Interaction of Sesbania mosaic virus (SeMV) RNA-dependent RNA polymerase (RdRp) with the p10 domain of polyprotein 2a and its implications in SeMV replication.

abstract：:Small heat shock proteins (sHsps) endow cells with stress tolerance. Of the various sHsps in mammals, HspB1, also known as Hsp27, is the most ubiquitous. To examine the structure and function of HspB1, we expressed, purified, and characterized HspB1 from Chinese hamster (Cricetulus griseus) ovary cells (CgHspB1). CgHs...

journal_title：FEBS open bio

authors： Sha E,Nakamura M,Ankai K,Yamamoto YY,Oka T,Yohda M

更新日期：2019-10-01 00:00:00

abstract：:A great number of studies have proven that sHsps protect cells by inhibiting protein aggregation under heat stress, while little is known about their function to protect cells under acid stress. In this work, we show that Hsp20.1 and Hsp14.1 oligomers dissociated to smaller oligomeric species or even dimer/monomer at ...

journal_title：FEBS open bio

authors： Liu L,Chen J,Yang B,Wang Y

更新日期：2015-03-05 00:00:00

abstract：:The Wilms tumor protein 1 (WT1) transcription factor has been associated in malignant melanoma with cell survival and metastasis, thus emerging as a candidate for targeted therapy. A lysine-arginine rich peptide, WT1-pTj, derived from the ZF domain of WT1 was evaluated as an antitumor agent against A2058 human melanom...

journal_title：FEBS open bio

authors： Massaoka MH,Matsuo AL,Figueiredo CR,Girola N,Faria CF,Azevedo RA,Travassos LR

更新日期：2014-01-21 00:00:00

abstract：:Postoperative cognitive dysfunction is a common complication in elderly patients after surgeries involving anesthesia, but the underlying mechanisms are poorly understood. Lithium is a conventional treatment for bipolar disorder, which exerts a neuroprotective role in various diseases by inhibiting glycogen synthase k...

journal_title：FEBS open bio

authors： Wang Y,An X,Zhang X,Liu J,Wang J,Yang Z

更新日期：2019-12-22 00:00:00

abstract：:Liver cancer stem cells (L-CSCs) are considered to be an important therapeutic target for hepatocellular carcinoma (HCC). This study provides a new in vitro long-term culture model for a specific subpopulation of L-CSCs enriched by cell surface markers. We combined CD13, CD133 and EpCAM to selectively enrich L-CSCs, w...

journal_title：FEBS open bio

authors： Zhang B,Wang HY,Wang DX,Zeng Q,Fan Z,Xi JF,Nan X,He LJ,Zhou JN,Pei XT,Yue W

更新日期：2020-09-01 00:00:00

abstract：:The pathogenic bacteria Streptococcus pyogenes can cause an array of diseases in humans, including moderate infections such as pharyngitis (strep throat) as well as life threatening conditions such as necrotizing fasciitis and puerperal fever. The antigen I/II family proteins are cell wall anchored adhesin proteins fo...

journal_title：FEBS open bio

authors： Hall M,Nylander S,Jenkinson HF,Persson K

更新日期：2014-03-12 00:00:00

abstract：:Increased glucose consumption is a known hallmark of cancer cells. Increased glycolysis provides ATP, reducing agents and substrates for macromolecular synthesis in intensely dividing cells. Therefore, inhibition of glycolysis is one strategy in anticancer therapy as well as in improved efficacy of conventional antica...

journal_title：FEBS open bio

authors： Korga A,Ostrowska M,Iwan M,Herbet M,Dudka J

更新日期：2019-05-01 00:00:00

abstract：:Oxidative stress in plants causes ferredoxin down-regulation and NADP(+) shortage, over-reduction of the photosynthetic electron transport chain, electron leakage to oxygen and generation of reactive oxygen species (ROS). Expression of cyanobacterial flavodoxin in tobacco chloroplasts compensates for ferredoxin declin...

journal_title：FEBS open bio

authors： Giró M,Ceccoli RD,Poli HO,Carrillo N,Lodeyro AF

更新日期：2011-11-11 00:00:00

abstract：:Niclosamide is a potent inhibitor of osteoclastogenesis and bone remodeling. DK-520 is an acyl derivative of Niclosamide and significantly increased both the plasma concentration and the duration of exposure of Niclosamide when dosed orally. However, at present the effect of DK-520 on osteoclastogenesis has not been r...

journal_title：FEBS open bio

authors： Jiao Y,Chen C,Hu X,Feng X,Shi Z,Cao J,Li Q,Zhu Y

更新日期：2020-08-01 00:00:00

abstract：:Receptor activator of nuclear factor-κB ligand (RANKL) is required for initiation of osteoclastogenesis, with the signaling pathway including the NF-kB, c-Fos, and nuclear factor of activated T cells, cytoplasmic 1 (NFATc1) transcription factors. Because NFATc1 expression is autoamplified, we investigated the molecula...

journal_title：FEBS open bio

authors： Park KL,Oh DG,Kim YO,Song KS,Ahn DW

更新日期：2018-09-10 00:00:00

abstract：:RAC3 is a coactivator of glucocorticoid receptor and nuclear factor-κB (NF-κB) that is usually over-expressed in tumors and which also has important functions in the immune system. We investigated the role of the inflammatory response in the control of RAC3 expression levels in vivo and in vitro. We found that inflamm...

journal_title：FEBS open bio

authors： Alvarado CV,Rubio MF,Fernández Larrosa PN,Panelo LC,Azurmendi PJ,Ruiz Grecco M,Martínez-Nöel GA,Costas MA

更新日期：2014-05-02 00:00:00

abstract：:Zinc deficiency impairs the immune system leading to frequent infections. Although zinc is known to play critical roles in maintaining healthy immune function, the underlying molecular targets are largely unknown. In this study, we demonstrate that zinc is important for the CD154-CD40-mediated activation of downstream...

journal_title：FEBS open bio

authors： Tepaamorndech S,Oort P,Kirschke CP,Cai Y,Huang L

更新日期：2017-03-27 00:00:00

abstract：:Prostate cancer (PCa) is the most frequently diagnosed male cancer. An earlier study of a cohort of 333 primary prostate carcinomas showed that 74% of these tumors fell into one of seven subtypes of a molecular taxonomy defined by specific gene fusions (ERG, ETV1/4 and FLI1) or mutations (SPOP, FOXA1 and IDH1). Molecu...

journal_title：FEBS open bio

authors： Tang L,Zhang L,Liu L,Dong L,Dong Y,Zhu W,Wang H

更新日期：2020-12-01 00:00:00

abstract：:PSMD9 (Proteasome Macropain non-ATPase subunit 9), a proteasomal assembly chaperone, harbors an uncharacterized PDZ-like domain. Here we report the identification of five novel interacting partners of PSMD9 and provide the first glimpse at the structure of the PDZ-domain, including the molecular details of the interac...

journal_title：FEBS open bio

authors： Sangith N,Srinivasaraghavan K,Sahu I,Desai A,Medipally S,Somavarappu AK,Verma C,Venkatraman P

更新日期：2014-06-06 00:00:00

abstract：:Dihydroorotate dehydrogenase (DHODH) is a flavin-binding enzyme essential for pyrimidine biosynthesis, which converts dihydroorotate to orotate. Three-dimensional structures of cytosolic DHODH of parasitic protozoa are of interest in drug discovery for neglected tropical diseases, especially because these enzymes poss...

journal_title：FEBS open bio

authors： Kubota T,Tani O,Yamaguchi T,Namatame I,Sakashita H,Furukawa K,Yamasaki K

更新日期：2018-03-06 00:00:00

abstract：:Growth hormone receptor (GHR), a member of the class I cytokine receptor family, plays key roles in cancer progression. Recently, GHR has been reported to be associated with breast cancer development, but the molecular mechanism of GHR in this malignancy is not fully understood. To investigate this issue, we stably in...

journal_title：FEBS open bio

authors： Zhu X,Li Y,Xu G,Fu C

更新日期：2020-06-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third main cause of cancer-relevant deaths worldwide, and its incidence has increased in recent decades. Previous studies have indicated that certain long non-coding RNAs (lncRNAs) have regulatory roles in tumor occurrence and progression. Often, lncRNAs are competitive endogenous RNAs (...

journal_title：FEBS open bio

authors： Liu J,Zhu J,Xiao Z,Wang X,Luo J

更新日期：2020-01-27 00:00:00

abstract：:Recent evidence has shown that miR-409-3p was down-regulated in several types of cancer, including osteosarcoma. However, the potential role of miR-409-3p in osteosarcoma remains largely unknown. In the present study, we showed that overexpression of miR-409-3p in osteosarcoma cells inhibited cell proliferation in vit...

journal_title：FEBS open bio

authors： Zhang J,Hou W,Jia J,Zhao Y,Zhao B

更新日期：2017-01-27 00:00:00

abstract：:Cell wall mannan of the pathogenic yeast Candida krusei was prepared using the antibiotic Benanomicin A, which has a lectin-like function. The chemical structure of this molecule was found to be similar to that of mannan prepared from the same yeast by the conventional method using Fehling reagent. Only a few degradat...

journal_title：FEBS open bio

authors： Kuraoka T,Ishiyama A,Oyamada H,Ogawa Y,Kobayashi H

更新日期：2018-12-10 00:00:00

abstract：:Extensive simple sequence repeat (SSR) surveys have been performed for eukaryotic prokaryotic and viral genomes, but information regarding SSRs in viroids is limited. We undertook a survey to examine the presence of SSRs in viroid genomes. Our results show that the distribution of SSRs in viroids may influence seconda...

journal_title：FEBS open bio

authors： Qin L,Zhang Z,Zhao X,Wu X,Chen Y,Tan Z,Li S

更新日期：2014-02-07 00:00:00

abstract：:Osteonecrosis of the femoral head (ONFH) is a common clinical disease with a high disability rate. Apoptosis of osteoblasts caused by high-dose short-term or low-dose long-term glucocorticoid (GC) administration is the biological basis of steroid-induced avascular necrosis of the femoral head (SANFH). The pathogenesis...

journal_title：FEBS open bio

authors： Peng P,Nie Z,Sun F,Peng H

更新日期：2020-11-15 00:00:00

abstract：:Osteosarcoma, one of the most common malignant bone tumors, is characterized by a high rate of metastasis, and the survival rate of patients with metastatic osteosarcoma is poor. Previous studies have reported that miRNAs often regulate the occurrence and development of various tumors. In this work, we identified miRN...

journal_title：FEBS open bio

authors： Zhu T,Fan D,Ye K,Liu B,Cui Z,Liu Z,Tian Y

更新日期：2020-04-01 00:00:00

abstract：:Adult T-cell leukemia/lymphoma (ATL), an aggressive T-cell malignancy that develops after long-term infection with human T-cell leukemia virus (HTLV-1), requires new treatments. Drug repositioning, reuse of a drug previously approved for the treatment of another condition to treat ATL, offers the possibility of reduce...

journal_title：FEBS open bio

authors： Kozako T,Soeda S,Yoshimitsu M,Arima N,Kuroki A,Hirata S,Tanaka H,Imakyure O,Tone N,Honda S,Soeda S

更新日期：2016-04-13 00:00:00

abstract：:Glioma is one of the most common types of malignant primary central nervous system tumor, and prognosis for this disease is poor. As autophagic drugs have been reported to induce glioma cell death, we investigated the potential prognostic role of autophagy-associated long non-coding RNA (lncRNA) in glioma patients. In...

journal_title：FEBS open bio

authors： Luan F,Chen W,Chen M,Yan J,Chen H,Yu H,Liu T,Mo L

更新日期：2019-03-05 00:00:00

abstract：:Human STIL (SCL/TAL1 interrupting locus) protein maintains centriole stability and spindle pole localisation. It helps in recruitment of CENPJ (Centromere protein J)/CPAP (centrosomal P4.1-associated protein) and other centrosomal proteins. Mutations in STIL protein are reported in several disorders, especially in der...

journal_title：FEBS open bio

authors： Kumar A,Rajendran V,Sethumadhavan R,Purohit R

更新日期：2012-09-25 00:00:00

abstract：:The extreme halophile Halococcus morrhuae (ATCC® 17082) contains a 108-nucleotide insertion in its 5S rRNA. Large rRNA expansions in Archaea are rare. This one almost doubles the length of the 5S rRNA. In order to understand how such an insertion is accommodated in the ribosome, we obtained a cryo-electron microscopy ...

journal_title：FEBS open bio

authors： Tirumalai MR,Kaelber JT,Park DR,Tran Q,Fox GE

更新日期：2020-10-01 00:00:00

abstract：:The antipsychotic drug olanzapine is widely prescribed to treat schizophrenia and other psychotic disorders. However, it often causes unwanted side effects, including diabetes, due to disruption of insulin-dependant glucose metabolism through a mechanism yet to be elucidated. To determine if olanzapine can affect the ...

journal_title：FEBS open bio

authors： Babkin P,George Thompson AM,Iancu CV,Walters DE,Choe JY

更新日期：2015-04-15 00:00:00

abstract：:miR-193a-3p is a tumor-related miRNA playing an essential role in tumorigenesis and progression of non-small cell lung cancer (NSCLC). The objective of the present study was to investigate the relationship between miR-193a-3p expression and clinical value and to further explore the potential signaling of miR-193a-3p i...

journal_title：FEBS open bio

authors： Gao X,Tang RX,Xie QN,Lin JY,Shi HL,Chen G,Li ZY

更新日期：2018-01-04 00:00:00

abstract：:Arbutin, a glycoside extracted from the plant Arctostaphylos uva-ursi, has been previously reported to possess antioxidant, anti-inflammatory and anticancer effects. Here, we investigated whether arbutin affects the proliferation of the cells of the osteosarcoma (OS) cell lines MG-63 and SW1353. Arbutin suppressed OS ...

journal_title：FEBS open bio

authors： Wang CQ,Wang XM,Li BL,Zhang YM,Wang L

更新日期：2020-11-03 00:00:00

abstract：:Sunitinib (Sun), a tyrosine kinase inhibitor of vascular endothelial growth factor receptor, is the standard first-line treatment against advanced clear cell renal cell carcinoma (RCC), but resistance to therapy is inevitable. Reactive oxygen species production is associated with sensitivity to chemotherapy, but the u...

journal_title：FEBS open bio

authors： Meng L,Chen D,Meng G,Lu L,Han C

更新日期：2021-01-16 00:00:00