Abstract:
RATIONALE:Cisplatin monotherapy-induced cardiotoxicity is rare, and the prevalence remains unknown. It's extremely important to stop cisplatin when cardiotoxicity is considered. PATIENT CONCERNS:A 53-year-old woman developed cervical cancer. She was administered cisplatin (37 mg/m/wk) for 3 weeks, but the left ventricular ejection fraction (LVEF) declined from 70% to 48%. DIAGNOSIS:Electrocardiogram showed first-degree atrioventricular block and ST-segment depression by 0.05 mv on leads II, III, and V3-5. Neither cardiac markers nor N-terminal pro-B-type natriuretic peptide (NT-pro BNP) was elevated. After a careful physical examination and laboratory investigation, we confirmed that cervical cancer did not progress and no other cause was evident. So we figured cardiotoxicity might be induced by cisplatin. INTERVENTIONS:Cisplatin was stopped and cardioprotective therapies were given to the patient. OUTCOMES:After discontinuing cisplatin and adding cardioprotective therapies, the LVEF increased to 50% and 53%, respectively (M-mode echocardiography) after 17 and 90 days, which further confirmed our diagnosis. LESSONS:According to this case and literature review, cisplatin-induced cardiotoxicity should be considered for the patient. When necessary, we should discontinue the suspected drug to confirm diagnosis. Cardioprotective therapies would minimize the drug-induced cardiovascular adverse events and improve patients' outcome.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Hu Y,Sun B,Zhao B,Mei D,Gu Q,Tian Zdoi
10.1097/MD.0000000000013807subject
Has Abstractpub_date
2018-12-01 00:00:00pages
e13807issue
52eissn
0025-7974issn
1536-5964pii
00005792-201812280-00046journal_volume
97pub_type
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