Abstract：
:The molecular epidemiology of 38 non-duplicate toxigenic Clostridioides (previously Clostridium) difficile isolates from inpatients from a hospital in Brazil during a 6-year period (2012-2017) were investigated by multilocus sequence typing (MLST) and ribotyping. These isolates were classified into 20 sequence types (ST), six (30%) of which were novel, revealing a high diversity in a single hospital. Classic hypervirulent strains ST1/RT027 and ST11/RT078 were not identified, while ST42 (almost all RT106) was the most common type, being detected in 11 (28.9%) strains. Noteworthy, six (15.8%) isolates were classified into five STs from clade 2, four of which were new ST and RT. Our study suggests that possible hypervirulent strains other than ST1/RT027 might be inadvertently circulating in Brazilian hospitals and highlights the importance of permanent surveillance on circulating strains in a national scale.
journal_name
Anaerobejournal_title
Anaerobeauthors
Diniz AN,de Oliveira Júnior CA,Vilela EG,Figueiredo HCP,Rupnik M,Wilcox MH,Fawley WN,Blanc DS,Faria Lobato FC,Silva ROSdoi
10.1016/j.anaerobe.2019.01.010subject
Has Abstractpub_date
2019-04-01 00:00:00pages
34-39eissn
1075-9964issn
1095-8274pii
S1075-9964(19)30018-6journal_volume
56pub_type
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