The clinical, immunological and microbiological impact of the 10-valent pneumococcal-Protein D conjugate vaccine in children with recurrent protracted bacterial bronchitis, chronic suppurative lung disease and bronchiectasis: A multi-centre, double-blind,

Abstract:

:We aimed to determine the efficacy of the 10-valent pneumococcal-Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in children aged 18-months to <18-years with recurrent protracted bacterial bronchitis (rPBB), chronic suppurative lung disease (CSLD) or bronchiectasis. In a multi-centre, double-blind randomised controlled trial, children received two doses, 2-months apart of the 10vPHiD-CV or quadrivalent meningococcal-ACYW135 conjugate vaccine. Active surveillance for acute exacerbations, respiratory symptoms and antibiotic use was undertaken through to 12-months after the second vaccine dose (clinical cohort only). Serum, saliva and nasopharyngeal swabs were collected to measure immunological and microbiological effects (immunology cohort). Between December 2012 and August 2015, 62 children were enrolled onto the clinical protocol (1 excluded from clinical analyses due to unblinding), while 74 contributed to the immunology cohort (overall mean age = 6.8-years (standard deviation = 3.7), 42 (56.8%) male). The absolute risk difference comparing the 10vPHiD-CV group (n = 31 children) to the MenACYW135 group (n = 30 children) for acute exacerbations was -0.5 exacerbations/100-weeks at risk (95% confidence interval (CI) -2.0, 0.9). Compared to the MenACYW135 group, children who received the 10vPHiD-CV were less likely to have respiratory symptoms in each fortnight of surveillance (incidence density ratio (IDR) 0.82, 95%CI 0.61, 1.10) and required fewer short-course (<14-days duration) antibiotics (IDR 0.81, 95% CI 0.61, 1.09). The vaccine was immunogenic and no serious adverse events related to the vaccine were reported. In conclusion, 10vPHiD-CV might have a future role in managing children with rPBB, CSLD and bronchiectasis, but larger multicentre trials are needed to confirm or refute findings from this preliminary study.

journal_name

Hum Vaccin Immunother

authors

O'Grady KF,Chang AB,Cripps A,Mulholland EK,Smith-Vaughan H,Wood N,Danchin M,Thornton R,Wilson A,Torzillo PJ,Morris PM,Richmond P,Rablin S,Arnold D,Connor A,Goyal V,Stoney T,Perrett K,Grimwood K

doi

10.1080/21645515.2018.1488562

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

2768-2779

issue

11

eissn

2164-5515

issn

2164-554X

journal_volume

14

pub_type

杂志文章
  • Coverage of HPV-Related Information on Chinese Social Media: a Content Analysis of Articles in Zhihu.

    abstract::Information about human papillomavirus (HPV) disease and its vaccination has been increasingly communicated and discussed on social media platforms. The current study aims to investigate the coverage of HPV-related information on one of the most popular Chinese social media - Zhihu. Data for this study were user-gener...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1729028

    authors: Li J,Zheng H

    更新日期:2020-10-02 00:00:00

  • Prevalent levels of RSV serum neutralizing antibodies in healthy adults outside the RSV-season.

    abstract::One of the main challenges in early clinical research with respiratory syncytial virus (RSV) live-attenuated vaccines (LAVs) is to assess immunogenicity in healthy adults. Healthy adults will have preexisting levels of serum neutralizing antibodies that could prematurely neutralize the LAV and underestimate the potent...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2019.1688040

    authors: Van Der Plas JL,Verdijk P,Van Brummelen EMJ,Jeeninga RE,Roestenberg M,Burggraaf J,Kamerling IMC

    更新日期:2020-06-02 00:00:00

  • Vaccination among Polish university students. Knowledge, beliefs and anti-vaccination attitudes.

    abstract::Anti-vaccination movement has existed as long as the vaccines themselves, but its mode of action and social influences evolved over time. Such attitude with no doubt has negative impact on vaccination rates and eradication of infectious diseases. In this study, we used an online survey to examine vaccination attitudes...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2017.1365994

    authors: Zarobkiewicz MK,Zimecka A,Zuzak T,Cieślak D,Roliński J,Grywalska E

    更新日期:2017-11-02 00:00:00

  • Rotavirus genotypes in Malaysia and universal rotavirus vaccination.

    abstract::Group A rotavirus (RV-A) genotypes isolated in Malaysia was studied to estimate the effectiveness of a universal RV-A vaccination in Malaysia. A simple mathematical model was used, with input from a two-year, two-center, prospective study on hospitalization of RV-A gastroenteritis (RVGE) in young children, published d...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.4161/hv.21577

    authors: Lee WS,Lim BT,Chai PF,Kirkwood CD,Lee JK

    更新日期:2012-10-01 00:00:00

  • HPV vaccine hesitancy among parents in Italy: a cross-sectional study.

    abstract::This cross-sectional survey determined the vaccine hesitancy related to Human papillomavirus (HPV) and the determinants among parents of adolescents aged 12 and 13 years in Italy. Data was collected through a self-administered questionnaire. Two-thirds of the parents (66.7%) had heard of HPV infection and knew that th...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1744367

    authors: Della Polla G,Pelullo CP,Napolitano F,Angelillo IF

    更新日期:2020-11-01 00:00:00

  • Rotavirus capsid VP6 protein acts as an adjuvant in vivo for norovirus virus-like particles in a combination vaccine.

    abstract::Rotavirus (RV) and norovirus (NoV) are the 2 leading causes of acute viral gastroenteritis worldwide. We have developed a non-live NoV and RV vaccine candidate consisting of NoV virus-like particles (VLPs) and recombinant polymeric RV VP6 protein produced in baculovirus-insect cell expression system. Both components h...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2015.1099772

    authors: Blazevic V,Malm M,Arinobu D,Lappalainen S,Vesikari T

    更新日期:2016-03-03 00:00:00

  • DNA is an efficient booster of dendritic cell-based vaccine.

    abstract::DC-based therapeutic vaccines as a promising strategy against chronic infections and cancer have been validated in several clinical trials. However, DC-based vaccines are complex and require many in vitro manipulations, which makes this a personalized and expensive therapeutic approach. In contrast, DNA-based vaccines...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2015.1020265

    authors: Li J,Valentin A,Beach RK,Alicea C,Felber BK,Pavlakis GN

    更新日期:2015-01-01 00:00:00

  • Utilization pattern of Haemophilus influenza type b vaccine in eight provinces of China.

    abstract:OBJECTIVE:In China, Hib vaccine is a private-sector vaccine that is an option for parents to select to give to their children; it must be paid for out-of-pocket because it is not included in the government's Expanded Program on Immunization (EPI). We evaluated utilization patterns of Hib vaccine to provide evidence in ...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2017.1420447

    authors: Li Y,Yue C,Wang Y,Zhu X,Martin K,Scherpbier RW,Liu J,Wang Z,Ma Y,Cheng H,Zhang Z,Wang Q,Li H,Xie S,Xiao Q,Wang H,An Z

    更新日期:2018-04-03 00:00:00

  • Type I interferon related genes are common genes on the early stage after vaccination by meta-analysis of microarray data.

    abstract::The objective of this study was to find common immune mechanism across different kinds of vaccines. A meta-analysis of microarray datasets was performed using publicly available microarray Gene Expression Omnibus (GEO) and Array Express data sets of vaccination records. Seven studies (out of 35) were selected for this...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,meta分析

    doi:10.1080/21645515.2015.1008884

    authors: Zhang J,Shao J,Wu X,Mao Q,Wang Y,Gao F,Kong W,Liang Z

    更新日期:2015-01-01 00:00:00

  • Key considerations for successful implementation of maternal immunization programs in low and middle income countries.

    abstract::The Maternal Neonatal Tetanus Elimination program is proof of concept for the feasibility and potential for maternal immunization to reduce neonatal mortality particularly in low and middle-income countries. Introduction of any additional vaccine into the antenatal space, such as Influenza and Pertussis, and potential...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.1080/21645515.2018.1564433

    authors: Krishnaswamy S,Lambach P,Giles ML

    更新日期:2019-01-01 00:00:00

  • Lot-to-lot consistency study of the fully liquid pentavalent DTwP-HepB-Hib vaccine Quinvaxem (®) demonstrating clinical equivalence, suitability of the vaccine as a booster and concomitant administration with measles vaccine.

    abstract::This double-blind, randomized study evaluated the immunogenicity and safety of three production lots of the fully liquid combination DTwP-Hep-Hib vaccine, Quinvaxem (®) (Crucell, The Netherlands) in 360 healthy infants aged 42-64 d old given at 6, 10 and 14 weeks of age (Core Study). The Core Study was followed by an...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.4161/hv.21095

    authors: Aspinall S,Traynor D,Bedford P,Hartmann K

    更新日期:2012-08-01 00:00:00

  • On-label and off-label use of high-dose influenza vaccine in the United States, 2010-2012.

    abstract::High-dose inactivated, influenza vaccine was licensed by the FDA in December 2009 for adults aged 65 y and older. The ACIP did not issue or state a preference for a specific vaccine in the elderly population. The extent of its on-label and off-label use is unknown. Using the MarketScan Commercial Claims and Encounters...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2015.1011026

    authors: McGrath LJ,Brookhart MA

    更新日期:2015-01-01 00:00:00

  • Long-term immunogenicity and safety of tetravalent dengue vaccine (CYD-TDV) in healthy populations in Singapore and Vietnam: 4-year follow-up of randomized, controlled, phase II trials.

    abstract::Dengue is prevalent in the Asia-Pacific region. Participants of two immunogenicity and safety phase II studies conducted in Singapore and Vietnam (NCT0088089 and NCT00875524, respectively) were followed for up to four years after third vaccine dose of a recombinant, live, attenuated, tetravalent dengue vaccine (CYD-TD...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/21645515.2019.1578595

    authors: Tran NH,Chansinghakul D,Chong CY,Low CY,Shek LP,Luong CQ,Fargo C,Wartel TA,Sun S,Skipetrova A,Bouckenooghe A

    更新日期:2019-01-01 00:00:00

  • Mass psychogenic illness following HPV immunization in Carmen de Bolivar, Colombia (2014): more uncertainty is required.

    abstract::The interesting article by Simas et. al. describes an outbreak case with over 600 individuals who exhibited neurological symptoms and which occurred in a town located at the northern region of Colombia in 2014. The community associated this event to the second-dose vaccination campaign against the Human Papillomavirus...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 评论,杂志文章

    doi:10.1080/21645515.2019.1577676

    authors: Idrovo AJ,Pinilla-Monsalve GD,Manrique-Hernández EF

    更新日期:2019-01-01 00:00:00

  • Current issues facing the introduction of human papillomavirus vaccine in China and future prospects.

    abstract::The introduction of human papillomavirus (HPV) vaccination in China aims to prevent HPV infection in all women. The issues that China might face include high cost of vaccines made in other countries, shortage in HPV vaccine supply, negative events attributed to vaccination (whether justified or not) that jeopardizes t...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.1080/21645515.2019.1611157

    authors: Wong LP,Han L,Li H,Zhao J,Zhao Q,Zimet GD

    更新日期:2019-01-01 00:00:00

  • Intravescical instillation of Calmette-Guérin bacillus and COVID-19 risk.

    abstract::It has been theorized that Calmette-Guérin bacillus may prevent or reduce the severity of COVID-19 through a nonspecific stimulation of the immune system. A preliminary assessment of SARS-CoV-2 infection rates and outcomes among 2803 individuals affected with high risk non-muscle-invasive bladder cancer and treated wi...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1805994

    authors: Fedeli U,Porreca A,Colicchia M,Schievano E,Artibani W,Biasio LR,Palù G

    更新日期:2020-09-03 00:00:00

  • The cellular and humoral immune response to influenza vaccination is comparable in asthmatic and healthy subjects.

    abstract::Annual influenza vaccination is recommended as a preventive measure for all patients with asthma since asthma exacerbations in children and adults are associated to viral infections including influenza. There is concern about the adequate immune response in asthmatics with ICS treatment. The production of antibodies t...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1759995

    authors: Velasco-Medina AA,García-León ML,Velázquez-Sámano G,Wong-Chew RM

    更新日期:2020-05-21 00:00:00

  • Challenges to optimising uptake and delivery of a HPV vaccination programme for men who have sex with men.

    abstract::Human papillomavirus (HPV) vaccine programmes targeted at men who have sex with men (MSM) may reduce HPV-related disease burden among this at-risk group in countries where uptake of the vaccine among adolescent girls is sub-optimal and where adolescent boys are not routinely vaccinated. There are challenges to optimis...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2018.1560783

    authors: Forster AS,Gilson R

    更新日期:2019-01-01 00:00:00

  • Dissecting the indirect effects caused by vaccines into the basic elements.

    abstract::Vaccination directly protects vaccinated individuals, but it also has the potential for indirectly protecting the unvaccinated in a population (herd protection). Unintended negative consequences such as the re-manifestation of infection, mainly expressed as age shifts, result from vaccination programs as well. We disc...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.1080/21645515.2015.1052196

    authors: Scarbrough Lefebvre CD,Terlinden A,Standaert B

    更新日期:2015-01-01 00:00:00

  • Safety and immunogenicity of 3 seasonal trivalent influenza vaccines in the Chinese military.

    abstract::Influenza, caused by the influenza virus, is a contagious acute viral respiratory disease with a high incidence rate and wide and rapid spread. Influenza-related morbidity, mortality, and hospitalization rates remain high and are increasing continuously in high-risk groups, with a significant impact on human health an...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/21645515.2016.1194147

    authors: Gao D,Yang H,Deng B,Yin G,Song W,Zhang H,Li Y

    更新日期:2016-10-02 00:00:00

  • Antigenic variability: Obstacles on the road to vaccines against traditionally difficult targets.

    abstract::Despite the impressive impact of vaccines on public health, the success of vaccines targeting many important pathogens and cancers has to date been limited. The burden of infectious diseases today is mainly caused by antigenically variable pathogens (AVPs), which escape immune responses induced by prior infection or v...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.1080/21645515.2016.1191718

    authors: Servín-Blanco R,Zamora-Alvarado R,Gevorkian G,Manoutcharian K

    更新日期:2016-10-02 00:00:00

  • From infancy and beyond… ensuring a lifetime of hepatitis B virus (HBV) vaccine-induced immunity.

    abstract::Despite the long-term efficacy and immune persistence observed following HBV vaccination of infants, the need for a booster dose following infant immunization continues to be deliberated. Evidence from HBV booster dose response studies and long-term immunization program reviews are the basis for the recommendation tha...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2018.1462428

    authors: Osiowy C

    更新日期:2018-01-01 00:00:00

  • An overview of sipuleucel-T: autologous cellular immunotherapy for prostate cancer.

    abstract::Sipuleucel-T, the first autologous active cellular immunotherapy approved by the United States Food and Drug Administration, is designed to stimulate an immune response to prostate cancer. Sipuleucel-T is manufactured by culturing a patient's peripheral blood mononuclear cells (including antigen presenting cells) with...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.4161/hv.18769

    authors: Wesley JD,Whitmore J,Trager J,Sheikh N

    更新日期:2012-04-01 00:00:00

  • Noninvasive vaccination against infectious diseases.

    abstract::The development of a successful vaccine, which should elicit a combination of humoral and cellular responses to control or prevent infections, is the first step in protecting against infectious diseases. A vaccine may protect against bacterial, fungal, parasitic, or viral infections in animal models, but to be effecti...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.1080/21645515.2018.1461296

    authors: Zheng Z,Diaz-Arévalo D,Guan H,Zeng M

    更新日期:2018-07-03 00:00:00

  • Immunogenicity and safety of intramuscular versus subcutaneous administration of a combined measles, mumps, rubella, and varicella vaccine to children 12 to 18 months of age.

    abstract::This randomized trial conducted in France compared intramuscular (IM) and subcutaneous (SC) administration of two doses of a measles, mumps, rubella, and varicella (MMRV) combination vaccine (ProQuad®) administered one month apart to 405 children 12-18 months of age (NCT00402831). The 2-dose regimen of MMRV administer...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/21645515.2018.1549452

    authors: Haas H,Richard P,Eymin C,Fiquet A,Kuter B,Soubeyrand B

    更新日期:2019-01-01 00:00:00

  • Pembrolizumab (Keytruda).

    abstract::The programmed cell death protein 1 (PD1) is one of the checkpoints that regulates the immune response. Ligation of PD1 with its ligands PDL1 and PDL2 results in transduction of negative signals to T-cells. PD1 expression is an important mechanism contributing to the exhausted effector T-cell phenotype. The expression...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章,评审

    doi:10.1080/21645515.2016.1199310

    authors: Kwok G,Yau TC,Chiu JW,Tse E,Kwong YL

    更新日期:2016-11-01 00:00:00

  • Understanding motivators and barriers of hospital-based obstetric and pediatric health care worker influenza vaccination programs in Australia.

    abstract::Understanding motivators and barriers of health care worker (HCW) vaccination programs is important for determining strategies to improve uptake. The aim of this study was to explore key drivers and HCW decision making related to recommended vaccines and seasonal influenza vaccination programs. We used a qualitative a...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2016.1153204

    authors: Tuckerman JL,Shrestha L,Collins JE,Marshall HS

    更新日期:2016-07-02 00:00:00

  • Optimized and enhanced DNA plasmid vector based in vivo construction of a neutralizing anti-HIV-1 envelope glycoprotein Fab.

    abstract::Monoclonal antibody preparations have demonstrated considerable clinical utility in the treatment of specific malignancies, as well as inflammatory and infectious diseases. Antibodies are conventionally delivered by passive administration, typically requiring costly large-scale laboratory development and production. A...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.4161/hv.26498

    authors: Muthumani K,Flingai S,Wise M,Tingey C,Ugen KE,Weiner DB

    更新日期:2013-10-01 00:00:00

  • EV71 vaccination impact on the incidence of encephalitis in patients with hand, foot and mouth disease.

    abstract::In order to analyze the effect of EV71 vaccination on the incidence of encephalitis in patients with HFMD, 292 cases were vaccinated, and 2,486 cases were not vaccinated which were collected in 2018 and 2019. It shows that the incidence rate of encephalitis in vaccinated patients was significantly lower than that in n...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2020.1851129

    authors: Li J,Yin X,Lin A,Nie X,Liu L,Liu S,Li N,Wang P,Song S,Wang S,Xu D

    更新日期:2021-01-31 00:00:00

  • Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.

    abstract::Different strategies have been proposed for the development of protein subunit vaccine candidates for tuberculosis (TB), which shows better safety than other types of candidates and the currently used Bacillus Calmette-Guérin (BCG) vaccine. In order to develop more effective protein subunits depending on the mechanism...

    journal_title:Human vaccines & immunotherapeutics

    pub_type: 杂志文章

    doi:10.1080/21645515.2015.1037057

    authors: Teng X,Tian M,Li J,Tan S,Yuan X,Yu Q,Jing Y,Zhang Z,Yue T,Zhou L,Fan X

    更新日期:2015-01-01 00:00:00