Presence of O-glycosidically linked oligosaccharides in the cell wall mannan of Candida krusei purified with Benanomicin A.

abstract：:Memory includes the processes of acquisition, consolidation and retrieval. In the study of aversive olfactory memory in Drosophila melanogaster, flies are first exposed to an odor (conditioned stimulus, CS+) that is associated with an electric shock (unconditioned stimulus, US), then to another odor (CS-) without the ...

journal_title：FEBS open bio

authors： Ueoka Y,Hiroi M,Abe T,Tabata T

更新日期：2017-02-22 00:00:00

abstract：:Oxidized cholesterol (oxysterols) plays an important and multifaceted role in lipid metabolism. Here we examined whether dietary oxysterols accelerate hepatic lipid accumulation and inflammation in nonhuman primates. We also examined the effect of the Niemann-Pick C1-like1 inhibitor, ezetimibe (Ez). Macaca fasciculari...

journal_title：FEBS open bio

authors： Deushi M,Osaka M,Nakano K,Osada K,Egashira K,Yoshida M

更新日期：2016-09-20 00:00:00

abstract：:Flavonoids represent one of the most important molecules of plant secondary metabolism, playing many different biochemical and physiological roles. Although their essential role in plant life and human health has been elucidated by many studies, their subcellular transport and accumulation in plant tissues remains unc...

journal_title：FEBS open bio

authors： Filippi A,Petrussa E,Peresson C,Bertolini A,Vianello A,Braidot E

更新日期：2015-08-29 00:00:00

abstract：:Receptor activator of nuclear factor-κB ligand (RANKL) is required for initiation of osteoclastogenesis, with the signaling pathway including the NF-kB, c-Fos, and nuclear factor of activated T cells, cytoplasmic 1 (NFATc1) transcription factors. Because NFATc1 expression is autoamplified, we investigated the molecula...

journal_title：FEBS open bio

authors： Park KL,Oh DG,Kim YO,Song KS,Ahn DW

更新日期：2018-09-10 00:00:00

abstract：:Ovarian cancer is the most common cause of gynaecological cancer-associated death; thus, promising biomarkers and new therapeutic targets for ovarian cancer must be explored. Here, we report that eukaryotic translation initiation factor 3 subunit D (EIF3D), a member of the EIF3 family, was overexpressed in ovarian can...

journal_title：FEBS open bio

authors： Lin Y,Zhang R,Zhang P

更新日期：2016-10-31 00:00:00

abstract：:Lactobionic acid (O-β-galactosyl-(1-4)-gluconic acid) (LBA) is a high-value lactose derivative, produced via oxidation of the reducing terminal of lactose. LBA can be produced by fermentation using certain microorganisms, although subsequent purification is challenging. Therefore, we have attempted to identify an enzy...

journal_title：FEBS open bio

authors： Lin SF,Li CK,Chung YP

更新日期：2019-01-16 00:00:00

abstract：:Eukaryotic protein O-mannosyltransferases (Pmts) are divided into three subfamilies (Pmt1, Pmt2, and Pmt4) and activity of Pmts in yeasts and animals requires assembly into complexes. In Saccharomyces cerevisiae, Pmt1 and Pmt2 form a heteromeric complex and Pmt 4 forms a homomeric complex. The filamentous fungus Asper...

journal_title：FEBS open bio

authors： Kriangkripipat T,Momany M

更新日期：2014-03-19 00:00:00

abstract：:Hypoxia-inducible factor (HIF) is a crucial regulator of cellular and systemic responses to low oxygen levels. Here we firstly cloned three HIF-α isoforms from the basal branches of Osteichthyes and used computational tools to characterise the molecular change underlying the functional divergence of HIF-α isoforms in ...

journal_title：FEBS open bio

authors： Chi W,Gan X,Xiao W,Wang W,He S

更新日期：2013-09-19 00:00:00

abstract：:A plant-derived Enterococcus mundtii 15-1A, that has been previously isolated from Brassica rapa L. subsp. nipposinica (L.H. Bailey) Hanelt var. linearifolia by our group, possesses two kinds of l-lactate dehydrogenase (l-LDH): LDH-1 and LDH-2. LDH-1 was activated under low concentration of fluctose-1,6-bisphosphate (...

journal_title：FEBS open bio

authors： Matoba Y,Miyasako M,Matsuo K,Oda K,Noda M,Higashikawa F,Kumagai T,Sugiyama M

更新日期：2014-09-06 00:00:00

abstract：:Identification of viral encoded proteins that interact with RNA-dependent RNA polymerase (RdRp) is an important step towards unraveling the mechanism of replication. Sesbania mosaic virus (SeMV) RdRp was shown to interact strongly with p10 domain of polyprotein 2a and moderately with the protease domain. Mutational an...

journal_title：FEBS open bio

authors： Govind K,Bakshi A,Savithri HS

更新日期：2014-03-29 00:00:00

abstract：:The Wilms tumor protein 1 (WT1) transcription factor has been associated in malignant melanoma with cell survival and metastasis, thus emerging as a candidate for targeted therapy. A lysine-arginine rich peptide, WT1-pTj, derived from the ZF domain of WT1 was evaluated as an antitumor agent against A2058 human melanom...

journal_title：FEBS open bio

authors： Massaoka MH,Matsuo AL,Figueiredo CR,Girola N,Faria CF,Azevedo RA,Travassos LR

更新日期：2014-01-21 00:00:00

abstract：:The Malayan pangolin (Manis javanica) is a mammal that feeds primarily on ants and termites, which contain the energy-rich carbohydrate chitin. Chitin is digestible by endogenous enzymes of the typical mammalian gastrointestinal tract, especially the acidic mammalian chitinase (AMCase). The objective of this research ...

journal_title：FEBS open bio

authors： Ma JE,Li LM,Jiang HY,Zhang XJ,Li J,Li GY,Chen JP

更新日期：2018-07-04 00:00:00

abstract：:Sorafenib is an inhibitor of a variety of tyrosine kinase receptors used to treat various cancers including hepatocellular, renal cell and thyroid carcinoma. It has been shown to change various targets associated with osteosarcoma, but the detailed mechanism remains unclear. In order to identify key genes, enriched pa...

journal_title：FEBS open bio

authors： Dai Z,Tang H,Pan Y,Chen J,Li Y,Zhu J

更新日期：2018-04-24 00:00:00

abstract：:Transglutaminases are a family of enzymes that catalyse the cross-linking of proteins by forming covalent bonds between lysine and glutamine residues in various polypeptides. Cross-linking reactions are involved in blood clots, skin formation, embryogenesis and apoptosis. Clinically, these enzymes appear to be implica...

journal_title：FEBS open bio

authors： Alvarez RG,Karki P,Langleite IE,Bakksjø RJ,Eichacker LA,Furnes C

更新日期：2020-04-01 00:00:00

abstract：:Centrins are members of the EF-hand family of calcium-binding proteins, which are highly conserved among eukaryotes. Centrins bind to several cellular targets, through a hydrophobic triad. However, the W(1)xxL(4)xxxL(8) triad in XPC (Xeroderma Pigmentosum Group C protein) is found in the reverse orientation, as in the...

journal_title：FEBS open bio

authors： Grecu D,Blouquit Y,Assairi L

更新日期：2013-12-05 00:00:00

abstract：:Immunoglobulin (Ig) A nephropathy (IgAN) is the most common glomerulonephritis, which is characterized by the deposition of IgA antibody in the glomerulus. Systematic dissection of immune composition may contribute to a better understanding of the alternations in the immune system in IgAN. To this end, here we applied...

journal_title：FEBS open bio

authors： Zhang X,Zeng J,Tong Y,Zhang L,Lu X,Zhu S,Li Z

更新日期：2020-12-01 00:00:00

abstract：:Metastasis is the primary contributor to colorectal cancer mortality. High-intensity focused ultrasound (HIFU) is an emerging technology for tumor therapy that exerts its effects through tumor ablation, mechanical disruption, and enhancement of immune responses. However, it remains unclear whether HIFU can influence t...

journal_title：FEBS open bio

authors： Li M,Wan G,Yu H,Xiong W

更新日期：2019-06-01 00:00:00

abstract：:Obesity during pregnancy has been shown to increase the risk of metabolic diseases in the offspring. However, the factors within the maternal milieu which affect offspring phenotypes and the underlying mechanisms remain unknown. The adipocyte hormone leptin plays a key role in regulating energy homeostasis and is know...

journal_title：FEBS open bio

authors： Denisova EI,Kozhevnikova VV,Bazhan NM,Makarova EN

更新日期：2020-01-01 00:00:00

abstract：:The human MET receptor tyrosine kinase contributes to vertebrate development and cell proliferation. As a proto-oncogene, it is a target in cancer therapies. MET is also relevant for bacterial infection by Listeria monocytogenes and is activated by the bacterial protein internalin B. The processes of ligand binding, r...

journal_title：FEBS open bio

authors： Harwardt MIE,Young P,Bleymüller WM,Meyer T,Karathanasis C,Niemann HH,Heilemann M,Dietz MS

更新日期：2017-08-29 00:00:00

abstract：:Flavin adenine dinucleotide (FAD), synthesized from riboflavin, is redox cofactor in energy production and plays an important role in cell survival. More recently, riboflavin deficiency has been linked to developmental disorders, but its role in stem cell differentiation remains unclear. Here, we show that FAD treatme...

journal_title：FEBS open bio

authors： Hirano K,Namihira M

更新日期：2017-10-17 00:00:00

abstract：:Zinc deficiency impairs the immune system leading to frequent infections. Although zinc is known to play critical roles in maintaining healthy immune function, the underlying molecular targets are largely unknown. In this study, we demonstrate that zinc is important for the CD154-CD40-mediated activation of downstream...

journal_title：FEBS open bio

authors： Tepaamorndech S,Oort P,Kirschke CP,Cai Y,Huang L

更新日期：2017-03-27 00:00:00

abstract：:The tumour microenvironment comprises a diverse range of cells, including fibroblasts, immune cells and endothelial cells, along with extracellular matrix. In particular, fibroblasts are of significant interest as these cells are reprogrammed during tumorigenesis to become cancer-associated fibroblasts (CAFs), which i...

journal_title：FEBS open bio

authors： Aguilera-Rojas M,Sharbati S,Stein T,Einspanier R

更新日期：2020-05-01 00:00:00

abstract：:Candida albicans is a harmless commensal resident in the human gut, and a prevalent opportunistic pathogen. A key part of its commensalism and pathogenesis is its ability to switch between different morphological forms, including white-to-opaque switching. The Wor1 protein was previously identified as a master regulat...

journal_title：FEBS open bio

authors： Dai B,Xu Y,Gao N,Chen J

更新日期：2020-12-22 00:00:00

abstract：:Redox-coupled folding pathways of bovine pancreatic ribonuclease A (RNase A) with four intramolecular disulfide (SS) bonds comprise three phases: (I) SS formation to generate partially oxidized intermediate ensembles with no rigid folded structure; (II) SS rearrangement from the three SS intermediate ensemble (3S) to ...

journal_title：FEBS open bio

authors： Arai K,Kumakura F,Iwaoka M

更新日期：2012-04-16 00:00:00

abstract：:Increased glucose consumption is a known hallmark of cancer cells. Increased glycolysis provides ATP, reducing agents and substrates for macromolecular synthesis in intensely dividing cells. Therefore, inhibition of glycolysis is one strategy in anticancer therapy as well as in improved efficacy of conventional antica...

journal_title：FEBS open bio

authors： Korga A,Ostrowska M,Iwan M,Herbet M,Dudka J

更新日期：2019-05-01 00:00:00

abstract：:We previously reported a profound augmentation in the hepatic levels of a pro-inflammatory precursor, arachidonic acid (AA), during liver tumorigenesis. Here, we report a critical role of the induced reactive oxygen species (ROS)-mediated cellular activation of a protein cross-linking enzyme, transglutaminase 2 (TG2),...

journal_title：FEBS open bio

authors： Qin XY,Lu J,Cai M,Kojima S

更新日期：2018-09-11 00:00:00

abstract：:Megakaryoblastic leukemia 1 (MKL1) is a member of the MKL family of serum response factor (SRF) coactivators. Here we have identified three rat MKL1 transcripts: two are homologues of mouse MKL1 transcripts, full-length MKL1 (FLMKL1) and basic, SAP, and coiled-coil domains (BSAC), the third is a novel transcript, MKL1...

journal_title：FEBS open bio

authors： Ishikawa M,Shiota J,Ishibashi Y,Hakamata T,Shoji S,Fukuchi M,Tsuda M,Shirao T,Sekino Y,Ohtsuka T,Baraban JM,Tabuchi A

更新日期：2013-09-07 00:00:00

abstract：:The identification of non-invasive biomarkers for the detection of renal cell carcinoma (RCC) in early-stage patients may help improve disease outcome. Certain long non-coding RNAs (lncRNAs) have been reported to be possible biomarkers for the diagnosis and prognosis of cancer. Here, we examined the suitability of the...

journal_title：FEBS open bio

authors： Xie J,Zhong Y,Chen R,Li G,Luo Y,Yang J,Sun Z,Liu Y,Liu P,Wang N,An J,Li C,Song Y

更新日期：2020-09-01 00:00:00

abstract：:Despite progress in the treatment of hepatocellular carcinoma (HCC), 5-year survival rates remain low. Thus, a more comprehensive approach to explore the mechanism of HCC is needed to provide new leads for targeted therapy. We performed an integrated analysis to discover the relationship between DNA methylation and ge...

journal_title：FEBS open bio

authors： Sun XJ,Wang MC,Zhang FH,Kong X

更新日期：2018-05-30 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease with increased risk of cardiovascular events and mortality that can be attributed to accelerated atherosclerosis. This pilot study aimed to investigate if changes in blood parameters were compatible with atherosclerotic events in RA patients. To this aim, 45 ...

journal_title：FEBS open bio

authors： Vona R,Di Franco M,Gambardella L,Di Lollo AC,Iannuccelli C,Valesini G,Malorni W,Straface E

更新日期：2018-11-06 00:00:00