Novel dendritic cell-based vaccination in late stage melanoma.

Abstract:

:Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that play an important role in stimulating an immune response of both CD4(+) T helper cells and CD8(+) cytotoxic T lymphocytes (CTLs). As such, DCs have been studied extensively in cancer immunotherapy for their capability to induce a specific anti-tumor response when loaded with tumor antigens. However, when the most relevant antigens of a tumor remain to be identified, alternative approaches are required. Formation of a dentritoma, a fused DC and tumor cells hybrid, is one strategy. Although initial studies of these hybrid cells are promising, several limitations interfere with its clinical and commercial application. Here we present early experience in clinical trials and an alternative approach to manufacturing this DC/tumor cell hybrid for use in the treatment of late stage and metastatic melanoma.

journal_name

Hum Vaccin Immunother

authors

Schneble EJ,Yu X,Wagner TE,Peoples GE

doi

10.4161/hv.29110

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

3132-8

issue

11

eissn

2164-5515

issn

2164-554X

journal_volume

10

pub_type

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