Suppression of a single pair of mushroom body output neurons in Drosophila triggers aversive associations.

abstract：:Sorafenib, the first-line agent for treatment of advanced hepatocellular carcinoma (HCC), improves median overall survival by approximately 3 months. In the present study, we investigated whether sorafenib combined with cucurbitacin B (CuB), a natural tetracyclic triterpenoid isolated from Cucurbitaceae, exerts enhanc...

journal_title：FEBS open bio

authors： Wang X,Li H,Li D,Bai Y,Zhang Y,Yan X,Li J,Zhao R,Liu J,Liu W,Shi M,Xu C,Yang T,Zhang T

更新日期：2020-11-11 00:00:00

abstract：:IL-1 family cytokines act as apical initiators of inflammation in many settings and can promote the production of a battery of inflammatory cytokines, chemokines and other inflammatory mediators in diverse cell types. IL-36α, IL-36β and IL-36γ, which belong to the extended IL-1 family, have been implicated as key init...

journal_title：FEBS open bio

authors： Sullivan GP,Davidovich PB,Sura-Trueba S,Belotcerkovskaya E,Henry CM,Clancy DM,Zinoveva A,Mametnabiev T,Garabadzhiu AV,Martin SJ

更新日期：2018-03-25 00:00:00

abstract：:Neural stem cells (NSC) from the adult hippocampus easily lose their activity in vitro. Efficient in vitro expansion of adult hippocampus-derived NSC is important for generation of tools for research and cell therapy. Here, we show that a single copy disruption or pharmacological inhibition of p38α enables successful ...

journal_title：FEBS open bio

authors： Yoshioka K,Namiki K,Sudo T,Kasuya Y

更新日期：2015-05-08 00:00:00

abstract：:Flavin adenine dinucleotide (FAD), synthesized from riboflavin, is redox cofactor in energy production and plays an important role in cell survival. More recently, riboflavin deficiency has been linked to developmental disorders, but its role in stem cell differentiation remains unclear. Here, we show that FAD treatme...

journal_title：FEBS open bio

authors： Hirano K,Namihira M

更新日期：2017-10-17 00:00:00

abstract：:The Wilms tumor protein 1 (WT1) transcription factor has been associated in malignant melanoma with cell survival and metastasis, thus emerging as a candidate for targeted therapy. A lysine-arginine rich peptide, WT1-pTj, derived from the ZF domain of WT1 was evaluated as an antitumor agent against A2058 human melanom...

journal_title：FEBS open bio

authors： Massaoka MH,Matsuo AL,Figueiredo CR,Girola N,Faria CF,Azevedo RA,Travassos LR

更新日期：2014-01-21 00:00:00

abstract：:The identification of biomarkers for early diagnosis of Parkinson's disease (PD) prior to the onset of symptoms may improve the effectiveness of therapy. To identify potential biomarkers, we downloaded microarray datasets of PD from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) between PD...

journal_title：FEBS open bio

authors： Jiang F,Wu Q,Sun S,Bi G,Guo L

更新日期：2019-08-01 00:00:00

abstract：:NrrF is a small regulatory RNA of the human pathogen Neisseria meningitidis. NrrF was previously shown to repress succinate dehydrogenase (sdhCDAB) under control of the ferric uptake regulator (Fur). Here, we provide evidence that cytochrome bc 1 , encoded by the polycistro...

journal_title：FEBS open bio

authors： Pannekoek Y,Huis In 't Veld R,Schipper K,Bovenkerk S,Kramer G,Speijer D,van der Ende A

更新日期：2017-08-05 00:00:00

abstract：:In this study, it was shown for the first time that l-amino acid oxidase of Pseudomonas sp. AIU813, renamed as l-amino acid oxidase/monooxygenase (l-AAO/MOG), exhibits l-lysine 2-monooxygenase as well as oxidase activity. l-Lysine oxidase activity of l-AAO/MOG was increased in a p-chloromercuribenzoate (p-CMB) concent...

journal_title：FEBS open bio

authors： Matsui D,Im DH,Sugawara A,Fukuta Y,Fushinobu S,Isobe K,Asano Y

更新日期：2014-02-07 00:00:00

abstract：:Glutathione transferases (GSTs) are involved in many processes in plant biochemistry, with their best characterised role being the detoxification of xenobiotics through their conjugation with glutathione. GSTs have also been implicated in noncatalytic roles, including the binding and transport of small heterocyclic li...

journal_title：FEBS open bio

authors： Ahmad L,Rylott EL,Bruce NC,Edwards R,Grogan G

更新日期：2016-12-22 00:00:00

abstract：:Osteoarthritis (OA) is a chronic degenerative disease that commonly affects the elderly. Current drug therapies for treating OA may cause adverse side effects, and so there remains a need to develop alternative treatments. Bergapten (BG) is a coumarin phytohormone that is widely found in fruits and has antioxidative a...

journal_title：FEBS open bio

authors： He Y,Zisan Z,Lu Z,Zheng L,Zhao J

更新日期：2019-06-01 00:00:00

abstract：:Synthetic biology circuits are often constructed with multiple gene expression units assembled in close proximity, and they can be used to perform complex functions in embryonic stem cells (ESCs). However, mutual interference between transcriptional units has not been well studied in mouse ESCs. To assess the efficien...

journal_title：FEBS open bio

authors： Lu XB,Guo YH,Huang W

更新日期：2020-04-01 00:00:00

abstract：:Cisplatin-based chemotherapy is the standard treatment of choice for head and neck squamous cell carcinoma (HNSCC). The efficiency of platinum-based therapies is directly influenced by the development of tumor resistance. Multiple signaling pathways have been linked to tumor resistance, including activation of nuclear...

journal_title：FEBS open bio

authors： Almeida LO,Abrahao AC,Rosselli-Murai LK,Giudice FS,Zagni C,Leopoldino AM,Squarize CH,Castilho RM

更新日期：2013-12-30 00:00:00

abstract：:Tight regulation of the eukaryotic cell cycle is paramount to ensure genomic integrity throughout life. Cell cycle checkpoints are present in each phase of the cell cycle and prevent cell cycle progression when genomic integrity is compromised. The G2 checkpoint is an intricate signaling network that regulates the pro...

journal_title：FEBS open bio

authors： de Gooijer MC,van den Top A,Bockaj I,Beijnen JH,Würdinger T,van Tellingen O

更新日期：2017-03-04 00:00:00

abstract：:Increased glucose consumption is a known hallmark of cancer cells. Increased glycolysis provides ATP, reducing agents and substrates for macromolecular synthesis in intensely dividing cells. Therefore, inhibition of glycolysis is one strategy in anticancer therapy as well as in improved efficacy of conventional antica...

journal_title：FEBS open bio

authors： Korga A,Ostrowska M,Iwan M,Herbet M,Dudka J

更新日期：2019-05-01 00:00:00

abstract：:Iron overload affects the cell cycle of various cell types, but the effect of iron overload on human pluripotent stem cells has not yet been reported. Here, we show that the proliferation capacities of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) were significantly inhibited by ...

journal_title：FEBS open bio

authors： Han Z,Xu Z,Chen L,Ye D,Yu Y,Zhang Y,Cao Y,Djibril B,Guo X,Gao X,Zhang W,Yu M,Liu S,Yan G,Jin M,Huang Q,Wang X,Hua B,Feng C,Yang F,Ma W,Liu Y

更新日期：2020-05-01 00:00:00

abstract：:The expense and time required for in vivo reproductive and developmental toxicity studies have driven the development of in vitro alternatives. Here, we used a new in vitro split luciferase-based assay to screen a library of 177 toxicants for inhibitors of apoptosome formation. The apoptosome contains seven Apoptotic ...

journal_title：FEBS open bio

authors： Tashakor A,H-Dehkordi M,O'Connell E,Gomez Ganau S,Gozalbes R,Eriksson LA,Hosseinkhani S,Fearnhead HO

更新日期：2019-07-01 00:00:00

abstract：:The gene encoding MG Orn has been identified from a metagenomic library created from the intertidal zone in Svalbard and encodes a protein of 184 amino acid residues. The mg orn gene has been cloned, recombinantly expressed in Escherichia coli, and purified to homogeneity. Biochemical characterization of the enzyme sh...

journal_title：FEBS open bio

authors： Piotrowski Y,Berg K,Klebl DP,Leiros I,Larsen AN

更新日期：2019-10-01 00:00:00

abstract：:Hirschmanniella mucronata is a plant-parasitic nematode that is widespread in rice production areas and causes 10-25% yield losses a year on average. Here, we investigated the mechanism of resistance to this nematode by comparing the transcriptomes of roots from resistant (Jiabali) and susceptible (Bawangbian) varieti...

journal_title：FEBS open bio

authors： Sun X,Zhang L,Tang Z,Shi X,Ma J,Cui R

更新日期：2019-11-01 00:00:00

abstract：:Post-transcriptional regulation of cytokine production is crucial to ensure appropriate immune responses. We previously demonstrated that poly-rC-binding protein-1 (PCBP1) can act as a trans-acting factor to stabilize transcripts encoding sortilin, which mediates cytokine trafficking. Here, we report that PCBP2, which...

journal_title：FEBS open bio

authors： Yabe-Wada T,Philpott CC,Onai N

更新日期：2020-03-01 00:00:00

abstract：:The Malayan pangolin (Manis javanica) is a mammal that feeds primarily on ants and termites, which contain the energy-rich carbohydrate chitin. Chitin is digestible by endogenous enzymes of the typical mammalian gastrointestinal tract, especially the acidic mammalian chitinase (AMCase). The objective of this research ...

journal_title：FEBS open bio

authors： Ma JE,Li LM,Jiang HY,Zhang XJ,Li J,Li GY,Chen JP

更新日期：2018-07-04 00:00:00

abstract：:Organisms living in temperate regions are sensitive to seasonal variations in the environment; they are known to accumulate energy as fat in their livers during the winter when days are shorter, temperatures are lower, and food is scarce. However, the effect of variations in photoperiod alone on hepatic lipid metaboli...

journal_title：FEBS open bio

authors： Fujisawa K,Takami T,Shintani H,Sasai N,Matsumoto T,Yamamoto N,Sakaida I

更新日期：2021-01-21 00:00:00

abstract：:Insulin signaling plays a central role in the regulation of facilitative glucose transporters (GLUTs) in humans. To establish Caenorhabditis elegans (C. elegans) as a model to study the mechanism underlying insulin regulation of GLUT, we identified that FGT-1 is most likely the only functional GLUT homolog in C. elega...

journal_title：FEBS open bio

authors： Kitaoka S,Morielli AD,Zhao FQ

更新日期：2016-04-21 00:00:00

abstract：:Mutations in the eye lens gap junction protein connexin 50 cause cataract. Earlier we identified a frameshift mutant of connexin 50 (c.670insA; p.Thr203AsnfsX47) in a family with autosomal recessive cataract. The mutant protein is smaller and contains 46 aberrant amino acids at the C-terminus after amino acid 202. Her...

journal_title：FEBS open bio

authors： Somaraju Chalasani ML,Muppirala M,G Ponnam SP,Kannabiran C,Swarup G

更新日期：2012-11-27 00:00:00

abstract：:The human MET receptor tyrosine kinase contributes to vertebrate development and cell proliferation. As a proto-oncogene, it is a target in cancer therapies. MET is also relevant for bacterial infection by Listeria monocytogenes and is activated by the bacterial protein internalin B. The processes of ligand binding, r...

journal_title：FEBS open bio

authors： Harwardt MIE,Young P,Bleymüller WM,Meyer T,Karathanasis C,Niemann HH,Heilemann M,Dietz MS

更新日期：2017-08-29 00:00:00

abstract：:Adult T-cell leukemia/lymphoma (ATL), an aggressive T-cell malignancy that develops after long-term infection with human T-cell leukemia virus (HTLV-1), requires new treatments. Drug repositioning, reuse of a drug previously approved for the treatment of another condition to treat ATL, offers the possibility of reduce...

journal_title：FEBS open bio

authors： Kozako T,Soeda S,Yoshimitsu M,Arima N,Kuroki A,Hirata S,Tanaka H,Imakyure O,Tone N,Honda S,Soeda S

更新日期：2016-04-13 00:00:00

abstract：:Neointimal hyperplasia (NIH) is a complicated inflammatory process contributing to vascular restenosis. The present study aimed to explore whether chemokine-like factor 1 (CKLF1) aggravates NIH via the nuclear factor-kappa B (NF-κB)/vascular cell adhesion molecule-1 (VCAM-1) pathway. We found the expression of CKLF1 a...

journal_title：FEBS open bio

authors： Liu X,Qu C,Zhang Y,Fang J,Teng L,Zhang R,Zhang X,Shen C

更新日期：2020-09-01 00:00:00

abstract：:Curcumin is a polyphenolic phytonutrient that has antineurodegenerative properties. In this study, we investigated the anti-amyloidogenic properties of curcumin. Following incubation with curcumin, intrinsic tryptophan fluorescence emission of apolipoprotein (apo) A-I was strongly quenched. At the same time, curcumin ...

journal_title：FEBS open bio

authors： Krishnamoorthy A,Tavoosi N,Chan GKL,Liu J,Ren G,Cavigiolio G,Ryan RO

更新日期：2018-01-10 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most malignant form of brain tumor and is associated with resistance to conventional therapy and poor patient survival. Prostate apoptosis response (Par)-4, a tumor suppressor, is expressed as both an intracellular and secretory/extracellular protein. Though secretory Par-4 induces...

journal_title：FEBS open bio

authors： Jagtap JC,Parveen D,Shah RD,Desai A,Bhosale D,Chugh A,Ranade D,Karnik S,Khedkar B,Mathur A,Natesh K,Chandrika G,Shastry P

更新日期：2014-11-21 00:00:00

abstract：:Small heat shock proteins (sHsps) endow cells with stress tolerance. Of the various sHsps in mammals, HspB1, also known as Hsp27, is the most ubiquitous. To examine the structure and function of HspB1, we expressed, purified, and characterized HspB1 from Chinese hamster (Cricetulus griseus) ovary cells (CgHspB1). CgHs...

journal_title：FEBS open bio

authors： Sha E,Nakamura M,Ankai K,Yamamoto YY,Oka T,Yohda M

更新日期：2019-10-01 00:00:00

abstract：:As a small fruit rich in anthocyanins, blueberry (Vaccinium corymbosum × angustifolium) has become a focus of research in recent years for identifying genes related to anthocyanin transport and stress resistance mechanisms based on transcriptome sequencing. However, the lack of validated, stably expressed reference ge...

journal_title：FEBS open bio

authors： Deng Y,Li Y,Sun H

更新日期：2020-08-01 00:00:00