Successful Treatment of Scrub Typhus-Associated Hemophagocytic Lymphohistiocytosis With Chloramphenicol: Report of 3 Pediatric Cases and Literature Review.

Abstract:

:Scrub typhus is caused by Orientia tsutsugamushi. Any delay in diagnosis can result in delayed treatment and severe complications, including secondary hemophagocytic lymphohistiocytosis, which is rare but potentially fatal.In this paper, the authors present 3 cases of secondary hemophagocytic lymphohistiocytosis associated with scrub typhus, successfully treated with chloramphenicol without additional antineoplastic therapy. All patients cured and achieved complete resolution.This report highlights the effectiveness of chloramphenicol without the need for chemotherapy in the treatment of scrub typhus-associated hemophagocytic lymphohistiocytosis in a pediatric population under the age of 8 years.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Zhou YH,Xia FQ,Van Poucke S,Zheng MH

doi

10.1097/MD.0000000000002928

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

e2928

issue

8

eissn

0025-7974

issn

1536-5964

pii

00005792-201602230-00057

journal_volume

95

pub_type

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