A monoclonal antibody to an abrin chimera recognizing a unique epitope on abrin A chain confers protection from abrin-induced lethality.

abstract：:In patients undergoing immunotherapy, the quality of the immune response is reduced, which may negatively affect the efficacy of vaccination. This study was conducted in order to evaluate the efficacy of the hepatitis B virus (HBV) vaccine in patients using immunomodulators. Seronegative patients for HBV who were usin...

journal_title：Human vaccines & immunotherapeutics

authors： Haykir Solay A,Eser F

更新日期：2019-01-01 00:00:00

abstract：:Despite a publicly funded immunization program and continuous promotional efforts, vaccine uptake for seasonal influenza in Quebec (Canada) remains under its goal of 80%. Missed opportunities can explain the low influenza vaccine rates among chronically ill children. To address that, demonstration projects using the l...

journal_title：Human vaccines & immunotherapeutics

authors： Dubé E,Gagnon D,Huot C,Paré R,Jacques S,Kossowski A,Quach C,Landry M

更新日期：2014-01-01 00:00:00

abstract：:In France, the incidence of invasive meningococcal disease (IMD) is around 1/100,000, with the following trends over the 2011-2018 period: a leading role of group B in subjects <15 years, a decrease of group C among <1 year since 2017, an increase of group W in all age groups including subjects <1 year since 2014 and ...

journal_title：Human vaccines & immunotherapeutics

authors： Taha MK,Gaudelus J,Deghmane AE,Caron F

更新日期：2020-10-02 00:00:00

abstract：:Influenza vaccination aims at reducing the incidence of serious disease, complications and death among those with the most risk of severe influenza disease. Influenza vaccine effectiveness (VE) through sentinel surveillance data from the PIDIRAC program (Daily Acute Respiratory Infection Surveillance of Catalonia) dur...

journal_title：Human vaccines & immunotherapeutics

authors： Torner N,Martínez A,Basile L,Marcos MA,Antón A,Mar Mosquera M,Isanta R,Cabezas C,Jané M,Domínguez A,Program Of Catalonia TP

更新日期：2015-01-01 00:00:00

abstract：:Hollingsworth and Isturiz (1) have raised several questions about our earlier review of the use of pneumococcal conjugate (PCV) or polysaccharide (PPV) vaccine for older adults (i.e., ≥65 y of age). (2) They begin by citing two metaanalyses published in 2009 and 2013 that concluded that prevention of pneumococcal pneu...

journal_title：Human vaccines & immunotherapeutics

authors： Fedson DS

更新日期：2014-01-01 00:00:00

abstract：:The present study is to measure the expression of programmed death (PD)-1 / programmed death ligand-1 (PD-L1) negative costimulatory molecules, soluble format sPD-1 in patients with immune thrombocytopenia (ITP), and to investigate their correlation with the secretion of cytokines. A total of 35 patients with ITP were...

journal_title：Human vaccines & immunotherapeutics

authors： Wang Y,Pang N,Wang X,Liu Y,Wang X,Wang L,Sun M,Yasen H,Zhao F,Fan W,Guo X,Ding J

更新日期：2018-04-03 00:00:00

abstract：:Although pancreatic cancer is but the eleventh most prevalent cancer in the US, it is predicted that of all the patients newly diagnosed with this disease in 2014, only 27% will still be alive at the end of the first year and only 6% will make it past 5 years. The choice of chemotherapy in the treatment of pancreatic ...

journal_title：Human vaccines & immunotherapeutics

authors： Hartley ML,Bade NA,Prins PA,Ampie L,Marshall JL

更新日期：2014-01-01 00:00:00

abstract：:Vaccinations are an important and effective cornerstone of preventive medical care. Growing technologic capabilities and use by both patients and providers present critical opportunities to leverage these tools to improve vaccination rates and public health. We propose the Social Ecological Model as a useful theoretic...

journal_title：Human vaccines & immunotherapeutics

authors： Kolff CA,Scott VP,Stockwell MS

更新日期：2018-07-03 00:00:00

abstract：BACKGROUND:Vitamin D is an immunomodulating hormone, which has been associated with susceptibility to infectious diseases. METHODS:Serum vitamin D levels in 135 children ages 3-17 y were measured at baseline and hemagglutinin influenza antibody titers were measured pre- and 21 d post influenza vaccination with live at...

journal_title：Human vaccines & immunotherapeutics

authors： Lin CJ,Martin JM,Cole KS,Zimmerman RK,Susick M,Moehling KK,Levine MZ,Spencer S,Flannery B,Nowalk MP

更新日期：2017-07-03 00:00:00

abstract：:Disseminated bacillus Calmette-Guérin (BCG) disease is a rare and serious adverse event following immunization (AEFI) with BCG. Here, we reported two cases of disseminated BCG disease in the same family and reviewed the literature to identify another 35 cases in China. The average age at onset was 3.7 ± 2.1 months amo...

journal_title：Human vaccines & immunotherapeutics

authors： Wang J,Wu QS,Jiang MB,Xu ZH

更新日期：2020-10-20 00:00:00

abstract：:Human papillomavirus (HPV) infection is a major cause of cervical cancer. HPV vaccine has been shown to be highly effective in preventing HPV infection, and understanding the genotypes of HPV infection can guide the utilization of HPV vaccine. This epidemiological study aimed to investigate the genotype distribution o...

journal_title：Human vaccines & immunotherapeutics

authors： Geng Y,Liu L

更新日期：2019-01-01 00:00:00

abstract：:Despite the long-term efficacy and immune persistence observed following HBV vaccination of infants, the need for a booster dose following infant immunization continues to be deliberated. Evidence from HBV booster dose response studies and long-term immunization program reviews are the basis for the recommendation tha...

journal_title：Human vaccines & immunotherapeutics

authors： Osiowy C

更新日期：2018-01-01 00:00:00

abstract：:Dengue is prevalent in the Asia-Pacific region. Participants of two immunogenicity and safety phase II studies conducted in Singapore and Vietnam (NCT0088089 and NCT00875524, respectively) were followed for up to four years after third vaccine dose of a recombinant, live, attenuated, tetravalent dengue vaccine (CYD-TD...

journal_title：Human vaccines & immunotherapeutics

authors： Tran NH,Chansinghakul D,Chong CY,Low CY,Shek LP,Luong CQ,Fargo C,Wartel TA,Sun S,Skipetrova A,Bouckenooghe A

更新日期：2019-01-01 00:00:00

abstract：:Hepatitis B virus (HBV) remains a challenging public-health issue in China. Hepatitis B carriers and patients suffer not only physically but also experience strong discrimination and stigma. China's rural population is 629 million. Thus, there is a great need to understand the situation surrounding HBV-related discrim...

journal_title：Human vaccines & immunotherapeutics

authors： Yu L,Wang J,Zhu D,Leng A,Wangen KR

更新日期：2016-01-01 00:00:00

abstract：:The immune system responds to tumor cells. The challenge has been how to effectively use these responses to treat or protect against cancer. Toward the goal of developing a cancer vaccine, we are pursuing methodologies for the discovery and testing of useful antigens. We present an array-based approach for discovering...

journal_title：Human vaccines & immunotherapeutics

authors： Whittemore K,Sykes K

更新日期：2013-10-01 00:00:00

abstract：:The Advisory Committee on Immunization Practices recommends administering diphtheria, tetanus and acellular pertussis (DTaP) vaccines to children at 2, 4, 6, 15-18 months, and 4-6 y of age; preferably with the same-brand vaccine for the whole series. We estimated age-appropriate DTaP dose completion and the proportion...

journal_title：Human vaccines & immunotherapeutics

authors： Masseria C,Buikema AR,Liu F,Krishnarajah G

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Socioeconomic and health inequalities remain a huge problem in post-apartheid South Africa. Despite substantial efforts at ensuring universal access to vaccines, many children remain under-vaccinated in the country. This study aimed to assess the prevalence and factors associated with incomplete vaccination ...

journal_title：Human vaccines & immunotherapeutics

authors： Ndwandwe D,Nnaji CA,Mashunye T,Uthman OA,Wiysonge CS

更新日期：2020-07-23 00:00:00

abstract：:Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that play an important role in stimulating an immune response of both CD4(+) T helper cells and CD8(+) cytotoxic T lymphocytes (CTLs). As such, DCs have been studied extensively in cancer immunotherapy for their capability to induce a specific anti...

journal_title：Human vaccines & immunotherapeutics

authors： Schneble EJ,Yu X,Wagner TE,Peoples GE

更新日期：2014-01-01 00:00:00

abstract：:The introduction of a serogroup A meningococcal conjugate vaccine in the African meningitis belt has been a remarkable success. Meningitis due to the serogroup A meningococcus, previously responsible for most epidemics, has fallen by 99% in vaccinated countries. Success must, however, not distract from the continuing ...

journal_title：Human vaccines & immunotherapeutics

authors： Stuart JM

更新日期：2018-05-04 00:00:00

abstract：:Meningococcal serogroup B (MenB) is the predominant cause of invasive meningococcal disease in the United States, with older adolescents and young adults attending college at increased risk. Notably, MenB caused all meningococcal disease outbreaks at US colleges between 2011 and 2018. MenB disease is vaccine-preventab...

journal_title：Human vaccines & immunotherapeutics

authors： McDaniel A,Dempsey A,Srivastava A

更新日期：2019-01-01 00:00:00

abstract：:Although immunotherapies have been employed for many decades, immune checkpoint inhibitors have only recently entered the oncologic landscape. Avelumab is a fully human monoclonal antibody that blocks the interaction between PD-L1 on tumor cells and PD-1 on T cells, thereby inhibiting immunosuppression in the tumor mi...

journal_title：Human vaccines & immunotherapeutics

authors： Collins JM,Gulley JL

更新日期：2019-01-01 00:00:00

abstract：:A novel coronavirus (2019-nCov) emerged in China, at the end of December 2019 which posed an International Public Health Emergency, and later declared as a global pandemic by the World Health Organization (WHO). The International Committee on Taxonomy of Viruses (ICTV) named it SARS-CoV-2 (Severe Acute Respiratory Syn...

journal_title：Human vaccines & immunotherapeutics

authors： Siddique R,Bai Q,Shereen MA,Nabi G,Han G,Rashid F,Ahmed S,Benzhanova A,Xue M,Khan S

更新日期：2020-10-16 00:00:00

abstract：:The durable long term clinical benefits seen for certain patients treated with immunotherapy agents has suggested there is significant therapeutic potential to be derived from these agents, as shown by the increasing prominence of this treatment strategy in upcoming clinical trials. There has been a renewed interest a...

journal_title：Human vaccines & immunotherapeutics

authors： O'Sullivan Coyne G,Gulley JL

更新日期：2014-01-01 00:00:00

abstract：:Hepatitis E virus (HEV) infection is one of the main causes of acute hepatitis worldwide. A recombinant hepatitis E vaccine, HEV 239, has been licensed in China for immunizing adults of 16 y old and above. The vaccine antigen contains pORF2 aa 368 - 606 of the HEV genotype 1 expressed in E. coli. The quality of the va...

journal_title：Human vaccines & immunotherapeutics

authors： Li SW,Zhao Q,Wu T,Chen S,Zhang J,Xia NS

更新日期：2015-01-01 00:00:00

abstract：:HIV sequence diversity and the propensity of eliciting immunodominant responses targeting inessential variable regions are hurdles in the development of an effective AIDS vaccine. We developed a DNA vaccine comprising conserved elements (CE) of SIV p27Gag and HIV-1 Env and found that priming vaccination with CE DNA is...

journal_title：Human vaccines & immunotherapeutics

authors： Hu X,Lu Z,Valentin A,Rosati M,Broderick KE,Sardesai NY,Marx PA,Mullins JI,Pavlakis GN,Felber BK

更新日期：2018-01-01 00:00:00

abstract：:Background: Compared with trivalent influenza vaccines, quadrivalent influenza vaccines are expected to provide wider protection against influenza B virus infections. We developed a novel quadrivalent subunit influenza vaccine which was distinct from the influenza vaccines available on the market in production process...

journal_title：Human vaccines & immunotherapeutics

authors： Ye H,Jia S,Zhang Y,Li J,Zhu F

更新日期：2020-11-01 00:00:00

abstract：:We previously reported higher anti-HPV-16 and -18 immune responses induced by HPV-16/18 vaccine compared with HPV-6/11/16/18 vaccine at Month 7 (one month after completion of full vaccination series) in women aged 18-45 y in an observer-blind study NCT00423046; the differences of immune response magnitudes were mainta...

journal_title：Human vaccines & immunotherapeutics

authors： Einstein MH,Levin MJ,Chatterjee A,Chakhtoura N,Takacs P,Catteau G,Dessy FJ,Moris P,Lin L,Struyf F,Dubin G,HPV-010 Study Group.

更新日期：2014-01-01 00:00:00

abstract：:Influenza viruses cause annual winter epidemics globally and influenza vaccination is most effective way to prevent the disease or severe outcomes from the illness, especially in developing countries. However, the majority of the world's total production capacity of influenza vaccine is concentrated in several large m...

journal_title：Human vaccines & immunotherapeutics

authors： Liu Y,Wu JY,Wang X,Chen JT,Xia M,Hu W,Zou Y,Yin WD

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Enterovirus A71(EV-A71)-associated hand, foot, and mouth disease (HFMD) has been reported worldwide, and poses a particularly heavy burden on patients, families, and society in China. Three Chinese companies have licensed inactivated EV-A71 vaccines, all of which have demonstrated good efficacy for prevent...

journal_title：Human vaccines & immunotherapeutics

authors： Wang X,An Z,Huo D,Jia L,Li J,Yang Y,Liang Z,Wang Q,Wang H

更新日期：2019-01-01 00:00:00

abstract：:Novel coronavirus disease 2019 (COVID-19) is caused by the SARS-CoV-2 virus, which belongs to the genus Coronaviridae with its high mutation rate. From the current perspective, we discuss the current status of COVID-19, new challenges, and potential interventions to control the pandemic in developing counties such as ...

journal_title：Human vaccines & immunotherapeutics

authors： Anjum FR,Anam S,Rahman SU

更新日期：2020-10-02 00:00:00