Abstract：
:Susceptibility breakpoints provide fundamental information for rational administration of antibiotics. The present investigation reports the first valnemulin susceptibility breakpoint (MIC<0.25 μg/mL) against Clostridium perfringens infections in rabbits based on the wild-type cutoff (COWT) and the pharmacokinetics/pharmacodynamic (PK/PD) cutoff (COPD). The established susceptibility breakpoint of valnemulin might be useful in resistance surveillance of pleuromutilins and development of clinical breakpoints.
journal_name
Anaerobejournal_title
Anaerobeauthors
Tao MT,Zhou YF,Sun J,Liu YH,Liao XPdoi
10.1016/j.anaerobe.2017.08.006subject
Has Abstractpub_date
2017-12-01 00:00:00pages
118-120eissn
1075-9964issn
1095-8274pii
S1075-9964(17)30165-8journal_volume
48pub_type
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