BBIQ, a pure TLR7 agonist, is an effective influenza vaccine adjuvant.

abstract：:Ebola virus disease (EVD) has become a great threat to humans across the world in recent years. The 2014 Ebola epidemic in West Africa caused numerous deaths and attracted worldwide attentions. Since no specific drugs and treatments against EVD was available, vaccination was considered as the most promising and effect...

journal_title：Human vaccines & immunotherapeutics

authors： Wang Y,Li J,Hu Y,Liang Q,Wei M,Zhu F

更新日期：2017-01-02 00:00:00

abstract：:Post licensure surveillance of adverse events following immunization (AEFI) is a fundamental activity to improve safety and maintain public confidence in vaccines.   Since 2011, the Liguria Region has been involved in the inter-regional project of post-marketing surveillance of AEFI, coordinated by the Italian Medicin...

journal_title：Human vaccines & immunotherapeutics

authors： Alicino C,Merlano C,Zappettini S,Schiaffino S,Della Luna G,Accardo C,Gasparini R,Durando P,Icardi G

更新日期：2015-01-01 00:00:00

abstract：:Meningococcal meningitis is caused by Neisseria meningitidis, a gram-negative, aerobic, encapsulated diplococcus. Meningococci are divided into numerous serogroups based on the composition of their capsular polysaccharide (Ps) antigens. At least 13 serogroups have been described: A, B, C, D, 29E, H, I, K, L, W-135, X,...

journal_title：Human vaccines & immunotherapeutics

authors： Verma R,Khanna P

更新日期：2012-12-01 00:00:00

abstract：:Vaccines dramatically reduce infection-related morbidity and mortality. Determining factors that modulate the host response is key to rational vaccine design and demands unsupervised analysis. To longitudinally resolve influenza-specific humoral immune response dynamics we constructed vaccine response profiles of infl...

journal_title：Human vaccines & immunotherapeutics

authors： Berger CT,Greiff V,Mehling M,Fritz S,Meier MA,Hoenger G,Conen A,Recher M,Battegay M,Reddy ST,Hess C

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:In an era of hesitance to use vaccines, the importance of effective communication for increasing vaccine acceptance is well known. This study aimed to assess the impact of a three-day residential course concerning empathy and counselling abilities on patients' ratings of the level of empathy of physicians an...

journal_title：Human vaccines & immunotherapeutics

authors： Maurici M,Arigliani M,Dugo V,Leo C,Pettinicchio V,Arigliani R,Franco E

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:Enterovirus A71(EV-A71)-associated hand, foot, and mouth disease (HFMD) has been reported worldwide, and poses a particularly heavy burden on patients, families, and society in China. Three Chinese companies have licensed inactivated EV-A71 vaccines, all of which have demonstrated good efficacy for prevent...

journal_title：Human vaccines & immunotherapeutics

authors： Wang X,An Z,Huo D,Jia L,Li J,Yang Y,Liang Z,Wang Q,Wang H

更新日期：2019-01-01 00:00:00

abstract：:In order to analyze the effect of EV71 vaccination on the incidence of encephalitis in patients with HFMD, 292 cases were vaccinated, and 2,486 cases were not vaccinated which were collected in 2018 and 2019. It shows that the incidence rate of encephalitis in vaccinated patients was significantly lower than that in n...

journal_title：Human vaccines & immunotherapeutics

authors： Li J,Yin X,Lin A,Nie X,Liu L,Liu S,Li N,Wang P,Song S,Wang S,Xu D

更新日期：2021-01-31 00:00:00

abstract：:Within the past few years, several measles outbreaks have occurred in the southeast of Iran. To learn about the effectiveness of the immunization services for producing a serologic response against measles, this follow-up study was designed and implemented in the southeast of Iran. In Iran, all routine immunization se...

journal_title：Human vaccines & immunotherapeutics

authors： Zahraei SM,Izadi S,Mokhtari-Azad T

更新日期：2016-12-01 00:00:00

abstract：:Vaccinations are an important and effective cornerstone of preventive medical care. Growing technologic capabilities and use by both patients and providers present critical opportunities to leverage these tools to improve vaccination rates and public health. We propose the Social Ecological Model as a useful theoretic...

journal_title：Human vaccines & immunotherapeutics

authors： Kolff CA,Scott VP,Stockwell MS

更新日期：2018-07-03 00:00:00

abstract：:Vaccination has been identified many decades ago as an effective means to prevent several diseases. However, in France, there is an emergence of vaccine hesitancy, that has caused a reduction of vaccination coverage rates. This issue reduces the effectiveness of the immunization process, and represents a real threat t...

journal_title：Human vaccines & immunotherapeutics

authors： Fokoun C

更新日期：2018-07-03 00:00:00

abstract：:In 1796, Edward Jenner introduced the concept of vaccination with cowpox virus, an Orthopoxvirus within the family Poxviridae that elicits cross protective immunity against related orthopoxviruses, including smallpox virus (variola virus). Over time, vaccinia virus (VACV) replaced cowpox virus as the smallpox vaccine,...

journal_title：Human vaccines & immunotherapeutics

authors： Verardi PH,Titong A,Hagen CJ

更新日期：2012-07-01 00:00:00

abstract：:Hollingsworth and Isturiz (1) have raised several questions about our earlier review of the use of pneumococcal conjugate (PCV) or polysaccharide (PPV) vaccine for older adults (i.e., ≥65 y of age). (2) They begin by citing two metaanalyses published in 2009 and 2013 that concluded that prevention of pneumococcal pneu...

journal_title：Human vaccines & immunotherapeutics

authors： Fedson DS

更新日期：2014-01-01 00:00:00

abstract：:This cross-sectional survey determined the vaccine hesitancy related to Human papillomavirus (HPV) and the determinants among parents of adolescents aged 12 and 13 years in Italy. Data was collected through a self-administered questionnaire. Two-thirds of the parents (66.7%) had heard of HPV infection and knew that th...

journal_title：Human vaccines & immunotherapeutics

authors： Della Polla G,Pelullo CP,Napolitano F,Angelillo IF

更新日期：2020-11-01 00:00:00

abstract：:Streptococcus pneumoniae causes pneumonia, meningitis, otitis media, and bacteremia. The mortality and morbidity of invasive pneumococcal disease are high among adults aged >65 years or those with underlying chronic or immunosuppressive conditions. A recent systematic review showed that patients treated with immunosup...

journal_title：Human vaccines & immunotherapeutics

authors： Kuronuma K,Takahashi H

更新日期：2019-01-01 00:00:00

abstract：:Since the introduction of DNA vaccines two decades ago, this attractive strategy has been hampered by its low immunogenicity in humans. Studies conducted to improve the immunogenicity of DNA vaccines have shown that understanding the mechanism of action of DNA vaccines might be the key to successfully improving their ...

journal_title：Human vaccines & immunotherapeutics

authors： Coban C,Kobiyama K,Jounai N,Tozuka M,Ishii KJ

更新日期：2013-10-01 00:00:00

abstract：:Anflu® is a seasonal trivalent inactivated split-virion influenza vaccine manufactured by Sinovac Biotech Co., Ltd. The objectives of this study were to evaluate the safety of Anflu® (2013-14 formulation: H1N1, H3N2 and BYAM) in infants and adults and its immunogenicity and cross-reactivity against mismatched influenz...

journal_title：Human vaccines & immunotherapeutics

authors： Shen Y,Hu Y,Meng F,Du W,Li W,Song Y,Ji X,Huo L,Fu Z,Yin W

更新日期：2016-05-03 00:00:00

abstract：:The interleukin 6 (IL6) family of proteins regulate important cellular processes and act through a variety of signaling pathways via a shared gp130 receptor. In the liver, there is a large body of evidence showing a protective and pro-regenerative role for IL6 cis and trans signaling. While a few studies suggest a pat...

journal_title：Human vaccines & immunotherapeutics

authors： Widjaja AA,Chothani SP,Cook SA

更新日期：2020-10-02 00:00:00

abstract：:The effective protective HIV vaccine should elicit either protective antibodies or effective T cell response, or both. To improve the efficacy of HIV-1 vaccines, HLA polymorphism and HIV-1 diversity are 2 key factors to be considered for vaccine development. In this study, we expressed a recombinant multi-epitope prot...

journal_title：Human vaccines & immunotherapeutics

authors： Yang Y,Zhu Q,Sun W,Guo J,Ning X,Li Q,Guo Y,Li J,Kou Z,Zhou Y

更新日期：2017-06-03 00:00:00

abstract：:The currently available drugs to treat hepatitis B virus (HBV) infection include interferons and nucleos(t)ide analogs, which can only induce disease remission and are inefficient for the functional cure of patients with chronic HBV infection (CHB). Since high titers of circulating hepatitis B surface antigen (HBsAg) ...

journal_title：Human vaccines & immunotherapeutics

authors： Gao Y,Zhang TY,Yuan Q,Xia NS

更新日期：2017-08-03 00:00:00

abstract：:Cancer immunotherapy has seen a tremendous number of failures and only few recent regulatory successes. This is a review dedicated to determine major regulatory and developmental issues around cancer immunotherapeutics. A three pillar approach should be used in setting a development path: discovery platforms and suffi...

journal_title：Human vaccines & immunotherapeutics

authors： Kudrin A

更新日期：2012-09-01 00:00:00

abstract：:Nationally, human papillomavirus (HPV) vaccination rates fall short of the Healthy People 2020 goal of 80% completion. Although strategies to increase these rates exist, low rates persist. We used concept mapping with state-level stakeholders to better understand barriers and facilitators to HPV vaccination. Concept m...

journal_title：Human vaccines & immunotherapeutics

authors： Ryan G,Avdic L,Daly E,Askelson N,Farris PE,Shannon J,McRee AL,Hanson J,Kenyon DB,Seegmiller L

更新日期：2020-12-17 00:00:00

abstract：:When the next pandemic emerges, will we be ready? Experts say that the number of animal to human "species jumps" is bound to increase as populations increase and the speed of travel between continents accelerates. Typical pandemic timelines no longer apply.(1) Pandemic H1N1 traveled the world in just weeks, as did SAR...

journal_title：Human vaccines & immunotherapeutics

authors： Spero D,Petrovsky N,De Groot AS

更新日期：2012-07-01 00:00:00

abstract：:S. aureus and S. pneumoniae are both common pathogens that are also carried by a large proportion of healthy individuals in the nasal and nasopharyngeal spaces. A negative association between carriage of S. aureus and S. pneumoniae has been reported in children in various epidemiologic studies from different geographi...

journal_title：Human vaccines & immunotherapeutics

authors： Reiss-Mandel A,Regev-Yochay G

更新日期：2016-01-01 00:00:00

abstract：:Overexpressed tumor-self antigens represent the largest group of candidate vaccine targets. Those exhibiting a role in oncogenesis may be some of the least studied but perhaps most promising. This review considers this subset of self antigens by highlighting vaccine efforts for some of the better known members and foc...

journal_title：Human vaccines & immunotherapeutics

authors： Bright RK,Bright JD,Byrne JA

更新日期：2014-01-01 00:00:00

abstract：:The objectives of this study were to estimate incidence density rates (IDR) of herpes zoster (HZ) and to analyze the association with sociodemographic characteristics and selected chronic medical conditions. The study cohort consisted of the adult population included in the Public Health System of the Autonomous Commu...

journal_title：Human vaccines & immunotherapeutics

authors： Esteban-Vasallo MD,Domínguez-Berjón MF,Gil-Prieto R,Astray-Mochales J,Gil de Miguel A

更新日期：2014-01-01 00:00:00

abstract：:Purpose: Gaps remain in the public's knowledge of the human papillomavirus (HPV). We assessed racial/ethnic and gender disparities in knowledge and awareness of HPV and the HPV vaccine among US adults. METHODS:Data from the Health Information National Trends Survey 4 Cycle 3 (September - December 2013) and Cycle 4 (A...

journal_title：Human vaccines & immunotherapeutics

authors： Adjei Boakye E,Tobo BB,Rojek RP,Mohammed KA,Geneus CJ,Osazuwa-Peters N

更新日期：2017-11-02 00:00:00

abstract：:Following the introduction of universal immunization against rotavirus, concerns were raised regarding pathogen-replacement of rotavirus by norovirus. The study aim was to examine the incidence and characteristics and norovirus gastroenteritis before and after the introduction of universal rotavirus immunization in Is...

journal_title：Human vaccines & immunotherapeutics

authors： Muhsen K,Kassem E,Rubenstein U,Goren S,Ephros M,Shulman LM,Cohen D

更新日期：2019-01-01 00:00:00

abstract：:The Advisory Committee on Immunization Practices recommends administering diphtheria, tetanus and acellular pertussis (DTaP) vaccines to children at 2, 4, 6, 15-18 months, and 4-6 y of age; preferably with the same-brand vaccine for the whole series. We estimated age-appropriate DTaP dose completion and the proportion...

journal_title：Human vaccines & immunotherapeutics

authors： Masseria C,Buikema AR,Liu F,Krishnarajah G

更新日期：2015-01-01 00:00:00

abstract：:Unvaccinated animal science and veterinary students are at risk of Q fever, a vaccine-preventable zoonotic disease transmitted from animals to humans. We investigated students' perspectives on Q fever prevention using a One Health approach combining animal, human and environmental health. Animal science and veterinary...

journal_title：Human vaccines & immunotherapeutics

authors： Rahaman MR,Milazzo A,Marshall H,Chaber AL,Bi P

更新日期：2020-11-12 00:00:00

abstract：:Cancer vaccines are designed to stimulate the body's immune system to kill tumor cells. To improve their immunogenicity, vaccine antigens must be combined with adjuvants which are able to stimulate the innate immunity and potentiate the adaptive immune response. In the last years a new generation of adjuvants mimickin...

journal_title：Human vaccines & immunotherapeutics

authors： Circelli L,Tornesello M,Buonaguro FM,Buonaguro L

更新日期：2017-08-03 00:00:00