The effect of diabetes mellitus on organ dysfunction with sepsis: an epidemiological study.

Abstract:

INTRODUCTION:Diabetes mellitus (DM) is one of the most common chronic co-morbid medical conditions in the USA and is frequently present in patients with sepsis. Previous studies reported that people with DM and severe sepsis are less likely to develop acute lung injury (ALI). We sought to determine whether organ dysfunction differed between people with and without DM and sepsis. METHODS:Using the National Hospital Discharge Survey US, sepsis cases from 1979 to 2003 were integrated with DM prevalence from the Centers for Disease Control and Prevention (CDC) Diabetes Surveillance System. RESULTS:During the study period 930 million acute-care hospitalisations and 14.3 million people with DM were identified. Sepsis occurred in 12.5 million hospitalisations and DM was present in 17% of patients with sepsis. In the population, acute respiratory failure was the most common organ dysfunction (13%) followed by acute renal failure (6%). People with DM were less likely to develop acute respiratory failure (9% vs. 14%, p < 0.05) and more likely to develop acute renal failure (13% vs. 7%, p < 0.05). Of people with DM and sepsis, 27% had a respiratory source of infection compared with 34% in people with no DM (p < 0.05). Among patients with a pulmonary source of sepsis, 16% of those with DM and 23% of those with no DM developed acute respiratory failure (p < 0.05); in non-pulmonary sepsis acute respiratory failure occurred in 6% of people with DM and 10% in those with no DM (p < 0.05). CONCLUSIONS:In sepsis, people with diabetes are less likely to develop acute respiratory failure, irrespective of source of infection. Future studies should determine the relationship of these findings to reduced risk of ALI in people with DM and causative mechanisms.

journal_name

Crit Care

authors

Esper AM,Moss M,Martin GS

doi

10.1186/cc7717

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

R18

issue

1

eissn

1364-8535

issn

1466-609X

pii

cc7717

journal_volume

13

pub_type

杂志文章
  • Early versus standard initiation of renal replacement therapy in furosemide stress test non-responsive acute kidney injury patients (the FST trial).

    abstract:BACKGROUND:The timing of initiation of renal replacement therapy (RRT) in severe acute kidney injury (AKI) remains controversial, with early initiation resulting in unnecessary therapy for some patients while expectant therapy may delay RRT for other patients. The furosemide stress test (FST) has been shown to predict ...

    journal_title:Critical care (London, England)

    pub_type: 临床试验,杂志文章

    doi:10.1186/s13054-018-2021-1

    authors: Lumlertgul N,Peerapornratana S,Trakarnvanich T,Pongsittisak W,Surasit K,Chuasuwan A,Tankee P,Tiranathanagul K,Praditpornsilpa K,Tungsanga K,Eiam-Ong S,Kellum JA,Srisawat N,FST Study Group.

    更新日期:2018-04-19 00:00:00

  • Erythropoietin improves long-term neurological outcome in acute ischemic stroke patients: a randomized, prospective, placebo-controlled clinical trial.

    abstract:INTRODUCTION:Mortality and disability following ischemic stroke (IS) remains unacceptably high with respect to the conventional therapies. This study tested the effect of erythropoietin (EPO) on long-term neurological outcome in patients after acute IS. This study aimed to evaluate the safety and efficacy of two consec...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s13054-015-0761-8

    authors: Tsai TH,Lu CH,Wallace CG,Chang WN,Chen SF,Huang CR,Tsai NW,Lan MY,Sung PH,Liu CF,Yip HK

    更新日期:2015-02-25 00:00:00

  • Risk management in patients with severe acute pancreatitis.

    abstract::Primary or secondary infection of necrotized areas by enteral bacteria is considered a primary cause of mortality in patients with severe acute pancreatitis (SAP). Indeed, 20-30% of patients die during the course of the disease from multiple organ dysfunction after infection. This is why strategies such as antibiotic ...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章

    doi:10.1186/cc3007

    authors: Gerlach H

    更新日期:2004-12-01 00:00:00

  • Nutrition of the COVID-19 patient in the intensive care unit (ICU): a practical guidance.

    abstract::Five to 10% of the coronavirus SARS-CoV-2-infected patients, i.e., with new coronavirus disease 2019 (COVID-19), are presenting with an acute respiratory distress syndrome (ARDS) requiring urgent respiratory and hemodynamic support in the intensive care unit (ICU). However, nutrition is an important element of care. T...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审

    doi:10.1186/s13054-020-03159-z

    authors: Thibault R,Seguin P,Tamion F,Pichard C,Singer P

    更新日期:2020-07-19 00:00:00

  • Effects of increasing compliance with minimal sedation on duration of mechanical ventilation: a quality improvement intervention.

    abstract:INTRODUCTION:In the past two decades, healthcare adopted industrial strategies for process measurement and control. In the industry model, care is taken to avoid minimal deviations from a standard. In healthcare there is scarce data to support that a similar strategy can lead to better outcomes. Briefly, when complianc...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc11335

    authors: Amaral AC,Kure L,Jeffs A

    更新日期:2012-05-08 00:00:00

  • Serum procalcitonin measurement as diagnostic and prognostic marker in febrile adult patients presenting to the emergency department.

    abstract:INTRODUCTION:Identification of bacterial infections is crucial if treatment is to be initiated early and antibiotics used rationally. The primary objective of this study was to test the efficiency of procalcitonin (PCT) in identifying bacterial/parasitic episodes among febrile adult patients presenting to an emergency ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc5926

    authors: Hausfater P,Juillien G,Madonna-Py B,Haroche J,Bernard M,Riou B

    更新日期:2007-01-01 00:00:00

  • The World Trade Center attack. Lessons for all aspects of health care.

    abstract::The attack on the World Trade Center had the potential to overwhelm New York's health services. Sadly, however, the predicted thousands of treatable patients failed to materialize. Horror and sadness has now been replaced by anger, fear, and the determination to be better prepared next time. This determination not onl...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审

    doi:10.1186/cc1053

    authors: Tamber PS,Vincent JL

    更新日期:2001-12-01 00:00:00

  • "Awake" extracorporeal membrane oxygenation (ECMO): pathophysiology, technical considerations, and clinical pioneering.

    abstract::Venovenous extracorporeal membrane oxygenation (vv-ECMO) has been classically employed as a rescue therapy for patients with respiratory failure not treatable with conventional mechanical ventilation alone. In recent years, however, the timing of ECMO initiation has been readdressed and ECMO is often started earlier i...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审

    doi:10.1186/s13054-016-1329-y

    authors: Langer T,Santini A,Bottino N,Crotti S,Batchinsky AI,Pesenti A,Gattinoni L

    更新日期:2016-06-30 00:00:00

  • G-CSF and IL-8 for early diagnosis of sepsis in neonates and critically ill children - safety and cost effectiveness of a new laboratory prediction model: study protocol of a randomized controlled trial [ISRCTN91123847].

    abstract:INTRODUCTION:Bacterial infection represents a serious risk in neonates and critically ill paediatric patients. Current clinical practice is characterized by frequent antibiotic treatment despite low incidence of true infection. However, some patients escape early diagnosis and progress to septic shock. Many new markers...

    journal_title:Critical care (London, England)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1186/cc2971

    authors: Horisberger T,Harbarth S,Nadal D,Baenziger O,Fischer JE

    更新日期:2004-12-01 00:00:00

  • Artificial neural networks as prediction tools in the critically ill.

    abstract::The past 25 years have witnessed the development of improved tools with which to predict short-term and long-term outcomes after critical illness. The general paradigm for constructing the best known tools has been the logistic regression model. Recently, a variety of alternative tools, such as artificial neural netwo...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章

    doi:10.1186/cc3507

    authors: Clermont G

    更新日期:2005-04-01 00:00:00

  • Intensivists at night: putting resources in the right place.

    abstract::During the past 50 years, caring for the critically ill has become increasingly complex and the need for an intensivist has become more evident. Management by intensivists has become a quality indicator for many ICUs. Numerous small studies have demonstrated the beneficial effect of intensivists on outcomes in the cri...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审

    doi:10.1186/cc13060

    authors: Levy MM

    更新日期:2013-10-14 00:00:00

  • Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus.

    abstract::COVID-19 has caused great devastation in the past year. Multi-organ point-of-care ultrasound (PoCUS) including lung ultrasound (LUS) and focused cardiac ultrasound (FoCUS) as a clinical adjunct has played a significant role in triaging, diagnosis and medical management of COVID-19 patients. The expert panel from 27 co...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审

    doi:10.1186/s13054-020-03369-5

    authors: Hussain A,Via G,Melniker L,Goffi A,Tavazzi G,Neri L,Villen T,Hoppmann R,Mojoli F,Noble V,Zieleskiewicz L,Blanco P,Ma IWY,Wahab MA,Alsaawi A,Al Salamah M,Balik M,Barca D,Bendjelid K,Bouhemad B,Bravo-Figueroa P,Br

    更新日期:2020-12-24 00:00:00

  • Refeeding syndrome influences outcome of anorexia nervosa patients in intensive care unit: an observational study.

    abstract:INTRODUCTION:Data on the epidemiology and management of anorexia nervosa (AN) in the intensive care unit (ICU) are scarce. The aim of this study was to evaluate the prevalence and associated morbidity and mortality of AN in French ICUs. METHODS:We randomly selected 30 ICUs throughout France. Thereafter, we retrospecti...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/cc9274

    authors: Vignaud M,Constantin JM,Ruivard M,Villemeyre-Plane M,Futier E,Bazin JE,Annane D,AZUREA group (AnorexieRea Study Group).

    更新日期:2010-01-01 00:00:00

  • Endothelial dysfunction is a potential contributor to multiple organ failure and mortality in aged mice subjected to septic shock: preclinical studies in a murine model of cecal ligation and puncture.

    abstract:INTRODUCTION:The goal of the current study was to investigate the effect of aging on the development of endothelial dysfunction in a murine model of sepsis, and to compare it with the effect of genetic deficiency of the endothelial isoform of nitric oxide synthase (eNOS). METHODS:Cecal ligation and puncture (CLP) was ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/s13054-014-0511-3

    authors: Coletta C,Módis K,Oláh G,Brunyánszki A,Herzig DS,Sherwood ER,Ungvári Z,Szabo C

    更新日期:2014-09-16 00:00:00

  • The association of clinical frailty with outcomes of patients reviewed by rapid response teams: an international prospective observational cohort study.

    abstract:BACKGROUND:Frailty is a state of vulnerability to poor resolution of homeostasis after a stressor event and is strongly associated with adverse outcomes. Therefore, the assessment of frailty may be an essential part of evaluation in any healthcare encounter that might result in an escalation of care. The purpose of the...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s13054-018-2136-4

    authors: So RKL,Bannard-Smith J,Subbe CP,Jones DA,van Rosmalen J,Lighthall GK,METHOD study investigators.

    更新日期:2018-09-22 00:00:00

  • Association of inflammatory biomarkers with subsequent clinical course in suspected late onset sepsis in preterm neonates.

    abstract:BACKGROUND:Sepsis is a major health issue in preterm infants. Biomarkers are used to diagnose and monitor patients with sepsis, but C-reactive protein (CRP) is proven not predictive at onset of late onset neonatal sepsis (LONS) diagnosis. The aim of this study was to evaluate the association of interleukin-6(IL-6), pro...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/s13054-020-03423-2

    authors: Kurul Ş,Simons SHP,Ramakers CRB,De Rijke YB,Kornelisse RF,Reiss IKM,Taal HR

    更新日期:2021-01-06 00:00:00

  • Brain dysfunction in sepsis: what can we learn from cerebral perfusion studies?

    abstract::Investigations on the relationship between sepsis, brain dysfunction, and cerebral perfusion are methodologically very difficult to perform. It is important to interpret the results of such studies in view of our limited ability to diagnose and quantify brain dysfunction and to consider our limited understanding of th...

    journal_title:Critical care (London, England)

    pub_type: 评论,社论

    doi:10.1186/cc6217

    authors: Steiner LA

    更新日期:2008-01-01 00:00:00

  • Year in review 2013: Critical Care--respirology.

    abstract::This review documents important progress made in 2013 in the field of critical care respirology, in particular with regard to acute respiratory failure and acute respiratory distress syndrome. Twenty-five original articles published in the respirology and critical care sections of Critical Care are discussed in the fo...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审

    doi:10.1186/s13054-014-0577-y

    authors: Curley GF,Slutsky AS

    更新日期:2014-10-15 00:00:00

  • Does anesthetic provide similar neuroprotection to therapeutic hypothermia after cardiac arrest?

    abstract::In the previous issue of Critical Care, Meybohm and colleagues provide evidence to support hypothermia as a kind of therapeutic option for patients suffering cardiac arrest. Although anesthetics had been used to induce hypothermia, sevoflurane post-conditioning fails to confer additional anti-inflammatory effects afte...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章

    doi:10.1186/cc8923

    authors: Zhang H

    更新日期:2010-01-01 00:00:00

  • Hippocrates is alive and weaning in Brazil.

    abstract::In a group of postoperative patients, Taniguchi and coworkers compared the effect of a computerized system for weaning against 'manual care'. The computerized system involved automatic adjustments to the level of pressure support to achieve a target respiratory rate. Manual care involved adjustments to the level of pr...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章

    doi:10.1186/cc7746

    authors: Adigüzel N,Güngör G,Tobin MJ

    更新日期:2009-01-01 00:00:00

  • Thromboelastometry and organ failure in trauma patients: a prospective cohort study.

    abstract:INTRODUCTION:Data on the incidence of a hypercoagulable state in trauma, as measured by thromboelastometry (ROTEM), is limited and the prognostic value of hypercoagulability after trauma on outcome is unclear. We aimed to determine the incidence of hypercoagulability after trauma, and to assess whether early hypercoagu...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s13054-014-0687-6

    authors: Müller MC,Balvers K,Binnekade JM,Curry N,Stanworth S,Gaarder C,Kolstadbraaten KM,Rourke C,Brohi K,Goslings JC,Juffermans NP

    更新日期:2014-12-25 00:00:00

  • Optimal Mode of clearance in critically ill patients with Acute Kidney Injury (OMAKI)--a pilot randomized controlled trial of hemofiltration versus hemodialysis: a Canadian Critical Care Trials Group project.

    abstract:INTRODUCTION:Among critically ill patients with acute kidney injury (AKI) needing continuous renal replacement therapy (CRRT), the effect of convective (via continuous venovenous hemofiltration [CVVH]) versus diffusive (via continuous venovenous hemodialysis [CVVHD]) solute clearance on clinical outcomes is unclear. Ou...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/cc11835

    authors: Wald R,Friedrich JO,Bagshaw SM,Burns KE,Garg AX,Hladunewich MA,House AA,Lapinsky S,Klein D,Pannu NI,Pope K,Richardson RM,Thorpe K,Adhikari NK

    更新日期:2012-10-24 00:00:00

  • Functional hemodynamic monitoring.

    abstract::Hemodynamic monitoring is a central component of intensive care. Patterns of hemodynamic variables often suggest cardiogenic, hypovolemic, obstructive, or distributive (septic) etiologies to cardiovascular insufficiency, thus defining the specific treatments required. Monitoring increases in invasiveness, as required,...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审

    doi:10.1186/cc3927

    authors: Pinsky MR,Payen D

    更新日期:2005-01-01 00:00:00

  • A positive fluid balance is an independent prognostic factor in patients with sepsis.

    abstract:INTRODUCTION:Intravenous fluid administration is an essential component of sepsis management, but a positive fluid balance has been associated with worse prognosis. We analyzed whether a positive fluid balance and its persistence over time was an independent prognostic factor in septic patients. METHODS:We prospective...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/s13054-015-0970-1

    authors: Acheampong A,Vincent JL

    更新日期:2015-06-15 00:00:00

  • Acute kidney injury is associated with a decrease in cortical renal perfusion during septic shock.

    abstract:BACKGROUND:Renal perfusion status remains poorly studied at the bedside during septic shock. We sought to measure cortical renal perfusion in patients with septic shock during their first 3 days of care using renal contrast enhanced ultrasound (CEUS). METHODS:We prospectively included 20 ICU patients with septic shock...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/s13054-018-2067-0

    authors: Harrois A,Grillot N,Figueiredo S,Duranteau J

    更新日期:2018-06-15 00:00:00

  • Propofol: neuroprotection in an in vitro model of traumatic brain injury.

    abstract:INTRODUCTION:The anaesthetic agent propofol (2,6-diisopropylphenol) has been shown to be an effective neuroprotective agent in different in vitro models of brain injury induced by oxygen and glucose deprivation. We examined its neuroprotective properties in an in vitro model of traumatic brain injury. METHODS:In this ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc7795

    authors: Rossaint J,Rossaint R,Weis J,Fries M,Rex S,Coburn M

    更新日期:2009-01-01 00:00:00

  • N-terminal pro-brain natriuretic peptide as an early prognostic factor in cancer patients developing septic shock.

    abstract:INTRODUCTION:The overall prognosis of critically ill patients with cancer has improved during the past decade. The aim of this study was to identify early prognostic factors of intensive care unit (ICU) mortality in patients with cancer. METHODS:We designed a prospective, consecutive, observational study over a one-ye...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc5721

    authors: Mokart D,Sannini A,Brun JP,Faucher M,Blaise D,Blache JL,Faucher C

    更新日期:2007-01-01 00:00:00

  • Argon neuroprotection.

    abstract::Certain noble gases, though inert, exhibit remarkable biological properties. Notably, xenon and argon provide neuroprotection in animal models of central nervous system injury. In the previous issue of Critical Care, Loetscher and colleagues provided further evidence that argon may have therapeutic properties for neur...

    journal_title:Critical care (London, England)

    pub_type: 评论,信件

    doi:10.1186/cc8847

    authors: Sanders RD,Ma D,Maze M

    更新日期:2010-01-01 00:00:00

  • Intensive insulin treatment improves forearm blood flow in critically ill patients: a randomized parallel design clinical trial.

    abstract:INTRODUCTION:Intensive insulin treatment of critically ill patients was seen as a promising method of treatment, though recent studies showed that reducing the blood glucose level below 6 mmol/l had a detrimental outcome. The mechanisms of the effects of insulin in the critically ill are not completely understood. The ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/cc8202

    authors: Žuran I,Poredos P,Skale R,Voga G,Gabrscek L,Pareznik R

    更新日期:2009-01-01 00:00:00

  • Prediction of fluid challenge effect: filling pressure when left ventricular function is abnormal, diastolic volume when left ventricular function is normal.

    abstract::Fluid resuscitation is a cornerstone of intensive care unit patient care, but prediction of the cardiovascular response remains difficult, despite many efforts in clinical research. The concept of responders and nonresponders illustrates such a difficulty. Many techniques have been tested, from strictly non-invasive t...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章

    doi:10.1186/cc10067

    authors: Payen D

    更新日期:2011-01-01 00:00:00