Mechanisms and pathways of innate immune activation and regulation in health and cancer.

Abstract:

:Research on innate immune signaling and regulation has recently focused on pathogen recognition receptors (PRRs) and their signaling pathways. Members of PRRs sense diverse microbial invasions or danger signals, and initiate innate immune signaling pathways, leading to proinflammatory cytokines production, which, in turn, instructs adaptive immune response development. Despite the diverse functions employed by innate immune signaling to respond to a variety of different pathogens, the innate immune response must be tightly regulated. Otherwise, aberrant, uncontrolled immune responses will lead to harmful, or even fatal, consequences. Therefore, it is essential to better discern innate immune signaling and many regulators, controlling various signaling pathways, have been identified. In this review, we focus on the recent advances in our understanding of the activation and regulation of innate immune signaling in the host response to pathogens and cancer.

journal_name

Hum Vaccin Immunother

authors

Cui J,Chen Y,Wang HY,Wang RF

doi

10.4161/21645515.2014.979640

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

3270-85

issue

11

eissn

2164-5515

issn

2164-554X

journal_volume

10

pub_type

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