Is cerebral glucose metabolism related to blood-brain barrier dysfunction and intrathecal IgG synthesis in Alzheimer disease?: A 18F-FDG PET/CT study.

Abstract:

:The aim of this study was to investigate the relationships between blood-brain barrier (BBB) dysfunction, intrathecal IgG synthesis, and brain glucose consumption as detectable by means of serum/cerebrospinal fluid (CSF) albumin index (Qalb) and IgG index [(CSF IgG/serum IgG) × Serum albumin/CSF albumin)] and 2-deoxy-2-(F) fluoro-D-glucose (F-FDG) positron emission tomography/computed tomography (PET/CT) in a selected population affected by Alzheimer disease (AD). The study included 134 newly diagnosed AD patients according to the NINCDS-ADRDA criteria. The mean (±SD) age of the patients was 70 (±6) years; 60 were male and 64 were female. Mini mental State Examination was equal to 18.9 (±7.2). All patients underwent a CSF assay and magnetic resonance before F-FDG PET scanning. The relationships were evaluated by means of statistical parametric mapping (SPM8). We found a significant negative correlation between the increase of Qalb and F-FDG uptake in the Brodmann Area 42 and 22 that corresponds to the left superior temporal gyrus, with higher Qalb values being related to a reduced glucose consumption in these areas. No significant relationships have been found between brain glucose consumption and IgG index. The results of our study suggest that BBB dysfunction is related to reduction of cortical activity in the left temporal cortex in AD subjects.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Chiaravalloti A,Fiorentini A,Francesco U,Martorana A,Koch G,Belli L,Toniolo S,Di Pietro B,Motta C,Schillaci O

doi

10.1097/MD.0000000000004206

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

e4206

issue

37

eissn

0025-7974

issn

1536-5964

pii

00005792-201609130-00002

journal_volume

95

pub_type

杂志文章

相关文献

MEDICINE文献大全
  • Association between high-density lipoprotein cholesterol and renal function in elderly hypertension: a cross-sectional study in Chinese population.

    abstract::Few studies have yet investigated the possible association between high-density lipoprotein cholesterol (HDL-C) and kidney function in elderly patients with primary hypertension. Accordingly, the aim of the present study was to evaluate the relationship between HDL-C and kidney function in elderly hypertension. A tota...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000651

    authors: Zhang YP,Lu MG,Duan DD,Liu YL,Liu M,Li Y,Kuang ZM,Lu Y,Liu X,Li XH,Yuan H

    更新日期:2015-04-01 00:00:00

  • Immature enteric ganglion cells were observed in a 13-year-old colon signet ring cell carcinoma patient: A case report and literature review.

    abstract:RATIONALE:All the enteric ganglion cells are fully mature by 2 to 5 years of age in human. No one had reported the presentation of immature enteric ganglion cells in elder ones. Colorectal carcinoma is also rare in the adolescent population. The coincidence of these 2 rare events in a 13-year-old boy has never been rep...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000007036

    authors: Li H,Huang K,Wang H,Wang L,Yang M,Wang L,Lin R,Liu H,Gao J,Shuai X,Liu X,Tao K,Wang G,Wang Z

    更新日期:2017-06-01 00:00:00

  • Predictive value of soluble ST-2 for changes of cardiac function and structure in breast cancer patients receiving chemotherapy.

    abstract::The current study was to evaluate soluble ST-2 level and left ventricular ejection fraction (LVEF) in patients with breast cancer receiving doxorubicin or trastuzumab treatment for 6 months and determine whether soluble ST-2 level can be used to predictive left ventricular function impairment.Patients who were diagnos...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000012447

    authors: Huang G,Zhai J,Huang X,Zheng D

    更新日期:2018-09-01 00:00:00

  • Hypermethylation of tumor suppressor genes is a risk factor for poor prognosis in ovarian cancer: A meta-analysis.

    abstract:OBJECTIVE:DNA methylation is the earliest and most studied epigenetic modification in cancer. The literature reported that the abnormal methylation level of multiple genes was associated with poor prognosis in ovarian cancer. However, due to a small sample size, the results reported in the literature vary widely. In th...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000014588

    authors: Feng LY,Chen CX,Li L

    更新日期:2019-02-01 00:00:00

  • Low-Dose Versus Standard-Dose Tissue Plasminogen Activator in Acute Ischemic Stroke in Asian Populations: A Meta-Analysis.

    abstract::Recent studies have investigated the most efficacious dose of intravenous tissue plasminogen activator (IV-tPA) for acute ischemic stroke (AIS) patients. There remains no definitive consensus concerning the superior efficacious IV-tPA dose (standard- vs. low-dose), prompting us to perform a meta-analysis comparing the...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000002412

    authors: Liu MD,Ning WD,Wang RC,Chen W,Yang Y,Lin Y,Hu DH,Lau WB,Qu Y

    更新日期:2015-12-01 00:00:00

  • Modified translaryngeal tracheostomy for ventilator-dependent cardiac patients: A pilot of nonrandomized study.

    abstract:INTRODUCTION:A significant proportion of ventilator-dependent cardiac patients need tracheostomy during intensive care unit (ICU) stay. Three different methods including traditional (surgical), percutaneous dilatation tracheostomy, translaryngeal tracheostomy (TLT), and classical Fantoni method have been developed. In ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000013590

    authors: Babaee T,Tabaei AS,Moludi J,Alavi SM,Tabaei SS

    更新日期:2018-12-01 00:00:00

  • Management of the extensive thoracic defects after deep sternal wound infection with the rectus abdominis myocutaneous flap: A retrospective case series.

    abstract::Deep sternal wound infection is a severe complication after open heart surgery. According to the different severity and dimensions of the deep sternal wound infection, the treatment method is different. In this study, we aimed to describe our experience with the rectus abdominis myocutaneous flap for large sternal wou...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006391

    authors: Li YH,Zheng Z,Yang J,Su LL,Liu Y,Han F,Liu JQ,Hu DH

    更新日期:2017-04-01 00:00:00

  • Deep femoral artery branch pseudoaneurysm formation and injury after hip fracture surgery: A case series and a literature review.

    abstract:INTRODUCTION:Complications involving vascular injuries after hip fracture are rare, and the diagnosis and management of deep femoral artery (DFA) injuries are challenging. We reported 4 cases of DFA injuries after hip fracture surgery and aimed to discuss their early detection, treatment, and prevention. METHODS:We re...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009872

    authors: Zhang BF,Cong YX,Wang PF,Huang H,Wang H,Zhuang Y

    更新日期:2018-02-01 00:00:00

  • Coinfection with cryptococcus and aspergillus in an immunocompetent adult: A case report.

    abstract:RATIONALE:Aspergillus and Cryptococcus exposure can cause serious secondary infections in human lungs, especially in immunocompromised patients or in conjunction with a chronic disease caused by low disease resistance. Primary invasive fungal infections are clinically rare; therefore, coexistence of 2 fungi at an infec...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000012612

    authors: Wang Q,Wang Z,Hao Y,Li W,Xin T,Chen M,Gao P

    更新日期:2018-09-01 00:00:00

  • Effect of prenatal and postnatal malnutrition on intellectual functioning in early school-aged children in rural western China.

    abstract::The aim of this study was to evaluate the effect of prenatal and postnatal malnutrition on the intellectual functioning of early school-aged children. We followed the offspring of women who had participated in a trial of prenatal supplementation with different combinations of micronutrients and who remained resident i...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000004161

    authors: Li C,Zhu N,Zeng L,Dang S,Zhou J,Yan H

    更新日期:2016-08-01 00:00:00

  • Rationale and design of a randomized trial of early intensive blood pressure lowering on cerebral perfusion parameters in thrombolysed acute ischemic stroke patients.

    abstract:BACKGROUND AND RATIONALE:Uncertainty persists over the optimal management of blood pressure (BP) in the early phase of acute ischemic stroke (AIS). This study aims to determine the safety and effects of intensive BP lowering on cerebral blood flow (CBF) and functional in AIS patients treated with intravenous thrombolys...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000012721

    authors: Sharma VK,Tan BYQ,Sim MY,Kulkarni A,Seow PA,Hong CS,Du Z,Wong LYH,Chen J,Chee EYH,Ng BSM,Low Y,Ngiam NJH,Yeo LLL,Teoh HL,Paliwal PR,Rathakrishnan R,Sinha AK,Chan BPL,Butcher K,Anderson CS

    更新日期:2018-10-01 00:00:00

  • Women successfully treated for severe intrahepatic cholestasis of pregnancy do not have increased risks for adverse perinatal outcomes.

    abstract::Intrahepatic cholestasis of pregnancy (ICP) increases adverse perinatal outcome (APO) incidence. Whether successful treatment of severe ICP reduces APO risk is unclear.This retrospective, single-center study in China enrolled consecutive women with ICP who had term delivery (≥37 weeks, singleton) between August 2013 a...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000016214

    authors: Yang J,Chen C,Liu M,Zhang S

    更新日期:2019-07-01 00:00:00

  • BDNF polymorphisms across the spectrum of psychiatric morbidity: A protocol for a systematic review and meta-analysis.

    abstract:BACKGROUND:Nowadays, psychiatric morbidities are more and more common, which imposes huge social and economic burden on all countries across the world. Mental illnesses are found to be related to genetics. Over the past few years, a large number of risk genes and loci related to psychiatric morbidities have been report...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022875

    authors: Su J,Liu P,Liu B,Zhang Y

    更新日期:2020-11-06 00:00:00

  • Risk factors of gender for renal progression in patients with early chronic kidney disease.

    abstract::Risk factors for chronic kidney disease (CKD), such as hypertension, hyperglycemia, albuminuria, renal structure, and sex hormones, have been reported to have different effects on males and females. Thus, CKD progression may differ depending on sex. In addition to CKD management, treatment at earlier stages can reduce...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000004203

    authors: Chang PY,Chien LN,Lin YF,Wu MS,Chiu WT,Chiou HY

    更新日期:2016-07-01 00:00:00

  • A 14-year literature survey on spine-related clinical research output by orthopedic surgeons from mainland China.

    abstract:BACKGROUND:In recent years, China is increasingly playing an active role in various fields of biomedical research. Many bibliometric studies have provided valuable insights to different fields of clinical studies. However, similar evaluation on spine surgery-related clinical research is still limited. We herein aimed t...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000011959

    authors: Si G,Liu X,Xu N,Yu M,Liu X

    更新日期:2018-08-01 00:00:00

  • Treatment of primary tracheal glomus tumors: Two case reports and a literature review.

    abstract:RATIONALE:Glomus tumors (GTs) are rare soft tissue neoplasms. Several treatment options have been reported for tracheal GTs including thoracotomy, bronchoscopic electrocautery, Nd: YAG laser, and cryotherapy. However, few studies have evaluated the ideal treatment for tracheal GTs. PATIENT CONCERNS:A 30-year old man w...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010374

    authors: Guo L,Wang K,Zhu H,Liu N,Zhu D

    更新日期:2018-04-01 00:00:00

  • Concurrent lymphoma and hemophilia B in a pediatric patient: A case report.

    abstract:INTRODUCTION:Lymphoma is the third most common cancer among children in the United States and Europe. Hemophilia is a congenital bleeding disorder characterized by deficiency of coagulation factor VIII or IX. Hemophilia B is a consequence of factor IX deficiency and has an incidence of 1 in 20,000 male births. A concur...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015474

    authors: Lu G,Qiao L,Li D,Liu Z,Zhao F,Yu D

    更新日期:2019-05-01 00:00:00

  • A case report of primary central nervous system lymphoma with intestinal obstruction as the initial symptom.

    abstract:RATIONALE:Primary central nervous system lymphoma (PCNSL) with initial manifestations of constipation and intestinal obstruction (IO) is rare. PATIENT CONCERNS:A 50-year-old Chinese male patient was admitted to the gastroenterology department due to constipation and abdominal distention for 8 days. He had experienced ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010080

    authors: Li X,Qi S,Jiao Y,Gao J,Du H

    更新日期:2018-03-01 00:00:00

  • Multiple versus single doses of dexamethasone in total hip arthroplasty: A protocol of randomized controlled trial.

    abstract:BACKGROUND:Reduction of post-operative pain, nausea, and vomiting in patients undergoing total hip arthroplasty (THA) may facilitate earlier discharge from hospital and reduce healthcare costs. The recommended dose regimen of dexamethasone in THA has not been determined. The purpose of this study was performed to compa...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000020147

    authors: Zhang B,Sun S,Sheng B

    更新日期:2020-05-01 00:00:00

  • Accuracy and safety of ultrasound-guided percutaneous needle core biopsy of renal masses: A single center experience in China.

    abstract::Our aim is to determine the sufficiency, accuracy, and safety of ultrasound-guided percutaneous needle core biopsy of renal masses in Chinese patients.Patients who had undergone ultrasound-guided needle core renal mass biopsy from June 2012 to June 2016 at West China Hospital, China were retrospectively reviewed. The ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010178

    authors: Wang X,Lv Y,Xu Z,Aniu M,Qiu Y,Wei B,Li X,Wei Q,Dong Q,Lin T

    更新日期:2018-03-01 00:00:00

  • Three primary synchronous malignancies of the uterus, cervix, and fallopian tube: A case report.

    abstract:RATIONALE:Multiple primary malignancies can occur in the same organ or in multiple organs or systems. Likewise, they can occur simultaneously or successively. Based on the timing of the diagnosis, they are classified as multiple synchronous (i.e., concurrent) or metachronous (i.e., successive) primary malignancies. The...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011107

    authors: Song L,Li Q,Yang K,Yin R,Wang D

    更新日期:2018-06-01 00:00:00

  • Relationship between ABO blood group and risk of venous thrombosis in cancer patients with peripherally inserted central catheters: A protocol for systematic review and meta-analysis.

    abstract:BACKGROUND:Peripherally inserted central catheter (PICC) is closely related to venous thromboembolism (VTE). It is a common complication of hospitalized patients, and its etiology is complex. How to prevent the occurrence of VTE is the focus of clinical work. In order to provide basis for individual prevention and accu...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000023091

    authors: Liu F,Zhang Q,Rao L,Song J

    更新日期:2020-11-06 00:00:00

  • Influence of blood pressure variability on early carotid atherosclerosis in hypertension with and without diabetes.

    abstract::Carotid intima-media thickness (IMT) has been one widely used index of early carotid atherosclerosis. We speculated that the influence of blood pressure variability (BPV) on early carotid atherosclerosis may be varied by the location of the carotid artery and diabetes history. Thus, the goal of this study was to evalu...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003864

    authors: Wu D,Li C,Chen Y,Xiong H,Tian X,Wu W,Huang W,Zhang YT,Zhang H

    更新日期:2016-06-01 00:00:00

  • Erratum: Association of Genetic Polymorphisms on VEGFA and VEGFR2 With Risk of Coronary Heart Disease: Erratum.

    abstract::[This corrects the article DOI: 10.1097/MD.0000000000003413.]. ...

    journal_title:Medicine

    pub_type: 已发布勘误

    doi:10.1097/01.md.0000484496.43819.1a

    authors:

    更新日期:2016-08-19 00:00:00

  • Implementation effectiveness of revised (post-2010) World Health Organization guidelines on prevention of mother-to-child transmission of HIV using routinely collected data in sub-Saharan Africa: A systematic literature review.

    abstract:BACKGROUND:To synthesize and evaluate the impact of implementing post-2010 World Health Organization (WHO) prevention of mother-to-child transmission (PMTCT) guidelines on attainment of PMTCT targets. METHODS:Retrospective and prospective cohort study designs that utilized routinely collected data with a focus on prov...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000008055

    authors: Gumede-Moyo S,Filteau S,Munthali T,Todd J,Musonda P

    更新日期:2017-10-01 00:00:00

  • A clinical evaluation denture adhesives used by patients with xerostomia.

    abstract::The purpose of study was to analyze the participants' opinions concerning the effectiveness of 6 denture adhesives (DA). The study group included 60 participants. Criteria for selecting the patients were as follows: reduced retention and stabilization of maxillary complete dentures and xerostomia. These features were ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000545

    authors: Bogucki ZA,Napadlek P,Dabrowa T

    更新日期:2015-02-01 00:00:00

  • Step Counter Use and Sedentary Time in Adults: A Meta-Analysis.

    abstract::Although step counters are increasingly being used in walking programmes to promote sedentary behavior changes in adults, their effectiveness remains unknown. The aim of this meta-analysis of randomized controlled trials (RCTs) was to assess the effectiveness of step counter use in reducing sedentary time among adults...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000001412

    authors: Qiu S,Cai X,Ju C,Sun Z,Yin H,Zügel M,Otto S,Steinacker JM,Schumann U

    更新日期:2015-09-01 00:00:00

  • The association between the composite quality measure "textbook outcome" and long term survival in operated colon cancer.

    abstract::The aim of this study was to investigate the relationship between textbook outcome and survival in patients with surgically treated colon cancer. A total of 804 surgical cases were enrolled between June 1, 2010 and December 31, 2014. Textbook outcome was defined as patients who had colon cancer surgery and met the six...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022447

    authors: Yang CC,Tian YF,Liu WS,Chou CL,Cheng LC,Chu SS,Lee CC

    更新日期:2020-10-02 00:00:00

  • The constitution and functional prediction of the microbiota in necrotizing enterocolitis with a gestational age of over 28 weeks.

    abstract:BACKGROUND:To explore the features and function of gut microbiota in necrotizing enterocolitis patients over 28 gestational age weeks through a case-control study. METHODS:Fecal samples from patients with NEC over 28 gestational week age and matched control cases were collected. DNA of the fecal samples was extracted ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000017206

    authors: Feng J,He Y,Liu D,Li L,Chen J,Yu J

    更新日期:2019-10-01 00:00:00

  • Roentgenographic Evaluation of the Spine in Patients With Osteogenesis Imperfecta.

    abstract::Osteogenesis imperfecta (OI) is a hereditary connective tissue disorder that leads to bone weakness and deformities, especially in the spine, which can lead to poor outcomes.The aim of this study was to find patterns and risk factors in spinal deformities in patients with OI.In a retrospective study, 70 patients with ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001841

    authors: de Lima MV,de Lima FV,Akkari M,Resende VR,Santili C

    更新日期:2015-11-01 00:00:00