Abstract：
:Valorization of lignin based on its biological activities is always suffering the restriction from lignin heterogeneity, including wide molecular weight distributions and variable functional group contents. In this work, organosolv ethanol lignin (OEL) from corn stalk was divided into four fractions by multiple organic solvent successive extraction and the anti-tyrosinase activities of four obtained fractions were compared to evaluate the effect of lignin heterogeneity on the anti-tyrosinase activity. The characterization revealed that the successive extraction realized the fractionation of the heterogeneous OEL into four relatively homogeneous parts with gradually increasing molecular weight and decreasing phenolic OH content. The enzymatic inhibition study showed that the four fractions exhibited obviously different anti-tyrosinase activities and the dichloromethane fraction had the highest tyrosinase inhibition rate (75.12%, 0.5 mg/mL), whose value was comparable to the positive control p-hydroxybenzaldehyde. Besides, the relationships between the anti-tyrosinase activity and the lignin properties (purity, molecular weight and phenolic OH) were discussed to elucidate the possible formation mechanism of differences among the four lignin fractions in anti-tyrosinase activity. Consequently, these results suggest that lignin heterogeneity has a significant effect on the tyrosinase inhibition rate, and lignin fractionation is an effective way to screen lignin fractions with high anti-tyrosinase activity.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Wang R,Wang G,Xia Y,Sui W,Si Cdoi
10.1016/j.ijbiomac.2019.01.089subject
Has Abstractpub_date
2019-05-01 00:00:00pages
107-113eissn
0141-8130issn
1879-0003pii
S0141-8130(18)36909-5journal_volume
128pub_type
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