Abstract:
:Hypoxia-inducible factor (HIF) is a crucial regulator of cellular and systemic responses to low oxygen levels. Here we firstly cloned three HIF-α isoforms from the basal branches of Osteichthyes and used computational tools to characterise the molecular change underlying the functional divergence of HIF-α isoforms in different lineages. Only the HIF-1α and HIF-2α in African lungfish and amphibians were found under positive selection. HIF-1α and -2α were less functionally divergent in basal ray-finned fish than in teleosts, and showed conserved but different transcriptional activity towards specific target genes.
journal_name
FEBS Open Biojournal_title
FEBS open bioauthors
Chi W,Gan X,Xiao W,Wang W,He Sdoi
10.1016/j.fob.2013.09.004subject
Has Abstractpub_date
2013-09-19 00:00:00pages
479-83issn
2211-5463pii
S2211-5463(13)00053-3journal_volume
3pub_type
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