Abstract：
:Fusobacterium nucleatum is a strictly anaerobic, Gram negative bacterial species that has been associated with dental infections, pre-term labor, appendicitis, inflammatory bowel disease, and, more recently, colorectal cancer. The species is unusual in its phenotypic and genotypic heterogeneity, with some strains demonstrating a more virulent phenotype than others; however, as yet the genetic basis for these differences is not understood. Bacteriophage are known to contribute to the virulence phenotype of several bacterial species. In this work, we set out to characterize the bacteriophage associated with F. nucleatum subsp. animalis strain 7-1, a highly invasive isolate from the human gastrointestinal tract. As well, we used computational approaches to predict and compare bacteriophage signatures across available sequenced F. nucleatum genomes.
journal_name
Anaerobejournal_title
Anaerobeauthors
Cochrane K,McGuire AM,Priest ME,Abouelleil A,Cerqueira GC,Lo R,Earl AM,Allen-Vercoe Edoi
10.1016/j.anaerobe.2015.10.013subject
Has Abstractpub_date
2016-04-01 00:00:00pages
125-129eissn
1075-9964issn
1095-8274journal_volume
38pub_type
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