A new split-luciferase complementation assay identifies pentachlorophenol as an inhibitor of apoptosome formation.

abstract：:The identification of non-invasive biomarkers for the detection of renal cell carcinoma (RCC) in early-stage patients may help improve disease outcome. Certain long non-coding RNAs (lncRNAs) have been reported to be possible biomarkers for the diagnosis and prognosis of cancer. Here, we examined the suitability of the...

journal_title：FEBS open bio

authors： Xie J,Zhong Y,Chen R,Li G,Luo Y,Yang J,Sun Z,Liu Y,Liu P,Wang N,An J,Li C,Song Y

更新日期：2020-09-01 00:00:00

abstract：:As a small fruit rich in anthocyanins, blueberry (Vaccinium corymbosum × angustifolium) has become a focus of research in recent years for identifying genes related to anthocyanin transport and stress resistance mechanisms based on transcriptome sequencing. However, the lack of validated, stably expressed reference ge...

journal_title：FEBS open bio

authors： Deng Y,Li Y,Sun H

更新日期：2020-08-01 00:00:00

abstract：:Extensive simple sequence repeat (SSR) surveys have been performed for eukaryotic prokaryotic and viral genomes, but information regarding SSRs in viroids is limited. We undertook a survey to examine the presence of SSRs in viroid genomes. Our results show that the distribution of SSRs in viroids may influence seconda...

journal_title：FEBS open bio

authors： Qin L,Zhang Z,Zhao X,Wu X,Chen Y,Tan Z,Li S

更新日期：2014-02-07 00:00:00

abstract：:Osteosarcoma is a malignant bone tumor, and clinically detectable metastases can be detected in ~ 15-20% of patients when they seek medical advice; patients with metastatic disease have extremely poor prognosis. Here, we examined the involvement of the microRNA miR-505 in osteosarcoma. Eighty-four patients seeking tre...

journal_title：FEBS open bio

authors： Li G,Liu F,Miao J,Hu Y

更新日期：2020-07-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third main cause of cancer-relevant deaths worldwide, and its incidence has increased in recent decades. Previous studies have indicated that certain long non-coding RNAs (lncRNAs) have regulatory roles in tumor occurrence and progression. Often, lncRNAs are competitive endogenous RNAs (...

journal_title：FEBS open bio

authors： Liu J,Zhu J,Xiao Z,Wang X,Luo J

更新日期：2020-01-27 00:00:00

abstract：:The antipsychotic drug olanzapine is widely prescribed to treat schizophrenia and other psychotic disorders. However, it often causes unwanted side effects, including diabetes, due to disruption of insulin-dependant glucose metabolism through a mechanism yet to be elucidated. To determine if olanzapine can affect the ...

journal_title：FEBS open bio

authors： Babkin P,George Thompson AM,Iancu CV,Walters DE,Choe JY

更新日期：2015-04-15 00:00:00

abstract：:Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor that is down-regulated in several cancer tissues and tumor cell lines. Overexpression of TXNIP causes cell cycle arrest at the G1/S checkpoint in the hepatocellular carcinoma cell line HuH-7. TXNIP contains putative phosphorylation sites, but the effe...

journal_title：FEBS open bio

authors： Kamitori K,Yamaguchi F,Dong Y,Hossain A,Katagi A,Noguchi C,Hirata Y,Tsukamoto I,Hatano N,Tokuda M

更新日期：2018-10-01 00:00:00

abstract：:Human STIL (SCL/TAL1 interrupting locus) protein maintains centriole stability and spindle pole localisation. It helps in recruitment of CENPJ (Centromere protein J)/CPAP (centrosomal P4.1-associated protein) and other centrosomal proteins. Mutations in STIL protein are reported in several disorders, especially in der...

journal_title：FEBS open bio

authors： Kumar A,Rajendran V,Sethumadhavan R,Purohit R

更新日期：2012-09-25 00:00:00

abstract：:Insulin signaling plays a central role in the regulation of facilitative glucose transporters (GLUTs) in humans. To establish Caenorhabditis elegans (C. elegans) as a model to study the mechanism underlying insulin regulation of GLUT, we identified that FGT-1 is most likely the only functional GLUT homolog in C. elega...

journal_title：FEBS open bio

authors： Kitaoka S,Morielli AD,Zhao FQ

更新日期：2016-04-21 00:00:00

abstract：:The tumour microenvironment comprises a diverse range of cells, including fibroblasts, immune cells and endothelial cells, along with extracellular matrix. In particular, fibroblasts are of significant interest as these cells are reprogrammed during tumorigenesis to become cancer-associated fibroblasts (CAFs), which i...

journal_title：FEBS open bio

authors： Aguilera-Rojas M,Sharbati S,Stein T,Einspanier R

更新日期：2020-05-01 00:00:00

abstract：:Flavonoids represent one of the most important molecules of plant secondary metabolism, playing many different biochemical and physiological roles. Although their essential role in plant life and human health has been elucidated by many studies, their subcellular transport and accumulation in plant tissues remains unc...

journal_title：FEBS open bio

authors： Filippi A,Petrussa E,Peresson C,Bertolini A,Vianello A,Braidot E

更新日期：2015-08-29 00:00:00

abstract：:Synthetic biology circuits are often constructed with multiple gene expression units assembled in close proximity, and they can be used to perform complex functions in embryonic stem cells (ESCs). However, mutual interference between transcriptional units has not been well studied in mouse ESCs. To assess the efficien...

journal_title：FEBS open bio

authors： Lu XB,Guo YH,Huang W

更新日期：2020-04-01 00:00:00

abstract：:DNA damage-inducible 1 (Ddi1) is a multidomain protein with one of the domains being retropepsin-like. HIV-1 protease inhibitors were found to reduce opportunistic infections caused by pathogens like Leishmania and Plasmodium, and some of them were shown to inhibit the growth of these parasites. In Leishmania, Ddi1 wa...

journal_title：FEBS open bio

authors： Kumar S,Suguna K

更新日期：2018-08-03 00:00:00

abstract：:The Wilms tumor protein 1 (WT1) transcription factor has been associated in malignant melanoma with cell survival and metastasis, thus emerging as a candidate for targeted therapy. A lysine-arginine rich peptide, WT1-pTj, derived from the ZF domain of WT1 was evaluated as an antitumor agent against A2058 human melanom...

journal_title：FEBS open bio

authors： Massaoka MH,Matsuo AL,Figueiredo CR,Girola N,Faria CF,Azevedo RA,Travassos LR

更新日期：2014-01-21 00:00:00

abstract：:Glioma is one of the most common types of malignant primary central nervous system tumor, and prognosis for this disease is poor. As autophagic drugs have been reported to induce glioma cell death, we investigated the potential prognostic role of autophagy-associated long non-coding RNA (lncRNA) in glioma patients. In...

journal_title：FEBS open bio

authors： Luan F,Chen W,Chen M,Yan J,Chen H,Yu H,Liu T,Mo L

更新日期：2019-03-05 00:00:00

abstract：:Postoperative cognitive dysfunction is a common complication in elderly patients after surgeries involving anesthesia, but the underlying mechanisms are poorly understood. Lithium is a conventional treatment for bipolar disorder, which exerts a neuroprotective role in various diseases by inhibiting glycogen synthase k...

journal_title：FEBS open bio

authors： Wang Y,An X,Zhang X,Liu J,Wang J,Yang Z

更新日期：2019-12-22 00:00:00

abstract：:One practical application of genome-scale metabolic reconstructions is to interrogate multispecies relationships. Here, we report a consensus metabolic model in four yeast species (Saccharomyces cerevisiae, S. paradoxus, S. mikatae, and S. bayanus) by integrating metabolic network simulations with RNA sequencing (RNA-...

journal_title：FEBS open bio

authors： Zhao Y,Wang Y,Zou L,Huang J

更新日期：2016-02-27 00:00:00

abstract：:The pathogenic bacteria Streptococcus pyogenes can cause an array of diseases in humans, including moderate infections such as pharyngitis (strep throat) as well as life threatening conditions such as necrotizing fasciitis and puerperal fever. The antigen I/II family proteins are cell wall anchored adhesin proteins fo...

journal_title：FEBS open bio

authors： Hall M,Nylander S,Jenkinson HF,Persson K

更新日期：2014-03-12 00:00:00

abstract：:The Malayan pangolin (Manis javanica) is a mammal that feeds primarily on ants and termites, which contain the energy-rich carbohydrate chitin. Chitin is digestible by endogenous enzymes of the typical mammalian gastrointestinal tract, especially the acidic mammalian chitinase (AMCase). The objective of this research ...

journal_title：FEBS open bio

authors： Ma JE,Li LM,Jiang HY,Zhang XJ,Li J,Li GY,Chen JP

更新日期：2018-07-04 00:00:00

abstract：:Recent evidence has shown that miR-409-3p was down-regulated in several types of cancer, including osteosarcoma. However, the potential role of miR-409-3p in osteosarcoma remains largely unknown. In the present study, we showed that overexpression of miR-409-3p in osteosarcoma cells inhibited cell proliferation in vit...

journal_title：FEBS open bio

authors： Zhang J,Hou W,Jia J,Zhao Y,Zhao B

更新日期：2017-01-27 00:00:00

abstract：:Due to its exceptionally small genome size and protogynous hermaphroditism, Monopterus albus has been proposed as a model for vertebrate sexual development. The Kiss/GPR54 system is a central regulator of sexual development in most vertebrates, but its role in sex reversal remains hypothetical. In contrast to mammals,...

journal_title：FEBS open bio

authors： Yi TL,Pei MT,Yang DQ

更新日期：2019-10-01 00:00:00

abstract：:Redox-coupled folding pathways of bovine pancreatic ribonuclease A (RNase A) with four intramolecular disulfide (SS) bonds comprise three phases: (I) SS formation to generate partially oxidized intermediate ensembles with no rigid folded structure; (II) SS rearrangement from the three SS intermediate ensemble (3S) to ...

journal_title：FEBS open bio

authors： Arai K,Kumakura F,Iwaoka M

更新日期：2012-04-16 00:00:00

abstract：:Hirschmanniella mucronata is a plant-parasitic nematode that is widespread in rice production areas and causes 10-25% yield losses a year on average. Here, we investigated the mechanism of resistance to this nematode by comparing the transcriptomes of roots from resistant (Jiabali) and susceptible (Bawangbian) varieti...

journal_title：FEBS open bio

authors： Sun X,Zhang L,Tang Z,Shi X,Ma J,Cui R

更新日期：2019-11-01 00:00:00

abstract：:Understanding the role of specific amino acid residues in the molecular mechanism of a protein's function is one of the most challenging problems in modern biology. A systematic bioinformatic analysis of protein families and superfamilies can help in the study of structure-function relationships and in the design of i...

journal_title：FEBS open bio

authors： Fesko K,Suplatov D,Švedas V

更新日期：2018-05-21 00:00:00

abstract：:The human MET receptor tyrosine kinase contributes to vertebrate development and cell proliferation. As a proto-oncogene, it is a target in cancer therapies. MET is also relevant for bacterial infection by Listeria monocytogenes and is activated by the bacterial protein internalin B. The processes of ligand binding, r...

journal_title：FEBS open bio

authors： Harwardt MIE,Young P,Bleymüller WM,Meyer T,Karathanasis C,Niemann HH,Heilemann M,Dietz MS

更新日期：2017-08-29 00:00:00

abstract：:Sorafenib, the first-line agent for treatment of advanced hepatocellular carcinoma (HCC), improves median overall survival by approximately 3 months. In the present study, we investigated whether sorafenib combined with cucurbitacin B (CuB), a natural tetracyclic triterpenoid isolated from Cucurbitaceae, exerts enhanc...

journal_title：FEBS open bio

authors： Wang X,Li H,Li D,Bai Y,Zhang Y,Yan X,Li J,Zhao R,Liu J,Liu W,Shi M,Xu C,Yang T,Zhang T

更新日期：2020-11-11 00:00:00

abstract：:PSMD9 (Proteasome Macropain non-ATPase subunit 9), a proteasomal assembly chaperone, harbors an uncharacterized PDZ-like domain. Here we report the identification of five novel interacting partners of PSMD9 and provide the first glimpse at the structure of the PDZ-domain, including the molecular details of the interac...

journal_title：FEBS open bio

authors： Sangith N,Srinivasaraghavan K,Sahu I,Desai A,Medipally S,Somavarappu AK,Verma C,Venkatraman P

更新日期：2014-06-06 00:00:00

abstract：:Candida albicans is a harmless commensal resident in the human gut, and a prevalent opportunistic pathogen. A key part of its commensalism and pathogenesis is its ability to switch between different morphological forms, including white-to-opaque switching. The Wor1 protein was previously identified as a master regulat...

journal_title：FEBS open bio

authors： Dai B,Xu Y,Gao N,Chen J

更新日期：2020-12-22 00:00:00

abstract：:Lysophosphatidylcholine acyltransferase 3 (LPCAT3) is an important enzyme in phospholipid remodeling, a process that influences the biophysical properties of cell membranes and thus cell function. Multiple lines of evidence suggest that LPCAT3 is involved in several diseases, including atherosclerosis, non-alcoholic s...

journal_title：FEBS open bio

authors： Du X,Hu J,Zhang Q,Liu Q,Xiang X,Dong J,Lou B,He S,Gu X,Cao Y,Li Y,Ding T

更新日期：2019-10-01 00:00:00

abstract：:Decorin (DCN) is a major member of the small leucine-rich proteoglycan (SLRP) family that is critically involved in tumorigenesis and the development of metastasis of cancers, including glioma. Overexpression of DCN was indicated to suppress glioma cell growth. However, the role of DCN in the migration of glioma cells...

journal_title：FEBS open bio

authors： Yao T,Zhang CG,Gong MT,Zhang M,Wang L,Ding W

更新日期：2016-05-31 00:00:00