Harnessing benefit from targeting tumor associated carbohydrate antigens.

abstract：:WHO defines adolescence age between 10 to 19 years. In India, there are 243 million adolescents which constitute 21 per cent of the total population. The global burden of disease in adolescents (2011) reports that the total number of disability adjusted life years (DALYs) worldwide among adolescents were 230 million w...

journal_title：Human vaccines & immunotherapeutics

authors： Verma R,Khanna P,Chawla S

更新日期：2015-01-01 00:00:00

abstract：:Cancer immunotherapy has seen a tremendous number of failures and only few recent regulatory successes. This review is a first in a series dedicated to evaluate the status of current global clinical pipeline for cancer vaccines. Apart from specific areas of medical need which can be addressed by cancer vaccines, the a...

journal_title：Human vaccines & immunotherapeutics

authors： Kudrin A,Hanna MG Jr

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:We studied completeness and timeliness of vaccination and determinants for low and delayed uptake in children born between 2008 and 2009 in Zhejiang province in eastern China. METHODS:We used data from a cross-sectional cluster survey conducted in 2011, which included 1146 children born from 1 Jan 2008 to 3...

journal_title：Human vaccines & immunotherapeutics

authors： Hu Y,Chen Y,Guo J,Tang X,Shen L

更新日期：2014-01-01 00:00:00

abstract：:This article aims to explore the trends of monoclonal antibodies (mAbs) research and commercialization, mainly to examine the development trajectories by a contrastive exploration of successful and unsuccessful mAb. This work is based on two sets of R&D project reports, consisting of 517 discontinued mAb project repor...

journal_title：Human vaccines & immunotherapeutics

authors： Lai Y,Suo S,Wang R,Kong X,Hu Y,Tang D,Shi H,Chen S,Hu H

更新日期：2018-04-03 00:00:00

abstract：:In a blinded randomized trial, preoperative receipt of the Merck V710 Staphylococcus aureus vaccine was associated with a higher mortality rate than placebo in patients who later developed postoperative S. aureus infections. Of the tested patients, all 12 V710 recipients (but only 1 of 13 placebo recipients) with unde...

journal_title：Human vaccines & immunotherapeutics

authors： McNeely TB,Shah NA,Fridman A,Joshi A,Hartzel JS,Keshari RS,Lupu F,DiNubile MJ

更新日期：2014-01-01 00:00:00

abstract：:Vaginal and vulvar cancers do not account for a large proportion of gynecologic malignancies but their impact is significant. Both vaginal and vulvar lesions have precursors and display levels of dysplasia before progression to invasive disease. Human Papillomavirus (HPV) is a known causative agent of such dysplasia a...

journal_title：Human vaccines & immunotherapeutics

authors： Buchanan TR,Graybill WS,Pierce JY

更新日期：2016-06-02 00:00:00

abstract：:Background: Rotavirus (RV) is worldwide an important cause of acute gastroenteritis (AGE) in infants and young children. There is no specific treatment for AGE caused by RV (RVGE) but since 2006 two safe and effective vaccines have been available. RV vaccination was included in the national immunization program (NIP) ...

journal_title：Human vaccines & immunotherapeutics

authors： Tafalla M,Gardovska D,Gopala K,Kozlovska L

更新日期：2019-01-01 00:00:00

abstract：:Purpose: Gaps remain in the public's knowledge of the human papillomavirus (HPV). We assessed racial/ethnic and gender disparities in knowledge and awareness of HPV and the HPV vaccine among US adults. METHODS:Data from the Health Information National Trends Survey 4 Cycle 3 (September - December 2013) and Cycle 4 (A...

journal_title：Human vaccines & immunotherapeutics

authors： Adjei Boakye E,Tobo BB,Rojek RP,Mohammed KA,Geneus CJ,Osazuwa-Peters N

更新日期：2017-11-02 00:00:00

abstract：:Cancer immunotherapy has seen a tremendous number of failures and only few recent regulatory successes. This is a review dedicated to determine major regulatory and developmental issues around cancer immunotherapeutics. A three pillar approach should be used in setting a development path: discovery platforms and suffi...

journal_title：Human vaccines & immunotherapeutics

authors： Kudrin A

更新日期：2012-09-01 00:00:00

abstract：:The present study is to measure the expression of programmed death (PD)-1 / programmed death ligand-1 (PD-L1) negative costimulatory molecules, soluble format sPD-1 in patients with immune thrombocytopenia (ITP), and to investigate their correlation with the secretion of cytokines. A total of 35 patients with ITP were...

journal_title：Human vaccines & immunotherapeutics

authors： Wang Y,Pang N,Wang X,Liu Y,Wang X,Wang L,Sun M,Yasen H,Zhao F,Fan W,Guo X,Ding J

更新日期：2018-04-03 00:00:00

abstract：:Allergen-specific IgG produced by immune mothers is associated with less predisposition to allergy development in their children. This finding has been described by several groups over the last few decades, but the mechanisms by which maternal IgG can inhibit allergy development are still not fully understood. With th...

journal_title：Human vaccines & immunotherapeutics

authors： Victor JR

更新日期：2017-03-04 00:00:00

abstract：:Malaria remains one of the most significant infectious diseases worldwide. Concordant with scaled intervention efforts and the emphasis of elimination and eradication on the agenda of many malaria control programs, the development of a malaria vaccine that reduces transmission of the parasite from human host to mosqui...

journal_title：Human vaccines & immunotherapeutics

authors： Nixon CP

更新日期：2016-12-01 00:00:00

abstract：:Adjuvants produce complex, but often subtle, effects on vaccine-induced immune responses that, nonetheless, play a critical role in vaccine efficacy. In-depth profiling of vaccine-induced cytokine, cellular, and antibody responses ("immunoprofiling") combined with machine-learning holds the promise of identifying adju...

journal_title：Human vaccines & immunotherapeutics

authors： Chaudhury S,Duncan EH,Atre T,Dutta S,Spring MD,Leitner WW,Bergmann-Leitner ES

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:Periodical assessments of population susceptibility to polioviruses (PV) is essential for evaluating population protection and planning appropriate vaccination strategies. The aim of the current work was to assess serological protective titers against all three polioviruses in the general population of Flore...

journal_title：Human vaccines & immunotherapeutics

authors： Giammanco GM,Bechini A,Urone N,Bonura F,Li Muli S,De Grazia S,Bellini I,Tiscione E,Boccalini S,Nastasi A

更新日期：2018-01-01 00:00:00

abstract：:Dendritic cells (DCs) are known to be a set of morphology, structure and function of heterogeneous professional antigen presenting cells (APCs), as well as the strongest functional antigen presenting cells, which can absorb, process and present antigens. As the key regulators of innate and adaptive immune responses, D...

journal_title：Human vaccines & immunotherapeutics

authors： Chen P,Liu X,Sun Y,Zhou P,Wang Y,Zhang Y

更新日期：2016-03-03 00:00:00

abstract：:Rabies is the most lethal zoonotic, vaccine-preventable viral disease in the world. Its treatment is complicated by insufficient vaccine supply and the requirement for four to five repeated injections, as commercially available inactivated rabies lack adjuvant and have low immunogenicity. In this study, we focused on ...

journal_title：Human vaccines & immunotherapeutics

authors： Ze L,Zonglin L,Ya'Nan W,Shaohui S,Huijuan Y,Wei C,Li W,Liao G

更新日期：2019-01-01 00:00:00

abstract：:Malaria has long been recognized as a public health problem. At the community level, vector control, and antimalarial medicines are the main means for reducing incidence, morbidity, and mortality of malaria. A vaccine not only would bring streamlining in the prevention of morbidity and mortality from malaria but also ...

journal_title：Human vaccines & immunotherapeutics

authors： Jindal H,Bhatt B,Malik JS,Sk S,Mehta B

更新日期：2014-01-01 00:00:00

abstract：:Leukemia-associated antigens such as proteinase-3 (PR3) and Wilms' tumor protein-1 (WT-1) are potential targets of T-cell responses, which can be monitored by T-cell assays within vaccination trials and after allogeneic stem cell transplantation (SCT). In chronic myeloid leukemia (CML) an aberrant cytokine profile of ...

journal_title：Human vaccines & immunotherapeutics

authors： Flörcken A,van Lessen A,Terwey TH,Dörken B,Arnold R,Pezzutto A,Westermann J

更新日期：2013-06-01 00:00:00

abstract：:In patients undergoing immunotherapy, the quality of the immune response is reduced, which may negatively affect the efficacy of vaccination. This study was conducted in order to evaluate the efficacy of the hepatitis B virus (HBV) vaccine in patients using immunomodulators. Seronegative patients for HBV who were usin...

journal_title：Human vaccines & immunotherapeutics

authors： Haykir Solay A,Eser F

更新日期：2019-01-01 00:00:00

abstract：:Abrin, obtained from the seeds of Abrus precatorius plant, is a potent toxin belonging to the family of type II ribosome-inactivating proteins. Recently, a recombinant vaccine consisting of the A subunits of abrin and its homolog Abrus precatorius agglutinin (APA) was demonstrated to protect mice from abrin lethality....

journal_title：Human vaccines & immunotherapeutics

authors： Kumar MS,Karande AA

更新日期：2016-01-01 00:00:00

abstract：:HIV sequence diversity and the propensity of eliciting immunodominant responses targeting inessential variable regions are hurdles in the development of an effective AIDS vaccine. We developed a DNA vaccine comprising conserved elements (CE) of SIV p27Gag and HIV-1 Env and found that priming vaccination with CE DNA is...

journal_title：Human vaccines & immunotherapeutics

authors： Hu X,Lu Z,Valentin A,Rosati M,Broderick KE,Sardesai NY,Marx PA,Mullins JI,Pavlakis GN,Felber BK

更新日期：2018-01-01 00:00:00

abstract：:The serious consequences of influenza infection during pregnancy have been recognized for almost a century. In this article, we reviewed the evidence on the immunogenicity, safety and impact of maternal influenza immunization for both mother and child. After vaccination, pregnant women have similar protective titers o...

journal_title：Human vaccines & immunotherapeutics

authors： Sakala IG,Honda-Okubo Y,Fung J,Petrovsky N

更新日期：2016-12-01 00:00:00

abstract：:Maternal vaccination offers the opportunity to protect pregnant women and their infants against potentially serious disease. As both pregnant women and their newborns are vulnerable to severe illness, the potential public health impact of mass maternal vaccination programs is remarkable. Several high-income countries ...

journal_title：Human vaccines & immunotherapeutics

authors： Regan AK

更新日期：2016-12-01 00:00:00

abstract：:A universal vaccine that provides long-lasting protection from both epidemic and pandemic influenza viruses remains the "holy grail" of influenza vaccine research. Though virus neutralization assays are the current benchmark of measuring vaccine effectiveness, it is clear that Fc-receptor functions can drastically imp...

journal_title：Human vaccines & immunotherapeutics

authors： Jegaskanda S,Vanderven HA,Wheatley AK,Kent SJ

更新日期：2017-06-03 00:00:00

abstract：AIM:Pertussis continues to be a common worldwide infection in pediatric and adult populations. We aimed to study epidemiological and clinical characteristics of infants and children admitted for pertussis to a tertiary-care hospital and to investigate the risk factors for pediatric intensive care unit (PICU) admission....

journal_title：Human vaccines & immunotherapeutics

authors： Di Camillo C,Vittucci AC,Antilici L,Ciarlitto C,Linardos G,Concato C,Lancella L,Villani A

更新日期：2020-08-05 00:00:00

abstract：:While most pathogens infect via mucosal surfaces, most current vaccines are delivered by injection. This situation remains despite awareness of the potential benefits of mucosal delivery for inducing protection against mucosa-infecting pathogens. A major obstacle to the development of such vaccines is the paucity of s...

journal_title：Human vaccines & immunotherapeutics

authors： Timothy AA,Tokanovic A,Snibson KJ,Edwards SJ,Pearse MJ,Scheerlinck JP,Sutton P

更新日期：2015-01-01 00:00:00

abstract：:The aim of this Phase IIIb, open-label, randomized study was to demonstrate the non-inferiority of immune responses and to assess the safety of a purified chick-embryo cell rabies vaccine (PCECV) in healthy Chinese children (6 to 17 years) and older adults (≥51 years) following 2 alternative intramuscular (IM) simulat...

journal_title：Human vaccines & immunotherapeutics

authors： Li R,Li Y,Wen S,Wen H,Nong Y,Mo Z,Xie F,Pellegrini M

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Febrile seizure is the most common childhood neurological disorder, is an important health problem with potential short- and long-term complications, also leading to economic burden and increased parental anxiety about fevers and seizures occurring in their children. There are no routine recommendation to de...

journal_title：Human vaccines & immunotherapeutics

authors： Carman KB,Calik M,Karal Y,Isikay S,Kocak O,Ozcelik A,Yazar AS,Nuhoglu C,Sag C,Kilic O,Dinleyici M,Lacinel Gurlevik S,Yimenicioglu S,Ekici A,Perk P,Tosun A,Isik I,Yarar C,Arslantas D,Dinleyici EC

更新日期：2019-01-01 00:00:00

abstract：:Rubella is a contagious viral disease, which mainly affects the fetus, if the mother is infected in the 1st trimester of her pregnancy. All adolescent girls (aged 11 to 19 y) and women of childbearing age are at risk of developing rubella. This disease is mild and self-limiting, and incubation period is 2-3 weeks. Hum...

journal_title：Human vaccines & immunotherapeutics

authors： Verma R,Khanna P,Chawla S

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:In China, Hib vaccine is a private-sector vaccine that is an option for parents to select to give to their children; it must be paid for out-of-pocket because it is not included in the government's Expanded Program on Immunization (EPI). We evaluated utilization patterns of Hib vaccine to provide evidence in ...

journal_title：Human vaccines & immunotherapeutics

authors： Li Y,Yue C,Wang Y,Zhu X,Martin K,Scherpbier RW,Liu J,Wang Z,Ma Y,Cheng H,Zhang Z,Wang Q,Li H,Xie S,Xiao Q,Wang H,An Z

更新日期：2018-04-03 00:00:00