Abstract:
:Tuberculosis (TB) is a significant cause of illness and death worldwide. Immunotherapy has been investigated in the treatment of TB. The purpose of this study was to perform a meta-analysis investigating the effectiveness of the M. vaccae vaccine. Medline, Cochrane, EMBASE, and Google Scholar were searched until November 5, 2015 using the keywords: tuberculosis, pulmonary TB, therapeutic vaccines, immunotherapy, M. vaccae, sputum smear. Randomized controlled trials (RCTs) or 2-arm prospective studies were included. The primary outcome was the sputum smear clearance rate at 1 or 2 months and 6 months after treatment. Secondary outcomes were improvement of chest X-ray findings, sputum culture negative rate at 1 or 2 months and 6 months, erythrocyte sedimentation rate (ESR), hemoglobin, and leukocyte count, weight gain, and mortality. Of 89 records identified, 13 RCTs were included in the meta-analysis. The number of patients ranged from 22 to 1337, and the mean age ranged from 26.4 to 44.3 y. Patients treated with M. vaccae were more likely to have negative sputum smear results at 1-2 months (pooled OR = 2.642, 95% CI: 1.623-4.301, P < .001) and at 6 months (pooled OR = 2.111, 95% CI: 1.141-3.908, P = .017), and have a negative sputum culture at 1 or 2 months (pooled OR = 2.660, 95% CI: 1.978-3.578, P < .001). The results of this meta-analysis suggest that M. vaccae immunotherapy may be effective in the treatment of pulmonary TB.
journal_name
Hum Vaccin Immunotherjournal_title
Human vaccines & immunotherapeuticsauthors
Huang CY,Hsieh WYdoi
10.1080/21645515.2017.1335374subject
Has Abstractpub_date
2017-09-02 00:00:00pages
1960-1971issue
9eissn
2164-5515issn
2164-554Xjournal_volume
13pub_type
杂志文章,meta分析,评审abstract::While the Saudi Arabian Ministry of Health has made seasonal influenza vaccination available for several years, there remains a scarcity of vaccination coverage reports outside of the capital city. Understanding factors that affect vaccine uptake is important in developing strategies to improve coverage. This analytic...
journal_title:Human vaccines & immunotherapeutics
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journal_title:Human vaccines & immunotherapeutics
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journal_title:Human vaccines & immunotherapeutics
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pub_type: 杂志文章,随机对照试验
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journal_title:Human vaccines & immunotherapeutics
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pub_type: 杂志文章,meta分析
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journal_title:Human vaccines & immunotherapeutics
pub_type: 杂志文章
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journal_title:Human vaccines & immunotherapeutics
pub_type: 杂志文章
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journal_title:Human vaccines & immunotherapeutics
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pub_type: 杂志文章,评审
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journal_title:Human vaccines & immunotherapeutics
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pub_type: 杂志文章,随机对照试验
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