Abstract:
:Due to its exceptionally small genome size and protogynous hermaphroditism, Monopterus albus has been proposed as a model for vertebrate sexual development. The Kiss/GPR54 system is a central regulator of sexual development in most vertebrates, but its role in sex reversal remains hypothetical. In contrast to mammals, fishes often possess more than one copy of the kiss and gpr54 genes. Our objectives were to identify all kiss/gpr54 genes in the genome of M. albus and to assess their involvement in sex reversal via their expression patterns (qPCR) in females, males, and intersex specimens. We identified only two genes: kiss2 and gpr54-2. kiss2 expression was extremely high in the gonads of males, intermediate in females, and low in intersex; and reduced in all tissues of intersex. gpr54 expression was also extremely high in the gonads of males, high in intersex, but low in females. gpr54 expression in brain was high in all three sexes. In conclusion, (a) kiss1 has been functionally replaced in M. albus; (b) the functions of gpr54-2 in brain are not sex-specific; (c) kiss2 appears to undergo a 'reset' in the expression during the sex change; and (d) sex-specific expression patterns in the gonads indicate that these two genes may play a role in sex reversal in fish.
journal_name
FEBS Open Biojournal_title
FEBS open bioauthors
Yi TL,Pei MT,Yang DQdoi
10.1002/2211-5463.12727subject
Has Abstractpub_date
2019-10-01 00:00:00pages
1835-1844issue
10issn
2211-5463journal_volume
9pub_type
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