Overexpressed oncogenic tumor-self antigens.

Abstract:

:Overexpressed tumor-self antigens represent the largest group of candidate vaccine targets. Those exhibiting a role in oncogenesis may be some of the least studied but perhaps most promising. This review considers this subset of self antigens by highlighting vaccine efforts for some of the better known members and focusing on TPD52, a new promising vaccine target. We shed light on the importance of both preclinical and clinical vaccine studies demonstrating that tolerance and autoimmunity (presumed to preclude this class of antigens from vaccine development) can be overcome and do not present the obstacle that might have been expected. The potential of this class of antigens for broad application is considered, possibly in the context of low tumor burden or adjuvant therapy, as is the need to understand mechanisms of tolerance that are relatively understudied.

journal_name

Hum Vaccin Immunother

authors

Bright RK,Bright JD,Byrne JA

doi

10.4161/hv.29475

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

3297-305

issue

11

eissn

2164-5515

issn

2164-554X

journal_volume

10

pub_type

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