Immunogenicity, reactogenicity and safety of a human rotavirus vaccine (RIX4414) in Korean infants: a randomized, double-blind, placebo-controlled, phase IV study.

abstract：:Tetanus is caused by a neurotoxin produced by Clostridium tetani (C. tetani), a spore-forming bacterium. Infection begins when tetanus spores are introduced into damaged tissue. Tetanus is characterized by muscle rigidity and painful muscle spasms caused by tetanus toxin's blockade of inhibitory neurons that normally ...

journal_title：Human vaccines & immunotherapeutics

authors： Verma R,Khanna P

更新日期：2012-10-01 00:00:00

abstract：:Haemophilus influenzae type b (Hib) and 7-valent pneumococcal (PCV7) vaccines both became recommended in Japan in 2010. In this study, cytokine production was investigated in peripheral blood mononuclear cells (PBMCs) cultures stimulated with diphtheria and tetanus toxoids combined with acellular pertussis vaccine (DP...

journal_title：Human vaccines & immunotherapeutics

authors： Kashiwagi Y,Miyata A,Kumagai T,Maehara K,Suzuki E,Nagai T,Ozaki T,Nishimura N,Okada K,Kawashima H,Nakayama T

更新日期：2014-01-01 00:00:00

abstract：:Abrin, obtained from the seeds of Abrus precatorius plant, is a potent toxin belonging to the family of type II ribosome-inactivating proteins. Recently, a recombinant vaccine consisting of the A subunits of abrin and its homolog Abrus precatorius agglutinin (APA) was demonstrated to protect mice from abrin lethality....

journal_title：Human vaccines & immunotherapeutics

authors： Kumar MS,Karande AA

更新日期：2016-01-01 00:00:00

abstract：:Background: Compared with trivalent influenza vaccines, quadrivalent influenza vaccines are expected to provide wider protection against influenza B virus infections. We developed a novel quadrivalent subunit influenza vaccine which was distinct from the influenza vaccines available on the market in production process...

journal_title：Human vaccines & immunotherapeutics

authors： Ye H,Jia S,Zhang Y,Li J,Zhu F

更新日期：2020-11-01 00:00:00

abstract：:Novel coronavirus disease 2019 (COVID-19) is caused by the SARS-CoV-2 virus, which belongs to the genus Coronaviridae with its high mutation rate. From the current perspective, we discuss the current status of COVID-19, new challenges, and potential interventions to control the pandemic in developing counties such as ...

journal_title：Human vaccines & immunotherapeutics

authors： Anjum FR,Anam S,Rahman SU

更新日期：2020-10-02 00:00:00

abstract：:Better adjuvants are needed for vaccines against seasonal influenza. TLR7 agonists are potent activators of innate immune responses and thereby may be promising adjuvants. Among the imidazoquinoline compounds, 1-benzyl-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine (BBIQ) was reported to be a highly active TLR7 agonist but...

journal_title：Human vaccines & immunotherapeutics

authors： Kaushik D,Dhingra S,Patil MT,Piplani S,Khanna V,Honda-Okubo Y,Li L,Fung J,Sakala IG,Salunke DB,Petrovsky N

更新日期：2020-08-02 00:00:00

abstract：:The impact of seasonal influenza has been under-appreciated in Asia and surveillance data lags in most other regions. The variety of influenza circulation patterns in Asia - largely due to the range of climates - has also only recently been recognized and its effect on the burden of disease is not fully understood. Re...

journal_title：Human vaccines & immunotherapeutics

authors： Young BE,Chen M

更新日期：2020-07-02 00:00:00

abstract：:The development of COVID-19 vaccines is occurring at a rapid pace, with the potential for a vaccine to be available within 6 months. So who should be prioritized for vaccination when in the first instance, there will be insufficient supply to meet demand? There is no doubt that health-care workers in all settings shou...

journal_title：Human vaccines & immunotherapeutics

authors： Russell FM,Greenwood B

更新日期：2020-11-03 00:00:00

abstract：:Several types of human papillomavirus (HPV) are causatively associated with cervical cancer, which is the second most common cancer in women worldwide. HPV-16 and 18 are among the high risk types and responsible for HPV infection in more than 70% of the cases. The majority of cervical cancer cases occur in developing ...

journal_title：Human vaccines & immunotherapeutics

authors： Waheed MT,Gottschamel J,Hassan SW,Lössl AG

更新日期：2012-03-01 00:00:00

abstract：:Pertussis has had a resurgence with the highest incidence and complication rates in young infants, and deaths occurring mainly at < age 3 months. Infants are infected by older individuals whose immunity has waned. Strategies such as targeted immunization of infant caregivers have had limited success. Pertussis vaccina...

journal_title：Human vaccines & immunotherapeutics

authors： Healy CM

更新日期：2016-08-02 00:00:00

abstract：:Tumor cells escape from immune recognition by several mechanisms such as down-regulating of MHC class I molecules, losing of tumor antigens, etc. The purpose of cancer immunotherapy is to robust or reconstruct the capacity of the immune system to recognize and kill tumor cells by overwhelming the mechanisms by which t...

journal_title：Human vaccines & immunotherapeutics

authors： Sheikhi A,Jafarzadeh A

更新日期：2017-08-03 00:00:00

abstract：:The study of influenza virus evolution in humans has revealed a significant role of glycosylation profile alterations in the viral glycoproteins - hemagglutinin (HA) and neuraminidase (NA), in the emergence of both seasonal and pandemic strains. Viral antigenic drift can modify the number and location of glycosylation...

journal_title：Human vaccines & immunotherapeutics

authors： Cruz E,Cain J,Crossett B,Kayser V

更新日期：2018-03-04 00:00:00

abstract：:Vaccination has been identified many decades ago as an effective means to prevent several diseases. However, in France, there is an emergence of vaccine hesitancy, that has caused a reduction of vaccination coverage rates. This issue reduces the effectiveness of the immunization process, and represents a real threat t...

journal_title：Human vaccines & immunotherapeutics

authors： Fokoun C

更新日期：2018-07-03 00:00:00

abstract：:Human papillomavirus (HPV) vaccine programmes targeted at men who have sex with men (MSM) may reduce HPV-related disease burden among this at-risk group in countries where uptake of the vaccine among adolescent girls is sub-optimal and where adolescent boys are not routinely vaccinated. There are challenges to optimis...

journal_title：Human vaccines & immunotherapeutics

authors： Forster AS,Gilson R

更新日期：2019-01-01 00:00:00

abstract：:One of the main challenges in early clinical research with respiratory syncytial virus (RSV) live-attenuated vaccines (LAVs) is to assess immunogenicity in healthy adults. Healthy adults will have preexisting levels of serum neutralizing antibodies that could prematurely neutralize the LAV and underestimate the potent...

journal_title：Human vaccines & immunotherapeutics

authors： Van Der Plas JL,Verdijk P,Van Brummelen EMJ,Jeeninga RE,Roestenberg M,Burggraaf J,Kamerling IMC

更新日期：2020-06-02 00:00:00

abstract：UNLABELLED:NmenB vaccine (4CMenB) is now available, but studies on the cost-effectiveness of vaccine introduction in a country outbreak situation are lacking. The aim of this study was to evaluate the cost-effectiveness of 4CMenB in the context of a hypothetical epidemic outbreak in Chile. We analyzed the direct and in...

journal_title：Human vaccines & immunotherapeutics

authors： Izquierdo G,Torres JP,Santolaya ME,Valenzuela MT,Vega J,Chomali M

更新日期：2015-01-01 00:00:00

abstract：:Immunogenicity and safety of ACWY-TT compared with licensed ACWY polysaccharide vaccine (MenPS) in healthy adults, and lot-to-lot consistency of three ACWY-TT lots were evaluated in a phase 3, open, controlled study. Adults aged 18-55 y were randomized to receive ACWY-TT (one of three lots) or MenPS. Serum bactericida...

journal_title：Human vaccines & immunotherapeutics

authors： Dbaibo G,Macalalad N,Aplasca-De Los Reyes MR,Dimaano E,Bianco V,Baine Y,Miller J

更新日期：2012-07-01 00:00:00

abstract：:Health literacy skills are cognitive and social skills which determine the motivation and ability of individuals to gain access to, understand, and use information in ways which promote and maintain good health'. Patients use these literacy skills to critically analyze information; to allow them to exert greater contr...

journal_title：Human vaccines & immunotherapeutics

authors： Rowlands G

更新日期：2014-01-01 00:00:00

abstract：:Unvaccinated animal science and veterinary students are at risk of Q fever, a vaccine-preventable zoonotic disease transmitted from animals to humans. We investigated students' perspectives on Q fever prevention using a One Health approach combining animal, human and environmental health. Animal science and veterinary...

journal_title：Human vaccines & immunotherapeutics

authors： Rahaman MR,Milazzo A,Marshall H,Chaber AL,Bi P

更新日期：2020-11-12 00:00:00

abstract：:The present study is to measure the expression of programmed death (PD)-1 / programmed death ligand-1 (PD-L1) negative costimulatory molecules, soluble format sPD-1 in patients with immune thrombocytopenia (ITP), and to investigate their correlation with the secretion of cytokines. A total of 35 patients with ITP were...

journal_title：Human vaccines & immunotherapeutics

authors： Wang Y,Pang N,Wang X,Liu Y,Wang X,Wang L,Sun M,Yasen H,Zhao F,Fan W,Guo X,Ding J

更新日期：2018-04-03 00:00:00

abstract：:Medical scientific societies have the core mission of producing, pooling and disseminating solid and updated scientific information. We report the successful experience of the partnership of four national Medical Scientific Societies active in Italy in producing scientific advice on vaccines and vaccination. In partic...

journal_title：Human vaccines & immunotherapeutics

authors： Bonanni P,Chiamenti G,Conforti G,Maio T,Odone A,Russo R,Scotti S,Signorelli C,Villani A,Scientific Board of “Lifetime Immunization Schedule”.

更新日期：2017-11-02 00:00:00

abstract：:The human commensal Staphylococcus aureus (SA) is a leading cause of skin/soft tissue and surgical-site infections, and bacteremia. Functional antibodies and T-cell-mediated immunity, particularly Th1/Th17 responses, are thought to mediate protection. Vaccine development may be hindered by modulation of vaccine-induce...

journal_title：Human vaccines & immunotherapeutics

authors： Ferraro A,Buonocore SM,Auquier P,Nicolas I,Wallemacq H,Boutriau D,van der Most RG

更新日期：2019-01-01 00:00:00

abstract：:Italy was one of the first countries in the world to introduce a routine vaccination program against HBV for newborns and 12-y-old children. From a clinical point of view, such strategy was clearly successful. The objective of our study was to verify whether, at 20 y from its implementation, hepatitis B universal vacc...

journal_title：Human vaccines & immunotherapeutics

authors： Boccalini S,Taddei C,Ceccherini V,Bechini A,Levi M,Bartolozzi D,Bonanni P

更新日期：2013-05-01 00:00:00

abstract：:Integrating additive or synergistic antitumor effects that focus on distinct elements of tumor biology are the most rational strategies for cancer treatment. Treatments for breast cancer have increased overall survival, but remain limited by lack of efficacy in a subset of breast cancer patients. The real challenge is...

journal_title：Human vaccines & immunotherapeutics

authors： Kieber-Emmons T,Monzavi-Karbassi B,Hutchins LF,Pennisi A,Makhoul I

更新日期：2017-02-01 00:00:00

abstract：:Cellular immunotherapy can be an effective adjuvant treatment for multiple myeloma (MM), as demonstrated by induction of durable remissions after allogeneic stem cell transplantation. However, anti-myeloma immunity is often hampered by suppressive mechanisms in the tumor micro-environment resulting in relapse or disea...

journal_title：Human vaccines & immunotherapeutics

authors： Roeven MW,Hobo W,Schaap N,Dolstra H

更新日期：2014-01-01 00:00:00

abstract：:Pertussis is one of the most prevalent vaccine-preventable diseases worldwide. The true infection rate is significantly higher than the reported incidence rate. An increased prevalence of pertussis in older populations has been found, mainly caused by waning immunity after vaccination. Vaccine-induced immunity differs...

journal_title：Human vaccines & immunotherapeutics

authors： Chen Z,He Q

更新日期：2017-04-03 00:00:00

abstract：:The pseudo-neutralization assay (PsV) described in the current report allows for the creation of HPV18 pseudovirions in order to evaluate whether the antibody responses elicited following vaccination with Gardasil(®) are sufficient to neutralize the activity of these pseudovirions in vitro. The PsV assay evaluates a b...

journal_title：Human vaccines & immunotherapeutics

authors： Roberts C,Swoyer R,Bryan J

更新日期：2012-04-01 00:00:00

abstract：:Typhax is an investigational typhoid fever vaccine candidate that was GMP manufactured applying Protein Capsular Matrix Vaccine (PCMV) technology. It consists of Vi polysaccharide antigen, derived from S. Typhi, non-covalently entrapped in a glutaraldehyde catalyzed cross-linked α-poly-L-lysine and CRM197 protein matr...

journal_title：Human vaccines & immunotherapeutics

authors： Griffin TJ 4th,Thanawastien A,Cartee RT,Mekalanos JJ,Killeen KP

更新日期：2019-01-01 00:00:00

abstract：:The introduction of a serogroup A meningococcal conjugate vaccine in the African meningitis belt has been a remarkable success. Meningitis due to the serogroup A meningococcus, previously responsible for most epidemics, has fallen by 99% in vaccinated countries. Success must, however, not distract from the continuing ...

journal_title：Human vaccines & immunotherapeutics

authors： Stuart JM

更新日期：2018-05-04 00:00:00

abstract：BACKGROUND:Over the past decade, there have been resurgences and large-scale outbreaks of mumps worldwide. Little evidence is available on the relationship between meteorological factors and the incidence of mumps. We aimed to explore the effects of meteorological factors on mumps incidence. METHODS:A Poisson regressi...

journal_title：Human vaccines & immunotherapeutics

authors： Yang Q,Yang Z,Ding H,Zhang X,Dong Z,Hu W,Liu X,Wang M,Hu G,Fu C

更新日期：2014-01-01 00:00:00