The development of a recombinant hepatitis E vaccine HEV 239.

Abstract:

:Hepatitis E virus (HEV) infection is one of the main causes of acute hepatitis worldwide. A recombinant hepatitis E vaccine, HEV 239, has been licensed in China for immunizing adults of 16 y old and above. The vaccine antigen contains pORF2 aa 368 - 606 of the HEV genotype 1 expressed in E. coli. The quality of the vaccine is controlled through a combination of biophysical, biochemical and immunochemical methods. The vaccine is well tolerated in adults. The efficacy of the HEV 239 vaccine against symptomatic and asymptomatic infection had been proven to be high during a Phase III clinical trial and long-term follow up. The safety and efficacy of HEV 239 vaccine in certain high-risk populations remains to be further investigated.

journal_name

Hum Vaccin Immunother

authors

Li SW,Zhao Q,Wu T,Chen S,Zhang J,Xia NS

doi

10.1080/21645515.2015.1008870

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

908-14

issue

4

eissn

2164-5515

issn

2164-554X

journal_volume

11

pub_type

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