Antibody immunoprophylaxis and immunotherapy for influenza virus infection: Utilization of monoclonal or polyclonal antibodies?

Abstract:

:Control programs for emerging influenza are in urgent need of novel therapeutic strategies to mitigate potentially devastating threats from pathogenic strains with pandemic potential. Current vaccines and antivirals have inherent limitations in efficacy, especially with rapid evolutionary changes of influenza viruses. Antibody-based antiviral protection harnesses the natural power of the immune system. Antibodies present prophylactic and therapeutic intervention options for prevention and control of influenza, especially for at-risk populations. Specific monoclonal antibodies are well defined in purity and initial efficacy but polyclonal antibodies are easier to scale-up and cost-effective with long-term efficacy, using batches with broadly neutralizing properties against influenza variants. This review presents the pros and cons of monoclonal versus polyclonal antibody therapy for influenza.

journal_name

Hum Vaccin Immunother

authors

Berry CM

doi

10.1080/21645515.2017.1363135

subject

Has Abstract

pub_date

2018-03-04 00:00:00

pages

796-799

issue

3

eissn

2164-5515

issn

2164-554X

journal_volume

14

pub_type

杂志文章,评审
  • Adolescent vaccines: Need special focus in India.

    abstract::WHO defines adolescence age between 10 to 19 years. In India, there are 243 million adolescents which constitute 21 per cent of the total population. The global burden of disease in adolescents (2011) reports that the total number of disability adjusted life years (DALYs) worldwide among adolescents were 230 million w...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.4161/hv.29757

    authors: Verma R,Khanna P,Chawla S

    更新日期:2015-01-01 00:00:00

  • No evidence of an increase in the incidence of norovirus gastroenteritis hospitalizations in young children after the introduction of universal rotavirus immunization in Israel.

    abstract::Following the introduction of universal immunization against rotavirus, concerns were raised regarding pathogen-replacement of rotavirus by norovirus. The study aim was to examine the incidence and characteristics and norovirus gastroenteritis before and after the introduction of universal rotavirus immunization in Is...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2019.1599522

    authors: Muhsen K,Kassem E,Rubenstein U,Goren S,Ephros M,Shulman LM,Cohen D

    更新日期:2019-01-01 00:00:00

  • Plant-derived vaccines: an approach for affordable vaccines against cervical cancer.

    abstract::Several types of human papillomavirus (HPV) are causatively associated with cervical cancer, which is the second most common cancer in women worldwide. HPV-16 and 18 are among the high risk types and responsible for HPV infection in more than 70% of the cases. The majority of cervical cancer cases occur in developing ...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.4161/hv.18568

    authors: Waheed MT,Gottschamel J,Hassan SW,Lössl AG

    更新日期:2012-03-01 00:00:00

  • Seroprevalence of antibodies to measles and rubella eight months after a vaccination campaign in the southeast of Iran.

    abstract::Eight months after the mass immunization campaign of November 2015 against measles and rubella in the southeast of Iran, in order to evaluate the sero-immunity level of the people living in the mentioned region, a serosurvey study was performed. Using a multi-stage probability proportional to size cluster sampling, th...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2018.1436920

    authors: Izadi S,Zahraei SM,Mokhtari-Azad T

    更新日期:2018-06-03 00:00:00

  • Development of a human papillomavirus competitive luminex immunoassay for 9 HPV types.

    abstract::In the clinical trials of the quadrivalent human papillomavirus (qHPV) vaccine, antibodies were measured by a competitive Luminex immunoassay (HPV-4 cLIA). A nine-valent HPV (9vHPV) vaccine targeting the types in the qHPV vaccine (HPV6/11/16/18), as well as 5 of the next most frequent HPV types found in cervical cance...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.4161/hv.29205

    authors: Roberts C,Green T,Hess E,Matys K,Brown MJ,Haupt RM,Luxembourg A,Vuocolo S,Saah A,Antonello J

    更新日期:2014-01-01 00:00:00

  • Recent changes of invasive meningococcal disease in France: arguments to revise the vaccination strategy in view of those of other countries.

    abstract::In France, the incidence of invasive meningococcal disease (IMD) is around 1/100,000, with the following trends over the 2011-2018 period: a leading role of group B in subjects <15 years, a decrease of group C among <1 year since 2017, an increase of group W in all age groups including subjects <1 year since 2014 and ...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1729030

    authors: Taha MK,Gaudelus J,Deghmane AE,Caron F

    更新日期:2020-10-02 00:00:00

  • Suppression of TGF-β and IL-10 receptors on self-differentiated dendritic cells by short-hairpin RNAs enhanced activation of effector T-cells against cholangiocarcinoma cells.

    abstract::Cholangiocarcinoma (CCA) is an aggressive tumor that is associated with high rates of recurrence and mortality. This is due, in part, to the fact that CCA cells and their microenvironment secrete immunosuppressive cytokines, transforming growth factor-β (TGF-β) and interleukin-10 (IL-10), that inhibit dendritic cell (...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2019.1701913

    authors: Thepmalee C,Panya A,Sujjitjoon J,Sawasdee N,Poungvarin N,Junking M,Yenchitsomanus PT

    更新日期:2020-10-02 00:00:00

  • A monoclonal antibody to an abrin chimera recognizing a unique epitope on abrin A chain confers protection from abrin-induced lethality.

    abstract::Abrin, obtained from the seeds of Abrus precatorius plant, is a potent toxin belonging to the family of type II ribosome-inactivating proteins. Recently, a recombinant vaccine consisting of the A subunits of abrin and its homolog Abrus precatorius agglutinin (APA) was demonstrated to protect mice from abrin lethality....

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2015.1067741

    authors: Kumar MS,Karande AA

    更新日期:2016-01-01 00:00:00

  • Environmental factors potentially associated with mumps transmission in yeshivas during a mumps outbreak among highly vaccinated students: Brooklyn, New York, 2009-2010.

    abstract::During 2009-2010, a large US mumps outbreak occurred affecting two-dose vaccinated 9th-12th grade Orthodox Jewish boys attending all-male yeshivas (private, traditional Jewish schools). Our objective was to understand mumps transmission dynamics in this well-vaccinated population. We surveyed 9th-12th grade male yeshi...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.4161/hv.22415

    authors: Fiebelkorn AP,Rosen JB,Brown C,Zimmerman CM,Renshowitz H,D'Andrea C,Gallagher KM,Harpaz R,Zucker JR

    更新日期:2013-01-01 00:00:00

  • DNA is an efficient booster of dendritic cell-based vaccine.

    abstract::DC-based therapeutic vaccines as a promising strategy against chronic infections and cancer have been validated in several clinical trials. However, DC-based vaccines are complex and require many in vitro manipulations, which makes this a personalized and expensive therapeutic approach. In contrast, DNA-based vaccines...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2015.1020265

    authors: Li J,Valentin A,Beach RK,Alicea C,Felber BK,Pavlakis GN

    更新日期:2015-01-01 00:00:00

  • Need to take special care of non-responders to hepatitis B vaccination among health-care workers, students and chronic patients.

    abstract::Both our research and that published by Sticchi et al. on immunological memory against hepatitis B virus (HBV) in health-care workers (HCWs) vaccinated as infants or adolescents confirm that in those testing negative after the primary course, one additional (fourth) booster dose is able to elicit an anti-HBs response ...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1810495

    authors: Bechini A,Bonanni P,Grazzini M,Paolini D,Arcangeli G,Mucci N,Bini C,Tiscione E,Zanella B,Boccalini S

    更新日期:2020-12-03 00:00:00

  • Q fever vaccination: Australian animal science and veterinary students' One Health perspectives on Q fever prevention.

    abstract::Unvaccinated animal science and veterinary students are at risk of Q fever, a vaccine-preventable zoonotic disease transmitted from animals to humans. We investigated students' perspectives on Q fever prevention using a One Health approach combining animal, human and environmental health. Animal science and veterinary...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1829900

    authors: Rahaman MR,Milazzo A,Marshall H,Chaber AL,Bi P

    更新日期:2020-11-12 00:00:00

  • Narrowing the policy gap: lessons from years 2 and 3 of the British Columbia influenza prevention policy.

    abstract::Influenza can be potentially fatal to vulnerable populations, particularly those in the hospital. Canada's National Advisory Committee on Immunization recommends that health-care workers (HCW) be immunized against influenza partly to avoid infecting high-risk populations. However, influenza immunization rates among HC...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2019.1692561

    authors: Di Castri AM,Halperin DM,McPherson CM,Nunn A,Farrar-Muir H,Kwong JC,Henry B

    更新日期:2020-06-02 00:00:00

  • HPV vaccine acceptability and willingness-related factors among Chinese adolescents: a nation-wide study.

    abstract:BACKGROUND:Adolescents are the primary target population for human papillomavirus (HPV) vaccination. The objective of this study is to explore the acceptability of HPV vaccines and evaluate factors related to willingness to be vaccinated among Chinese adolescents. METHODS:A nation-wide survey was conducted across 14 s...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1812314

    authors: Zhang X,Wang Z,Ren Z,Li Z,Ma W,Gao X,Zhang R,Qiao Y,Li J

    更新日期:2020-10-29 00:00:00

  • Effects of prophylactic ibuprofen and paracetamol administration on the immunogenicity and reactogenicity of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugated vaccine (PHiD-CV) co-administered with DTPa-combined vaccines

    abstract::Prophylactic paracetamol administration impacts vaccine immune response; this study ( www.clinicaltrials.gov : NCT01235949) is the first to assess PHiD-CV immunogenicity following prophylactic ibuprofen administration. In this phase IV, multicenter, open-label, randomized, controlled, non-inferiority study in Romania ...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1080/21645515.2016.1223001

    authors: Falup-Pecurariu O,Man SC,Neamtu ML,Chicin G,Baciu G,Pitic C,Cara AC,Neculau AE,Burlea M,Brinza IL,Schnell CN,Sas V,Lupu VV,François N,Swinnen K,Borys D

    更新日期:2017-03-04 00:00:00

  • Intravescical instillation of Calmette-Guérin bacillus and COVID-19 risk.

    abstract::It has been theorized that Calmette-Guérin bacillus may prevent or reduce the severity of COVID-19 through a nonspecific stimulation of the immune system. A preliminary assessment of SARS-CoV-2 infection rates and outcomes among 2803 individuals affected with high risk non-muscle-invasive bladder cancer and treated wi...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1805994

    authors: Fedeli U,Porreca A,Colicchia M,Schievano E,Artibani W,Biasio LR,Palù G

    更新日期:2020-09-03 00:00:00

  • Immune persistence after pertussis vaccination.

    abstract::Pertussis is one of the most prevalent vaccine-preventable diseases worldwide. The true infection rate is significantly higher than the reported incidence rate. An increased prevalence of pertussis in older populations has been found, mainly caused by waning immunity after vaccination. Vaccine-induced immunity differs...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.1080/21645515.2016.1259780

    authors: Chen Z,He Q

    更新日期:2017-04-03 00:00:00

  • Comparative humoral and cellular immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine in healthy women aged 18-45 years: follow-up through Month 48 in a Phase III randomized study.

    abstract::We previously reported higher anti-HPV-16 and -18 immune responses induced by HPV-16/18 vaccine compared with HPV-6/11/16/18 vaccine at Month 7 (one month after completion of full vaccination series) in women aged 18-45 y in an observer-blind study NCT00423046; the differences of immune response magnitudes were mainta...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,随机对照试验

    doi:10.4161/hv.36117

    authors: Einstein MH,Levin MJ,Chatterjee A,Chakhtoura N,Takacs P,Catteau G,Dessy FJ,Moris P,Lin L,Struyf F,Dubin G,HPV-010 Study Group.

    更新日期:2014-01-01 00:00:00

  • Public awareness regarding children vaccination in Jordan.

    abstract::Immunization can contribute to a dramatic reduction in number of vaccine-preventable diseases among children. The aim of this study is to investigate mothers' awareness about child vaccines and vaccination in Jordan. This study was a community-based, cross-sectional study that was performed at public places in Irbid C...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.4161/hv.28608

    authors: Masadeh MM,Alzoubi KH,Al-Azzam SI,Al-Agedi HS,Abu Rashid BE,Mukattash TL

    更新日期:2014-01-01 00:00:00

  • The immunogenicity and safety of an investigational meningococcal serogroups A, C, W-135, Y tetanus toxoid conjugate vaccine (ACWY-TT) compared with a licensed meningococcal tetravalent polysaccharide vaccine: a randomized, controlled non-inferiority stud

    abstract::Immunogenicity and safety of ACWY-TT compared with licensed ACWY polysaccharide vaccine (MenPS) in healthy adults, and lot-to-lot consistency of three ACWY-TT lots were evaluated in a phase 3, open, controlled study. Adults aged 18-55 y were randomized to receive ACWY-TT (one of three lots) or MenPS. Serum bactericida...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,随机对照试验

    doi:10.4161/hv.20211

    authors: Dbaibo G,Macalalad N,Aplasca-De Los Reyes MR,Dimaano E,Bianco V,Baine Y,Miller J

    更新日期:2012-07-01 00:00:00

  • Moderate influenza vaccine effectiveness against hospitalisation with A(H3N2) and A(H1N1) influenza in 2013-14: Results from the InNHOVE network.

    abstract::We conducted a multicentre test negative case control study to estimate the 2013-14 influenza vaccine effectiveness (IVE) against hospitalised laboratory confirmed influenza in 12 hospitals in France, Italy and Spain. We included all ≥18 years hospitalised patients targeted by local influenza vaccination campaign repo...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,多中心研究

    doi:10.1080/21645515.2015.1126013

    authors: Rondy M,Castilla J,Launay O,Costanzo S,Ezpeleta C,Galtier F,de Gaetano Donati K,Moren A

    更新日期:2016-05-03 00:00:00

  • Armed conflict, a neglected determinant of childhood vaccination: some children are left behind.

    abstract::Vaccination is an indisputable intervention that has tremendously mitigated the global burden of vaccine-preventable diseases (VPDs). The number of armed conflicts globally seems to be at an all-time high, with devastating effects on vaccination coverage. This paper will examine how armed conflicts affect childhood va...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2019.1688043

    authors: Ngo NV,Pemunta NV,Muluh NE,Adedze M,Basil N,Agwale S

    更新日期:2020-06-02 00:00:00

  • Awareness and acceptance of human papillomavirus (HPV) vaccination among males attending a major sexual health clinic in Wuxi, China: A cross-sectional study.

    abstract:OBJECTIVE:To study the awareness and acceptance of human papillomavirus (HPV) vaccination among sexually active men having sex with men (MSM) and men not having sex with men (MNSM) attending the largest sexual health clinic in Wuxi, China. METHODS:A questionnaire about participants' socio-demographic characteristics a...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2015.1099771

    authors: Zou H,Meng X,Jia T,Zhu C,Chen X,Li X,Xu J,Ma W,Zhang X

    更新日期:2016-06-02 00:00:00

  • Reactogenicity and safety of a liquid human rotavirus vaccine (RIX4414) in healthy adults, children and infants in China: randomized, double-blind, placebo-controlled Phase I studies.

    abstract::We report the findings of three randomized, double-blind, placebo-controlled Phase I studies undertaken to support licensure of the liquid formulation of the human G1P[8] rotavirus (RV) vaccine (RIX4414; GlaxoSmithKline Biologicals SA) in China. Healthy adults aged 18-45 y (n=48) and children aged 2-6 y (n=50) receive...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,随机对照试验

    doi:10.4161/hv.25076

    authors: Li RC,Li YP,Mo ZJ,Luo D,Huang T,Kong JL,Wang LH,Song NS,Liu A,Zhang H,Liao X,Karkada N,Han HH

    更新日期:2013-08-01 00:00:00

  • Improvement of influenza vaccine strain A/Vietnam/1194/2004 (H5N1) growth with the neuraminidase packaging sequence from A/Puerto Rico/8/34.

    abstract::H5N1 influenza candidate vaccine viruses were developed using the "6+2" approach. The hemagglutinin (HA) and neuraminidase (NA) genes were derived from the popular H5N1 virus and the remaining six internal segments were derived from the A/Puerto Rico/8/34 strain (H1N1, PR8). However, some of these candidate strains ha...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.4161/hv.18468

    authors: Pan W,Dong Z,Meng W,Zhang W,Li T,Li C,Zhang B,Chen L

    更新日期:2012-02-01 00:00:00

  • Application of a novel nanoemulsion adjuvant for rabies vaccine which stabilizes a Krebs cycle intermediate (SDH) in an animal model.

    abstract::Rabies is the most lethal zoonotic, vaccine-preventable viral disease in the world. Its treatment is complicated by insufficient vaccine supply and the requirement for four to five repeated injections, as commercially available inactivated rabies lack adjuvant and have low immunogenicity. In this study, we focused on ...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2018.1531966

    authors: Ze L,Zonglin L,Ya'Nan W,Shaohui S,Huijuan Y,Wei C,Li W,Liao G

    更新日期:2019-01-01 00:00:00

  • Mechanistic insight into the induction of cellular immune responses by encapsulated and admixed archaeosome-based vaccine formulations.

    abstract::Archaeosomes are liposomes formulated using total polar lipids (TPLs) or semi-synthetic glycolipids derived from archaea. Conventional archaeosomes with entrapped antigen exhibit robust adjuvant activity as demonstrated by increased antigen-specific humoral and cell-mediated responses and enhanced protective immunity ...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1788300

    authors: Agbayani G,Jia Y,Akache B,Chandan V,Iqbal U,Stark FC,Deschatelets L,Lam E,Hemraz UD,Régnier S,Krishnan L,McCluskie MJ

    更新日期:2020-09-01 00:00:00

  • Two-year antibody persistence in children vaccinated at 12-15 months with a measles-mumps-rubella virus vaccine without human serum albumin.

    abstract::One combined measles-mumps-rubella (MMR) vaccine without Human Serum Albumin (HSA) is currently licensed in the USA (M-M-R II; Merck, USA) and another has been developed (Priorix™ [MMR-RIT, GSK, Belgium]). In this follow-up study, children from USA or Puerto Rico, who had received one dose of M-M-R II or MMR-RIT at 12...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/21645515.2017.1309486

    authors: Berry AA,Abu-Elyazeed R,Diaz-Perez C,Mufson MA,Harrison CJ,Leonardi M,Twiggs JD,Peltier C,Grogg S,Carbayo A,Shapiro S,Povey M,Baccarini C,Innis BL,Henry O

    更新日期:2017-07-03 00:00:00

  • Introduction of a new Rotavirus vaccine: Initial results of uptake and impact on laboratory confirmed cases in Anglia and Essex, United Kingdom, July 2015.

    abstract::Rotavirus gastroenteritis accounts for an estimated 130,000 GP consultations and 13,000 hospitalisations for children under 5 y old each year in England and Wales. In July 2013, an oral live attenuated rotavirus vaccine (Rotarix®) was introduced into the UK infant immunisation program as a 2 dose schedule at 2 and 3 m...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2015.1108501

    authors: Inns T,Trindall A,Dunling-Hall S,Shankar AG

    更新日期:2016-04-02 00:00:00

  • Kyasanur Forest Disease in India: innovative options for intervention.

    abstract::Kyasanur Forest Disease (KFD) is a tick-borne hemorrhagic fever of human, caused by Kyasanur forest disease virus (KFDV) in India. The tick, Haemaphysalis spinigera, has been incriminated as the vector of KFDV. In human, KFD clinically presents with high fever, frontal headache, and severe myalgia, followed by bleedin...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.1080/21645515.2019.1602431

    authors: Rajaiah P

    更新日期:2019-01-01 00:00:00