High-intensity focused ultrasound inhibits invasion and metastasis of colon cancer cells by enhancing microRNA-124-mediated suppression of STAT3.

abstract：:IL-1 family cytokines act as apical initiators of inflammation in many settings and can promote the production of a battery of inflammatory cytokines, chemokines and other inflammatory mediators in diverse cell types. IL-36α, IL-36β and IL-36γ, which belong to the extended IL-1 family, have been implicated as key init...

journal_title：FEBS open bio

authors： Sullivan GP,Davidovich PB,Sura-Trueba S,Belotcerkovskaya E,Henry CM,Clancy DM,Zinoveva A,Mametnabiev T,Garabadzhiu AV,Martin SJ

更新日期：2018-03-25 00:00:00

abstract：:Inorganic polyphosphate (polyP) is a linear polymer containing tens to hundreds of orthophosphate residues linked by high-energy phosphoanhydride bonds. PolyP promotes osteocalcification and bone mineralization in both mouse and human osteoblastic cells. In the present study, we examined the molecular mechanism by whi...

journal_title：FEBS open bio

authors： Tsutsumi K,Sasase T

更新日期：2019-09-01 00:00:00

abstract：:Flavonoids represent one of the most important molecules of plant secondary metabolism, playing many different biochemical and physiological roles. Although their essential role in plant life and human health has been elucidated by many studies, their subcellular transport and accumulation in plant tissues remains unc...

journal_title：FEBS open bio

authors： Filippi A,Petrussa E,Peresson C,Bertolini A,Vianello A,Braidot E

更新日期：2015-08-29 00:00:00

abstract：:Inovirus XacF1 (7325 nucleotides) is integrated into the genome of Xanthomonas citri pv. citri (Xcc) strains at the host dif site (attB) by the host XerC/D recombination system. The XacF1 attP sequence is located within the coding region of ORF12, a possible phage regulator. After integration, this open reading frame ...

journal_title：FEBS open bio

authors： Ahmad AA,Kawabe M,Askora A,Kawasaki T,Fujie M,Yamada T

更新日期：2017-09-19 00:00:00

abstract：:Sunitinib (Sun), a tyrosine kinase inhibitor of vascular endothelial growth factor receptor, is the standard first-line treatment against advanced clear cell renal cell carcinoma (RCC), but resistance to therapy is inevitable. Reactive oxygen species production is associated with sensitivity to chemotherapy, but the u...

journal_title：FEBS open bio

authors： Meng L,Chen D,Meng G,Lu L,Han C

更新日期：2021-01-16 00:00:00

abstract：:The expression of death receptor 6 (DR6) is abnormal in some cancer types, but the function and underlying molecular mechanisms of DR6 in tumor progression are not yet clear. In the present study, our analysis of ovarian cancer RNA sequencing data from The Cancer Genome Atlas revealed that DR6 is upregulated in human ...

journal_title：FEBS open bio

authors： Shi B,Bao J,Liu Y,Shi J

更新日期：2018-08-07 00:00:00

abstract：:Cisplatin-based chemotherapy is the standard treatment of choice for head and neck squamous cell carcinoma (HNSCC). The efficiency of platinum-based therapies is directly influenced by the development of tumor resistance. Multiple signaling pathways have been linked to tumor resistance, including activation of nuclear...

journal_title：FEBS open bio

authors： Almeida LO,Abrahao AC,Rosselli-Murai LK,Giudice FS,Zagni C,Leopoldino AM,Squarize CH,Castilho RM

更新日期：2013-12-30 00:00:00

abstract：:Ki-67 (MKI67) is a marker of cellular proliferation of cancer. Here, we show that Ki-67 is post-transcriptionally regulated through alternative polyadenylation (APA) and microRNAs in breast cancer. We show that shortening of the Ki-67 3'UTR results in the loss of the binding sites for the suppressive miRNAs and thus r...

journal_title：FEBS open bio

authors： Yan H,Tian R,Wang W,Zhang M,Wu J,He J

更新日期：2018-01-26 00:00:00

abstract：:Due to its exceptionally small genome size and protogynous hermaphroditism, Monopterus albus has been proposed as a model for vertebrate sexual development. The Kiss/GPR54 system is a central regulator of sexual development in most vertebrates, but its role in sex reversal remains hypothetical. In contrast to mammals,...

journal_title：FEBS open bio

authors： Yi TL,Pei MT,Yang DQ

更新日期：2019-10-01 00:00:00

abstract：:One practical application of genome-scale metabolic reconstructions is to interrogate multispecies relationships. Here, we report a consensus metabolic model in four yeast species (Saccharomyces cerevisiae, S. paradoxus, S. mikatae, and S. bayanus) by integrating metabolic network simulations with RNA sequencing (RNA-...

journal_title：FEBS open bio

authors： Zhao Y,Wang Y,Zou L,Huang J

更新日期：2016-02-27 00:00:00

abstract：:Osteonecrosis of the femoral head (ONFH) is a common clinical disease with a high disability rate. Apoptosis of osteoblasts caused by high-dose short-term or low-dose long-term glucocorticoid (GC) administration is the biological basis of steroid-induced avascular necrosis of the femoral head (SANFH). The pathogenesis...

journal_title：FEBS open bio

authors： Peng P,Nie Z,Sun F,Peng H

更新日期：2020-11-15 00:00:00

abstract：:Hirschmanniella mucronata is a plant-parasitic nematode that is widespread in rice production areas and causes 10-25% yield losses a year on average. Here, we investigated the mechanism of resistance to this nematode by comparing the transcriptomes of roots from resistant (Jiabali) and susceptible (Bawangbian) varieti...

journal_title：FEBS open bio

authors： Sun X,Zhang L,Tang Z,Shi X,Ma J,Cui R

更新日期：2019-11-01 00:00:00

abstract：:Lysophosphatidylcholine acyltransferase 3 (LPCAT3) is an important enzyme in phospholipid remodeling, a process that influences the biophysical properties of cell membranes and thus cell function. Multiple lines of evidence suggest that LPCAT3 is involved in several diseases, including atherosclerosis, non-alcoholic s...

journal_title：FEBS open bio

authors： Du X,Hu J,Zhang Q,Liu Q,Xiang X,Dong J,Lou B,He S,Gu X,Cao Y,Li Y,Ding T

更新日期：2019-10-01 00:00:00

abstract：:Heterocyst-forming cyanobacteria grow as filaments that can be hundreds of cells long. Proteinaceous septal junctions provide cell-cell binding and communication functions in the filament. In Anabaena sp. strain PCC 7120, the SepJ protein is important for the formation of septal junctions. SepJ consists of integral me...

journal_title：FEBS open bio

authors： Ramos-León F,Mariscal V,Battchikova N,Aro EM,Flores E

更新日期：2017-08-30 00:00:00

abstract：:Neural stem cells (NSC) from the adult hippocampus easily lose their activity in vitro. Efficient in vitro expansion of adult hippocampus-derived NSC is important for generation of tools for research and cell therapy. Here, we show that a single copy disruption or pharmacological inhibition of p38α enables successful ...

journal_title：FEBS open bio

authors： Yoshioka K,Namiki K,Sudo T,Kasuya Y

更新日期：2015-05-08 00:00:00

abstract：:Identification of viral encoded proteins that interact with RNA-dependent RNA polymerase (RdRp) is an important step towards unraveling the mechanism of replication. Sesbania mosaic virus (SeMV) RdRp was shown to interact strongly with p10 domain of polyprotein 2a and moderately with the protease domain. Mutational an...

journal_title：FEBS open bio

authors： Govind K,Bakshi A,Savithri HS

更新日期：2014-03-29 00:00:00

abstract：:A great number of studies have proven that sHsps protect cells by inhibiting protein aggregation under heat stress, while little is known about their function to protect cells under acid stress. In this work, we show that Hsp20.1 and Hsp14.1 oligomers dissociated to smaller oligomeric species or even dimer/monomer at ...

journal_title：FEBS open bio

authors： Liu L,Chen J,Yang B,Wang Y

更新日期：2015-03-05 00:00:00

abstract：:Nisin is the most prominent and applied bacteriocin that serves as a model for class I lantibiotics. The nisin leader peptide importantly determines interactions between precursor nisin and its modification enzymes NisB and NisC that mature nisin posttranslationally. NisB dehydrates serines and threonines, while NisC ...

journal_title：FEBS open bio

authors： Khusainov R,Moll GN,Kuipers OP

更新日期：2013-05-30 00:00:00

abstract：:The expense and time required for in vivo reproductive and developmental toxicity studies have driven the development of in vitro alternatives. Here, we used a new in vitro split luciferase-based assay to screen a library of 177 toxicants for inhibitors of apoptosome formation. The apoptosome contains seven Apoptotic ...

journal_title：FEBS open bio

authors： Tashakor A,H-Dehkordi M,O'Connell E,Gomez Ganau S,Gozalbes R,Eriksson LA,Hosseinkhani S,Fearnhead HO

更新日期：2019-07-01 00:00:00

abstract：:RAC3 is a coactivator of glucocorticoid receptor and nuclear factor-κB (NF-κB) that is usually over-expressed in tumors and which also has important functions in the immune system. We investigated the role of the inflammatory response in the control of RAC3 expression levels in vivo and in vitro. We found that inflamm...

journal_title：FEBS open bio

authors： Alvarado CV,Rubio MF,Fernández Larrosa PN,Panelo LC,Azurmendi PJ,Ruiz Grecco M,Martínez-Nöel GA,Costas MA

更新日期：2014-05-02 00:00:00

abstract：:The identification of biomarkers for early diagnosis of Parkinson's disease (PD) prior to the onset of symptoms may improve the effectiveness of therapy. To identify potential biomarkers, we downloaded microarray datasets of PD from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) between PD...

journal_title：FEBS open bio

authors： Jiang F,Wu Q,Sun S,Bi G,Guo L

更新日期：2019-08-01 00:00:00

abstract：:The pathogenic bacteria Streptococcus pyogenes can cause an array of diseases in humans, including moderate infections such as pharyngitis (strep throat) as well as life threatening conditions such as necrotizing fasciitis and puerperal fever. The antigen I/II family proteins are cell wall anchored adhesin proteins fo...

journal_title：FEBS open bio

authors： Hall M,Nylander S,Jenkinson HF,Persson K

更新日期：2014-03-12 00:00:00

abstract：:In this study, we showed that cyanocobalamin dodecylamine, a ribose 5'-carbamate derivative of cyanocobalamin, was absorbed and accumulated to significant levels by Caenorhabditis elegans and was not further metabolized. The levels of methylmalonic acid and homocysteine, which serve as indicators of cobalamin deficien...

journal_title：FEBS open bio

authors： Bito T,Yabuta Y,Ichiyanagi T,Kawano T,Watanabe F

更新日期：2014-08-01 00:00:00

abstract：:Synthetic biology circuits are often constructed with multiple gene expression units assembled in close proximity, and they can be used to perform complex functions in embryonic stem cells (ESCs). However, mutual interference between transcriptional units has not been well studied in mouse ESCs. To assess the efficien...

journal_title：FEBS open bio

authors： Lu XB,Guo YH,Huang W

更新日期：2020-04-01 00:00:00

abstract：:Osteosarcoma is the most common primary solid malignancy of the bone, and its high mortality usually correlates with early metastasis. In this study, we developed a risk score model to help predict metastasis at the time of diagnosis. We downloaded and mined four expression profile datasets associated with osteosarcom...

journal_title：FEBS open bio

authors： Dong S,Huo H,Mao Y,Li X,Dong L

更新日期：2019-02-02 00:00:00

abstract：:Nitrobindins (Nbs), constituting a heme-protein family spanning from bacteria to Homo sapiens, display an all-β-barrel structural organization. Human Nb has been described as a domain of the nuclear protein named THAP4, whose physiological function is still unknown. We report the first evidence of the heme-Fe(III)-bas...

journal_title：FEBS open bio

authors： De Simone G,di Masi A,Polticelli F,Ascenzi P

更新日期：2018-11-09 00:00:00

abstract：:Human type 2 diabetes is associated with β-cell apoptosis, and human islets from diabetic donors are ∼80% deficient in PAK1 protein. Toward addressing linkage of PAK1 to β-cell survival, PAK1-siRNA targeted MIN6 pancreatic β-cells were found to exhibit increased caspase-3 cleavage, cytosolic cytochrome-C and the pro-a...

journal_title：FEBS open bio

authors： Wang Z,Thurmond DC

更新日期：2012-09-08 00:00:00

abstract：:Insulin signaling plays a central role in the regulation of facilitative glucose transporters (GLUTs) in humans. To establish Caenorhabditis elegans (C. elegans) as a model to study the mechanism underlying insulin regulation of GLUT, we identified that FGT-1 is most likely the only functional GLUT homolog in C. elega...

journal_title：FEBS open bio

authors： Kitaoka S,Morielli AD,Zhao FQ

更新日期：2016-04-21 00:00:00

abstract：:Transglutaminases are a family of enzymes that catalyse the cross-linking of proteins by forming covalent bonds between lysine and glutamine residues in various polypeptides. Cross-linking reactions are involved in blood clots, skin formation, embryogenesis and apoptosis. Clinically, these enzymes appear to be implica...

journal_title：FEBS open bio

authors： Alvarez RG,Karki P,Langleite IE,Bakksjø RJ,Eichacker LA,Furnes C

更新日期：2020-04-01 00:00:00

abstract：:The base excision repair pathway plays an important role in correcting damage induced by either physiological or external effects. This repair pathway removes incorrect bases from the DNA. The uracil base is among the most frequently occurring erroneous bases in DNA, and is cut out from the phosphodiester backbone via...

journal_title：FEBS open bio

authors： Papp-Kádár V,Balázs Z,Vékey K,Ozohanics O,Vértessy BG

更新日期：2019-02-09 00:00:00