Overexpressed oncogenic tumor-self antigens.

Abstract:

:Overexpressed tumor-self antigens represent the largest group of candidate vaccine targets. Those exhibiting a role in oncogenesis may be some of the least studied but perhaps most promising. This review considers this subset of self antigens by highlighting vaccine efforts for some of the better known members and focusing on TPD52, a new promising vaccine target. We shed light on the importance of both preclinical and clinical vaccine studies demonstrating that tolerance and autoimmunity (presumed to preclude this class of antigens from vaccine development) can be overcome and do not present the obstacle that might have been expected. The potential of this class of antigens for broad application is considered, possibly in the context of low tumor burden or adjuvant therapy, as is the need to understand mechanisms of tolerance that are relatively understudied.

journal_name

Hum Vaccin Immunother

authors

Bright RK,Bright JD,Byrne JA

doi

10.4161/hv.29475

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

3297-305

issue

11

eissn

2164-5515

issn

2164-554X

journal_volume

10

pub_type

杂志文章,评审
  • Immunogenicity and safety of purified chick-embryo cell rabies vaccine under Zagreb 2-1-1 or 5-dose Essen regimen in Chinese children 6 to 17 years old and adults over 50 years: a randomized open-label study.

    abstract::The aim of this Phase IIIb, open-label, randomized study was to demonstrate the non-inferiority of immune responses and to assess the safety of a purified chick-embryo cell rabies vaccine (PCECV) in healthy Chinese children (6 to 17 years) and older adults (≥51 years) following 2 alternative intramuscular (IM) simulat...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,随机对照试验

    doi:10.4161/21645515.2014.994460

    authors: Li R,Li Y,Wen S,Wen H,Nong Y,Mo Z,Xie F,Pellegrini M

    更新日期:2015-01-01 00:00:00

  • A microarray method for identifying tumor antigens by screening a tumor cDNA expression library against cancer sera.

    abstract::The immune system responds to tumor cells. The challenge has been how to effectively use these responses to treat or protect against cancer. Toward the goal of developing a cancer vaccine, we are pursuing methodologies for the discovery and testing of useful antigens. We present an array-based approach for discovering...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.4161/hv.25634

    authors: Whittemore K,Sykes K

    更新日期:2013-10-01 00:00:00

  • Post-marketing surveillance of adverse events following measles, mumps, rubella and varicella (MMRV) vaccine: retrospecive study in apulia region (ITALY), 2009-2017.

    abstract::Since 2006, some Italian Regions introduced the active offer of measles, mumps, rubella, and varicella (MMRV) vaccine for all newborns during the second years of life. In 2011, Italian Drug Authority (AIFA) recommended the discontinuation of the MMRV use for an increased risk of febrile seizures following vaccination;...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2019.1704124

    authors: Stefanizzi P,De Nitto S,Patano F,Bianchi FP,Ferorelli D,Stella P,Ancona D,Bavaro V,Tafuri S

    更新日期:2020-08-02 00:00:00

  • Emerging anti-cancer antibodies and combination therapies targeting HER3/ERBB3.

    abstract::Cancer progression depends on stepwise accumulation of oncogenic mutations and a select group of growth factors essential for tumor growth, metastasis and angiogenesis. Agents blocking the epidermal growth factor receptor (EGFR, also called HER1 and ERBB1) and the co-receptor called HER2/ERBB2 have been approved over ...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.1080/21645515.2015.1102809

    authors: Gaborit N,Lindzen M,Yarden Y

    更新日期:2016-03-03 00:00:00

  • Two-year antibody persistence in children vaccinated at 12-15 months with a measles-mumps-rubella virus vaccine without human serum albumin.

    abstract::One combined measles-mumps-rubella (MMR) vaccine without Human Serum Albumin (HSA) is currently licensed in the USA (M-M-R II; Merck, USA) and another has been developed (Priorix™ [MMR-RIT, GSK, Belgium]). In this follow-up study, children from USA or Puerto Rico, who had received one dose of M-M-R II or MMR-RIT at 12...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/21645515.2017.1309486

    authors: Berry AA,Abu-Elyazeed R,Diaz-Perez C,Mufson MA,Harrison CJ,Leonardi M,Twiggs JD,Peltier C,Grogg S,Carbayo A,Shapiro S,Povey M,Baccarini C,Innis BL,Henry O

    更新日期:2017-07-03 00:00:00

  • Mixing of diphtheria, tetanus, and acellular pertussis (DTaP) vaccines in a population of children in managed care.

    abstract::The Advisory Committee on Immunization Practices recommends administering diphtheria, tetanus and acellular pertussis (DTaP) vaccines to children at 2, 4, 6, 15-18 months, and 4-6 y of age; preferably with the same-brand vaccine for the whole series. We estimated age-appropriate DTaP dose completion and the proportion...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.4161/21645515.2014.985506

    authors: Masseria C,Buikema AR,Liu F,Krishnarajah G

    更新日期:2015-01-01 00:00:00

  • Persistence of immune memory among adults with normal and high antibody response to primary hepatitis B vaccination: Results from a five-year follow-up study in China.

    abstract::Immune memory after hepatitis B vaccination among adults is still under investigation. In this study, adults who had normal and high antibody response to the primary series of hepatitis B vaccination (HepB) were followed up at 5 years after the primary immunization. A booster dose was given to those who had low hepati...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2018.1477911

    authors: Wu W,Lv J,Liu J,Yan B,Feng Y,Xu A,Zhang L

    更新日期:2018-01-01 00:00:00

  • Mechanistic insight into the induction of cellular immune responses by encapsulated and admixed archaeosome-based vaccine formulations.

    abstract::Archaeosomes are liposomes formulated using total polar lipids (TPLs) or semi-synthetic glycolipids derived from archaea. Conventional archaeosomes with entrapped antigen exhibit robust adjuvant activity as demonstrated by increased antigen-specific humoral and cell-mediated responses and enhanced protective immunity ...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1788300

    authors: Agbayani G,Jia Y,Akache B,Chandan V,Iqbal U,Stark FC,Deschatelets L,Lam E,Hemraz UD,Régnier S,Krishnan L,McCluskie MJ

    更新日期:2020-09-01 00:00:00

  • Allergen immunotherapy for allergic respiratory diseases.

    abstract::Allergen specific immunotherapy involves the repeated administration of allergen products in order to induce clinical and immunologic tolerance to the offending allergen. Immunotherapy is the only etiology-based treatment that has the potential for disease modification, as reflected by longterm remission following its...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.4161/hv.21629

    authors: Cappella A,Durham SR

    更新日期:2012-10-01 00:00:00

  • Influences on HPV vaccination across levels of the social ecological model: perspectives from state level stakeholders.

    abstract::Nationally, human papillomavirus (HPV) vaccination rates fall short of the Healthy People 2020 goal of 80% completion. Although strategies to increase these rates exist, low rates persist. We used concept mapping with state-level stakeholders to better understand barriers and facilitators to HPV vaccination. Concept m...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1839290

    authors: Ryan G,Avdic L,Daly E,Askelson N,Farris PE,Shannon J,McRee AL,Hanson J,Kenyon DB,Seegmiller L

    更新日期:2020-12-17 00:00:00

  • Human papillomavirus vaccination uptake: a longitudinal study showing ethnic differences in the influence of the intention-to-vaccinate among parent-daughter dyads.

    abstract:INTRODUCTION:It is unclear what role daughters play in the decision-making process regarding HPV vaccination. Therefore, we explored the impact of HPV vaccination intention among parents and their 12-13 year-old daughters on HPV vaccination uptake. METHODS:In February 2014 parents/guardians and their 12-13 year-old da...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1808411

    authors: Jongen VW,van der Loeff MFS,Boyd A,Petrignani M,Prins M,van der Wal M,Nielen A,de Melker H,Paulussen TGWM,Alberts CJ

    更新日期:2020-09-23 00:00:00

  • Ebola vaccines in clinical trial: The promising candidates.

    abstract::Ebola virus disease (EVD) has become a great threat to humans across the world in recent years. The 2014 Ebola epidemic in West Africa caused numerous deaths and attracted worldwide attentions. Since no specific drugs and treatments against EVD was available, vaccination was considered as the most promising and effect...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.1080/21645515.2016.1225637

    authors: Wang Y,Li J,Hu Y,Liang Q,Wei M,Zhu F

    更新日期:2017-01-02 00:00:00

  • Panblok-H1+advax H1N1/2009pdm vaccine: Insights into rapid development of a delta inulin adjuvanted recombinant pandemic influenza vaccine.

    abstract::Timely vaccine supply is critical during influenza pandemics but is impeded by current virus-based manufacturing methods. The 2009 H1N1/2009pdm 'swine flu' pandemic reinforced the need for innovation in pandemic vaccine design. We report on insights gained during rapid development of a pandemic vaccine based on recomb...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1080/21645515.2017.1279765

    authors: Honda-Okubo Y,Rajapaksha H,Sajkov D,Gordon D,Cox MMJ,Petrovsky N

    更新日期:2017-06-03 00:00:00

  • Comparison of immune persistence among inactivated and live attenuated hepatitis a vaccines 2 years after a single dose.

    abstract:OBJECTIVE:Compare immune persistence from one dose of each of 3 different hepatitis A vaccines when given to school-age children: a domestic, live attenuated hepatitis A vaccine (H2 vaccine); a domestic inactivated hepatitis A vaccine (Healive®); and an imported, inactivated hepatitis A vaccine (Havrix®),. METHODS:Sch...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/21645515.2015.1134069

    authors: Zhang X,An J,Tu A,Liang X,Cui F,Zheng H,Tang Y,Liu J,Wang X,Zhang N,Li H

    更新日期:2016-09-01 00:00:00

  • Updated medical care cost estimates for HPV-associated cancers: implications for cost-effectiveness analyses of HPV vaccination in the United States.

    abstract::Estimates of medical care costs for cervical and other cancers associated with human papillomavirus (HPV) are higher in studies published in recent years than in studies published before 2012. The purpose of this report is (1) to review and summarize the recent cancer cost estimates and (2) to illustrate how the estim...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.1080/21645515.2019.1603562

    authors: Chesson HW,Meites E,Ekwueme DU,Saraiya M,Markowitz LE

    更新日期:2019-01-01 00:00:00

  • Improving vaccine uptake: an overview.

    abstract::A task group was formed with the aim to improve the quality of the service offered by ensuring that all children waiting for an appointment for vaccination would be offered one at the earliest opportunity. Children aged between 12 mo-5 y that were not completely immunized for their age were identified and included in ...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.4161/hv.24695

    authors: Falconer MA

    更新日期:2013-06-01 00:00:00

  • Kyasanur Forest Disease in India: innovative options for intervention.

    abstract::Kyasanur Forest Disease (KFD) is a tick-borne hemorrhagic fever of human, caused by Kyasanur forest disease virus (KFDV) in India. The tick, Haemaphysalis spinigera, has been incriminated as the vector of KFDV. In human, KFD clinically presents with high fever, frontal headache, and severe myalgia, followed by bleedin...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.1080/21645515.2019.1602431

    authors: Rajaiah P

    更新日期:2019-01-01 00:00:00

  • Understanding motivators and barriers of hospital-based obstetric and pediatric health care worker influenza vaccination programs in Australia.

    abstract::Understanding motivators and barriers of health care worker (HCW) vaccination programs is important for determining strategies to improve uptake. The aim of this study was to explore key drivers and HCW decision making related to recommended vaccines and seasonal influenza vaccination programs. We used a qualitative a...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2016.1153204

    authors: Tuckerman JL,Shrestha L,Collins JE,Marshall HS

    更新日期:2016-07-02 00:00:00

  • Influenza immunization during pregnancy: Benefits for mother and infant.

    abstract::The serious consequences of influenza infection during pregnancy have been recognized for almost a century. In this article, we reviewed the evidence on the immunogenicity, safety and impact of maternal influenza immunization for both mother and child. After vaccination, pregnant women have similar protective titers o...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.1080/21645515.2016.1215392

    authors: Sakala IG,Honda-Okubo Y,Fung J,Petrovsky N

    更新日期:2016-12-01 00:00:00

  • Factors affecting the seroconversion rate of 12-month-old babies after the first injection of measles vaccine in the southeast of Iran.

    abstract::Within the past few years, several measles outbreaks have occurred in the southeast of Iran. To learn about the effectiveness of the immunization services for producing a serologic response against measles, this follow-up study was designed and implemented in the southeast of Iran. In Iran, all routine immunization se...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2016.1214346

    authors: Zahraei SM,Izadi S,Mokhtari-Azad T

    更新日期:2016-12-01 00:00:00

  • Biosafety considerations for attenuated measles virus vectors used in virotherapy and vaccination.

    abstract::Attenuated measles virus (MV) is one of the most effective and safe vaccines available, making it attractive candidate vector to prevent infectious diseases. Attenuated MV have acquired the ability to use the complement regulator CD46 as a major receptor to mediate virus entry and intercellular fusion. Therefore, atte...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.1080/21645515.2015.1122146

    authors: Baldo A,Galanis E,Tangy F,Herman P

    更新日期:2016-05-03 00:00:00

  • Safety and immunogenicity of trivalent inactivated influenza vaccine in adults 60 years of age and older: a phase II, a randomized, comparative trial in Kazakhstan.

    abstract:BACKGROUND:The study was aimed at comparative evaluation of seasonal influenza vaccine RIBSP versus commercial vaccine VAXIGRIP® for immunogenicity and safety in the course of clinical trial phase II on healthy subjects up to 60 years. METHODS:The trial involved 150 subjects in randomized 2:1 groups that received eith...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2019.1705691

    authors: Sarsenbayeva G,Issagulov T,Kassenov M,Abitay R,Orynbayev M,Stukova M,Pisareva M,Davlyatshin T,Lespek K,Khairullin B

    更新日期:2020-08-02 00:00:00

  • Comparative assessment of immunization coverage of migrant children between national immunization program vaccines and non-national immunization program vaccines in East China.

    abstract::This study aimed to describe the disparities in immunization coverage between National Immunization Program (NIP) vaccines and non-NIP vaccines in Yiwu and to identify potential determinants. A face-to-face interview-based questionnaire survey among 423 migrant children born from 1 June 2010 to 31 May 2013 was conduct...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2015.1012015

    authors: Hu Y,Luo S,Tang X,Lou L,Chen Y,Guo J

    更新日期:2015-01-01 00:00:00

  • Public awareness regarding children vaccination in Jordan.

    abstract::Immunization can contribute to a dramatic reduction in number of vaccine-preventable diseases among children. The aim of this study is to investigate mothers' awareness about child vaccines and vaccination in Jordan. This study was a community-based, cross-sectional study that was performed at public places in Irbid C...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.4161/hv.28608

    authors: Masadeh MM,Alzoubi KH,Al-Azzam SI,Al-Agedi HS,Abu Rashid BE,Mukattash TL

    更新日期:2014-01-01 00:00:00

  • Application of a novel nanoemulsion adjuvant for rabies vaccine which stabilizes a Krebs cycle intermediate (SDH) in an animal model.

    abstract::Rabies is the most lethal zoonotic, vaccine-preventable viral disease in the world. Its treatment is complicated by insufficient vaccine supply and the requirement for four to five repeated injections, as commercially available inactivated rabies lack adjuvant and have low immunogenicity. In this study, we focused on ...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2018.1531966

    authors: Ze L,Zonglin L,Ya'Nan W,Shaohui S,Huijuan Y,Wei C,Li W,Liao G

    更新日期:2019-01-01 00:00:00

  • Priming effect of bivalent and quadrivalent vaccine for HPV 31/33/45/52: an exploratory analysis from two clinical trials.

    abstract::The main objective of this post hoc analysis is to compare the magnitude of the immune response to HPV31/33/45/52 and 58 after a dose of 9vHPV vaccine given to naïve (previously unvaccinated) subjects and subjects previously vaccinated with a dose of 2vHPV or 4vHPV vaccine. Results from two clinical trials conducted i...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2019.1669413

    authors: Sauvageau C,Panicker G,Unger ER,De Serres G,Schiller J,Ouakki M,Gilca V

    更新日期:2020-03-03 00:00:00

  • Efficacy of Mycobacterium vaccae immunotherapy for patients with tuberculosis: A systematic review and meta-analysis.

    abstract::Tuberculosis (TB) is a significant cause of illness and death worldwide. Immunotherapy has been investigated in the treatment of TB. The purpose of this study was to perform a meta-analysis investigating the effectiveness of the M. vaccae vaccine. Medline, Cochrane, EMBASE, and Google Scholar were searched until Novem...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,meta分析,评审

    doi:10.1080/21645515.2017.1335374

    authors: Huang CY,Hsieh WY

    更新日期:2017-09-02 00:00:00

  • Pertussis in early life: underdiagnosed, severe, and risky disease. A seven-year experience in a pediatric tertiary-care hospital.

    abstract:AIM:Pertussis continues to be a common worldwide infection in pediatric and adult populations. We aimed to study epidemiological and clinical characteristics of infants and children admitted for pertussis to a tertiary-care hospital and to investigate the risk factors for pediatric intensive care unit (PICU) admission....

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1791617

    authors: Di Camillo C,Vittucci AC,Antilici L,Ciarlitto C,Linardos G,Concato C,Lancella L,Villani A

    更新日期:2020-08-05 00:00:00

  • A phase 1, randomized, open-label, active-controlled trial to assess the safety of a meningococcal serogroup B bivalent rLP2086 vaccine in healthy adults.

    abstract::Neisseria meningitidis serogroup B (MnB) is a significant cause of invasive meningococcal disease, but no broadly protective vaccine is yet approved. We assessed the safety and immunogenicity of a bivalent MnB vaccine composed of lipidated subfamily A and B variants of recombinant LP2086 (rLP2086, also known as factor...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,随机对照试验

    doi:10.4161/hv.19983

    authors: Sheldon EA,Schwartz H,Jiang Q,Giardina PC,Perez JL

    更新日期:2012-07-01 00:00:00

  • Narrowing the policy gap: lessons from years 2 and 3 of the British Columbia influenza prevention policy.

    abstract::Influenza can be potentially fatal to vulnerable populations, particularly those in the hospital. Canada's National Advisory Committee on Immunization recommends that health-care workers (HCW) be immunized against influenza partly to avoid infecting high-risk populations. However, influenza immunization rates among HC...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2019.1692561

    authors: Di Castri AM,Halperin DM,McPherson CM,Nunn A,Farrar-Muir H,Kwong JC,Henry B

    更新日期:2020-06-02 00:00:00