Dendritic cell targeted vaccines: Recent progresses and challenges.

Abstract:

:Dendritic cells (DCs) are known to be a set of morphology, structure and function of heterogeneous professional antigen presenting cells (APCs), as well as the strongest functional antigen presenting cells, which can absorb, process and present antigens. As the key regulators of innate and adaptive immune responses, DCs are at the center of the immune system and capable of interacting with both B cells and T cells, thereby manipulating the humoral and cellular immune responses. DCs provide an essential link between the innate and adaptive immunity, and the strong immune activation function of DCs and their properties of natural adjuvants, make them a valuable target for antigen delivery. Targeting antigens to DC-specific endocytic receptors in combination with the relevant antibodies or ligands along with immunostimulatory adjuvants has been recently recognized as a promising strategy for designing an effective vaccine that elicits a strong and durable T cell response against intracellular pathogens and cancer. This opinion article provides a brief summary of the rationales, superiorities and challenges of existing DC-targeting approaches.

journal_name

Hum Vaccin Immunother

authors

Chen P,Liu X,Sun Y,Zhou P,Wang Y,Zhang Y

doi

10.1080/21645515.2015.1105415

subject

Has Abstract

pub_date

2016-03-03 00:00:00

pages

612-22

issue

3

eissn

2164-5515

issn

2164-554X

journal_volume

12

pub_type

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