A new therapeutic potential for cancers: One CAR with 2 different engines!

abstract：:The thymus is a largely neglected organ but plays a significant role in the regulation of adaptive immune responses. The effect of aging on the thymus and immune senescence is well established, and the resulting inflammaging is found to be implicated in the development of many chronic diseases including atherosclerosi...

journal_title：Human vaccines & immunotherapeutics

authors： Kellogg C,Equils O

更新日期：2020-10-16 00:00:00

abstract：:Eight months after the mass immunization campaign of November 2015 against measles and rubella in the southeast of Iran, in order to evaluate the sero-immunity level of the people living in the mentioned region, a serosurvey study was performed. Using a multi-stage probability proportional to size cluster sampling, th...

journal_title：Human vaccines & immunotherapeutics

authors： Izadi S,Zahraei SM,Mokhtari-Azad T

更新日期：2018-06-03 00:00:00

abstract：:Varicella is a potentially serious infectious disease caused by Varicella-Zoster Virus (VZV). In Italy childhood varicella vaccine have gradually introduced into national immunization program since 2003 and from 2017 a two-doses schedule has been stated nationally for all newborns and has become compulsory for school ...

journal_title：Human vaccines & immunotherapeutics

authors： Balbi O,Baldi S,Rizza S,Pietroiusti A,Perrone S,Coppeta L

更新日期：2020-07-09 00:00:00

abstract：:Varicella zoster virus (VZV) is primarily known for causing varicella in childhood, but can reactivate again as herpes zoster (HZ) after a period of latency, mainly in persons older than 50 years. Universal varicella vaccination was introduced in Germany in 2004, while HZ vaccination has not been recommended yet. We a...

journal_title：Human vaccines & immunotherapeutics

authors： Horn J,Karch A,Damm O,Kretzschmar ME,Siedler A,Ultsch B,Weidemann F,Wichmann O,Hengel H,Greiner W,Mikolajczyk RT

更新日期：2016-07-02 00:00:00

abstract：:In late September 2016, the Americas became the first region in the world to have eliminated endemic transmission of measles virus. Several other countries have also verified measles elimination, and countries in all six World Health Organization regions have adopted measles elimination goals. The public health strate...

journal_title：Human vaccines & immunotherapeutics

authors： Gastañaduy PA,Banerjee E,DeBolt C,Bravo-Alcántara P,Samad SA,Pastor D,Rota PA,Patel M,Crowcroft NS,Durrheim DN

更新日期：2018-01-01 00:00:00

abstract：:The rapid evolution of influenza A viruses poses a great challenge to vaccine development. Analytical and machine learning models have been applied to facilitate the process of antigenicity determination. In this study, we designed deep convolutional neural networks (CNNs) to predict Influenza antigenicity. Our model ...

journal_title：Human vaccines & immunotherapeutics

authors： Lee EK,Tian H,Nakaya HI

更新日期：2020-11-01 00:00:00

abstract：:In Japan, government support for human papillomavirus (HPV) vaccination began in November 2010. However, the mass media repeatedly reported on severe adverse events. The Japanese Ministry of Health, Labor and Welfare suspended proactive recommendations for HPV vaccines in June 2013. Japan's HPV vaccination rate droppe...

journal_title：Human vaccines & immunotherapeutics

authors： Tozawa-Ono A,Kamada M,Teramoto K,Hareyama H,Kodama S,Kasai T,Iwanari O,Koizumi T,Ozawa N,Suzuki M,Kinoshita K

更新日期：2020-10-29 00:00:00

abstract：:The currently available drugs to treat hepatitis B virus (HBV) infection include interferons and nucleos(t)ide analogs, which can only induce disease remission and are inefficient for the functional cure of patients with chronic HBV infection (CHB). Since high titers of circulating hepatitis B surface antigen (HBsAg) ...

journal_title：Human vaccines & immunotherapeutics

authors： Gao Y,Zhang TY,Yuan Q,Xia NS

更新日期：2017-08-03 00:00:00

abstract：:Immunotherapy shows promise for positively changing the landscape of the management of many advanced solid tumors, including gastrointestinal (GI) malignancies. Many of these developments have been focused on vaccine-based, monoclonal antibody therapies and more recently, checkpoint inhibitors, although many small mol...

journal_title：Human vaccines & immunotherapeutics

authors： Murphy AG,Zheng L

更新日期：2015-01-01 00:00:00

abstract：:The interleukin 6 (IL6) family of proteins regulate important cellular processes and act through a variety of signaling pathways via a shared gp130 receptor. In the liver, there is a large body of evidence showing a protective and pro-regenerative role for IL6 cis and trans signaling. While a few studies suggest a pat...

journal_title：Human vaccines & immunotherapeutics

authors： Widjaja AA,Chothani SP,Cook SA

更新日期：2020-10-02 00:00:00

abstract：:The interesting article by Simas et. al. describes an outbreak case with over 600 individuals who exhibited neurological symptoms and which occurred in a town located at the northern region of Colombia in 2014. The community associated this event to the second-dose vaccination campaign against the Human Papillomavirus...

journal_title：Human vaccines & immunotherapeutics

authors： Idrovo AJ,Pinilla-Monsalve GD,Manrique-Hernández EF

更新日期：2019-01-01 00:00:00

abstract：:A 68-year-old woman under maintenance hemodialysis was admitted to our hospital with fever and dyspnea that had developed two days after the second vaccination with the 23-valent pneumococcal polysaccharide vaccine (PPV23). She had received the first vaccination with PPV23 five years earlier without any complications....

journal_title：Human vaccines & immunotherapeutics

authors： Kikuchi R,Iwai Y,Watanabe Y,Nakamura H,Aoshiba K

更新日期：2019-01-01 00:00:00

abstract：:Polymeric carriers in the form of cellulose acetate phthalate (CAP) and alginate (ALG) microspheres were used for encapsulation of plasmid DNA for oral mucosal immunization. Access into the intestinal mucosa by pVAX1 eukaryotic expression plasmid vectors carrying gene-coding sequences, either for the cholera enterotox...

journal_title：Human vaccines & immunotherapeutics

authors： Rosli R,Nograles N,Hanafi A,Nor Shamsudin M,Abdullah S

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the incidence of adverse events following administration of an Inactivated poliomyelitis vaccine (IPV) manufactured by Serum Institute of India Pvt. Ltd., Pune, India. METHODS:A single 0.5 ml dose of the IPV was administered intramuscularly to children attending private clinics or out-patient dep...

journal_title：Human vaccines & immunotherapeutics

authors： Sharma H,Dhere R,Parekh S,Shewale S

更新日期：2017-11-02 00:00:00

abstract：:Streptococcus pneumoniae causes pneumonia, meningitis, otitis media, and bacteremia. The mortality and morbidity of invasive pneumococcal disease are high among adults aged >65 years or those with underlying chronic or immunosuppressive conditions. A recent systematic review showed that patients treated with immunosup...

journal_title：Human vaccines & immunotherapeutics

authors： Kuronuma K,Takahashi H

更新日期：2019-01-01 00:00:00

abstract：:A 9-valent HPV (9vHPV) vaccine has been developed to protect against HPV type 6/11/16/18/31/33/45/52/58-related infection and disease. Previous safety analyses from 7 clinical trials conducted in 9vHPV vaccine recipients 9-26 years of age, including comparisons of 9vHPV and quadrivalent HPV (qHPV) vaccines in girls an...

journal_title：Human vaccines & immunotherapeutics

authors： Moreira ED,Giuliano AR,de Hoon J,Iversen OE,Joura EA,Restrepo J,Van Damme P,Vandermeulen C,Ellison MC,Krick A,Shields C,Heiles B,Luxembourg A

更新日期：2018-02-01 00:00:00

abstract：:Individuals fail to elicit protective antibody after hepatitis B vaccination remain at risk for hepatitis B virus infection. Analysis of the transcriptome of peripheral blood mononuclear cells (PBMCs) is essential to elucidate the characteristics of gene expression in non-responders. In this study, we enrolled seven r...

journal_title：Human vaccines & immunotherapeutics

authors： Qiu S,He P,Fang X,Tong H,Lv J,Liu J,Zhang L,Zhai X,Wang L,Hu Z,Yu Y

更新日期：2018-07-03 00:00:00

abstract：:Malaria remains one of the most significant infectious diseases worldwide. Concordant with scaled intervention efforts and the emphasis of elimination and eradication on the agenda of many malaria control programs, the development of a malaria vaccine that reduces transmission of the parasite from human host to mosqui...

journal_title：Human vaccines & immunotherapeutics

authors： Nixon CP

更新日期：2016-12-01 00:00:00

abstract：:Novel coronavirus disease 2019 (COVID-19) is caused by the SARS-CoV-2 virus, which belongs to the genus Coronaviridae with its high mutation rate. From the current perspective, we discuss the current status of COVID-19, new challenges, and potential interventions to control the pandemic in developing counties such as ...

journal_title：Human vaccines & immunotherapeutics

authors： Anjum FR,Anam S,Rahman SU

更新日期：2020-10-02 00:00:00

abstract：:The immune system becomes less effective with age, and older age is associated with an increased susceptibility to diseases and reduced responses to vaccination. Furthermore, some adult populations, such as those with diabetes mellitus, are at increased risk of acute hepatitis B virus (HBV) infection. Decreasing respo...

journal_title：Human vaccines & immunotherapeutics

authors： Van Der Meeren O,Crasta P,Cheuvart B,De Ridder M

更新日期：2015-01-01 00:00:00

abstract：:Health literacy skills are cognitive and social skills which determine the motivation and ability of individuals to gain access to, understand, and use information in ways which promote and maintain good health'. Patients use these literacy skills to critically analyze information; to allow them to exert greater contr...

journal_title：Human vaccines & immunotherapeutics

authors： Rowlands G

更新日期：2014-01-01 00:00:00

abstract：:We aimed to determine the efficacy of the 10-valent pneumococcal-Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in children aged 18-months to <18-years with recurrent protracted bacterial bronchitis (rPBB), chronic suppurative lung disease (CSLD) or bronchiectasis. In a multi-centre, double-blind randomi...

journal_title：Human vaccines & immunotherapeutics

authors： O'Grady KF,Chang AB,Cripps A,Mulholland EK,Smith-Vaughan H,Wood N,Danchin M,Thornton R,Wilson A,Torzillo PJ,Morris PM,Richmond P,Rablin S,Arnold D,Connor A,Goyal V,Stoney T,Perrett K,Grimwood K

更新日期：2018-01-01 00:00:00

abstract：:In 2000, China was declared polio-free. However, in 2018, wild poliovirus (WPV) was still endemic in two of its neighboring countries, making WPV importation and outbreak alarming possibilities. This study documents the seroprevalence of poliovirus antibodies before and after the polio vaccine switch in 2012 and 2017 ...

journal_title：Human vaccines & immunotherapeutics

authors： Li J,Zhang Z,Zhang H,Li M,Li X,Lu L,Huang F,Wu J

更新日期：2020-07-23 00:00:00

abstract：BACKGROUND:Febrile seizure is the most common childhood neurological disorder, is an important health problem with potential short- and long-term complications, also leading to economic burden and increased parental anxiety about fevers and seizures occurring in their children. There are no routine recommendation to de...

journal_title：Human vaccines & immunotherapeutics

authors： Carman KB,Calik M,Karal Y,Isikay S,Kocak O,Ozcelik A,Yazar AS,Nuhoglu C,Sag C,Kilic O,Dinleyici M,Lacinel Gurlevik S,Yimenicioglu S,Ekici A,Perk P,Tosun A,Isik I,Yarar C,Arslantas D,Dinleyici EC

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Adolescents are the primary target population for human papillomavirus (HPV) vaccination. The objective of this study is to explore the acceptability of HPV vaccines and evaluate factors related to willingness to be vaccinated among Chinese adolescents. METHODS:A nation-wide survey was conducted across 14 s...

journal_title：Human vaccines & immunotherapeutics

authors： Zhang X,Wang Z,Ren Z,Li Z,Ma W,Gao X,Zhang R,Qiao Y,Li J

更新日期：2020-10-29 00:00:00

abstract：:Background: Compared with trivalent influenza vaccines, quadrivalent influenza vaccines are expected to provide wider protection against influenza B virus infections. We developed a novel quadrivalent subunit influenza vaccine which was distinct from the influenza vaccines available on the market in production process...

journal_title：Human vaccines & immunotherapeutics

authors： Ye H,Jia S,Zhang Y,Li J,Zhu F

更新日期：2020-11-01 00:00:00

abstract：:Cancer immunotherapy has seen a tremendous number of failures and only few recent regulatory successes. This is a review dedicated to determine major regulatory and developmental issues around cancer immunotherapeutics. A three pillar approach should be used in setting a development path: discovery platforms and suffi...

journal_title：Human vaccines & immunotherapeutics

authors： Kudrin A

更新日期：2012-09-01 00:00:00

abstract：:Last decades, the number of routine childhood vaccinations has increased considerably, which consequently has led to multiple vaccine injections per consultation. Implementation of additional vaccines will probably lead to more than 2 vaccine injections per consult, which might be a barrier for parents to vaccinate th...

journal_title：Human vaccines & immunotherapeutics

authors： Kaaijk P,Kleijne DE,Knol MJ,Harmsen IA,Ophorst OJ,Rots NY

更新日期：2014-01-01 00:00:00

abstract：:Neisseria meningitidis serogroup B (MnB) is a significant cause of invasive meningococcal disease, but no broadly protective vaccine is yet approved. We assessed the safety and immunogenicity of a bivalent MnB vaccine composed of lipidated subfamily A and B variants of recombinant LP2086 (rLP2086, also known as factor...

journal_title：Human vaccines & immunotherapeutics

authors： Sheldon EA,Schwartz H,Jiang Q,Giardina PC,Perez JL

更新日期：2012-07-01 00:00:00

abstract：:We conducted a multicentre test negative case control study to estimate the 2013-14 influenza vaccine effectiveness (IVE) against hospitalised laboratory confirmed influenza in 12 hospitals in France, Italy and Spain. We included all ≥18 years hospitalised patients targeted by local influenza vaccination campaign repo...

journal_title：Human vaccines & immunotherapeutics

authors： Rondy M,Castilla J,Launay O,Costanzo S,Ezpeleta C,Galtier F,de Gaetano Donati K,Moren A

更新日期：2016-05-03 00:00:00