Evaluation of the thermal stability and the protective efficacy of spray-dried HPV vaccine, Gardasil® 9.

abstract：:Objective: The objective of this study was to analyze the 100 most cited studies on vaccine.Methods: A comprehensive search of studies on vaccine was performed in the Web of Science Core Collection without year or language restrictions. The 100 top-cited studies were retrieved after screening abstracts or full-texts. ...

journal_title：Human vaccines & immunotherapeutics

authors： Zhang Y,Quan L,Xiao B,Du L

更新日期：2019-01-01 00:00:00

abstract：:Raising high titer antibodies in animals is usually performed by protein immunization, which requires the long and sometimes difficult step of production of the recombinant protein. DNA immunization is an alternative to recombinant proteins, only requiring the building of an eukaryotic expression plasmid. Thanks to ef...

journal_title：Human vaccines & immunotherapeutics

authors： Burgain A,Rochard A,Trollet C,Mazuet C,Popoff MR,Escriou V,Scherman D,Bigey P

更新日期：2013-10-01 00:00:00

abstract：:Hepatitis B vaccination rates in China have recently increased. This study aimed to investigate infant vaccination coverage for birth cohorts from 1997 to 2011 in rural regions and to assess catch-up vaccination potential. We used questionnaire-based interviews from a cross-section of 6,529 individuals from seven prov...

journal_title：Human vaccines & immunotherapeutics

authors： Wangen KR,Zhu D,Wang J

更新日期：2019-01-01 00:00:00

abstract：:Despite the impressive impact of vaccines on public health, the success of vaccines targeting many important pathogens and cancers has to date been limited. The burden of infectious diseases today is mainly caused by antigenically variable pathogens (AVPs), which escape immune responses induced by prior infection or v...

journal_title：Human vaccines & immunotherapeutics

authors： Servín-Blanco R,Zamora-Alvarado R,Gevorkian G,Manoutcharian K

更新日期：2016-10-02 00:00:00

abstract：:In Chronic Myeloid Leukemia (CML), standard treatment consists of modern tyrosine-kinase inhibitors (TKI). Nevertheless, there is evidence that immune responses against leukemia-associated antigens (LAA) may play an important role in disease control. Dendritic cell (DC)- based immunotherapy is able to induce T cell re...

journal_title：Human vaccines & immunotherapeutics

authors： Flörcken A,Kopp J,Kölsch U,Meisel C,Dörken B,Pezzutto A,Westermann J

更新日期：2016-05-03 00:00:00

abstract：:Pneumococci are capable of vaccine escape by genetic recombination at the targeted capsular locus, significantly reducing long-term vaccine effectiveness. Recently, efforts have been redirected to understanding pneumococcal biology related to potential next-generation vaccine candidates. A variety of serotype-independ...

journal_title：Human vaccines & immunotherapeutics

authors： Abry MF,Kimenyi KM,Osowo FO,Odhiambo WO,Sewe SO,Kulohoma BW

更新日期：2015-01-01 00:00:00

abstract：:Although pancreatic cancer is but the eleventh most prevalent cancer in the US, it is predicted that of all the patients newly diagnosed with this disease in 2014, only 27% will still be alive at the end of the first year and only 6% will make it past 5 years. The choice of chemotherapy in the treatment of pancreatic ...

journal_title：Human vaccines & immunotherapeutics

authors： Hartley ML,Bade NA,Prins PA,Ampie L,Marshall JL

更新日期：2014-01-01 00:00:00

abstract：:One of the main challenges in early clinical research with respiratory syncytial virus (RSV) live-attenuated vaccines (LAVs) is to assess immunogenicity in healthy adults. Healthy adults will have preexisting levels of serum neutralizing antibodies that could prematurely neutralize the LAV and underestimate the potent...

journal_title：Human vaccines & immunotherapeutics

authors： Van Der Plas JL,Verdijk P,Van Brummelen EMJ,Jeeninga RE,Roestenberg M,Burggraaf J,Kamerling IMC

更新日期：2020-06-02 00:00:00

abstract：:Control programs for emerging influenza are in urgent need of novel therapeutic strategies to mitigate potentially devastating threats from pathogenic strains with pandemic potential. Current vaccines and antivirals have inherent limitations in efficacy, especially with rapid evolutionary changes of influenza viruses....

journal_title：Human vaccines & immunotherapeutics

authors： Berry CM

更新日期：2018-03-04 00:00:00

abstract：:Integrating additive or synergistic antitumor effects that focus on distinct elements of tumor biology are the most rational strategies for cancer treatment. Treatments for breast cancer have increased overall survival, but remain limited by lack of efficacy in a subset of breast cancer patients. The real challenge is...

journal_title：Human vaccines & immunotherapeutics

authors： Kieber-Emmons T,Monzavi-Karbassi B,Hutchins LF,Pennisi A,Makhoul I

更新日期：2017-02-01 00:00:00

abstract：:Vaccination is an indisputable intervention that has tremendously mitigated the global burden of vaccine-preventable diseases (VPDs). The number of armed conflicts globally seems to be at an all-time high, with devastating effects on vaccination coverage. This paper will examine how armed conflicts affect childhood va...

journal_title：Human vaccines & immunotherapeutics

authors： Ngo NV,Pemunta NV,Muluh NE,Adedze M,Basil N,Agwale S

更新日期：2020-06-02 00:00:00

abstract：INTRODUCTION:It is unclear what role daughters play in the decision-making process regarding HPV vaccination. Therefore, we explored the impact of HPV vaccination intention among parents and their 12-13 year-old daughters on HPV vaccination uptake. METHODS:In February 2014 parents/guardians and their 12-13 year-old da...

journal_title：Human vaccines & immunotherapeutics

authors： Jongen VW,van der Loeff MFS,Boyd A,Petrignani M,Prins M,van der Wal M,Nielen A,de Melker H,Paulussen TGWM,Alberts CJ

更新日期：2020-09-23 00:00:00

abstract：:Hepatitis B vaccine is the most effective strategy to control hepatitis B virus (HBV) infection and disease. It is considered that an anti-HBs (antibodies against HBV surface antigen) titer >10 mIU/ml, measured shortly after a complete vaccination schedule, provides protection against infection. Approximately 4-10% of...

journal_title：Human vaccines & immunotherapeutics

authors： Cassaniti I,Calarota SA,Adzasehoun KM,Chiesa A,Comolli G,Parea M,Baldanti F

更新日期：2016-11-01 00:00:00

abstract：:Vaccine information of varying quality is available through many different sources. We describe the creation, release and utilization of ReadyVax, a new mobile smartphone app providing access to trustworthy, evidence-based vaccine information for a target audience of healthcare providers, pharmacists, and patients (in...

journal_title：Human vaccines & immunotherapeutics

authors： Bednarczyk RA,Frew PM,Salmon DA,Whitney E,Omer SB

更新日期：2017-05-04 00:00:00

abstract：:Human papillomavirus is considered the causative factor for cervical cancer, which accounts for approximately 5% of the global cancer burden and more than 600,000 new cases annually that are attributable to HPV infection worldwide. The first-generation prophylactic HPV vaccines, Gardasil® and Cervarix®, were licensed ...

journal_title：Human vaccines & immunotherapeutics

authors： Zhang Z,Zhang J,Xia N,Zhao Q

更新日期：2017-10-03 00:00:00

abstract：:Despite the long-term efficacy and immune persistence observed following HBV vaccination of infants, the need for a booster dose following infant immunization continues to be deliberated. Evidence from HBV booster dose response studies and long-term immunization program reviews are the basis for the recommendation tha...

journal_title：Human vaccines & immunotherapeutics

authors： Osiowy C

更新日期：2018-01-01 00:00:00

abstract：:Hepatitis B virus (HBV) remains a challenging public-health issue in China. Hepatitis B carriers and patients suffer not only physically but also experience strong discrimination and stigma. China's rural population is 629 million. Thus, there is a great need to understand the situation surrounding HBV-related discrim...

journal_title：Human vaccines & immunotherapeutics

authors： Yu L,Wang J,Zhu D,Leng A,Wangen KR

更新日期：2016-01-01 00:00:00

abstract：:The human commensal Staphylococcus aureus (SA) is a leading cause of skin/soft tissue and surgical-site infections, and bacteremia. Functional antibodies and T-cell-mediated immunity, particularly Th1/Th17 responses, are thought to mediate protection. Vaccine development may be hindered by modulation of vaccine-induce...

journal_title：Human vaccines & immunotherapeutics

authors： Ferraro A,Buonocore SM,Auquier P,Nicolas I,Wallemacq H,Boutriau D,van der Most RG

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Community acquired pneumonia (CAP) is a major cause of morbidity and mortality worldwide, and is a leading cause of hospitalization in previously healthy individuals without predisposing risk factors or comorbidities. In this study we determined PCV13 serotype distribution in adults aged ≥50 years with radio...

journal_title：Human vaccines & immunotherapeutics

authors： Regev-Yochay G,Chowers M,Chazan B,Gonzalez E,Gray S,Zhang Z,Pride M

更新日期：2018-01-01 00:00:00

abstract：:Immunization can contribute to a dramatic reduction in number of vaccine-preventable diseases among children. The aim of this study is to investigate mothers' awareness about child vaccines and vaccination in Jordan. This study was a community-based, cross-sectional study that was performed at public places in Irbid C...

journal_title：Human vaccines & immunotherapeutics

authors： Masadeh MM,Alzoubi KH,Al-Azzam SI,Al-Agedi HS,Abu Rashid BE,Mukattash TL

更新日期：2014-01-01 00:00:00

abstract：:Background: The expansion of available vaccines in recent years has increased the overall costs of the vaccine program and put pressure on providers responsible for vaccination. In England in 2016-17, GP practices responsible for vaccinating their local population were paid £227 million. However, the costs to general ...

journal_title：Human vaccines & immunotherapeutics

authors： Crocker-Buque T,Mohan K,Ramsay M,Edelstein M,Mounier-Jack S

更新日期：2019-01-01 00:00:00

abstract：:Malaria remains one of the most significant infectious diseases worldwide. Concordant with scaled intervention efforts and the emphasis of elimination and eradication on the agenda of many malaria control programs, the development of a malaria vaccine that reduces transmission of the parasite from human host to mosqui...

journal_title：Human vaccines & immunotherapeutics

authors： Nixon CP

更新日期：2016-12-01 00:00:00

abstract：:Canadian Pharmacists are easy to reach. Although Québec pharmacists are not allowed to administer vaccines, they can: (1) promote vaccination, (2) counsel patients on vaccination, (3) sell vaccines and (4) provide vaccine administration by a nurse. Our objectives were to describe immunization services given in Québec ...

journal_title：Human vaccines & immunotherapeutics

authors： Sauvageau C,Dubé E,Bradet R,Mondor M,Lavoie F,Moisan J

更新日期：2013-09-01 00:00:00

abstract：:Cancer immunotherapy has seen a tremendous number of failures and only few recent regulatory successes. This is a review dedicated to determine major regulatory and developmental issues around cancer immunotherapeutics. A three pillar approach should be used in setting a development path: discovery platforms and suffi...

journal_title：Human vaccines & immunotherapeutics

authors： Kudrin A

更新日期：2012-09-01 00:00:00

abstract：:Intradermal immunization has become a forefront of vaccine improvement, both scientifically and commercially. Newer technologies are being developed to address the need to reduce the dose required for vaccination and to improve the reliability and ease of injection, which have been major hurdles in expanding the numbe...

journal_title：Human vaccines & immunotherapeutics

authors： Levin Y,Kochba E,Hung I,Kenney R

更新日期：2015-01-01 00:00:00

abstract：:Hepatitis A virus (HAV) is considered one of the most important vaccine-preventable diseases in travelers. HAV spreads from person to person via the fecal-oral route and gives rise to an estimated 1.4 million cases worldwide each year. In developing countries with poor sanitary conditions people tend to be infected du...

journal_title：Human vaccines & immunotherapeutics

authors： Aasheim ET,Seymour M,Balogun K,Ngui SL,Williams CJ,Shankar AG

更新日期：2013-11-01 00:00:00

abstract：:Individuals fail to elicit protective antibody after hepatitis B vaccination remain at risk for hepatitis B virus infection. Analysis of the transcriptome of peripheral blood mononuclear cells (PBMCs) is essential to elucidate the characteristics of gene expression in non-responders. In this study, we enrolled seven r...

journal_title：Human vaccines & immunotherapeutics

authors： Qiu S,He P,Fang X,Tong H,Lv J,Liu J,Zhang L,Zhai X,Wang L,Hu Z,Yu Y

更新日期：2018-07-03 00:00:00

abstract：:Pregnant women are risk group for influenza infection. Results of new subunit vaccines application have not been studied enough. Prospective, randomized, open-label comparative study of subunit (Agrippal) and polymeric subunit (Grippol plus) vaccines. 42 pairs of mothers-infants were participated in the study. Protect...

journal_title：Human vaccines & immunotherapeutics

authors： Kostinov MP,Cherdantsev AP,Kuselman AI,Akhmatova NK,Kostinova AM,Deryabina EV,Demina EO,Kostinov AM

更新日期：2018-01-01 00:00:00

abstract：:Kyasanur Forest Disease (KFD) is a tick-borne hemorrhagic fever of human, caused by Kyasanur forest disease virus (KFDV) in India. The tick, Haemaphysalis spinigera, has been incriminated as the vector of KFDV. In human, KFD clinically presents with high fever, frontal headache, and severe myalgia, followed by bleedin...

journal_title：Human vaccines & immunotherapeutics

authors： Rajaiah P

更新日期：2019-01-01 00:00:00

abstract：:Since the introduction of DNA vaccines two decades ago, this attractive strategy has been hampered by its low immunogenicity in humans. Studies conducted to improve the immunogenicity of DNA vaccines have shown that understanding the mechanism of action of DNA vaccines might be the key to successfully improving their ...

journal_title：Human vaccines & immunotherapeutics

authors： Coban C,Kobiyama K,Jounai N,Tozuka M,Ishii KJ

更新日期：2013-10-01 00:00:00