Identification and analysis of micro-exons in AP2/ERF and MADS gene families.

abstract：:Increased glucose consumption is a known hallmark of cancer cells. Increased glycolysis provides ATP, reducing agents and substrates for macromolecular synthesis in intensely dividing cells. Therefore, inhibition of glycolysis is one strategy in anticancer therapy as well as in improved efficacy of conventional antica...

journal_title：FEBS open bio

authors： Korga A,Ostrowska M,Iwan M,Herbet M,Dudka J

更新日期：2019-05-01 00:00:00

abstract：:Arbutin, a glycoside extracted from the plant Arctostaphylos uva-ursi, has been previously reported to possess antioxidant, anti-inflammatory and anticancer effects. Here, we investigated whether arbutin affects the proliferation of the cells of the osteosarcoma (OS) cell lines MG-63 and SW1353. Arbutin suppressed OS ...

journal_title：FEBS open bio

authors： Wang CQ,Wang XM,Li BL,Zhang YM,Wang L

更新日期：2020-11-03 00:00:00

abstract：:Neural stem cells (NSC) from the adult hippocampus easily lose their activity in vitro. Efficient in vitro expansion of adult hippocampus-derived NSC is important for generation of tools for research and cell therapy. Here, we show that a single copy disruption or pharmacological inhibition of p38α enables successful ...

journal_title：FEBS open bio

authors： Yoshioka K,Namiki K,Sudo T,Kasuya Y

更新日期：2015-05-08 00:00:00

abstract：:Abscisic acid (ABA) response elements (ABREs) are a group of cis-acting DNA elements that have been identified from promoter analysis of many ABA-regulated genes in plants. We are interested in understanding the mechanism of binding specificity between ABREs and a class of bZIP transcription factors known as ABRE bind...

journal_title：FEBS open bio

authors： Sarkar AK,Lahiri A

更新日期：2013-01-22 00:00:00

abstract：:Immunoglobulin (Ig) A nephropathy (IgAN) is the most common glomerulonephritis, which is characterized by the deposition of IgA antibody in the glomerulus. Systematic dissection of immune composition may contribute to a better understanding of the alternations in the immune system in IgAN. To this end, here we applied...

journal_title：FEBS open bio

authors： Zhang X,Zeng J,Tong Y,Zhang L,Lu X,Zhu S,Li Z

更新日期：2020-12-01 00:00:00

abstract：:Mediterranean Carthamus tinctorius (Safflower) is used for treatment of inflammatory conditions and neuropsychiatric disorders. Recently C. tinctorius lignans arctigenin and trachelogenin but not matairesinol were described to interfere with the activity of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO)...

journal_title：FEBS open bio

authors： Temml V,Kuehnl S,Schuster D,Schwaiger S,Stuppner H,Fuchs D

更新日期：2013-09-07 00:00:00

abstract：:Oxidative stress in plants causes ferredoxin down-regulation and NADP(+) shortage, over-reduction of the photosynthetic electron transport chain, electron leakage to oxygen and generation of reactive oxygen species (ROS). Expression of cyanobacterial flavodoxin in tobacco chloroplasts compensates for ferredoxin declin...

journal_title：FEBS open bio

authors： Giró M,Ceccoli RD,Poli HO,Carrillo N,Lodeyro AF

更新日期：2011-11-11 00:00:00

abstract：:The gene encoding MG Orn has been identified from a metagenomic library created from the intertidal zone in Svalbard and encodes a protein of 184 amino acid residues. The mg orn gene has been cloned, recombinantly expressed in Escherichia coli, and purified to homogeneity. Biochemical characterization of the enzyme sh...

journal_title：FEBS open bio

authors： Piotrowski Y,Berg K,Klebl DP,Leiros I,Larsen AN

更新日期：2019-10-01 00:00:00

abstract：:Osteosarcoma is the most common primary solid malignancy of the bone, and its high mortality usually correlates with early metastasis. In this study, we developed a risk score model to help predict metastasis at the time of diagnosis. We downloaded and mined four expression profile datasets associated with osteosarcom...

journal_title：FEBS open bio

authors： Dong S,Huo H,Mao Y,Li X,Dong L

更新日期：2019-02-02 00:00:00

abstract：:Shiga toxin (Stx) causes fatal systemic complications. Stx induces apoptosis, but the mechanism of which is unclear. We report that Stx induced rapid reduction of short-lived anti-apoptotic proteins followed by activation of caspase 9 and the progression of apoptosis. Proteasome inhibitors prevented the reduction of a...

journal_title：FEBS open bio

authors： Hattori T,Watanabe-Takahashi M,Ohoka N,Hamabata T,Furukawa K,Nishikawa K,Naito M

更新日期：2015-06-12 00:00:00

abstract：:The proton-coupled folate transporter (PCFT, SLC46A1) transports folic acid across the plasma membrane, together with an excess of protons such that the net charge translocation is positive. We developed 3D structural models of PCFT threaded onto the X-ray structures of major facilitator superfamily (MFS) members that...

journal_title：FEBS open bio

authors： Date SS,Chen CY,Chen Y,Jansen M

更新日期：2016-02-22 00:00:00

abstract：:The expression of death receptor 6 (DR6) is abnormal in some cancer types, but the function and underlying molecular mechanisms of DR6 in tumor progression are not yet clear. In the present study, our analysis of ovarian cancer RNA sequencing data from The Cancer Genome Atlas revealed that DR6 is upregulated in human ...

journal_title：FEBS open bio

authors： Shi B,Bao J,Liu Y,Shi J

更新日期：2018-08-07 00:00:00

abstract：:Human type 2 diabetes is associated with β-cell apoptosis, and human islets from diabetic donors are ∼80% deficient in PAK1 protein. Toward addressing linkage of PAK1 to β-cell survival, PAK1-siRNA targeted MIN6 pancreatic β-cells were found to exhibit increased caspase-3 cleavage, cytosolic cytochrome-C and the pro-a...

journal_title：FEBS open bio

authors： Wang Z,Thurmond DC

更新日期：2012-09-08 00:00:00

abstract：:An imbalance of branched-chain amino acids (BCAAs) in the brain may result in neuropathological conditions, such as autism spectrum disorders. The L-type amino acid transporter 1 (LAT1), encoded by the solute carrier transporter 7a5 (Slc7a5) gene, is critical for maintaining normal levels of BCAAs in the brain. Howeve...

journal_title：FEBS open bio

authors： Onishi Y,Hiraiwa M,Kamada H,Iezaki T,Yamada T,Kaneda K,Hinoi E

更新日期：2019-01-07 00:00:00

abstract：:RAC3 is a coactivator of glucocorticoid receptor and nuclear factor-κB (NF-κB) that is usually over-expressed in tumors and which also has important functions in the immune system. We investigated the role of the inflammatory response in the control of RAC3 expression levels in vivo and in vitro. We found that inflamm...

journal_title：FEBS open bio

authors： Alvarado CV,Rubio MF,Fernández Larrosa PN,Panelo LC,Azurmendi PJ,Ruiz Grecco M,Martínez-Nöel GA,Costas MA

更新日期：2014-05-02 00:00:00

abstract：:Extensive simple sequence repeat (SSR) surveys have been performed for eukaryotic prokaryotic and viral genomes, but information regarding SSRs in viroids is limited. We undertook a survey to examine the presence of SSRs in viroid genomes. Our results show that the distribution of SSRs in viroids may influence seconda...

journal_title：FEBS open bio

authors： Qin L,Zhang Z,Zhao X,Wu X,Chen Y,Tan Z,Li S

更新日期：2014-02-07 00:00:00

abstract：:Redox-coupled folding pathways of bovine pancreatic ribonuclease A (RNase A) with four intramolecular disulfide (SS) bonds comprise three phases: (I) SS formation to generate partially oxidized intermediate ensembles with no rigid folded structure; (II) SS rearrangement from the three SS intermediate ensemble (3S) to ...

journal_title：FEBS open bio

authors： Arai K,Kumakura F,Iwaoka M

更新日期：2012-04-16 00:00:00

abstract：:Inorganic polyphosphate (polyP) is a linear polymer containing tens to hundreds of orthophosphate residues linked by high-energy phosphoanhydride bonds. PolyP promotes osteocalcification and bone mineralization in both mouse and human osteoblastic cells. In the present study, we examined the molecular mechanism by whi...

journal_title：FEBS open bio

authors： Tsutsumi K,Sasase T

更新日期：2019-09-01 00:00:00

abstract：:Tight regulation of the eukaryotic cell cycle is paramount to ensure genomic integrity throughout life. Cell cycle checkpoints are present in each phase of the cell cycle and prevent cell cycle progression when genomic integrity is compromised. The G2 checkpoint is an intricate signaling network that regulates the pro...

journal_title：FEBS open bio

authors： de Gooijer MC,van den Top A,Bockaj I,Beijnen JH,Würdinger T,van Tellingen O

更新日期：2017-03-04 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) has been identified as a crucial inflammatory cytokine in immune homeostasis. Previous studies have reported conflicting effects of TSLP on sepsis in mice, and the effect of TSLP on sepsis in humans has not been investigated. In this study, we used the ELISA to measure serum levels ...

journal_title：FEBS open bio

authors： Yu Q,Li Y,Wang H,Xiong H

更新日期：2019-12-01 00:00:00

abstract：:Hirschmanniella mucronata is a plant-parasitic nematode that is widespread in rice production areas and causes 10-25% yield losses a year on average. Here, we investigated the mechanism of resistance to this nematode by comparing the transcriptomes of roots from resistant (Jiabali) and susceptible (Bawangbian) varieti...

journal_title：FEBS open bio

authors： Sun X,Zhang L,Tang Z,Shi X,Ma J,Cui R

更新日期：2019-11-01 00:00:00

abstract：:Osteosarcoma is a malignant bone tumor, and clinically detectable metastases can be detected in ~ 15-20% of patients when they seek medical advice; patients with metastatic disease have extremely poor prognosis. Here, we examined the involvement of the microRNA miR-505 in osteosarcoma. Eighty-four patients seeking tre...

journal_title：FEBS open bio

authors： Li G,Liu F,Miao J,Hu Y

更新日期：2020-07-01 00:00:00

abstract：:Glutathione transferases (GSTs) are involved in many processes in plant biochemistry, with their best characterised role being the detoxification of xenobiotics through their conjugation with glutathione. GSTs have also been implicated in noncatalytic roles, including the binding and transport of small heterocyclic li...

journal_title：FEBS open bio

authors： Ahmad L,Rylott EL,Bruce NC,Edwards R,Grogan G

更新日期：2016-12-22 00:00:00

abstract：:A plant-derived Enterococcus mundtii 15-1A, that has been previously isolated from Brassica rapa L. subsp. nipposinica (L.H. Bailey) Hanelt var. linearifolia by our group, possesses two kinds of l-lactate dehydrogenase (l-LDH): LDH-1 and LDH-2. LDH-1 was activated under low concentration of fluctose-1,6-bisphosphate (...

journal_title：FEBS open bio

authors： Matoba Y,Miyasako M,Matsuo K,Oda K,Noda M,Higashikawa F,Kumagai T,Sugiyama M

更新日期：2014-09-06 00:00:00

abstract：:A great number of studies have proven that sHsps protect cells by inhibiting protein aggregation under heat stress, while little is known about their function to protect cells under acid stress. In this work, we show that Hsp20.1 and Hsp14.1 oligomers dissociated to smaller oligomeric species or even dimer/monomer at ...

journal_title：FEBS open bio

authors： Liu L,Chen J,Yang B,Wang Y

更新日期：2015-03-05 00:00:00

abstract：:Despite significant advances in understanding of the causes of and treatment of myocardial infarction (MI) in recent years, morbidity and mortality is still high. The aim of this study was to identify miRNA and genes potentially associated with MI. mRNA and miRNA expression datasets were downloaded from the Gene Expre...

journal_title：FEBS open bio

authors： Wu K,Zhao Q,Li Z,Li N,Xiao Q,Li X,Zhao Q

更新日期：2018-04-19 00:00:00

abstract：:Nisin is the most prominent and applied bacteriocin that serves as a model for class I lantibiotics. The nisin leader peptide importantly determines interactions between precursor nisin and its modification enzymes NisB and NisC that mature nisin posttranslationally. NisB dehydrates serines and threonines, while NisC ...

journal_title：FEBS open bio

authors： Khusainov R,Moll GN,Kuipers OP

更新日期：2013-05-30 00:00:00

abstract：:Lactobionic acid (O-β-galactosyl-(1-4)-gluconic acid) (LBA) is a high-value lactose derivative, produced via oxidation of the reducing terminal of lactose. LBA can be produced by fermentation using certain microorganisms, although subsequent purification is challenging. Therefore, we have attempted to identify an enzy...

journal_title：FEBS open bio

authors： Lin SF,Li CK,Chung YP

更新日期：2019-01-16 00:00:00

abstract：:Flavin adenine dinucleotide (FAD), synthesized from riboflavin, is redox cofactor in energy production and plays an important role in cell survival. More recently, riboflavin deficiency has been linked to developmental disorders, but its role in stem cell differentiation remains unclear. Here, we show that FAD treatme...

journal_title：FEBS open bio

authors： Hirano K,Namihira M

更新日期：2017-10-17 00:00:00

abstract：:The identification of non-invasive biomarkers for the detection of renal cell carcinoma (RCC) in early-stage patients may help improve disease outcome. Certain long non-coding RNAs (lncRNAs) have been reported to be possible biomarkers for the diagnosis and prognosis of cancer. Here, we examined the suitability of the...

journal_title：FEBS open bio

authors： Xie J,Zhong Y,Chen R,Li G,Luo Y,Yang J,Sun Z,Liu Y,Liu P,Wang N,An J,Li C,Song Y

更新日期：2020-09-01 00:00:00