Antigenic variability: Obstacles on the road to vaccines against traditionally difficult targets.

abstract：:Last decades, the number of routine childhood vaccinations has increased considerably, which consequently has led to multiple vaccine injections per consultation. Implementation of additional vaccines will probably lead to more than 2 vaccine injections per consult, which might be a barrier for parents to vaccinate th...

journal_title：Human vaccines & immunotherapeutics

authors： Kaaijk P,Kleijne DE,Knol MJ,Harmsen IA,Ophorst OJ,Rots NY

更新日期：2014-01-01 00:00:00

abstract：:HIV vaccine strategies are expected to be a crucial component for controlling the HIV epidemic. Despite the large spectrum of potential candidate vaccines for both prophylactic and therapeutic use, the overall development process of an efficacious HIV vaccine strategy is lengthy. The design of clinical trials and the ...

journal_title：Human vaccines & immunotherapeutics

authors： Richert L,Lhomme E,Fagard C,Lévy Y,Chêne G,Thiébaut R

更新日期：2015-01-01 00:00:00

abstract：:This was a randomized, placebo-controlled, Phase I/II study conducted in a Japanese cohort to assess the safety and immunogenicity of Clostridium difficile vaccine (the same formulation as that used in the ongoing global Phase III study). Healthy Japanese adults aged 40-75 years were randomized to receive either C. di...

journal_title：Human vaccines & immunotherapeutics

authors： Matsuoka O,Patel DM,Sasaki S,Oka H,Sasaki T,Pietrobon PJ,Laot T,Bouckenooghe A,Menezes J,de Bruyn G

更新日期：2018-02-01 00:00:00

abstract：:The impact of seasonal influenza has been under-appreciated in Asia and surveillance data lags in most other regions. The variety of influenza circulation patterns in Asia - largely due to the range of climates - has also only recently been recognized and its effect on the burden of disease is not fully understood. Re...

journal_title：Human vaccines & immunotherapeutics

authors： Young BE,Chen M

更新日期：2020-07-02 00:00:00

abstract：:Research on innate immune signaling and regulation has recently focused on pathogen recognition receptors (PRRs) and their signaling pathways. Members of PRRs sense diverse microbial invasions or danger signals, and initiate innate immune signaling pathways, leading to proinflammatory cytokines production, which, in t...

journal_title：Human vaccines & immunotherapeutics

authors： Cui J,Chen Y,Wang HY,Wang RF

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Health authorities recommend influenza vaccination to diabetic patients. Nevertheless, the vaccination coverage of adults was low in China. This study aimed to estimate influenza vaccination intentions and actual uptake among diabetic patients in China and identify the motivators and barriers associated with...

journal_title：Human vaccines & immunotherapeutics

authors： Ye L,Fang T,Cui J,Zhu G,Ma R,Sun Y,Li P,Li H,Dong H,Xu G

更新日期：2020-05-27 00:00:00

abstract：:Development of live-attenuated human respiratory syncytial virus (HRSV) vaccines has proven to be difficult. Several vaccine candidates were found to be over-attenuated and displayed limited immunogenicity. Recently, we identified three synthetic cationic lipopeptides that enhanced paramyxovirus infections in vitro. T...

journal_title：Human vaccines & immunotherapeutics

authors： Tien Nguyen D,Boes J,van Amerongen G,van Remmerden Y,Yüksel S,Guichelaar T,Osterhaus AD,de Swart RL

更新日期：2013-12-01 00:00:00

abstract：:Control programs for emerging influenza are in urgent need of novel therapeutic strategies to mitigate potentially devastating threats from pathogenic strains with pandemic potential. Current vaccines and antivirals have inherent limitations in efficacy, especially with rapid evolutionary changes of influenza viruses....

journal_title：Human vaccines & immunotherapeutics

authors： Berry CM

更新日期：2018-03-04 00:00:00

abstract：:Dynamically changing social situation associated with migrations, increasing freedom rights, popularity of anti-vaccine movements and the resulting from that decrease in herd immunity, forces the medical society and the governments of various countries to reflect on the attitude toward vaccinations. Issues of freedoms...

journal_title：Human vaccines & immunotherapeutics

authors： Patryn RK,Zagaja A

更新日期：2016-08-02 00:00:00

abstract：:The 4-component vaccine 4CMenB, developed against invasive disease caused by meningococcal serogroup B, is approved for use in infants in several countries worldwide. 4CMenB is mostly used as 3 + 1 schedule, except for the UK, where a 2 + 1 schedule is used, and where the vaccine showed an effectiveness of 82.9%. Here...

journal_title：Human vaccines & immunotherapeutics

authors： Biolchi A,Tomei S,Santini L,Welsch JA,Toneatto D,Gaitatzis N,Bai X,Borrow R,Giuliani MM,Mori E,Pizza M

更新日期：2019-01-01 00:00:00

abstract：:Vaccination directly protects vaccinated individuals, but it also has the potential for indirectly protecting the unvaccinated in a population (herd protection). Unintended negative consequences such as the re-manifestation of infection, mainly expressed as age shifts, result from vaccination programs as well. We disc...

journal_title：Human vaccines & immunotherapeutics

authors： Scarbrough Lefebvre CD,Terlinden A,Standaert B

更新日期：2015-01-01 00:00:00

abstract：:Objective: The objective of this study was to analyze the 100 most cited studies on vaccine.Methods: A comprehensive search of studies on vaccine was performed in the Web of Science Core Collection without year or language restrictions. The 100 top-cited studies were retrieved after screening abstracts or full-texts. ...

journal_title：Human vaccines & immunotherapeutics

authors： Zhang Y,Quan L,Xiao B,Du L

更新日期：2019-01-01 00:00:00

abstract：:Combined therapy using chemotherapeutic drugs and immunotherapeutics offers some promise for treating patients with cancer. In this study, we evaluated whether cisplatin delivered by intratumoral (IT)-electroporation (EP) might enhance antitumor activity against established B16 melanoma and whether further addition of...

journal_title：Human vaccines & immunotherapeutics

authors： Kim H,Sin JI

更新日期：2012-11-01 00:00:00

abstract：:Within the past few years, several measles outbreaks have occurred in the southeast of Iran. To learn about the effectiveness of the immunization services for producing a serologic response against measles, this follow-up study was designed and implemented in the southeast of Iran. In Iran, all routine immunization se...

journal_title：Human vaccines & immunotherapeutics

authors： Zahraei SM,Izadi S,Mokhtari-Azad T

更新日期：2016-12-01 00:00:00

abstract：:When the next pandemic emerges, will we be ready? Experts say that the number of animal to human "species jumps" is bound to increase as populations increase and the speed of travel between continents accelerates. Typical pandemic timelines no longer apply.(1) Pandemic H1N1 traveled the world in just weeks, as did SAR...

journal_title：Human vaccines & immunotherapeutics

authors： Spero D,Petrovsky N,De Groot AS

更新日期：2012-07-01 00:00:00

abstract：:Allergen specific immunotherapy involves the repeated administration of allergen products in order to induce clinical and immunologic tolerance to the offending allergen. Immunotherapy is the only etiology-based treatment that has the potential for disease modification, as reflected by longterm remission following its...

journal_title：Human vaccines & immunotherapeutics

authors： Cappella A,Durham SR

更新日期：2012-10-01 00:00:00

abstract：:H5N1 influenza candidate vaccine viruses were developed using the "6+2" approach. The hemagglutinin (HA) and neuraminidase (NA) genes were derived from the popular H5N1 virus and the remaining six internal segments were derived from the A/Puerto Rico/8/34 strain (H1N1, PR8). However, some of these candidate strains ha...

journal_title：Human vaccines & immunotherapeutics

authors： Pan W,Dong Z,Meng W,Zhang W,Li T,Li C,Zhang B,Chen L

更新日期：2012-02-01 00:00:00

abstract：:In a blinded randomized trial, preoperative receipt of the Merck V710 Staphylococcus aureus vaccine was associated with a higher mortality rate than placebo in patients who later developed postoperative S. aureus infections. Of the tested patients, all 12 V710 recipients (but only 1 of 13 placebo recipients) with unde...

journal_title：Human vaccines & immunotherapeutics

authors： McNeely TB,Shah NA,Fridman A,Joshi A,Hartzel JS,Keshari RS,Lupu F,DiNubile MJ

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Enterovirus A71(EV-A71)-associated hand, foot, and mouth disease (HFMD) has been reported worldwide, and poses a particularly heavy burden on patients, families, and society in China. Three Chinese companies have licensed inactivated EV-A71 vaccines, all of which have demonstrated good efficacy for prevent...

journal_title：Human vaccines & immunotherapeutics

authors： Wang X,An Z,Huo D,Jia L,Li J,Yang Y,Liang Z,Wang Q,Wang H

更新日期：2019-01-01 00:00:00

abstract：:Higher-valent pneumococcal conjugate vaccines (PCVs) were licensed from 2009 in Europe; similar worldwide clinical effectiveness was observed for PCVs in routine use. Despite a proven medical need, PCV vaccination in Southern Europe remained suboptimal until 2015/16. We searched PubMed for manuscripts published betwee...

journal_title：Human vaccines & immunotherapeutics

authors： Moreira M,Castro O,Palmieri M,Efklidou S,Castagna S,Hoet B

更新日期：2017-06-03 00:00:00

abstract：:MENK, a penta-peptide is considered as being involved in the regulatory feedback loop between the immune and neuroendocrine systems, with marked modulation of various functions of human immune cells. The aim of the present work was to investigate change of lymphocyte subpopulations in peripheral blood of 50 cancer pat...

journal_title：Human vaccines & immunotherapeutics

authors： Wang Q,Gao X,Yuan Z,Wang Z,Meng Y,Cao Y,Plotnikoff NP,Griffin N,Shan F

更新日期：2014-01-01 00:00:00

abstract：:The objective of this study was to find common immune mechanism across different kinds of vaccines. A meta-analysis of microarray datasets was performed using publicly available microarray Gene Expression Omnibus (GEO) and Array Express data sets of vaccination records. Seven studies (out of 35) were selected for this...

journal_title：Human vaccines & immunotherapeutics

authors： Zhang J,Shao J,Wu X,Mao Q,Wang Y,Gao F,Kong W,Liang Z

更新日期：2015-01-01 00:00:00

abstract：:Alzheimer disease is a devastating chronic disease without adequate therapy. More than 10 years ago, it was demonstrated in transgenic mouse models that vaccination may be a novel, disease-modifying therapy for Alzheimer. Subsequent clinical development has been a roller-coaster with some positive and many negative ne...

journal_title：Human vaccines & immunotherapeutics

authors： Fettelschoss A,Zabel F,Bachmann MF

更新日期：2014-01-01 00:00:00

abstract：:Influenza may cause severe complications for pregnant women. In this study antibody response against 2009 H1N1 influenza virus in pregnant women was investigated. This seroprevalance cross sectional and questionnaire based study was conducted using a convenient sampling method. Blood samples of pregnant women were che...

journal_title：Human vaccines & immunotherapeutics

authors： Honarvar B,Moghadami M,Moattari A,Emami A,Tabatabaee HR,Jahromi BN,Asadi N,Mousavizadeh A,Lankarani KB,Joulaei H,Ghaffarpasand F

更新日期：2012-05-01 00:00:00

abstract：:In late September 2016, the Americas became the first region in the world to have eliminated endemic transmission of measles virus. Several other countries have also verified measles elimination, and countries in all six World Health Organization regions have adopted measles elimination goals. The public health strate...

journal_title：Human vaccines & immunotherapeutics

authors： Gastañaduy PA,Banerjee E,DeBolt C,Bravo-Alcántara P,Samad SA,Pastor D,Rota PA,Patel M,Crowcroft NS,Durrheim DN

更新日期：2018-01-01 00:00:00

abstract：:We report the findings of three randomized, double-blind, placebo-controlled Phase I studies undertaken to support licensure of the liquid formulation of the human G1P[8] rotavirus (RV) vaccine (RIX4414; GlaxoSmithKline Biologicals SA) in China. Healthy adults aged 18-45 y (n=48) and children aged 2-6 y (n=50) receive...

journal_title：Human vaccines & immunotherapeutics

authors： Li RC,Li YP,Mo ZJ,Luo D,Huang T,Kong JL,Wang LH,Song NS,Liu A,Zhang H,Liao X,Karkada N,Han HH

更新日期：2013-08-01 00:00:00

abstract：:Tuberculosis (TB) is a significant cause of illness and death worldwide. Immunotherapy has been investigated in the treatment of TB. The purpose of this study was to perform a meta-analysis investigating the effectiveness of the M. vaccae vaccine. Medline, Cochrane, EMBASE, and Google Scholar were searched until Novem...

journal_title：Human vaccines & immunotherapeutics

authors： Huang CY,Hsieh WY

更新日期：2017-09-02 00:00:00

abstract：:The ESCULAPIO Project aims at increasing awareness on vaccine preventable infectious diseases (VPID) and vaccinations in different target populations and to spread the culture of prevention. Information/training interventions on VPID have been developed and health promotion activities for the general population, stude...

journal_title：Human vaccines & immunotherapeutics

authors： Bechini A,Bonanni P,Lauri S,Tiscione E,Levi M,Prato R,Fortunato F,Martinelli D,Gasparini R,Panatto D,Amicizia D,Coppola RC,Pellizzari B,Tabacchi G,Costantino C,Vitale F,Iannazzo S,Boccalini S

更新日期：2017-02-01 00:00:00

abstract：:HIV sequence diversity and the propensity of eliciting immunodominant responses targeting inessential variable regions are hurdles in the development of an effective AIDS vaccine. We developed a DNA vaccine comprising conserved elements (CE) of SIV p27Gag and HIV-1 Env and found that priming vaccination with CE DNA is...

journal_title：Human vaccines & immunotherapeutics

authors： Hu X,Lu Z,Valentin A,Rosati M,Broderick KE,Sardesai NY,Marx PA,Mullins JI,Pavlakis GN,Felber BK

更新日期：2018-01-01 00:00:00

abstract：:The relationship between obesity and vaccine efficacy is a serious issue. Previous studies have shown that vaccine efficacy is lower in the obese than in the non-obese. Here, we examined the influence of obesity on the efficacy of influenza vaccination using high fat diet (HFD) and regular fat diet (RFD) mice that wer...

journal_title：Human vaccines & immunotherapeutics

authors： Park HL,Shim SH,Lee EY,Cho W,Park S,Jeon HJ,Ahn SY,Kim H,Nam JH

更新日期：2014-01-01 00:00:00