Allergen immunotherapy for allergic respiratory diseases.

Abstract:

:Allergen specific immunotherapy involves the repeated administration of allergen products in order to induce clinical and immunologic tolerance to the offending allergen. Immunotherapy is the only etiology-based treatment that has the potential for disease modification, as reflected by longterm remission following its discontinuation and possibly prevention of disease progression and onset of new allergic sensitizations. Whereas subcutaneous immunotherapy is of proven value in allergic rhinitis and asthma there is a risk of untoward side effects including rarely anaphylaxis. Recently the sublingual route has emerged as an effective and safer alternative. Whereas the efficacy of SLIT in seasonal allergy is now well-documented in adults and children, the available data for perennial allergies and asthma is less reliable and particularly lacking in children. This review evaluates the efficacy, safety and longterm benefits of SCIT and SLIT and highlights new findings regarding mechanisms, potential biomarkers and recent novel approaches for allergen immunotherapy.

journal_name

Hum Vaccin Immunother

authors

Cappella A,Durham SR

doi

10.4161/hv.21629

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

1499-512

issue

10

eissn

2164-5515

issn

2164-554X

pii

21629

journal_volume

8

pub_type

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