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The early stage peptidoglycan biosynthesis Mur enzymes are antibacterial and antisporulation drug targets for recurrent Clostridioides difficile infection.

Abstract：

:Sporulation during Clostridioides difficile infection (CDI) contributes to recurrent disease. Cell division and sporulation both require peptidoglycan biosynthesis. We show C. difficile growth and sporulation is attenuated by antisenses to murA and murC or the MurA inhibitor fosfomycin. Thus, targeting the early steps of peptidoglycan biosynthesis might reduce the onset of recurrent CDI.

journal_name

Anaerobe

journal_title

Anaerobe

authors

Sapkota M,Marreddy RKR,Wu X,Kumar M,Hurdle JG

doi

10.1016/j.anaerobe.2019.102129

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

102129

eissn

1075-9964

issn

1095-8274

pii

S1075-9964(19)30201-X

journal_volume

61

pub_type

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