Abstract：
:Clostridia represent a diverse group of spore-forming gram positive anaerobes that include several pathogenic species. In general, diseases caused by clostridia are a result of intoxication of the infected host. Thus, clostridial toxins have been targeted for diagnostic, therapeutic, and preventive strategies against infection. Studying the mechanisms of action of clostridial toxins has not only shed light on the pathogenesis of infection but has provided important new insights into cell biology and immunology. A primary purpose of this manuscript is to provide a succinct review on the mechanisms of disease caused by intoxication by the pathogens Clostridium tetani, Clostridium novyi, and Clostridium sordellii.
journal_name
Anaerobejournal_title
Anaerobeauthors
Aronoff DMdoi
10.1016/j.anaerobe.2013.08.009subject
Has Abstractpub_date
2013-12-01 00:00:00pages
98-101eissn
1075-9964issn
1095-8274pii
S1075-9964(13)00141-8journal_volume
24pub_type
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