSCLC underwent tumor resection and lymph node (LN) dissection from January 2018 to...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020074
更新日期:2020-05-01 00:00:00
abstract::Administration of intravenous vancomycin has been associated with the development of linear IgA bullous disease (LABD). In contrast to the idiopathic variant, vancomycin-induced LABD (VILABD) appears to be more transient and to be associated with lower morbidity. The characteristics of this entity remain undefined. Ou...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/00005792-199901000-00001
更新日期:1999-01-01 00:00:00
abstract:RATIONALE:Scedosporium species is rare pathogen of ocular infection. The accurate diagnosis is delaying in many cases and the clinical prognosis is poor due to its resistance to antifungal agents. This report describes a patient with infectious scleritis and corneal ulcer caused by Scedosporium auranticum infection who...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016063
更新日期:2019-07-01 00:00:00
abstract::Increased prevalence of metabolic syndrome was found in patients with schizophrenia. Brain-derived neurotrophic factor (BDNF) was involved in energy metabolism and the pathophysiology of schizophrenia, but differently in males and females. We aimed to investigate the serum BDNF levels in patients with schizophrenia wi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007089
更新日期:2017-06-01 00:00:00
abstract::The evaluation of the electrically induced bulbocavernosus reflex (BCR) using electromyography (EMG) is a useful tool for evaluating the integrity of sacral spinal segments 2 to 4, and that of their afferent and efferent connections in the urogenital region. In the current retrospective study, the value of this techni...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007014
更新日期:2017-05-01 00:00:00
abstract::This study is to investigate the subgingival bacterial diversity and community structure in the Uygur subjects with peri-implantitis.Totally 40 cases of gingival crevicular fluid were collected from Uygur subjects and divided into the Control group (healthy implants) and Case group (peri-implantitis), respectively. DN...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009774
更新日期:2018-02-01 00:00:00
abstract:RATIONALE:Cisplatin monotherapy-induced cardiotoxicity is rare, and the prevalence remains unknown. It's extremely important to stop cisplatin when cardiotoxicity is considered. PATIENT CONCERNS:A 53-year-old woman developed cervical cancer. She was administered cisplatin (37 mg/m/wk) for 3 weeks, but the left ventric...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000013807
更新日期:2018-12-01 00:00:00
abstract::The inferior border of the femoral head (IBFH) is widely used as a landmark in femoral artery puncture during invasive coronary angiography (ICA). However, application of this technique can be challenging especially in obese patients. This study was performed to investigate the association between body mass index (BMI...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010070
更新日期:2018-03-01 00:00:00