Abstract:
:"Non-specific effects" of vaccines go beyond the specific protective effects against the targeted diseases. They, if real, could theoretically be beneficial, neutral or negative. This article intends to answer the following questions: Do the non-specific effects of vaccines exist? Almost certainly yes, and they can be important in low-income countries Are non-specific effects also present in high-income countries? At least to some extent, it seems quite logical Can non-specific effects be systematically identified by the current systems of side effects/unintended reactions monitoring? Most likely not Could the Institute of Medicine proposals and some ongoing attempts solve the issue? It seems unlikely Could there be better, feasible and ethically acceptable ways to achieve the aforementioned objective? A proposal is presented about this issue, with the potential both to solve the problem with the most valid methods, and to overcome the ethical problems that have so far precluded the adoption of RCTs to study possible vaccine non-specific effects, monitored by long follow-up.
journal_name
Hum Vaccin Immunotherjournal_title
Human vaccines & immunotherapeuticsauthors
Donzelli A,Schivalocchi A,Giudicatti Gdoi
10.1080/21645515.2018.1502520subject
Has Abstractpub_date
2018-01-01 00:00:00pages
2904-2910issue
12eissn
2164-5515issn
2164-554Xjournal_volume
14pub_type
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journal_title:Human vaccines & immunotherapeutics
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Human vaccines & immunotherapeutics
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journal_title:Human vaccines & immunotherapeutics
pub_type: 杂志文章,随机对照试验
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journal_title:Human vaccines & immunotherapeutics
pub_type: 杂志文章
doi:10.1080/21645515.2015.1011026
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pub_type: 杂志文章
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doi:10.1080/21645515.2020.1791509
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journal_title:Human vaccines & immunotherapeutics
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Human vaccines & immunotherapeutics
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pub_type: 杂志文章,随机对照试验
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更新日期:2012-07-01 00:00:00
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pub_type: 杂志文章
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