Abstract:
:High-density lipoproteins (HDL) are known to have vasoprotective functions in peripheral arteries and many of these functions extend to brain-derived endothelial cells. Importantly, several novel brain-relevant HDL functions have been discovered using brain endothelial cells and in 3D bioengineered human arteries. The cerebrovascular benefits of HDL in healthy humans may partly explain epidemiological evidence suggesting a protective association of circulating HDL levels against Alzheimer's Disease (AD) risk. As several methods exist to prepare HDL from plasma, here we compared cerebrovascular functions relevant to AD using HDL isolated by density gradient ultracentrifugation relative to apoB-depleted plasma prepared by polyethylene-glycol precipitation, a common high-throughput method to evaluate HDL cholesterol efflux capacity in clinical biospecimens. We found that apoB-depleted plasma was functionally equivalent to HDL isolated by ultracentrifugation in terms of its ability to reduce vascular Aβ accumulation, suppress TNFα-induced vascular inflammation and delay Aβ fibrillization. However, only HDL isolated by ultracentrifugation was able to suppress Aβ-induced vascular inflammation, improve Aβ clearance, and induce endothelial nitric oxide production.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Button EB,Gilmour M,Cheema HK,Martin EM,Agbay A,Robert J,Wellington CLdoi
10.3390/ijms20030462subject
Has Abstractpub_date
2019-01-22 00:00:00issue
3issn
1422-0067pii
ijms20030462journal_volume
20pub_type
杂志文章abstract::Stem/progenitor cells are promising candidates for the regeneration of parenchyma in acute and chronic renal failure. However, recent data exhibit that survival of stem/progenitor cells after implantation in diseased renal parenchyma is restricted. To elaborate basic parameters improving survival, cell seeding was sim...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms151223240
更新日期:2014-12-15 00:00:00
abstract::Despite recent clinical trial advances and improvements in clinical care, kidney disease due to diabetes remains the most common cause of chronic kidney failure worldwide. In the search for new treatments, recent attentions have turned to drug repurposing opportunities, including study of the histone deacetylase (HDAC...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19092630
更新日期:2018-09-05 00:00:00
abstract::The application of combined nitrogen, especially nitrate, to soybean plants is known to strongly inhibit nodule formation, growth and nitrogen fixation. In the present study, we measured the effects of supplying 5 mM nitrate on the growth of nodules, primary root, and lateral roots under light at 28 °C or dark at 18 °...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15034464
更新日期:2014-03-13 00:00:00
abstract::Anthocyanins are the largest class of water soluble plant pigments and a common part of the human diet. They may have many potential health benefits, including antioxidant, anti-inflammatory, anti-cancer, and cardioprotective activities. However, anthocyanin metabolism is not well understood. Studies suggest that anth...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18020446
更新日期:2017-02-18 00:00:00
abstract::Persistent inflammation is a complication associated with many ocular diseases. Changes in ocular vessels can amplify disease responses and contribute to vision loss by influencing the delivery of leukocytes to the eye, vascular leakage, and perfusion. Here, we report the anti-inflammatory activity for AXT107, a non-R...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21145142
更新日期:2020-07-21 00:00:00
abstract::Lung cancer is the most common cancer worldwide. Disappointingly, despite great effort in encouraging screening or, at least, a close surveillance of high-risk individuals, most of lung cancers are diagnosed when already surgically unresectable because of local advancement or metastasis. In these cases, the treatment ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18071374
更新日期:2017-06-27 00:00:00
abstract::Long noncoding RNA (lncRNA), circular RNA (circRNA), and microRNA (miRNA) are important in the regulation of life activities. However, their function is unclear in Paulownia fortunei. To identify lncRNAs, circRNAs, and miRNA, and investigate their roles in the infection progress of Paulownia witches' broom (PaWB) dise...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19082463
更新日期:2018-08-20 00:00:00
abstract::Factor binding IST-1 (FBI-1) plays an important role in oncogenic transformation and tumorigenesis. As FBI-1 is over-expressed in multiple human cancers, the regulation of itself would provide new effective options for cancer intervention. In this work, we aimed to study the role that EPAS-1 plays in regulating FBI-1....
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms150915689
更新日期:2014-09-04 00:00:00
abstract::The purpose of the study was to investigate the antioxidant characteristics of Anisomeles indica methanol extract and the inhibitory effect of ovatodiolide on melanogenesis. In the study, the antioxidant capacities of A. indica methanol extract such as DPPH assay, ABTS radical scavenging assay, reducing capacity and m...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms13056220
更新日期:2012-01-01 00:00:00
abstract::Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evalu...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms161126071
更新日期:2015-11-24 00:00:00
abstract::CD46 is generally overexpressed in many human cancers, representing a prime target for CD46-binding adenoviruses (Ads). This could help to overcome low anti-tumoral activity by coxsackie-adenoviral receptor (CAR)-targeting cancer gene therapy viruses. However, because of scarce side-by-side information about CAR and C...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19092694
更新日期:2018-09-10 00:00:00
abstract::Hyperhomocysteinemia (HHcy) exerts a wide range of biological effects and is associated with a number of diseases, including cardiovascular disease, dementia, neural tube defects, and cancer. Although mechanisms of HHcy toxicity are not fully uncovered, there has been a significant progress in their understanding. The...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20133140
更新日期:2019-06-27 00:00:00
abstract::A conformational analysis of nine macrocyclic thioether musks has been carried out using molecular mechanics (MMFF), density functional theory (DFT) using both B3LYP and M06 functionals, as well as Hartree-Fock and post-Hartree-Fock (MP2) ab initio methods. 6-Thia-, 10-thia- and 4-methyl-5-thia-14-tetradecananolide, 4...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms10083488
更新日期:2009-08-04 00:00:00
abstract::Nowadays, it is well accepted that inflammation is a critical player in cancer, being, in most cases, the main character of the process. Different types of tumor arise from sites of infection or chronic inflammation. This non-resolving inflammation is responsible for tumor development at different levels: it promotes ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms22031224
更新日期:2021-01-27 00:00:00
abstract::Cell therapy has been evaluated to enhance heart function after injury. Delivered cells mostly act via paracrine mechanisms, including secreted growth factors, cytokines, and vesicles, such as exosomes (Exo). Intramyocardial injection of cardiac-resident progenitor cells (CPC)-derived Exo reduced scarring and improved...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20030468
更新日期:2019-01-22 00:00:00
abstract::Recently, we reported an inhibitory effect of guanine substitutions on the conformational switch from antiparallel to parallel quadruplexes (G4) induced by dehydrating agents. As a possible cause, we proposed a difference in the sensitivity of parallel and antiparallel quadruplexes to the guanine substitutions in the ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21176123
更新日期:2020-08-25 00:00:00
abstract::The estrogen receptor (ER) signaling regulates numerous physiological processes mainly through activation of gene transcription (genomic pathways). Caveolin1 (CAV1) is a membrane-resident protein that behaves as platform to enable different signaling molecules and receptors for membrane-initiated pathways. CAV1 direct...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21175989
更新日期:2020-08-20 00:00:00
abstract::Ceramide and diacylglycerol are linked to insulin resistance in rodents, but in humans the data are inconsistent. Insulin resistance is frequently observed with aging, but the role of ceramide and diacylglycerol is not clarified. Training improves metabolic health and, therefore, we aimed to elucidate the influence of...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20051240
更新日期:2019-03-12 00:00:00
abstract::Previously, we demonstrated that the immediate administration of multitarget anxiolytic afobazole slows down the progression of neuronal damage in a 6-hydroxidodamine (6-OHDA) model of Parkinson's disease due to the activation of chaperone Sigma1R. The aim of the present study is to evaluate the therapeutic potential ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21207620
更新日期:2020-10-15 00:00:00
abstract::The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological regulation of blood pressure, and of heart and kidney functions. ...
journal_title:International journal of molecular sciences
pub_type: 社论
doi:10.3390/ijms20163991
更新日期:2019-08-16 00:00:00
abstract::To examine the effect of melatonin given to rats simultaneously with fructose on initial and fully developed metabolic syndrome, male Wistar rats had free access to chow and 5% or 10% fructose drinking solution for 8 weeks. As compared to controls, systolic blood pressure augmented significantly under both treatments ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms14022502
更新日期:2013-01-25 00:00:00
abstract::The application of autologous mesenchymal stem cells (MSC) for the treatment of bone defects requires two invasive procedures and several weeks of ex vivo cell expansion. To overcome these limitations, the administration of allogeneic MSC may be attractive, because they are anticipated to be immunoprivileged. Because ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19092526
更新日期:2018-08-25 00:00:00
abstract::3,3'-Diindolylmethane (DIM) is a naturally derived chemopreventive compound. It comes from glucobrassicin, an indole glucosinolate enriched in cruciferous vegetables, and is formed in the acidic environment of the stomach after ingestion. Mouse double minute 2 homolog (MDM2) is an important, multi-functional oncogenic...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21134642
更新日期:2020-06-30 00:00:00
abstract::Going from bench to bedside is a simplified description of translational research, with the ultimate goal being to improve the health status of mankind. Tumor endothelial cells (TECs) perform angiogenesis to support the growth, establishment, and dissemination of tumors to distant organs. TECs have various features th...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21093238
更新日期:2020-05-03 00:00:00
abstract::The innate immune system has numerous mechanisms to fight against pathogens, including the formation of neutrophil extracellular traps (NETs). By spreading out chromatin, antimicrobial peptides and enzymes, neutrophils efficiently trap pathogens like bacteria and facilitate their elimination. During this process, high...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19061679
更新日期:2018-06-05 00:00:00
abstract::Glioblastoma (GBM) is the most common malignant brain tumor and its malignant phenotypic characteristics are classified as grade IV tumors. Molecular interactions, such as protein-protein, protein-ncRNA, and protein-peptide interactions are crucial to transfer the signaling communications in cellular signaling pathway...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22020517
更新日期:2021-01-06 00:00:00
abstract::The vast majority of marketed drugs are orally administrated. As such, drug absorption is one of the important drug metabolism and pharmacokinetics parameters that should be assessed in the process of drug discovery and development. A nonlinear quantitative structure-activity relationship (QSAR) model was constructed ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21103582
更新日期:2020-05-19 00:00:00
abstract::A series of novel purpurinimides with long wavelength absorption were designed and synthesized to develop novel and potential photosensitizers. These compounds were investigated through reduction, oxidation, rearrangement reaction and amidation reactions of methyl pheophorbide a. They demonstrated a considerable batho...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15058091
更新日期:2014-05-08 00:00:00
abstract::In this article, we present a method for the enhanced molecular dynamics simulation of protein and DNA systems called potential of mean force (PMF)-enriched sampling. The method uses partitions derived from the potentials of mean force, which we determined from DNA and protein structures in the Protein Data Bank (PDB)...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19113405
更新日期:2018-10-30 00:00:00
abstract::Generally, the prevalence of epilepsy does not exceed 0.9% of the population and approximately 70% of epilepsy patients may be adequately controlled with antiepileptic drugs (AEDs). Moreover, status epilepticus (SE) or even a single seizure may produce neurodegeneration within the brain and SE has been recognized as o...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21072340
更新日期:2020-03-28 00:00:00