Different roles of interleukin 6 and interleukin 11 in the liver: implications for therapy.

Abstract:

:The interleukin 6 (IL6) family of proteins regulate important cellular processes and act through a variety of signaling pathways via a shared gp130 receptor. In the liver, there is a large body of evidence showing a protective and pro-regenerative role for IL6 cis and trans signaling. While a few studies suggest a pathological role for IL6 trans-signaling in the liver. IL11 is often thought of as similar to IL6 and redundancy has been inferred. However, recent studies reveal that IL6R and IL11RA are expressed on dissimilar cell types and these cytokines actually have very different roles in biology and pathology. In the liver, IL6R is mostly expressed on immune cells, whereas IL11RA is highly expressed on hepatocytes and hepatic stellate cells, both of which exhibit autocrine IL11 activity. In contrast to the beneficial effects of IL6 in the liver, IL11 causes liver disease and its expression in stromal and parenchymal cells leads to fibrosis, inflammation, steatosis and hepatic failure. In this review, we address IL6 and IL11 in the context of liver function. We end by discussing the possibility of IL6 gain-of-function versus IL11 inhibition as therapeutic approaches to treat liver disease. 1,2.

journal_name

Hum Vaccin Immunother

authors

Widjaja AA,Chothani SP,Cook SA

doi

10.1080/21645515.2020.1761203

subject

Has Abstract

pub_date

2020-10-02 00:00:00

pages

2357-2362

issue

10

eissn

2164-5515

issn

2164-554X

journal_volume

16

pub_type

杂志文章
  • Potential effect of PCV13 introduction on Emergency Department accesses for lower respiratory tract infections in elderly and at risk adults.

    abstract::Liguria, an administrative region in northern Italy characterized by a decade of high PCV coverage in paediatric age group, has issued new PCV13 recommendations for free active immunization in adults with risk factors and subjects aged ≥ 70 years old. Main aims of this study are: (1) a descriptive epidemiology of the ...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.4161/hv.34419

    authors: Ansaldi F,Orsi A,Trucchi C,De Florentiis D,Ceravolo A,Coppelli M,Schiaffino S,Turello V,Rosselli R,Carloni R,Icardi G,Study Group LP,Canepa P,Sticchi L,Zanetti R,Cremonesi I,Brasesco P,Moscatelli P

    更新日期:2015-01-01 00:00:00

  • Antigenic variability: Obstacles on the road to vaccines against traditionally difficult targets.

    abstract::Despite the impressive impact of vaccines on public health, the success of vaccines targeting many important pathogens and cancers has to date been limited. The burden of infectious diseases today is mainly caused by antigenically variable pathogens (AVPs), which escape immune responses induced by prior infection or v...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.1080/21645515.2016.1191718

    authors: Servín-Blanco R,Zamora-Alvarado R,Gevorkian G,Manoutcharian K

    更新日期:2016-10-02 00:00:00

  • Acute respiratory failure due to eosinophilic pneumonia following pneumococcal vaccination.

    abstract::A 68-year-old woman under maintenance hemodialysis was admitted to our hospital with fever and dyspnea that had developed two days after the second vaccination with the 23-valent pneumococcal polysaccharide vaccine (PPV23). She had received the first vaccination with PPV23 five years earlier without any complications....

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2019.1631134

    authors: Kikuchi R,Iwai Y,Watanabe Y,Nakamura H,Aoshiba K

    更新日期:2019-01-01 00:00:00

  • Reactogenicity and safety of a liquid human rotavirus vaccine (RIX4414) in healthy adults, children and infants in China: randomized, double-blind, placebo-controlled Phase I studies.

    abstract::We report the findings of three randomized, double-blind, placebo-controlled Phase I studies undertaken to support licensure of the liquid formulation of the human G1P[8] rotavirus (RV) vaccine (RIX4414; GlaxoSmithKline Biologicals SA) in China. Healthy adults aged 18-45 y (n=48) and children aged 2-6 y (n=50) receive...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,随机对照试验

    doi:10.4161/hv.25076

    authors: Li RC,Li YP,Mo ZJ,Luo D,Huang T,Kong JL,Wang LH,Song NS,Liu A,Zhang H,Liao X,Karkada N,Han HH

    更新日期:2013-08-01 00:00:00

  • Empathy in vaccination counselling: a survey on the impact of a three-day residential course.

    abstract:BACKGROUND:In an era of hesitance to use vaccines, the importance of effective communication for increasing vaccine acceptance is well known. This study aimed to assess the impact of a three-day residential course concerning empathy and counselling abilities on patients' ratings of the level of empathy of physicians an...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2018.1536587

    authors: Maurici M,Arigliani M,Dugo V,Leo C,Pettinicchio V,Arigliani R,Franco E

    更新日期:2019-01-01 00:00:00

  • The development of a recombinant hepatitis E vaccine HEV 239.

    abstract::Hepatitis E virus (HEV) infection is one of the main causes of acute hepatitis worldwide. A recombinant hepatitis E vaccine, HEV 239, has been licensed in China for immunizing adults of 16 y old and above. The vaccine antigen contains pORF2 aa 368 - 606 of the HEV genotype 1 expressed in E. coli. The quality of the va...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.1080/21645515.2015.1008870

    authors: Li SW,Zhao Q,Wu T,Chen S,Zhang J,Xia NS

    更新日期:2015-01-01 00:00:00

  • The burden of infant group B streptococcal infections in Ontario: Analysis of administrative data to estimate the potential benefits of new vaccines.

    abstract::Group B streptococcus (GBS) is a leading bacterial cause of neonatal sepsis and meningitis in many countries as well as an important cause of disease in pregnant women. Currently, serotype-specific conjugate vaccines are being developed. We conducted an epidemiological analysis of health administrative data to estimat...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2018.1511666

    authors: Hartley J,Li Y,Kunkel L,Crowcroft NS

    更新日期:2019-01-01 00:00:00

  • Characterization of an age-response relationship to GSK's recombinant hepatitis B vaccine in healthy adults: An integrated analysis.

    abstract::The immune system becomes less effective with age, and older age is associated with an increased susceptibility to diseases and reduced responses to vaccination. Furthermore, some adult populations, such as those with diabetes mellitus, are at increased risk of acute hepatitis B virus (HBV) infection. Decreasing respo...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2015.1039758

    authors: Van Der Meeren O,Crasta P,Cheuvart B,De Ridder M

    更新日期:2015-01-01 00:00:00

  • Safety, immunogenicity and cross-reactivity of a Northern hemisphere 2013-2014 seasonal trivalent inactivated split influenza virus vaccine, Anflu®.

    abstract::Anflu® is a seasonal trivalent inactivated split-virion influenza vaccine manufactured by Sinovac Biotech Co., Ltd. The objectives of this study were to evaluate the safety of Anflu® (2013-14 formulation: H1N1, H3N2 and BYAM) in infants and adults and its immunogenicity and cross-reactivity against mismatched influenz...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2015.1123357

    authors: Shen Y,Hu Y,Meng F,Du W,Li W,Song Y,Ji X,Huo L,Fu Z,Yin W

    更新日期:2016-05-03 00:00:00

  • A reflection on invasive pneumococcal disease and pneumococcal conjugate vaccination coverage in children in Southern Europe (2009-2016).

    abstract::Higher-valent pneumococcal conjugate vaccines (PCVs) were licensed from 2009 in Europe; similar worldwide clinical effectiveness was observed for PCVs in routine use. Despite a proven medical need, PCV vaccination in Southern Europe remained suboptimal until 2015/16. We searched PubMed for manuscripts published betwee...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.1080/21645515.2016.1263409

    authors: Moreira M,Castro O,Palmieri M,Efklidou S,Castagna S,Hoet B

    更新日期:2017-06-03 00:00:00

  • Recent changes of invasive meningococcal disease in France: arguments to revise the vaccination strategy in view of those of other countries.

    abstract::In France, the incidence of invasive meningococcal disease (IMD) is around 1/100,000, with the following trends over the 2011-2018 period: a leading role of group B in subjects <15 years, a decrease of group C among <1 year since 2017, an increase of group W in all age groups including subjects <1 year since 2014 and ...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1729030

    authors: Taha MK,Gaudelus J,Deghmane AE,Caron F

    更新日期:2020-10-02 00:00:00

  • Immunotherapeutic approaches to treat multiple myeloma.

    abstract::Cellular immunotherapy can be an effective adjuvant treatment for multiple myeloma (MM), as demonstrated by induction of durable remissions after allogeneic stem cell transplantation. However, anti-myeloma immunity is often hampered by suppressive mechanisms in the tumor micro-environment resulting in relapse or disea...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.4161/hv.27380

    authors: Roeven MW,Hobo W,Schaap N,Dolstra H

    更新日期:2014-01-01 00:00:00

  • Hepatitis B-related knowledge and vaccination in association with discrimination against Hepatitis B in rural China.

    abstract::Hepatitis B virus (HBV) remains a challenging public-health issue in China. Hepatitis B carriers and patients suffer not only physically but also experience strong discrimination and stigma. China's rural population is 629 million. Thus, there is a great need to understand the situation surrounding HBV-related discrim...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2015.1069932

    authors: Yu L,Wang J,Zhu D,Leng A,Wangen KR

    更新日期:2016-01-01 00:00:00

  • Antibody-mediated immunotherapy against chronic hepatitis B virus infection.

    abstract::The currently available drugs to treat hepatitis B virus (HBV) infection include interferons and nucleos(t)ide analogs, which can only induce disease remission and are inefficient for the functional cure of patients with chronic HBV infection (CHB). Since high titers of circulating hepatitis B surface antigen (HBsAg) ...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2017.1319021

    authors: Gao Y,Zhang TY,Yuan Q,Xia NS

    更新日期:2017-08-03 00:00:00

  • Strategies implemented to address vaccine hesitancy in France: A review article.

    abstract::Vaccination has been identified many decades ago as an effective means to prevent several diseases. However, in France, there is an emergence of vaccine hesitancy, that has caused a reduction of vaccination coverage rates. This issue reduces the effectiveness of the immunization process, and represents a real threat t...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.1080/21645515.2018.1458807

    authors: Fokoun C

    更新日期:2018-07-03 00:00:00

  • Comparative humoral and cellular immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine in healthy women aged 18-45 years: follow-up through Month 48 in a Phase III randomized study.

    abstract::We previously reported higher anti-HPV-16 and -18 immune responses induced by HPV-16/18 vaccine compared with HPV-6/11/16/18 vaccine at Month 7 (one month after completion of full vaccination series) in women aged 18-45 y in an observer-blind study NCT00423046; the differences of immune response magnitudes were mainta...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,随机对照试验

    doi:10.4161/hv.36117

    authors: Einstein MH,Levin MJ,Chatterjee A,Chakhtoura N,Takacs P,Catteau G,Dessy FJ,Moris P,Lin L,Struyf F,Dubin G,HPV-010 Study Group.

    更新日期:2014-01-01 00:00:00

  • Product review: avelumab, an anti-PD-L1 antibody.

    abstract::Although immunotherapies have been employed for many decades, immune checkpoint inhibitors have only recently entered the oncologic landscape. Avelumab is a fully human monoclonal antibody that blocks the interaction between PD-L1 on tumor cells and PD-1 on T cells, thereby inhibiting immunosuppression in the tumor mi...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.1080/21645515.2018.1551671

    authors: Collins JM,Gulley JL

    更新日期:2019-01-01 00:00:00

  • The polio endgame.

    abstract::Paralytic poliomyelitis is a disease that became a public health issue at the beginning of the twentieth century and was more or less eliminated in developed countries by the early 1970s. The Global Polio Eradication Initiative of WHO has now eradicated endemic polio from all but three countries although re-introducti...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.4161/21645515.2014.981115

    authors: Minor P

    更新日期:2014-01-01 00:00:00

  • Public health and economic impact of switching from a trivalent to a quadrivalent inactivated influenza vaccine in Mexico.

    abstract::Most influenza vaccines in Mexico are trivalent, containing two influenza A strains and a single B strain. Quadrivalent influenza vaccines (QIVs) extend protection by including an additional B strain to cover both co-circulating B lineages. Here, we retrospectively estimated how a switch to QIV in Mexico would have im...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2019.1678997

    authors: Ruiz-Palacios GM,Beigel JH,Guerrero ML,Bellier L,Tamayo R,Cervantes P,Alvarez FP,Galindo-Fraga A,Aguilar-Ituarte F,Lopez JG

    更新日期:2020-04-02 00:00:00

  • Suppression of TGF-β and IL-10 receptors on self-differentiated dendritic cells by short-hairpin RNAs enhanced activation of effector T-cells against cholangiocarcinoma cells.

    abstract::Cholangiocarcinoma (CCA) is an aggressive tumor that is associated with high rates of recurrence and mortality. This is due, in part, to the fact that CCA cells and their microenvironment secrete immunosuppressive cytokines, transforming growth factor-β (TGF-β) and interleukin-10 (IL-10), that inhibit dendritic cell (...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2019.1701913

    authors: Thepmalee C,Panya A,Sujjitjoon J,Sawasdee N,Poungvarin N,Junking M,Yenchitsomanus PT

    更新日期:2020-10-02 00:00:00

  • Glycoconjugate vaccine strategies for protection against invasive Salmonella infections.

    abstract::Salmonella enterica serovars Typhi and Paratyphi A and B and certain non-typhoidal Salmonella enterica (NTS) serovars are important causes of invasive Salmonella disease worldwide. NTS serovars Typhimurium and Enteritidis typically cause gastroenteritis in healthy children and adults in industrialized countries but in...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.4161/hv.19158

    authors: Simon R,Levine MM

    更新日期:2012-04-01 00:00:00

  • Acute gastroenteritis hospitalizations among children aged < 5 years before and after introduction of rotavirus vaccines: a hospital-based surveillance study in Galicia, Spain.

    abstract::Rotavirus vaccines were licensed in Spain between late 2006 and early 2007. Rotavirus vaccination was recommended but not reimbursed by the Spanish National Health System. Significant coverage rates have been reached in Galicia, with an average of 47% since the period July 2007-June 2008. We aim to explore eventual va...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.4161/hv.20178

    authors: Martinón-Torres F,Martinón-Torres N,Bouzón Alejandro M,Redondo Collazo L,Pértega-Díaz S,Seoane-Pillado MT,Aboal Viñas J,San-Martín M

    更新日期:2012-07-01 00:00:00

  • Serotype distribution and clinical characteristics associated with streptococcus pneumoniae among Chinese children and adults with invasive pneumococcal disease: a multicenter observational study.

    abstract::Few studies in China focused on serotypes of Streptococcus pneumoniae in patients with invasive pneumococcal disease (IPD). We aimed at investigating the serotype distribution for IPD-causing S. pneumoniae and vaccine coverage among Chinese children and adults. This was a multicenter, observational study to collect S....

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1757996

    authors: Li MC,Wang Y,Zhang H,Liu Y,Chen XJ,Yang HW,Ma P,Wang DC,Zhang BC,Dong AY,Wang CX,Li Y,Bai P,Tang WM,Wang J,Shao ZJ,Xu YC

    更新日期:2020-06-12 00:00:00

  • Influenza immunization of chronically ill children in pediatric tertiary care hospitals.

    abstract::Despite a publicly funded immunization program and continuous promotional efforts, vaccine uptake for seasonal influenza in Quebec (Canada) remains under its goal of 80%. Missed opportunities can explain the low influenza vaccine rates among chronically ill children. To address that, demonstration projects using the l...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.4161/21645515.2014.970498

    authors: Dubé E,Gagnon D,Huot C,Paré R,Jacques S,Kossowski A,Quach C,Landry M

    更新日期:2014-01-01 00:00:00

  • Post-marketing surveillance of adverse events following measles, mumps, rubella and varicella (MMRV) vaccine: retrospecive study in apulia region (ITALY), 2009-2017.

    abstract::Since 2006, some Italian Regions introduced the active offer of measles, mumps, rubella, and varicella (MMRV) vaccine for all newborns during the second years of life. In 2011, Italian Drug Authority (AIFA) recommended the discontinuation of the MMRV use for an increased risk of febrile seizures following vaccination;...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2019.1704124

    authors: Stefanizzi P,De Nitto S,Patano F,Bianchi FP,Ferorelli D,Stella P,Ancona D,Bavaro V,Tafuri S

    更新日期:2020-08-02 00:00:00

  • Percentages of PD-1+CD4+T cells and PD-L1+DCs are increased and sPD-1 level is elevated in patients with immune thrombocytopenia.

    abstract::The present study is to measure the expression of programmed death (PD)-1 / programmed death ligand-1 (PD-L1) negative costimulatory molecules, soluble format sPD-1 in patients with immune thrombocytopenia (ITP), and to investigate their correlation with the secretion of cytokines. A total of 35 patients with ITP were...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2017.1342913

    authors: Wang Y,Pang N,Wang X,Liu Y,Wang X,Wang L,Sun M,Yasen H,Zhao F,Fan W,Guo X,Ding J

    更新日期:2018-04-03 00:00:00

  • Hepatitis B vaccination among 1997-2011 birth cohorts in rural China: the potential for further catch-up vaccination and factors associated with infant coverage rates.

    abstract::Hepatitis B vaccination rates in China have recently increased. This study aimed to investigate infant vaccination coverage for birth cohorts from 1997 to 2011 in rural regions and to assess catch-up vaccination potential. We used questionnaire-based interviews from a cross-section of 6,529 individuals from seven prov...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2018.1520582

    authors: Wangen KR,Zhu D,Wang J

    更新日期:2019-01-01 00:00:00

  • Current and future effects of varicella and herpes zoster vaccination in Germany - Insights from a mathematical model in a country with universal varicella vaccination.

    abstract::Varicella zoster virus (VZV) is primarily known for causing varicella in childhood, but can reactivate again as herpes zoster (HZ) after a period of latency, mainly in persons older than 50 years. Universal varicella vaccination was introduced in Germany in 2004, while HZ vaccination has not been recommended yet. We a...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2015.1135279

    authors: Horn J,Karch A,Damm O,Kretzschmar ME,Siedler A,Ultsch B,Weidemann F,Wichmann O,Hengel H,Greiner W,Mikolajczyk RT

    更新日期:2016-07-02 00:00:00

  • Overview of cancer vaccines: considerations for development.

    abstract::Cancer immunotherapy has seen a tremendous number of failures and only few recent regulatory successes. This is a review dedicated to determine major regulatory and developmental issues around cancer immunotherapeutics. A three pillar approach should be used in setting a development path: discovery platforms and suffi...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.4161/hv.20518

    authors: Kudrin A

    更新日期:2012-09-01 00:00:00

  • Noninvasive vaccination against infectious diseases.

    abstract::The development of a successful vaccine, which should elicit a combination of humoral and cellular responses to control or prevent infections, is the first step in protecting against infectious diseases. A vaccine may protect against bacterial, fungal, parasitic, or viral infections in animal models, but to be effecti...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.1080/21645515.2018.1461296

    authors: Zheng Z,Diaz-Arévalo D,Guan H,Zeng M

    更新日期:2018-07-03 00:00:00