Evaluation of immunogen delivery by DNA immunization using non-invasive bioluminescence imaging.

abstract：:Rotavirus (RV) infection is the primary cause for childhood gastroenteritis worldwide. In Korea, RV infection is most common among children less than 5 years of age. This post-licensure study was conducted to further evaluate the RV vaccine (RIX4414) to provide additional local clinical data to the Korean Food and Dru...

journal_title：Human vaccines & immunotherapeutics

authors： Kim JS,Bae CW,Lee KY,Park MS,Choi YY,Kim KN,Kim JD,Park WS,Sin JB,Kim EA,Lee SG,Kim CS,Cha SH,Hong YJ,Shin SM,Shim GH,Choi KM,Yang JW,Liu A,Suryakiran PV,Han HH

更新日期：2012-06-01 00:00:00

abstract：:Hepatitis E virus (HEV) infection is one of the main causes of acute hepatitis worldwide. A recombinant hepatitis E vaccine, HEV 239, has been licensed in China for immunizing adults of 16 y old and above. The vaccine antigen contains pORF2 aa 368 - 606 of the HEV genotype 1 expressed in E. coli. The quality of the va...

journal_title：Human vaccines & immunotherapeutics

authors： Li SW,Zhao Q,Wu T,Chen S,Zhang J,Xia NS

更新日期：2015-01-01 00:00:00

abstract：:Immune memory after hepatitis B vaccination among adults is still under investigation. In this study, adults who had normal and high antibody response to the primary series of hepatitis B vaccination (HepB) were followed up at 5 years after the primary immunization. A booster dose was given to those who had low hepati...

journal_title：Human vaccines & immunotherapeutics

authors： Wu W,Lv J,Liu J,Yan B,Feng Y,Xu A,Zhang L

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the incidence of adverse events following administration of an Inactivated poliomyelitis vaccine (IPV) manufactured by Serum Institute of India Pvt. Ltd., Pune, India. METHODS:A single 0.5 ml dose of the IPV was administered intramuscularly to children attending private clinics or out-patient dep...

journal_title：Human vaccines & immunotherapeutics

authors： Sharma H,Dhere R,Parekh S,Shewale S

更新日期：2017-11-02 00:00:00

abstract：:Influenza and pneumococcal vaccinations are recommended in the elderly to reduce life-threatening complications like sepsis. Protection may be reduced with increasing age. We aimed to assess the effectiveness of both vaccines in the elderly by performing a retrospective cohort study of 138,877 individuals aged ≥60 y i...

journal_title：Human vaccines & immunotherapeutics

authors： Rose N,Storch J,Mikolajetz A,Lehmann T,Reinhart K,Pletz MW,Forstner C,Vollmar HC,Freytag A,Fleischmann-Struzek C

更新日期：2021-01-07 00:00:00

abstract：:HIV-infected patients are 30- to 100-fold more susceptible to invasive pneumococcal diseases than are healthy adults. Pneumococcal vaccination may be the best way to decrease the large pneumococcal disease burden, but the optimal timing of vaccination is still unclear. In this study, HIV-infected subjects aged ≥18 yea...

journal_title：Human vaccines & immunotherapeutics

authors： Song JY,Cheong HJ,Noh JY,Choi MJ,Yoon JG,Kim WJ

更新日期：2020-01-01 00:00:00

abstract：:Influenza, caused by the influenza virus, is a contagious acute viral respiratory disease with a high incidence rate and wide and rapid spread. Influenza-related morbidity, mortality, and hospitalization rates remain high and are increasing continuously in high-risk groups, with a significant impact on human health an...

journal_title：Human vaccines & immunotherapeutics

authors： Gao D,Yang H,Deng B,Yin G,Song W,Zhang H,Li Y

更新日期：2016-10-02 00:00:00

abstract：:Salmonella enterica serovar Paratyphi A (S. Paratyphi A) is a human restricted pathogen that can cause systemic infection (paratyphoid fever) with recently increased incidence particularly in developing countries. Currently there is no licensed vaccine for prevention of infection from S. Paratyphi A. In this study the...

journal_title：Human vaccines & immunotherapeutics

authors： Ali A,An SJ,Cui C,Haque A,Carbis R

更新日期：2014-01-01 00:00:00

abstract：:The purpose of this study is to mine CAR-T patents and therapies under development, to design a landscape of the sector and to understand key therapy segments and their current trends. The study analyzed the entire market, consisting of 1624 patent families and 509 biologics under development, to depict an overview of...

journal_title：Human vaccines & immunotherapeutics

authors： Picanco-Castro V,Gonçalves Pereira C,Swiech K,Ribeiro Malmegrim KC,Tadeu Covas D,Silveira Porto G

更新日期：2020-06-02 00:00:00

abstract：:Measles virus (MV) is the only human virus within the morbillivirus genus of the Paramyxoviridae. The veterinary members are canine distemper virus (CDV), peste des petits ruminants virus (PPRV), Rinderpest Virus (RPV) as well as the marine morbilliviruses phocine distemper virus (PDV), dolphin morbillivirus (DMV) and...

journal_title：Human vaccines & immunotherapeutics

authors： Cosby SL,Weir L

更新日期：2018-01-02 00:00:00

abstract：:Human papillomavirus (HPV) vaccines are efficacious against HPV infections and associated lesions in women HPV-naïve at vaccination. However, vaccine efficacy (VE) against oncogenic, high-risk HPV (HR-HPV) types in women infected with any other HR-HPV type at first vaccination (baseline) remains unclear. This post-hoc...

journal_title：Human vaccines & immunotherapeutics

authors： Hu S,Xu X,Zhu F,Hong Y,Hu Y,Zhang X,Pan Q,Zhang W,Zhang C,Yang X,Yu J,Zhu J,Zhu Y,Chen F,Zhao S,Karkada N,Tang H,Bi D,Struyf F,Zhao F

更新日期：2020-11-12 00:00:00

abstract：:Archaeosomes are liposomes formulated using total polar lipids (TPLs) or semi-synthetic glycolipids derived from archaea. Conventional archaeosomes with entrapped antigen exhibit robust adjuvant activity as demonstrated by increased antigen-specific humoral and cell-mediated responses and enhanced protective immunity ...

journal_title：Human vaccines & immunotherapeutics

authors： Agbayani G,Jia Y,Akache B,Chandan V,Iqbal U,Stark FC,Deschatelets L,Lam E,Hemraz UD,Régnier S,Krishnan L,McCluskie MJ

更新日期：2020-09-01 00:00:00

abstract：:In 1796, Edward Jenner introduced the concept of vaccination with cowpox virus, an Orthopoxvirus within the family Poxviridae that elicits cross protective immunity against related orthopoxviruses, including smallpox virus (variola virus). Over time, vaccinia virus (VACV) replaced cowpox virus as the smallpox vaccine,...

journal_title：Human vaccines & immunotherapeutics

authors： Verardi PH,Titong A,Hagen CJ

更新日期：2012-07-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the most common cause of respiratory tract infections in both children and elderly people. In this study we evaluated the short- and long-term protective efficacy of a single intranasal (IN) immunization with a RSV vaccine formulation consisting of a codon-optimized fusion (F) prot...

journal_title：Human vaccines & immunotherapeutics

authors： Garg R,Latimer L,Gerdts V,Potter A,van Drunen Littel-van den Hurk S

更新日期：2017-12-02 00:00:00

abstract：:Few studies in China focused on serotypes of Streptococcus pneumoniae in patients with invasive pneumococcal disease (IPD). We aimed at investigating the serotype distribution for IPD-causing S. pneumoniae and vaccine coverage among Chinese children and adults. This was a multicenter, observational study to collect S....

journal_title：Human vaccines & immunotherapeutics

authors： Li MC,Wang Y,Zhang H,Liu Y,Chen XJ,Yang HW,Ma P,Wang DC,Zhang BC,Dong AY,Wang CX,Li Y,Bai P,Tang WM,Wang J,Shao ZJ,Xu YC

更新日期：2020-06-12 00:00:00

abstract：:Better adjuvants are needed for vaccines against seasonal influenza. TLR7 agonists are potent activators of innate immune responses and thereby may be promising adjuvants. Among the imidazoquinoline compounds, 1-benzyl-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine (BBIQ) was reported to be a highly active TLR7 agonist but...

journal_title：Human vaccines & immunotherapeutics

authors： Kaushik D,Dhingra S,Patil MT,Piplani S,Khanna V,Honda-Okubo Y,Li L,Fung J,Sakala IG,Salunke DB,Petrovsky N

更新日期：2020-08-02 00:00:00

abstract：:The Maternal Neonatal Tetanus Elimination program is proof of concept for the feasibility and potential for maternal immunization to reduce neonatal mortality particularly in low and middle-income countries. Introduction of any additional vaccine into the antenatal space, such as Influenza and Pertussis, and potential...

journal_title：Human vaccines & immunotherapeutics

authors： Krishnaswamy S,Lambach P,Giles ML

更新日期：2019-01-01 00:00:00

abstract：:In order to analyze the effect of EV71 vaccination on the incidence of encephalitis in patients with HFMD, 292 cases were vaccinated, and 2,486 cases were not vaccinated which were collected in 2018 and 2019. It shows that the incidence rate of encephalitis in vaccinated patients was significantly lower than that in n...

journal_title：Human vaccines & immunotherapeutics

authors： Li J,Yin X,Lin A,Nie X,Liu L,Liu S,Li N,Wang P,Song S,Wang S,Xu D

更新日期：2021-01-31 00:00:00

abstract：:In the clinical trials of the quadrivalent human papillomavirus (qHPV) vaccine, antibodies were measured by a competitive Luminex immunoassay (HPV-4 cLIA). A nine-valent HPV (9vHPV) vaccine targeting the types in the qHPV vaccine (HPV6/11/16/18), as well as 5 of the next most frequent HPV types found in cervical cance...

journal_title：Human vaccines & immunotherapeutics

authors： Roberts C,Green T,Hess E,Matys K,Brown MJ,Haupt RM,Luxembourg A,Vuocolo S,Saah A,Antonello J

更新日期：2014-01-01 00:00:00

abstract：:Hepatitis A is a vaccine-preventable infection caused by the HA virus (HAV) with transitional to intermediate endemicity in China. An inactivated vaccine first licensed in China in 2010 (Avaxim® 80U Pediatric) is indicated for primary and booster vaccination in children from 12 months to 15 years of age. This Phase IV...

journal_title：Human vaccines & immunotherapeutics

authors： Shi N,Rasuli A,Thollot Y

更新日期：2019-01-01 00:00:00

abstract：:Dynamically changing social situation associated with migrations, increasing freedom rights, popularity of anti-vaccine movements and the resulting from that decrease in herd immunity, forces the medical society and the governments of various countries to reflect on the attitude toward vaccinations. Issues of freedoms...

journal_title：Human vaccines & immunotherapeutics

authors： Patryn RK,Zagaja A

更新日期：2016-08-02 00:00:00

abstract：:Pertussis has had a resurgence with the highest incidence and complication rates in young infants, and deaths occurring mainly at < age 3 months. Infants are infected by older individuals whose immunity has waned. Strategies such as targeted immunization of infant caregivers have had limited success. Pertussis vaccina...

journal_title：Human vaccines & immunotherapeutics

authors： Healy CM

更新日期：2016-08-02 00:00:00

abstract：OBJECTIVES:Economic evaluations on influenza vaccination from low resource settings are scarce and have not been evaluated using a systematic approach. Our objective was to conduct a systematic review on the value for money of influenza vaccination in low- and middle-income countries. METHODS:PubMed and EMBASE were se...

journal_title：Human vaccines & immunotherapeutics

authors： Ott JJ,Klein Breteler J,Tam JS,Hutubessy RC,Jit M,de Boer MR

更新日期：2013-07-01 00:00:00

abstract：:Immunocompromising conditions increase the risk of invasive pneumococcal disease (IPD). Vaccine uptake in patients with these conditions may be low in part because of concerns about decreased immunogenicity and safety in these high-risk groups. We conducted a literature search to identify publications describing antib...

journal_title：Human vaccines & immunotherapeutics

authors： Chilson E,Scott DA,Schmoele-Thoma B,Watson W,Moran MM,Isturiz R

更新日期：2020-11-01 00:00:00

abstract：:This study aims to quantify clinical and economic burden of rotavirus (RV) infection pre- and post-vaccine introduction in commercially insured and Medicaid populations. Beneficiaries with continuous enrollment for ≥6 months while <5 years of age were identified separately in commercial (2000-2010) and Medicaid (2002-...

journal_title：Human vaccines & immunotherapeutics

authors： Krishnarajah G,Demissie K,Lefebvre P,Gaur S,Sheng Duh M

更新日期：2014-01-01 00:00:00

abstract：:This study aimed to describe the disparities in immunization coverage between National Immunization Program (NIP) vaccines and non-NIP vaccines in Yiwu and to identify potential determinants. A face-to-face interview-based questionnaire survey among 423 migrant children born from 1 June 2010 to 31 May 2013 was conduct...

journal_title：Human vaccines & immunotherapeutics

authors： Hu Y,Luo S,Tang X,Lou L,Chen Y,Guo J

更新日期：2015-01-01 00:00:00

abstract：:Maternal immunization holds tremendous promise to improve maternal and neonatal health for a number of infectious conditions. The unique susceptibilities of pregnant women to infectious conditions, as well as the ability of maternally-derived antibody to offer vital neonatal protection (via placental transfer), togeth...

journal_title：Human vaccines & immunotherapeutics

authors： Moniz MH,Beigi RH

更新日期：2014-01-01 00:00:00

abstract：UNLABELLED:NmenB vaccine (4CMenB) is now available, but studies on the cost-effectiveness of vaccine introduction in a country outbreak situation are lacking. The aim of this study was to evaluate the cost-effectiveness of 4CMenB in the context of a hypothetical epidemic outbreak in Chile. We analyzed the direct and in...

journal_title：Human vaccines & immunotherapeutics

authors： Izquierdo G,Torres JP,Santolaya ME,Valenzuela MT,Vega J,Chomali M

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:It is unclear what role daughters play in the decision-making process regarding HPV vaccination. Therefore, we explored the impact of HPV vaccination intention among parents and their 12-13 year-old daughters on HPV vaccination uptake. METHODS:In February 2014 parents/guardians and their 12-13 year-old da...

journal_title：Human vaccines & immunotherapeutics

authors： Jongen VW,van der Loeff MFS,Boyd A,Petrignani M,Prins M,van der Wal M,Nielen A,de Melker H,Paulussen TGWM,Alberts CJ

更新日期：2020-09-23 00:00:00

abstract：:Variations of post-translational modifications are important for stability and in vivo behavior of therapeutic antibodies. A recombinant humanized anti-cocaine monoclonal antibody (h2E2) was characterized for heterogeneity of N-linked glycosylation and disulfide bonds. In addition, charge heterogeneity, which is parti...

journal_title：Human vaccines & immunotherapeutics

authors： Kirley TL,Norman AB

更新日期：2015-01-01 00:00:00